LOCUS BC035807 1806 bp mRNA linear HUM 27-JAN-2004
DEFINITION Homo sapiens intestinal cell (MAK-like) kinase, mRNA (cDNA clone
IMAGE:5745248), complete cds.
ACCESSION BC035807
VERSION BC035807.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1806)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 1806)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (31-JUL-2002) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Life Technologies, Inc.
cDNA Library Preparation: Life Technologies, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: National Institutes of Health Intramural
Sequencing Center (NISC),
Gaithersburg, Maryland;
Web site: http://www.nisc.nih.gov/
Contact: nisc_mgc@nhgri.nih.gov
Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
Young,A., Zhang,L.-H. and Green,E.D.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 79 Row: l Column: 17
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 27477121
This clone has the following problem: The cds is short compared to
the longest cds in the locus.
FEATURES Location/Qualifiers
source 1..1806
/db_xref="H-InvDB:HIT000051517"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="IMAGE:5745248"
/tissue_type="Brain, adult medulla"
/clone_lib="NIH_MGC_119"
/lab_host="DH10B"
/note="Vector: pCMV-SPORT6"
gene 1..1806
/gene="ICK"
/gene_synonym="KIAA0936"
/gene_synonym="LCK2"
/gene_synonym="MGC46090"
/gene_synonym="MRK"
/db_xref="GeneID:22858"
CDS 412..1290
/gene="ICK"
/gene_synonym="KIAA0936"
/gene_synonym="LCK2"
/gene_synonym="MGC46090"
/gene_synonym="MRK"
/codon_start=1
/product="ICK protein"
/protein_id="AAH35807.1"
/db_xref="GeneID:22858"
/translation="MNRYTTIRQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEE
CMNLREVKSLKKLNHANVVKLKEVIRENDHLYFIFEYMKENLYQLIKERNKLFPESAI
RNIMYQILQGLAFIHKHGFFHRDLKPENLLCMGPELVKIADFGLAREIRSKPPYTDYV
STRWYRAPEVLLRSTNYSSPIDVWAVGCIMAEVYTLRPLFPGASEIDTIFKICQVLGT
PKKTDWPEGYQLSSAMNFRWPQCVPNNLKTLIPNASSEAVQLLRDMLQWDPKKRPTAS
QVFFHFLVITFISNSE"
misc_feature 418..1254
/gene="ICK"
/gene_synonym="KIAA0936"
/gene_synonym="LCK2"
/gene_synonym="MGC46090"
/gene_synonym="MRK"
/note="S_TKc; Region: Serine/Threonine protein kinases,
catalytic domain. Phosphotransferases of the serine or
threonine-specific kinase subfamily. The enzymatic
activity of these protein kinases is controlled by
phosphorylation of specific residues in the activation
segment of the catalytic domain, sometimes combined with
reversible conformational changes in the C-terminal
autoregulatory tail"
/db_xref="CDD:cd00180"
BASE COUNT 594 a 332 c 365 g 515 t
ORIGIN
1 gttatgagaa ggatattgac ggatattcca gaacaactga ttcttttgta atgttaacct
61 tttaaagttt gactttgaca ctaacattaa ggacttatat gtaatatagc taatgcatca
121 ttctgcagag aagagtattc ctttccactt acaactaaat aagacctgct tttgctggag
181 ctgtgctagg ctgagggaat tccacactga attttacaag cgggatggat ttctctaagg
241 cagaagactg atttttggaa atatgtattt gggagacagt cacgtcctat tgaatacctt
301 gtgctggtgc tgccatcgaa aaatctggtt acactctggg gaggactgct accactgcag
361 aactgaacca cttcggccgt gagatgagtg tccggcctga gcaggcacac catgaataga
421 tacacaacaa tcaggcagct cggggatgga acctacggtt ccgtcctgct gggaagaagc
481 attgagtctg gggagctgat cgctattaaa aaaatgaaaa gaaaatttta ttcctgggag
541 gaatgcatga accttcggga ggttaagtct ttaaagaagc tcaaccatgc caatgtagtc
601 aaattaaaag aagttatcag ggaaaatgat catctttatt ttatcttcga gtacatgaag
661 gaaaatcttt accagctcat taaagagaga aataagttgt ttcctgagtc tgctataagg
721 aatatcatgt atcagatatt acaaggactc gcatttattc acaaacacgg cttctttcat
781 cgagacttaa agcctgagaa cctcctctgc atgggaccag aacttgtgaa aattgcagac
841 tttggtttgg cccgagaaat acgatcaaaa cctccatata cagattatgt atctaccaga
901 tggtacaggg ctccagaagt actcctgagg tctaccaact acagctcccc cattgacgtc
961 tgggcggtgg gctgcatcat ggcagaagtt tacaccctca ggccactctt ccctggagcc
1021 agtgaaattg acacaatatt caaaatttgc caagtgctgg ggacaccaaa aaagactgac
1081 tggcctgaag gctatcaact ttcaagtgca atgaacttcc gttggccaca gtgtgtaccc
1141 aataacttaa agaccttgat tcccaatgct agcagtgaag cagtccagct cctgagagac
1201 atgcttcagt gggatcccaa gaaacgacca acagctagtc aggttttctt ccattttctt
1261 gttataacgt tcatatctaa ctctgaataa tttctatgaa ttgcacagga aatatttagt
1321 atttagtatt atgggtgaga aatagtacag aataccacta atggtgtact atataaggta
1381 tgagaactta aaatagtttg aaacttactg ggtataaagt agttacaatg taaacaatat
1441 agttgctttg aaaattggca tgtaattcac atgatatatc accatttata tggaaatgga
1501 aataaacata tatttatccg tctttggaga atgttttcaa atctattctc tatgagttac
1561 aattatatag tagtttgttt ataagccggt actggttgtt gaaaggcaac ttcatattat
1621 gtaaaagtcc aactgactca taacctgaag agattgacag atgagataga cctaggatag
1681 taactgcact tagtatttca tagcacttta cagtgtgcaa atgcttgaat atattttata
1741 tgatttttaa tccaataaag actccatgag acaggcaaaa aaaaaaaaaa aaaaaaaaaa
1801 aaaaaa
//