LOCUS       BC034013                3180 bp    mRNA    linear   HUM 15-JUL-2006
DEFINITION  Homo sapiens Rho guanine nucleotide exchange factor (GEF) 1, mRNA
            (cDNA clone MGC:21456 IMAGE:3451036), complete cds.
ACCESSION   BC034013
VERSION     BC034013.1
KEYWORDS    MGC.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3180)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
   PUBMED   12477932
REFERENCE   2  (bases 1 to 3180)
  CONSRTM   NIH MGC Project
  TITLE     Direct Submission
  JOURNAL   Submitted (02-JUL-2002) National Institutes of Health, Mammalian
            Gene Collection (MGC), Bethesda, MD 20892-2590, USA
  REMARK    NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT     Contact: MGC help desk
            Email: cgapbs-r@mail.nih.gov
            Tissue Procurement: ATCC
            cDNA Library Preparation: Life Technologies, Inc.
            cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
            DNA Sequencing by: Sequencing Group at the Stanford Human Genome
            Center, Stanford University School of Medicine, Stanford, CA  94305
            Web site:       http://www-shgc.stanford.edu
            Contact:  (Dickson, Mark) mcd@paxil.stanford.edu
            Dickson, M., Schmutz, J., Grimwood, J., Rodriquez, A., and Myers,
            R. M.
            
            Clone distribution: MGC clone distribution information can be found
            through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
            Series: IRAK Plate: 20 Row: a Column: 19
            This clone was selected for full length sequencing because it
            passed the following selection criteria: Similarity but not
            identity to protein.
FEATURES             Location/Qualifiers
     source          1..3180
                     /db_xref="H-InvDB:HIT000042038"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /clone="MGC:21456 IMAGE:3451036"
                     /tissue_type="Placenta, choriocarcinoma"
                     /clone_lib="NIH_MGC_10"
                     /lab_host="DH10B"
                     /note="Vector: pCMV-SPORT6"
     gene            1..3180
                     /gene="ARHGEF1"
                     /gene_synonym="GEF1"
                     /gene_synonym="LBCL2"
                     /gene_synonym="P115-RHOGEF"
                     /gene_synonym="SUB1.5"
                     /db_xref="GeneID:9138"
                     /db_xref="HGNC:HGNC:681"
                     /db_xref="MIM:601855"
     CDS             21..2804
                     /gene="ARHGEF1"
                     /gene_synonym="GEF1"
                     /gene_synonym="LBCL2"
                     /gene_synonym="P115-RHOGEF"
                     /gene_synonym="SUB1.5"
                     /codon_start=1
                     /product="Rho guanine nucleotide exchange factor (GEF) 1"
                     /protein_id="AAH34013.2"
                     /db_xref="GeneID:9138"
                     /db_xref="HGNC:HGNC:681"
                     /db_xref="MIM:601855"
                     /translation="MASLSTWSSPAEPREMEDFARGAASPGPSRPGLVPVSIIGAEDE
                     DFENELETNSEEQNSQFQSLEQVKRRPAHLMALLQHVALQFEPGPLLCCLHADMLGSL
                     GPKEAKKAFLDFYHSFLEKTAVLRVPVPPNVAFELDRTRADLISEDVQRRFVQEVVQS
                     QQVAVGRQLEDFRSKRLMGMTPWEQELAQLEAWVGRDRASYEARERHVAERLLMHLEE
                     MQHTISTDEEKSAAVVNAIGLYMRHLGVRTKSGDKKSGRNFFRKKVMGNRRSDEPAKT
                     KKGLSSILDAARWNRGEPQVPDFRHLKAEVDAEKPGATDRKGGVGMPSRDRNIGAPGQ
                     DTPGVSLHPLSLDSPDREPGADAPLELGDSSPQGPMSLESLAPPESTDEGAETESPEP
                     GDEGEPGRSGLELEPEEPPGWRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRML
                     RVLHDLFFQPMAECLFFPLEELQNIFPSLDELIEVHSLFLDRLMKRRQESGYLIEEIG
                     DVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRR
                     LQLKDMIPTEMQRLTKYPLLLQSIGQNTEEPTEREKVELAAECCREILHHVNQAVRDM
                     EDLLRLKDYQRRLDLSHLRQSSDPMLSEFKNLDITKKKLVHEGPLTWRVTKDKAVEVH
                     VLLLDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVATDHKAF
                     YVLFTWDQEAQIYELVAQTVSERKNWCALITETAGSLKVPAPASRPKPRPSPSSTREP
                     LLSSSENGNGGRETSPADARTERILSDLLPFCRPGPEGQLAATALRKVLSLKQLLFPA
                     EEDNGAGPPRDGDGVPGGGPLSPARTQEIQENLLSLEETMKQLEELEEEFCRLRPLLS
                     QLGGNSVPQPGCT"
BASE COUNT          648 a          990 c         1011 g          531 t
ORIGIN      
        1 cttcggttcc ggtggcggcg atggcttctc tttccacctg gagcagccct gcagagccca
       61 gggagatgga agacttcgcc cgaggggcgg cctccccagg cccctcccgg cctggcctgg
      121 ttcccgtcag catcatcggg gctgaggatg aggattttga gaacgagctg gagacaaact
      181 cagaagagca aaacagccag ttccagagcc tggagcaggt gaagcggcgc ccagcccacc
      241 tcatggccct cctgcagcac gtggccctgc agtttgagcc aggacccctg ctttgctgtc
      301 tgcatgccga catgctgggc tcactgggcc ccaaggaggc caagaaggcc ttcctggact
      361 tctaccacag cttcctggag aagacagcgg ttctccgggt gccggtccct cccaacgtcg
      421 cctttgaact tgaccgcact agggctgacc tcatctccga ggatgtccag cggcggttcg
      481 tgcaggaggt ggtgcaaagc cagcaggtag ccgtgggccg gcagctggag gacttccgtt
      541 ccaagcggct catgggcatg acgccctggg agcaggagct ggcccagctg gaggcttggg
      601 ttgggcggga ccgagccagc tacgaggccc gggagcggca cgtggcggag cggctgctca
      661 tgcacctgga ggagatgcaa cataccatct ctaccgacga agaaaagagt gctgccgtgg
      721 tcaacgccat tggcctgtac atgcgccacc ttggggtgcg gaccaagagt ggagacaaga
      781 agtcggggag gaacttcttc cggaaaaagg tgatggggaa ccggcggtcg gacgagcctg
      841 ccaagaccaa gaaggggctg agcagcatcc tggatgccgc ccgctggaac cggggagagc
      901 cccaggttcc agattttcga cacctcaaag cagaggttga tgccgagaag ccaggtgcta
      961 cagaccggaa gggaggcgtg gggatgccct ctcgggaccg gaatatcggg gctcctgggc
     1021 aggacacccc tggagtctct ctgcaccctc tgtccctgga cagcccagac cgggaaccag
     1081 gtgctgacgc ccccctggag ctgggggact catccccgca gggcccaatg agcctggagt
     1141 ccttggcgcc cccagagagt accgacgagg gggccgaaac cgagagcccc gagcctggag
     1201 atgaggggga gccggggcgg tcgggactgg agcttgaacc agaagagcct cccggctggc
     1261 gggaactcgt ccccccagac accctgcaca gcctgcccaa gagccaggtg aagcggcagg
     1321 aggtcatcag cgagctgctg gtgacagagg cggcccacgt gcgcatgctg cgggtgctgc
     1381 acgacctctt cttccagccc atggcagaat gcctgttctt ccccttggag gagctgcaga
     1441 acatcttccc cagcctggac gagctcatcg aggtgcattc cctgttcctc gatcgcctga
     1501 tgaagcggag gcaggagagt ggctacctca tcgaggagat cggagacgtg ctgctggccc
     1561 ggtttgatgg tgctgagggc tcctggttcc agaaaatctc ctcccgcttc tgcagccgcc
     1621 agtcatttgc cttagagcag ctcaaagcca agcaacgcaa ggaccctcgg ttctgtgcct
     1681 tcgtgcagga agctgagagc cgcccgcggt gccgccgcct gcagctgaag gacatgatcc
     1741 ccacggagat gcagcggctg accaagtacc ccctgctcct gcagagcatc gggcagaaca
     1801 cagaagagcc cacagaacgg gagaaagtgg agctggcagc cgagtgctgc cgggaaattc
     1861 tacaccacgt caaccaagcc gtgcgtgaca tggaggacct gctgaggctc aaggactatc
     1921 agcggcgcct ggacttgtcc caccttcggc agagcagcga ccctatgctg agcgagttca
     1981 agaacctgga catcaccaag aagaaattgg tccacgaggg cccactgacg tggcgggtga
     2041 ctaaggacaa ggcagtggag gtgcatgtgc tgctgctgga cgacctgctg ctgctgctcc
     2101 agcgccagga cgagcggctg ctgctcaagt cccatagccg gacactgacg cccacgcccg
     2161 atggcaagac catgctgcgg cccgtgctgc ggctcacctc cgccatgacc cgcgaggtgg
     2221 ccaccgatca caaagccttc tacgtccttt ttacctggga ccaggaggcc cagatatacg
     2281 agctggtggc acagactgtg tcggagcgga aaaactggtg tgctctcatc actgagactg
     2341 ccggatccct gaaagtccct gcccctgcct ctcgccctaa gccccggccc agcccgagca
     2401 gcacccgaga acccctcctc agcagctctg agaacggcaa tggtggccga gagacgtctc
     2461 cagctgatgc ccggaccgag agaatcctca gtgacctcct gcccttctgc agaccaggcc
     2521 ccgagggcca gctcgctgcc acggcccttc ggaaagtgct gtccctgaag cagcttctgt
     2581 ttccggcgga ggaagacaat ggggcggggc ctcctcgaga tggggatggg gtcccagggg
     2641 gcggccccct gagcccagca cggacccagg aaatccagga gaacctgctc agcttggagg
     2701 agaccatgaa gcagctggag gagttggagg aggaattttg ccgcctgaga cccctcctgt
     2761 ctcagcttgg ggggaactct gtcccccagc ctggctgcac ttgaggttcc cgcccaggaa
     2821 ggccttttgc aagaaggaga ggaatggggg agaggacgtg agggaccacc cccacccaca
     2881 cagctgccgc agcatctcac accccgaggg cctgaggaga gggagctgtg ggccacgcct
     2941 gggaggggcc cagctggggt tactggcccc gcatgagcct cggccatctc tccctcctgc
     3001 cctctgcttg ggggactcag ggctccattc tggagggcac cacggtgacc cgggccatct
     3061 cagtattgcc tgtgggggcc acccctccac ccccaccccc aagtgccttc gctctgtttt
     3121 tataccctga attggaggtt tattttttaa tatatattat ctaagaaaaa aaaaaaaaaa
//