LOCUS       BC033692                3774 bp    mRNA    linear   HUM 01-SEP-2006
DEFINITION  Homo sapiens 3-hydroxy-3-methylglutaryl-Coenzyme A reductase, mRNA
            (cDNA clone MGC:45281 IMAGE:5212903), complete cds.
ACCESSION   BC033692
VERSION     BC033692.1
KEYWORDS    MGC.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3774)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
   PUBMED   12477932
REFERENCE   2  (bases 1 to 3774)
  CONSRTM   NIH MGC Project
  TITLE     Direct Submission
  JOURNAL   Submitted (02-JUL-2002) National Institutes of Health, Mammalian
            Gene Collection (MGC), Bethesda, MD 20892-2590, USA
  REMARK    NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT     Contact: MGC help desk
            Email: cgapbs-r@mail.nih.gov
            Tissue Procurement: Life Technologies, Inc.
            cDNA Library Preparation: Life Technologies, Inc.
            cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
            DNA Sequencing by: National Institutes of Health Intramural
            Sequencing Center (NISC),
            Gaithersburg, Maryland;
            Web site: http://www.nisc.nih.gov/
            Contact: nisc_mgc@nhgri.nih.gov
            Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
            Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
            Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
            Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
            Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
            McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
            Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
            Young,A., Zhang,L.-H. and Green,E.D.
            
            Clone distribution: MGC clone distribution information can be found
            through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
            Series: IRAK Plate: 68 Row: o Column: 13
            This clone was selected for full length sequencing because it
            passed the following selection criteria: matched mRNA gi: 4557642.
FEATURES             Location/Qualifiers
     source          1..3774
                     /db_xref="H-InvDB:HIT000041908"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /clone="MGC:45281 IMAGE:5212903"
                     /tissue_type="Blood, adult leukocytes"
                     /clone_lib="NIH_MGC_118"
                     /lab_host="DH10B"
                     /note="Vector: pCMV-SPORT6"
     gene            1..3774
                     /gene="HMGCR"
                     /db_xref="GeneID:3156"
                     /db_xref="HGNC:HGNC:5006"
                     /db_xref="MIM:142910"
     CDS             93..2600
                     /gene="HMGCR"
                     /codon_start=1
                     /product="HMGCR protein"
                     /protein_id="AAH33692.1"
                     /db_xref="GeneID:3156"
                     /db_xref="HGNC:HGNC:5006"
                     /db_xref="MIM:142910"
                     /translation="MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNNKIC
                     GWNYECPKFEEDVLSSDIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFS
                     SFVFSTVVIHFLDKELTGLNEALPFFLLLIDLSRASTLAKFALSSNSQDEVRENIARG
                     MAILGPTFTLDALVECLVIGVGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSL
                     VLELSRESREGRPIWQLSHFARVLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIAD
                     PSPQNSTADTSKVSLGLDENVSKRIEPSVSLWQFYLSKMISMDIEQVITLSLALLLAV
                     KYIFFEQTETESTLSLKNPITSPVVTQKKVPDNCCRREPMLVRNNQKCDSVEEETGIN
                     RERKVEVIKPLVAETDTPNRATFVVGNSSLLDTSSVLVTQEPEIELPREPRPNEECLQ
                     ILGNAEKGAKFLSDAEIIQLVNAKHIPAYKLETLMETHERGVSIRRQLLSKKLSEPSS
                     LQYLPYRDYNYSLLGGGASSRVLADGMTRGPVVRLPRACDSAEVKAWLETSEGFAVIK
                     EAFDSTSRFARLQKLHTSIAGRNLYIRFQSRSGDAMGMNMISKGTEKALSKLHEYFPE
                     MQILAVSGNYCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREVLKTTTEAMIEVNINK
                     NLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITLMEASGPTNEDLYI
                     SCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLARIVCGTVMAGEL
                     SLMAALAAGHLVKSHMIHNRSKINLQDLQGACTKKTA"
BASE COUNT         1168 a          707 c          816 g         1083 t
ORIGIN      
        1 cgactgcgtt aactggagcc aggctgagcg tcggcgccgg ggttcggtgg cctctagtga
       61 gatctggagg atccaaggat tctgtagcta caatgttgtc aagacttttt cgaatgcatg
      121 gcctctttgt ggcctcccat ccctgggaag tcatagtggg gacagtgaca ctgaccatct
      181 gcatgatgtc catgaacatg tttactggta acaataagat ctgtggttgg aattatgaat
      241 gtccaaagtt tgaagaggat gttttgagca gtgacattat aattctgaca ataacacgat
      301 gcatagccat cctgtatatt tacttccagt tccagaattt acgtcaactt ggatcaaaat
      361 atattttggg tattgctggc cttttcacaa ttttctcaag ttttgtattc agtacagttg
      421 tcattcactt cttagacaaa gaattgacag gcttgaatga agctttgccc tttttcctac
      481 ttttgattga cctttccaga gcaagcacat tagcaaagtt tgccctcagt tccaactcac
      541 aggatgaagt aagggaaaat attgctcgtg gaatggcaat tttaggtcct acgtttaccc
      601 tcgatgctct tgttgaatgt cttgtgattg gagttggtac catgtcaggg gtacgtcagc
      661 ttgaaattat gtgctgcttt ggctgcatgt cagttcttgc caactacttc gtgttcatga
      721 ctttcttccc agcttgtgtg tccttggtat tagagctttc tcgggaaagc cgcgagggtc
      781 gtccaatttg gcagctcagc cattttgccc gagttttaga agaagaagaa aataagccga
      841 atcctgtaac tcagagggtc aagatgatta tgtctctagg cttggttctt gttcatgctc
      901 acagtcgctg gatagctgat ccttctcctc aaaacagtac agcagatact tctaaggttt
      961 cattaggact ggatgaaaat gtgtccaaga gaattgaacc aagtgtttcc ctctggcagt
     1021 tttatctctc taaaatgatc agcatggata ttgaacaagt tattacccta agtttagctc
     1081 tccttctggc tgtcaagtac atcttctttg aacaaacaga gacagaatct acactctcat
     1141 taaaaaaccc tatcacatct cctgtagtga cacaaaagaa agtcccagac aattgttgta
     1201 gacgtgaacc tatgctggtc agaaataacc agaaatgtga ttcagtagag gaagagacag
     1261 ggataaaccg agaaagaaaa gttgaggtta taaaaccctt agtggctgaa acagataccc
     1321 caaacagagc tacatttgtg gttggtaact cctccttact cgatacttca tcagtactgg
     1381 tgacacagga acctgaaatt gaacttccca gggaacctcg gcctaatgaa gaatgtctac
     1441 agatacttgg gaatgcagag aaaggtgcaa aattccttag tgatgctgag atcatccagt
     1501 tagtcaatgc taagcatatc ccagcctaca agttggaaac tctgatggaa actcatgagc
     1561 gtggtgtatc tattcgccga cagttacttt ccaagaagct ttcagaacct tcttctctcc
     1621 agtacctacc ttacagggat tataattact ccttgcttgg tggaggtgcc agcagccgag
     1681 tccttgcaga tgggatgact cgtggcccag ttgtgcgtct tccacgtgct tgtgactctg
     1741 cagaagtgaa agcctggctc gaaacatctg aagggttcgc agtgataaag gaggcatttg
     1801 acagcactag cagatttgca cgtctacaga aacttcatac aagtatagct ggacgcaacc
     1861 tttatatccg tttccagtcc aggtcagggg atgccatggg gatgaacatg atttcaaagg
     1921 gtacagagaa agcactttca aaacttcacg agtatttccc tgaaatgcag attctagccg
     1981 ttagtggtaa ctattgtact gacaagaaac ctgctgctat aaattggata gagggaagag
     2041 gaaaatctgt tgtttgtgaa gctgtcattc cagccaaggt tgtcagagaa gtattaaaga
     2101 ctaccacaga ggctatgatt gaggtcaaca ttaacaagaa tttagtgggc tctgccatgg
     2161 ctgggagcat aggaggctac aacgcccatg cagcaaacat tgtcaccgcc atctacattg
     2221 cctgtggaca ggatgcagca cagaatgttg gtagttcaaa ctgtattact ttaatggaag
     2281 caagtggtcc cacaaatgaa gatttatata tcagctgcac catgccatct atagagatag
     2341 gaacggtggg tggtgggacc aacctactac ctcagcaagc ctgtttgcag atgctaggtg
     2401 ttcaaggagc atgcaaagat aatcctgggg aaaatgcccg gcagcttgcc cgaattgtgt
     2461 gtgggaccgt aatggctggg gaattgtcac ttatggcagc attggcagca ggacatcttg
     2521 tcaaaagtca catgattcac aacaggtcga agatcaattt acaagacctc caaggagctt
     2581 gcaccaagaa gacagcctga atagcccgac agttctgaac tggaacatgg gcattgggtt
     2641 ctaaaggact aacataaaat ctgtgaatta aaaaagctca atgcattgtc ttgtggagga
     2701 tgaatagatg tgatcactga gacagccact tggtttttgg ctctttcaga gaggtctcag
     2761 gttctttcca tgcagactcc tcagatctga acacagttta gtgctttaca tgctgtgctc
     2821 tttgaagaga tttcaacaag aatattgtat gttaaagcat cagagatggt aatctacagc
     2881 tcacctctga aggcaaatat aagctgggaa aaaagttttg atgaaattct tgaagttcat
     2941 ggtgatcagt gcaattgacc ttctccctca ctcctgccag ttgaaaatgg atttttaaat
     3001 tatactgtag ctgatgaaac tcctgatttt gtagttaatt tattaagtct gggatgtaga
     3061 acttcaagaa gtaagagcta agttctaagt tcatgtttgt aaattaatac ttcatttggt
     3121 gctggtctat tttgattttg gggggtaatc agcattattc ttcagaaggg gacctgtttt
     3181 cttcaaggga agaaacactc ttattcccaa actacagaat aatgtgttaa acatgctaaa
     3241 tagttctatc aggaaaacaa atcactgtat ttatctccgc aggctatttg ttcagagagg
     3301 ccttttgttt aaatataaat gtttaaatat aaatgtttgt ctggattggc tataacatgt
     3361 ctttcagcat taggctttta agaaacacag ggttttgtat tctttactaa agatatcaga
     3421 gctcttaatg ttgcttagat gagggtgact gtcaagtaca agcaagactg ggaccttaga
     3481 aatcattgta gaaacacagt tttgaaagaa aaataccatg tctctaagcc aactttaatt
     3541 gcttaaaaga catttttatt tagttgaaaa atctagtttt ttttgtaaac tgtatcaaat
     3601 ctgtatatgt tgtaataaaa cttatgctag tttattggaa gtgttcaaga aataaaaatc
     3661 aacttgtgta ctgataaaat aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     3721 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa
//