LOCUS BC033692 3774 bp mRNA linear HUM 01-SEP-2006 DEFINITION Homo sapiens 3-hydroxy-3-methylglutaryl-Coenzyme A reductase, mRNA (cDNA clone MGC:45281 IMAGE:5212903), complete cds. ACCESSION BC033692 VERSION BC033692.1 KEYWORDS MGC. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 3774) AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A. CONSRTM Mammalian Gene Collection Program Team TITLE Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002) PUBMED 12477932 REFERENCE 2 (bases 1 to 3774) CONSRTM NIH MGC Project TITLE Direct Submission JOURNAL Submitted (02-JUL-2002) National Institutes of Health, Mammalian Gene Collection (MGC), Bethesda, MD 20892-2590, USA REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov COMMENT Contact: MGC help desk Email: cgapbs-r@mail.nih.gov Tissue Procurement: Life Technologies, Inc. cDNA Library Preparation: Life Technologies, Inc. cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL) DNA Sequencing by: National Institutes of Health Intramural Sequencing Center (NISC), Gaithersburg, Maryland; Web site: http://www.nisc.nih.gov/ Contact: nisc_mgc@nhgri.nih.gov Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B., Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S., Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P., Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R., Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C., McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W., Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L., Young,A., Zhang,L.-H. and Green,E.D. Clone distribution: MGC clone distribution information can be found through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov Series: IRAK Plate: 68 Row: o Column: 13 This clone was selected for full length sequencing because it passed the following selection criteria: matched mRNA gi: 4557642. FEATURES Location/Qualifiers source 1..3774 /db_xref="H-InvDB:HIT000041908" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /clone="MGC:45281 IMAGE:5212903" /tissue_type="Blood, adult leukocytes" /clone_lib="NIH_MGC_118" /lab_host="DH10B" /note="Vector: pCMV-SPORT6" gene 1..3774 /gene="HMGCR" /db_xref="GeneID:3156" /db_xref="HGNC:HGNC:5006" /db_xref="MIM:142910" CDS 93..2600 /gene="HMGCR" /codon_start=1 /product="HMGCR protein" /protein_id="AAH33692.1" /db_xref="GeneID:3156" /db_xref="HGNC:HGNC:5006" /db_xref="MIM:142910" /translation="MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNNKIC GWNYECPKFEEDVLSSDIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFS SFVFSTVVIHFLDKELTGLNEALPFFLLLIDLSRASTLAKFALSSNSQDEVRENIARG MAILGPTFTLDALVECLVIGVGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSL VLELSRESREGRPIWQLSHFARVLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIAD PSPQNSTADTSKVSLGLDENVSKRIEPSVSLWQFYLSKMISMDIEQVITLSLALLLAV KYIFFEQTETESTLSLKNPITSPVVTQKKVPDNCCRREPMLVRNNQKCDSVEEETGIN RERKVEVIKPLVAETDTPNRATFVVGNSSLLDTSSVLVTQEPEIELPREPRPNEECLQ ILGNAEKGAKFLSDAEIIQLVNAKHIPAYKLETLMETHERGVSIRRQLLSKKLSEPSS LQYLPYRDYNYSLLGGGASSRVLADGMTRGPVVRLPRACDSAEVKAWLETSEGFAVIK EAFDSTSRFARLQKLHTSIAGRNLYIRFQSRSGDAMGMNMISKGTEKALSKLHEYFPE MQILAVSGNYCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREVLKTTTEAMIEVNINK NLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITLMEASGPTNEDLYI SCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLARIVCGTVMAGEL SLMAALAAGHLVKSHMIHNRSKINLQDLQGACTKKTA" BASE COUNT 1168 a 707 c 816 g 1083 t ORIGIN 1 cgactgcgtt aactggagcc aggctgagcg tcggcgccgg ggttcggtgg cctctagtga 61 gatctggagg atccaaggat tctgtagcta caatgttgtc aagacttttt cgaatgcatg 121 gcctctttgt ggcctcccat ccctgggaag tcatagtggg gacagtgaca ctgaccatct 181 gcatgatgtc catgaacatg tttactggta acaataagat ctgtggttgg aattatgaat 241 gtccaaagtt tgaagaggat gttttgagca gtgacattat aattctgaca ataacacgat 301 gcatagccat cctgtatatt tacttccagt tccagaattt acgtcaactt ggatcaaaat 361 atattttggg tattgctggc cttttcacaa ttttctcaag ttttgtattc agtacagttg 421 tcattcactt cttagacaaa gaattgacag gcttgaatga agctttgccc tttttcctac 481 ttttgattga cctttccaga gcaagcacat tagcaaagtt tgccctcagt tccaactcac 541 aggatgaagt aagggaaaat attgctcgtg gaatggcaat tttaggtcct acgtttaccc 601 tcgatgctct tgttgaatgt cttgtgattg gagttggtac catgtcaggg gtacgtcagc 661 ttgaaattat gtgctgcttt ggctgcatgt cagttcttgc caactacttc gtgttcatga 721 ctttcttccc agcttgtgtg tccttggtat tagagctttc tcgggaaagc cgcgagggtc 781 gtccaatttg gcagctcagc cattttgccc gagttttaga agaagaagaa aataagccga 841 atcctgtaac tcagagggtc aagatgatta tgtctctagg cttggttctt gttcatgctc 901 acagtcgctg gatagctgat ccttctcctc aaaacagtac agcagatact tctaaggttt 961 cattaggact ggatgaaaat gtgtccaaga gaattgaacc aagtgtttcc ctctggcagt 1021 tttatctctc taaaatgatc agcatggata ttgaacaagt tattacccta agtttagctc 1081 tccttctggc tgtcaagtac atcttctttg aacaaacaga gacagaatct acactctcat 1141 taaaaaaccc tatcacatct cctgtagtga cacaaaagaa agtcccagac aattgttgta 1201 gacgtgaacc tatgctggtc agaaataacc agaaatgtga ttcagtagag gaagagacag 1261 ggataaaccg agaaagaaaa gttgaggtta taaaaccctt agtggctgaa acagataccc 1321 caaacagagc tacatttgtg gttggtaact cctccttact cgatacttca tcagtactgg 1381 tgacacagga acctgaaatt gaacttccca gggaacctcg gcctaatgaa gaatgtctac 1441 agatacttgg gaatgcagag aaaggtgcaa aattccttag tgatgctgag atcatccagt 1501 tagtcaatgc taagcatatc ccagcctaca agttggaaac tctgatggaa actcatgagc 1561 gtggtgtatc tattcgccga cagttacttt ccaagaagct ttcagaacct tcttctctcc 1621 agtacctacc ttacagggat tataattact ccttgcttgg tggaggtgcc agcagccgag 1681 tccttgcaga tgggatgact cgtggcccag ttgtgcgtct tccacgtgct tgtgactctg 1741 cagaagtgaa agcctggctc gaaacatctg aagggttcgc agtgataaag gaggcatttg 1801 acagcactag cagatttgca cgtctacaga aacttcatac aagtatagct ggacgcaacc 1861 tttatatccg tttccagtcc aggtcagggg atgccatggg gatgaacatg atttcaaagg 1921 gtacagagaa agcactttca aaacttcacg agtatttccc tgaaatgcag attctagccg 1981 ttagtggtaa ctattgtact gacaagaaac ctgctgctat aaattggata gagggaagag 2041 gaaaatctgt tgtttgtgaa gctgtcattc cagccaaggt tgtcagagaa gtattaaaga 2101 ctaccacaga ggctatgatt gaggtcaaca ttaacaagaa tttagtgggc tctgccatgg 2161 ctgggagcat aggaggctac aacgcccatg cagcaaacat tgtcaccgcc atctacattg 2221 cctgtggaca ggatgcagca cagaatgttg gtagttcaaa ctgtattact ttaatggaag 2281 caagtggtcc cacaaatgaa gatttatata tcagctgcac catgccatct atagagatag 2341 gaacggtggg tggtgggacc aacctactac ctcagcaagc ctgtttgcag atgctaggtg 2401 ttcaaggagc atgcaaagat aatcctgggg aaaatgcccg gcagcttgcc cgaattgtgt 2461 gtgggaccgt aatggctggg gaattgtcac ttatggcagc attggcagca ggacatcttg 2521 tcaaaagtca catgattcac aacaggtcga agatcaattt acaagacctc caaggagctt 2581 gcaccaagaa gacagcctga atagcccgac agttctgaac tggaacatgg gcattgggtt 2641 ctaaaggact aacataaaat ctgtgaatta aaaaagctca atgcattgtc ttgtggagga 2701 tgaatagatg tgatcactga gacagccact tggtttttgg ctctttcaga gaggtctcag 2761 gttctttcca tgcagactcc tcagatctga acacagttta gtgctttaca tgctgtgctc 2821 tttgaagaga tttcaacaag aatattgtat gttaaagcat cagagatggt aatctacagc 2881 tcacctctga aggcaaatat aagctgggaa aaaagttttg atgaaattct tgaagttcat 2941 ggtgatcagt gcaattgacc ttctccctca ctcctgccag ttgaaaatgg atttttaaat 3001 tatactgtag ctgatgaaac tcctgatttt gtagttaatt tattaagtct gggatgtaga 3061 acttcaagaa gtaagagcta agttctaagt tcatgtttgt aaattaatac ttcatttggt 3121 gctggtctat tttgattttg gggggtaatc agcattattc ttcagaaggg gacctgtttt 3181 cttcaaggga agaaacactc ttattcccaa actacagaat aatgtgttaa acatgctaaa 3241 tagttctatc aggaaaacaa atcactgtat ttatctccgc aggctatttg ttcagagagg 3301 ccttttgttt aaatataaat gtttaaatat aaatgtttgt ctggattggc tataacatgt 3361 ctttcagcat taggctttta agaaacacag ggttttgtat tctttactaa agatatcaga 3421 gctcttaatg ttgcttagat gagggtgact gtcaagtaca agcaagactg ggaccttaga 3481 aatcattgta gaaacacagt tttgaaagaa aaataccatg tctctaagcc aactttaatt 3541 gcttaaaaga catttttatt tagttgaaaa atctagtttt ttttgtaaac tgtatcaaat 3601 ctgtatatgt tgtaataaaa cttatgctag tttattggaa gtgttcaaga aataaaaatc 3661 aacttgtgta ctgataaaat aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 3721 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa //