LOCUS BC028010 2903 bp mRNA linear HUM 06-APR-2004
DEFINITION Homo sapiens oxysterol binding protein-like 7, mRNA (cDNA clone
IMAGE:5213141), complete cds.
ACCESSION BC028010
VERSION BC028010.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2903)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 2903)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (08-APR-2002) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Life Technologies, Inc.
cDNA Library Preparation: Life Technologies, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: National Institutes of Health Intramural
Sequencing Center (NISC),
Gaithersburg, Maryland;
Web site: http://www.nisc.nih.gov/
Contact: nisc_mgc@nhgri.nih.gov
Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
Young,A., Zhang,L.-H. and Green,E.D.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 62 Row: g Column: 19
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 22035613
This clone has the following problem: The cds is short compared to
the longest cds in the locus.
FEATURES Location/Qualifiers
source 1..2903
/db_xref="H-InvDB:HIT000259000"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="IMAGE:5213141"
/tissue_type="Blood, adult leukocytes"
/clone_lib="NIH_MGC_118"
/lab_host="DH10B"
/note="Vector: pCMV-SPORT6"
gene 1..2903
/gene="OSBPL7"
/gene_synonym="FLJ20260"
/gene_synonym="ORP7"
/db_xref="GeneID:114881"
/db_xref="MIM:606735"
CDS 203..1276
/gene="OSBPL7"
/gene_synonym="FLJ20260"
/gene_synonym="ORP7"
/codon_start=1
/product="OSBPL7 protein"
/protein_id="AAH28010.1"
/db_xref="GeneID:114881"
/db_xref="MIM:606735"
/translation="MDFQERDPPFLPESAQSSKPSSAQQASELWEVVEEPRVRLGTEG
VMPERQEGHLLKKRKWPLKGWHKRYFVLEDGILHYATTRQDITKGKLHGSIDVRLSVM
SINKKAQRIDLDTEDNIYHLKIKSQDLFQSWVAQLRAHRLAHRLDMPRGSLPSTAHRK
VPGAQLPTAATASALPGLGPREKVSSWLRDSDGLDRCSHELSECQGKLQELHRLLQSL
ESLHRIPSAPVIPTHQASVTTERPKKGKRTSRMWCTQSFAKDDTIGRVGRLHGSVPNL
SRYLESRDSSGTRGLPPTDYAHLQRSFWALAQKVHSSLSSVLAALTMERDQLRDMHQG
SELSRMGVRPGGQGDWCGERASS"
misc_feature 353..622
/gene="OSBPL7"
/gene_synonym="FLJ20260"
/gene_synonym="ORP7"
/note="PH; Region: Pleckstrin homology domain. Domain
commonly found in eukaryotic signalling proteins. The
domain family possesses multiple functions including the
abilities to bind inositol phosphates, and various
proteins. PH domains have been found to possess inserted
domains (such as in PLC gamma, syntrophins) and to be
inserted within other domains. Mutations in Brutons
tyrosine kinase (Btk) within its PH domain cause X-linked
agammaglobulinaemia (XLA) in patients. Point mutations
cluster into the positively charged end of the molecule
around the predicted binding site for phosphatidylinositol
lipids"
/db_xref="CDD:smart00233"
BASE COUNT 621 a 931 c 818 g 533 t
ORIGIN
1 cagcagctgc tgccactgct cagcgcggtg aggagggagc cggtgactcg gagacggtga
61 ctcagaggca gagcggcgca agggccaagg agtactggcg tccatggacc ctggggaccc
121 cgtcaggagc aggtgacatc cttccccttc caccctgctc cctgctctac atccccagca
181 gggagtggcc tctcccttct ccatggactt ccaagagagg gacccgccct tcctgcctga
241 gagcgctcag tcctcaaagc ccagcagtgc tcagcaggcc tctgagctgt gggaggtggt
301 ggaggagcct cgggtcaggc tggggacaga gggtgtcatg cctgagaggc aggaaggtca
361 cctgctcaag aagaggaagt ggcctctgaa gggctggcac aagagatact ttgtgctcga
421 ggacgggatc cttcattatg caacaacccg gcaagacatc accaagggga agctccatgg
481 ctccatcgat gtccggctgt cggtcatgtc catcaacaaa aaggcccagc gcattgacct
541 tgacactgaa gacaacatct accacctcaa gatcaaatcc caggacctat tccagagctg
601 ggtggcgcag ctgcgtgccc accgcctagc ccaccgcctg gacatgcccc gtggctcact
661 gcccagtact gctcaccgga aggttcctgg tgcccagctt ccaacagcag ctactgcctc
721 agccctacct gggcttggac cgcgggagaa agtgtcttcc tggctgaggg acagtgatgg
781 gctggaccgc tgctctcatg agctctctga gtgtcagggg aagctccagg aactacacag
841 gctcctccag agcctggagt ccctgcaccg aatcccctca gcccctgtta tccccacaca
901 ccaggcctca gtgacaaccg aaagacccaa gaaggggaaa cggacaagcc gcatgtggtg
961 cacccagagc tttgccaagg atgacaccat tggacgggtt ggtcgtctcc atggctctgt
1021 tcccaacctg tctcgctacc tggagtctcg ggactcctcg ggcacccgtg ggctgccacc
1081 cacagactat gcccacctgc agcgcagctt ctgggccctg gcccagaagg tgcacagctc
1141 cctcagcagc gtcctggccg ccctcaccat ggaacgggac caactgaggg acatgcacca
1201 gggctcagag ttgtcaagaa tgggggtgag gcctggggga cagggtgact ggtgcgggga
1261 gagggcttca agctgaggac tgccagcctg gggtccgata gcagatctgg gtcagggtgg
1321 ggggttggca gaggcagtct ctgcagagat gcggcaaggt ggggaggacc tcatcctcct
1381 ggcaccgtgt ccctcaccct ctccctgcag gtctctgagg cctccactgg ccagaggcgc
1441 ctccactcac tgtccacctc ctccgacacc acggcggact ctttcagctc cctcaaccct
1501 gaggagcaag aagctctgta ccggggaccc acgccaggtg gccagtgcat ctggaaaccc
1561 aactcaatgc cccccgacca tgagcgaaac ttcggcttca cccagtttgc cttggagctg
1621 aatgagctga cagcagagct gaaacggtcg ctgccttcca ccgacacgag actccggcca
1681 gaccagaggt acctggagga ggggaacata caggccgctg aggcccagaa gagaaggatc
1741 gagcagctgc agcgagacag gcgcaaagtc atggaggaaa acaacatcgt acaccaggct
1801 cgcttcttca ggcggcagac ggatagcagc gggaaagagt ggtgggtgac caacaatacc
1861 tactggaggc tgcgggccga gccaggctac gggaacatgg atggggccgt gctctggtag
1921 ccctggcccc gggggcagga ggctctggtt cctcactcct cctgcctcca ccccctacca
1981 tggacacatg ggtgaggccg ggctccccgc ctcactgccc ttgagaccaa aggggcagcc
2041 ctggccctcc ctcccctctg ctggccagag ggtctgcatc tcagcccacc cccaacccca
2101 ccgtttgggg tgagaagcag aatctgtgct tccccagtct ccttgcccca gacaaccagc
2161 atgtaagacc cttcccgctt caccattccg attcctgtcc cctttggggt acttggggga
2221 gactctggct cccaggatct gttccctatt tcagtgcctt cctaggacac aggggactcc
2281 ttgacgctcc ccaggctttc tgtgcccagg cctctgtccc cagcggtgag gttgcagtga
2341 gtgaaggaga ggaggtgatc tgttctccct ccccttctgc ccatctccag catcttcttc
2401 cccttccctg gccctgcagg gccttctcca gctccctttg gttagtccct ggccatccct
2461 cctgtcctgg atcccttctc cctaactgca aaatgcctgc agcttccagc tccttcgtcc
2521 ctgatcctca agcggttccc tcccgtctca gctcagcgga tcccccagag tggaggaggc
2581 ctctccatga ggaggggagc agcccaaggc acctgtcctc tgacccaccg gcagcgagtg
2641 cgcaggtgtg agtgtaagtt catgtaggag agtgtatgcg tgtgcgcctg tgccctgctt
2701 gcaggcaagc agggctccct catgtagccc ggccttcccc ctgctggggg tccaccacat
2761 cgctgctctt tctcacagtc tgcctctgat gagggcgaat tgctatgaca ttccaagctc
2821 caataaagac tgtcccagaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
2881 aaaaaaaaaa aaaaaaaaaa aaa
//