LOCUS BC033867 3062 bp mRNA linear HUM 07-OCT-2003
DEFINITION Homo sapiens activin A receptor, type I, mRNA (cDNA clone MGC:45017
IMAGE:5209711), complete cds.
ACCESSION BC033867
VERSION BC033867.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3062)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 3062)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (02-JUL-2002) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Life Technologies, Inc.
cDNA Library Preparation: Life Technologies, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: National Institutes of Health Intramural
Sequencing Center (NISC),
Gaithersburg, Maryland;
Web site: http://www.nisc.nih.gov/
Contact: nisc_mgc@nhgri.nih.gov
Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
Young,A., Zhang,L.-H. and Green,E.D.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 68 Row: n Column: 2
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 10862690.
FEATURES Location/Qualifiers
source 1..3062
/db_xref="H-InvDB:HIT000042004"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:45017 IMAGE:5209711"
/tissue_type="Lung, Spleen, fetal, pooled"
/clone_lib="NIH_MGC_122"
/lab_host="DH10B"
/note="Vector: pCMV-SPORT6"
gene 1..3062
/gene="ACVR1"
/gene_synonym="ACTRI"
/gene_synonym="ACVRLK2"
/gene_synonym="ALK2"
/gene_synonym="SKR1"
/db_xref="GeneID:90"
/db_xref="MIM:102576"
CDS 431..1960
/gene="ACVR1"
/gene_synonym="ACTRI"
/gene_synonym="ACVRLK2"
/gene_synonym="ALK2"
/gene_synonym="SKR1"
/codon_start=1
/product="ACVR1 protein"
/protein_id="AAH33867.1"
/db_xref="GeneID:90"
/db_xref="MIM:102576"
/translation="MVDGVMILPVLIMIALPSPSMEDEKPKVNPKLYMCVCEGLSCGN
EDHCEGQQCFSSLSINDGFHVYQKGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRN
ITAQLPTKGKSFPGTQNFHLEVGLIILSVVFAVCLLACLLGVALRKFKRRNQERLNPR
DVEYGTIEGLITTNVGDSTLADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGR
YGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSS
TQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAH
RDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQ
VDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCV
DQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKIDNSLDKLKTD
C"
misc_feature 488..751
/gene="ACVR1"
/gene_synonym="ACTRI"
/gene_synonym="ACVRLK2"
/gene_synonym="ALK2"
/gene_synonym="SKR1"
/note="Activin_recp; Region: Activin types I and II
receptor domain. This Pfam entry consists of both TGF-beta
receptor types. This is an alignment of the hydrophilic
cysteine-rich ligand-binding domains, Both receptor types,
(type I and II) posses a 9 amino acid cysteine box, with
the the consensus CCX{4-5}CN. The type I receptors also
possess 7 extracellular residues preceding the cysteine
box"
/db_xref="CDD:pfam01064"
misc_feature 965..1054
/gene="ACVR1"
/gene_synonym="ACTRI"
/gene_synonym="ACVRLK2"
/gene_synonym="ALK2"
/gene_synonym="SKR1"
/note="GS; Region: GS motif"
/db_xref="CDD:smart00467"
misc_feature 1052..1921
/gene="ACVR1"
/gene_synonym="ACTRI"
/gene_synonym="ACVRLK2"
/gene_synonym="ALK2"
/gene_synonym="SKR1"
/note="pkinase; Region: Protein kinase domain"
/db_xref="CDD:pfam00069"
BASE COUNT 851 a 654 c 702 g 855 t
ORIGIN
1 gaagagatgt gggcctctgg ggccgctgga ttcagtaact tccgtcgggt tctagactgg
61 ctcggctctg tccagtttgt gccagatagt ctcccacccc ctccccaccc ctcctttccc
121 ctggagattt gaacgctgct tgcatgggag aaaagctact tagagaagaa aacgttccac
181 ttagtaacag aagaaaagtc ttggttaaaa agttgtcatg aatttggctt ttggagagag
241 gcagcaagcc tggagcattg gtaagcgtca cactgccaaa gtgagagctg ctggagaact
301 cataatccca ggaacgcctc ttctactctc cgagtacccc agtgaccaga gtgagagaag
361 ctctgaacga gggcacgcgg cttgaaggac tgtgggcaga tgtgaccaag agcctgcatt
421 aagttgtaca atggtagatg gagtgatgat tcttcctgtg cttatcatga ttgctctccc
481 ctcccctagt atggaagatg agaagcccaa ggtcaacccc aaactctaca tgtgtgtgtg
541 tgaaggtctc tcctgcggta atgaggacca ctgtgaaggc cagcagtgct tttcctcact
601 gagcatcaac gatggcttcc acgtctacca gaaaggctgc ttccaggttt atgagcaggg
661 aaagatgacc tgtaagaccc cgccgtcccc tggccaagct gtggagtgct gccaagggga
721 ctggtgtaac aggaacatca cggcccagct gcccactaaa ggaaaatcct tccctggaac
781 acagaatttc cacttggagg ttggcctcat tattctctct gtagtgttcg cagtatgtct
841 tttagcctgc ctgctgggag ttgctctccg aaaatttaaa aggcgcaacc aagaacgcct
901 caatccccga gacgtggagt atggcactat cgaagggctc atcaccacca atgttggaga
961 cagcacttta gcagatttat tggatcattc gtgtacatca ggaagtggct ctggtcttcc
1021 ttttctggta caaagaacag tggctcgcca gattacactg ttggagtgtg tcgggaaagg
1081 caggtatggt gaggtgtgga ggggcagctg gcaaggggaa aatgttgccg tgaagatctt
1141 ctcctcccgt gatgagaagt catggttcag ggaaacggaa ttgtacaaca ctgtgatgct
1201 gaggcatgaa aatatcttag gtttcattgc ttcagacatg acatcaagac actccagtac
1261 ccagctgtgg ttaattacac attatcatga aatgggatcg ttgtacgact atcttcagct
1321 tactactctg gatacagtta gctgccttcg aatagtgctg tccatagcta gtggtcttgc
1381 acatttgcac atagagatat ttgggaccca agggaaacca gccattgccc atcgagattt
1441 aaagagcaaa aatattctgg ttaagaagaa tggacagtgt tgcatagcag atttgggcct
1501 ggcagtcatg cattcccaga gcaccaatca gcttgatgtg gggaacaatc cccgtgtggg
1561 caccaagcgc tacatggccc ccgaagttct agatgaaacc atccaggtgg attgtttcga
1621 ttcttataaa agggtcgata tttgggcctt tggacttgtt ttgtgggaag tggccaggcg
1681 gatggtgagc aatggtatag tggaggatta caagccaccg ttctacgatg tggttcccaa
1741 tgacccaagt tttgaagata tgaggaaggt agtctgtgtg gatcaacaaa ggccaaacat
1801 acccaacaga tggttctcag acccgacatt aacctctctg gccaagctaa tgaaagaatg
1861 ctggtatcaa aatccatccg caagactcac agcactgcgt atcaaaaaga ctttgaccaa
1921 aattgataat tccctcgaca aattgaaaac tgactgttga cattttcata gtgtcaagaa
1981 ggaagatttg acgttgttgt cattgtccag ctgggaccta atgctggcct gactggttgt
2041 cagaatggaa tccatctgtc tccctcccca aatggctgct ttgacaaggc agacgtcgta
2101 cccagccatg tgttggggag acatcaaaac caccctaacc tcgctcgatg actgtgaact
2161 gggcatttca cgaactgttc acactgcaga gactaatgtt ggacagacac tgttgcaaag
2221 gtagggactg gaggaacaca gagaaatcct aaaagagatc tgggcattaa gtcagtggct
2281 ttgcatagct ttcacaagtc tcctagacac tccccacggg aaactcaagg aggtggtgaa
2341 tttttaatca gcaatattgc ctgtgcttct cttctttatt gcactaggaa ttctttgcat
2401 tccttacttg cactgttact cttaatttta aagacccaac ttgccaaaat gttggctgcg
2461 tactccactg gtctgtcttt ggataatagg aattcaattt ggcaaaacaa aatgtaatgt
2521 cagactttgc tgcattttac acatgtgctg atgtttacaa tgatgccgaa cattaggaat
2581 tgtttataca caactttgca aattatttat tacttgtgca cttagtagtt tttacaaaac
2641 tgctttgtgc atatgttaaa gcttattttt atgtggtctt atgattttat tacagaaatg
2701 tttttaacac tatactctaa aatggacatt ttcttttatt atcagttaaa atcacatttt
2761 aagtgcttca catttgtatg tgtgtagact gtaacttttt ttcagttcat atgcagaacg
2821 tatttagcca ttacccacgt gacaccaccg aatatattac tgatttagaa gcaaagattt
2881 cagtagaatt ttagtcctga acgctacggg gaaaatgcat tttcttcaga attatccatt
2941 acgtgcattt aaactctgcc agaaaaaaat aactattttg ttttaatcta ctttttgtat
3001 ttagtagtta tttgtataaa ttaaataaac tgttttcaag tcaaaaaaaa aaaaaaaaaa
3061 aa
//