LOCUS BC033088 1710 bp mRNA linear HUM 07-OCT-2003
DEFINITION Homo sapiens lamin A/C, mRNA (cDNA clone MGC:45654 IMAGE:3623265),
complete cds.
ACCESSION BC033088
VERSION BC033088.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1710)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 1710)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (25-JUN-2002) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Genome Sequence Centre,
BC Cancer Agency, Vancouver, BC, Canada
info@bcgsc.bc.ca
Steven Jones, Jennifer Asano, Ian Bosdet, Yaron Butterfield,
Susanna Chan, Readman Chiu, Chris Fjell, Erin Garland, Ran Guin,
Letticia Hsiao, Martin Krzywinski, Reta Kutsche, Oliver Lee, Soo
Sen Lee, Victor Ling, Carrie Mathewson, Candice McLeavy, Steven
Ness, Pawan Pandoh, Anna-Liisa Prabhu, Parvaneh Saeedi, Jacqueline
Schein, Duane Smailus, Michael Smith, Lorraine Spence, Jeff Stott,
Michael Thorne, Miranada Tsai, Natasja van den Bosch, Jill Vardy,
George Yang, Scott Zuyderduyn, Marco Marra.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 43 Row: b Column: 12
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 27436944.
FEATURES Location/Qualifiers
source 1..1710
/db_xref="H-InvDB:HIT000041792"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:45654 IMAGE:3623265"
/tissue_type="Pancreas, adenocarcinoma"
/clone_lib="NIH_MGC_39"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene 1..1710
/gene="LMNA"
/gene_synonym="CMD1A"
/gene_synonym="CMT2B1"
/gene_synonym="EMD2"
/gene_synonym="FPL"
/gene_synonym="FPLD"
/gene_synonym="HGPS"
/gene_synonym="LDP1"
/gene_synonym="LFP"
/gene_synonym="LMN1"
/gene_synonym="LMNC"
/gene_synonym="PRO1"
/db_xref="GeneID:4000"
/db_xref="MIM:150330"
CDS 194..1591
/gene="LMNA"
/gene_synonym="CMD1A"
/gene_synonym="CMT2B1"
/gene_synonym="EMD2"
/gene_synonym="FPL"
/gene_synonym="FPLD"
/gene_synonym="HGPS"
/gene_synonym="LDP1"
/gene_synonym="LFP"
/gene_synonym="LMN1"
/gene_synonym="LMNC"
/gene_synonym="PRO1"
/codon_start=1
/product="LMNA protein"
/protein_id="AAH33088.1"
/db_xref="GeneID:4000"
/db_xref="MIM:150330"
/translation="METPSQRRATRSGAQASSTPLSPTRITRLQEKEDLQELNDRLAV
YIDRVRSLETENAGLRLRITESEEVVSREVSGIKAAYEAELGDARKTLDSVAKERARL
QLELSKVREEFKELKACNTKKEGDLIAAQARLKDLEALLNSKEAALSTALSEKRTLEG
ELHDLRGQVAKLEAALGEAKKQLQDEMLRRVDAENRLQTMKEELDFQKNIYSEELRET
KRRHETRLVEIDNGKQREFESRLADALQELRAQHEDQVEQYKKELEKTYSAKLDNARQ
SAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRDLEDSLARERDTS
RRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGEEERLRLSPS
PTSQRSRGRASSHSSQTQGGGSVTKKRKLESTESRSSFSQHARTSGRVAVEEVDEDED
GDDLLHHHHVSGSRR"
misc_feature 281..1327
/gene="LMNA"
/gene_synonym="CMD1A"
/gene_synonym="CMT2B1"
/gene_synonym="EMD2"
/gene_synonym="FPL"
/gene_synonym="FPLD"
/gene_synonym="HGPS"
/gene_synonym="LDP1"
/gene_synonym="LFP"
/gene_synonym="LMN1"
/gene_synonym="LMNC"
/gene_synonym="PRO1"
/note="filament; Region: Intermediate filament protein"
/db_xref="CDD:pfam00038"
BASE COUNT 387 a 523 c 562 g 238 t
ORIGIN
1 gccgcaccta caccagccaa cccagatccc gaggtccgac agcgcccggc ccagatcccc
61 acgcctgcca ggagcaagcc gagagccagc cggccggcgc actccgactc cgagcagtct
121 ctgtccttcg acccgagccc cgcgcccttt ccgggacccc tgccccgcgg gcagcgctgc
181 caacctgccg gccatggaga ccccgtccca gcggcgcgcc acccgcagcg gggcgcaggc
241 cagctccact ccgctgtcgc ccacccgcat cacccggctg caggagaagg aggacctgca
301 ggagctcaat gatcgcttgg cggtctacat cgaccgtgtg cgctcgctgg aaacggagaa
361 cgcagggctg cgccttcgca tcaccgagtc tgaagaggtg gtcagccgcg aggtgtccgg
421 catcaaggcc gcctacgagg ccgagctcgg ggatgcccgc aagacccttg actcagtagc
481 caaggagcgc gcccgcctgc agctggagct gagcaaagtg cgtgaggagt ttaaggagct
541 gaaagcgtgc aataccaaga aggagggtga cctgatagct gctcaggctc ggctgaagga
601 cctggaggct ctgctgaact ccaaggaggc cgcactgagc actgctctca gtgagaagcg
661 cacgctggag ggcgagctgc atgatctgcg gggccaggtg gccaagcttg aggcagccct
721 aggtgaggcc aagaagcaac ttcaggatga gatgctgcgg cgggtggatg ctgagaacag
781 gctgcagacc atgaaggagg aactggactt ccagaagaac atctacagtg aggagctgcg
841 tgagaccaag cgccgtcatg agacccgact ggtggagatt gacaatggga agcagcgtga
901 gtttgagagc cggctggcgg atgcgctgca ggaactgcgg gcccagcatg aggaccaggt
961 ggagcagtat aagaaggagc tggagaagac ttattctgcc aagctggaca atgccaggca
1021 gtctgctgag aggaacagca acctggtggg ggccgcccac gaggagctgc agcagtcgcg
1081 catccgcatc gacagcctct ctgcccagct cagccagctc cagaagcagc tggcagccaa
1141 ggaggcgaag cttcgagacc tggaggactc actggcccgt gagcgggaca ccagccggcg
1201 gctgctggcg gaaaaggagc gggagatggc cgagatgcgg gcaaggatgc agcagcagct
1261 ggacgagtac caggagcttc tggacatcaa gctggccctg gacatggaga tccacgccta
1321 ccgcaagctc ttggagggcg aggaggagag gctacgcctg tcccccagcc ctacctcgca
1381 gcgcagccgt ggccgtgctt cctctcactc atcccagaca cagggtgggg gcagcgtcac
1441 caaaaagcgc aaactggagt ccactgagag ccgcagcagc ttctcacagc acgcacgcac
1501 tagcgggcgc gtggccgtgg aggaggtgga cgaggatgag gatggagatg acctgctcca
1561 tcaccaccac gtgagtggta gccgccgctg aggccgagcc tgcactgggg ccacccagcc
1621 aggcctgggg gcagcctctc cccagcctcc ccgtgccaaa aatcttttca ttaaagaatg
1681 ttttggaact ttaaaaaaaa aaaaaaaaaa
//