LOCUS BC027946 4265 bp mRNA linear HUM 04-AUG-2008
DEFINITION Homo sapiens amyloid beta (A4) precursor protein-binding, family B,
member 2, mRNA (cDNA clone MGC:35575 IMAGE:5203925), complete cds.
ACCESSION BC027946
VERSION BC027946.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4265)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 4265)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (08-APR-2002) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Life Technologies, Inc.
cDNA Library Preparation: Life Technologies, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: National Institutes of Health Intramural
Sequencing Center (NISC),
Gaithersburg, Maryland;
Web site: http://www.nisc.nih.gov/
Contact: nisc_mgc@nhgri.nih.gov
Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
Young,A., Zhang,L.-H. and Green,E.D.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 49 Row: f Column: 20
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 50083290.
FEATURES Location/Qualifiers
source 1..4265
/db_xref="H-InvDB:HIT000050929"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:35575 IMAGE:5203925"
/tissue_type="Lung, Spleen, fetal, pooled"
/clone_lib="NIH_MGC_122"
/lab_host="DH10B"
/note="Vector: pCMV-SPORT6"
gene 1..4265
/gene="APBB2"
/gene_synonym="FE65L"
/gene_synonym="FE65L1"
/db_xref="GeneID:323"
/db_xref="HGNC:HGNC:582"
/db_xref="MIM:602710"
CDS 471..2681
/gene="APBB2"
/gene_synonym="FE65L"
/gene_synonym="FE65L1"
/codon_start=1
/product="amyloid beta (A4) precursor protein-binding,
family B, member 2"
/protein_id="AAH27946.2"
/db_xref="GeneID:323"
/db_xref="HGNC:HGNC:582"
/db_xref="MIM:602710"
/translation="MSEVLPADSGVDTLAVFMASSGTTDVTNRNSPATPPNTLNLRSS
HNELLNAEIKHTETKNSTPPKCRKKYALTNIQAAMGLSDPAAQPLLGNGSANIKLVKN
GENQLRKAAEQGQQDPNKNLSPTAVINITSEKLEGKEPHPQDSSSCEILPSQPRRTKS
FLNYYADLETSARELEQNQGNHHGTAEEKSQPVQGQASTIIGNGDLLLQKPNRPQSSP
EDGQVATVSSSPETKKDHPKTGAKTDCALHRIQNLAPSDEESSWTTLSQDSASPSSPD
ETDIWSDHSFQTDPDLPPGWKRVSDIAGTYYWHIPTGTTQWERPVSIPADLQGSRKGS
LSSVTPSPTPENEDLHAATVNPDPSLKEFEGATLRYASLKLRNAPHPDDDDSCSINSD
PEAKCFAVRSLGWVEMAEEDLAPGKSSVAVNNCIRQLSYCKNDIRDTVGIWGEGKDMY
LILENDMLSLVDPMDRSVLHSQPIVSIRVWGVGRDNGRDFAYVARDKDTRILKCHVFR
CDTPAKAIATSLHEICSKIMAERKNAKALACSSLQERANVNLDVPLQDFPTPKTELVQ
KFHVQYLGMLPVDKPVGMDILNSAIENLMTSSNKEDWLSVNMNVADATVTVISEKNEE
EVLVECRVRFLSFMGVGKDVHTFAFIMDTGNQRFECHVFWCEPNAGNVSEAVQAACML
RYQKCLVARPPSQKVRPPPPPADSVTRRVTTNVKRGVLSLIDTLKQKRPVTEMP"
BASE COUNT 1285 a 986 c 935 g 1059 t
ORIGIN
1 ctggagcaga gccgctgggc gccggagccg aggcgagcgc cgcgcgcacc actggttgga
61 gttgctgtgg gtgagctgct gtggtctgta gccaagcatg ctgtggtcgg atctgcccag
121 ccgtggaaca gaaacatttg ctggatggaa aatccataaa agaaagctcc tgtgaaaagc
181 tgaggctgac aataatttaa gcaaaatcag atcgatctct ttgggctgcc tgacctcctt
241 gggtgcttgc tattaattaa cagactttgt ggggaaaaaa aggagcttgc cttctgagct
301 ttgtaccaaa gacctgggaa aactaaccat ctcagtcttt cctgaggact tgggaactgc
361 cgaggcctct gccaatgtgt tgactgtcgc tatgggctca ctgttgtcca ggcagctcat
421 atttcaaatt ataacctatt tcctgcacca ttgctgacgc ctggtgatcc atgtcagaag
481 tacttccagc tgactcaggt gttgacacct tggcagtgtt tatggccagc agcggaacta
541 cagacgtcac aaatcggaac agcccagcca caccaccaaa cacccttaac ctccgatcct
601 cccacaatga actgttgaac gctgaaataa aacacacaga aaccaagaac agcacacctc
661 ccaaatgcag gaaaaaatat gcactaacta acatccaggc ggccatgggc ctctcggatc
721 cagctgcaca gcccctgctg ggaaatggct ctgccaacat caagctggtg aaaaatgggg
781 agaaccagct ccgtaaggct gcagagcaag ggcagcagga ccccaacaaa aacctgagcc
841 ccactgcagt catcaacata acttctgaga agttagaggg taaagagccc cacccacagg
901 attcctcgag ctgtgagatt ttaccctccc agcccaggag aactaagagc ttcctaaatt
961 actatgcaga tctggaaacc tcagccagag aactagagca gaaccaaggc aatcaccatg
1021 ggactgcgga agagaaatcc cagccagtcc agggccaggc ctccaccatc attgggaatg
1081 gtgatttgct gctgcagaaa ccaaacagac cccagtccag ccctgaagac ggccaagtag
1141 ccacagtgtc atccagccca gaaaccaaga aggatcatcc gaaaacaggg gccaaaaccg
1201 actgtgcact gcaccggatc cagaacctgg caccgagcga tgaggagtcc agctggacaa
1261 cgttgtccca agacagtgcc tcacccagct ccccggatga aacagatata tggagtgatc
1321 actcatttca gactgatcca gatttgccgc ctggctggaa aagagtcagt gacattgccg
1381 ggacctatta ttggcacatc ccaacaggaa cgactcagtg ggaacggccc gtctccatcc
1441 cagcagatct ccagggttct aggaaagggt cacttagttc tgtaacgcca tctcccaccc
1501 cagagaacga ggatttgcat gcagccactg ttaacccgga ccccagttta aaagagtttg
1561 aaggagcaac cctacgctat gcatctttga aactcagaaa tgccccacac cctgatgatg
1621 atgattcttg tagtatcaac agtgacccag aagccaagtg ttttgctgtg cgttctctgg
1681 gatgggtaga gatggcagaa gaggacctcg cccccggtaa aagtagtgtt gcggtcaaca
1741 actgcatcag gcaactttcc tactgcaaaa atgacatccg agacacagtc gggatttggg
1801 gagaggggaa agacatgtac ctgatcctgg agaatgacat gctcagcctg gtggacccca
1861 tggaccgcag cgtgctgcac tcgcagccca tcgtcagcat ccgcgtgtgg ggcgtgggcc
1921 gcgacaatgg ccgggatttt gcttatgtag caagagataa agatacaaga attttgaaat
1981 gtcatgtatt tcgatgtgac acaccagcaa aagccattgc cacaagtctc cacgagatct
2041 gctccaagat tatggctgaa cggaagaatg ccaaagcgct ggcctgcagc tccttacagg
2101 aaagggccaa tgtgaacctc gatgtccctt tgcaagattt tccaacacca aagactgagc
2161 tggtccagaa gttccacgtg cagtacttgg gcatgttacc tgtagacaaa ccagtcggaa
2221 tggatatttt gaacagtgcc atagaaaatc ttatgacctc atccaacaag gaggactggc
2281 tgtcagtgaa catgaacgtg gctgatgcca ctgtgactgt catcagtgaa aagaatgaag
2341 aggaagtctt agtggaatgt cgtgtgcgat tcctgtcctt catgggtgtt gggaaggacg
2401 tccacacatt tgccttcatc atggacacgg ggaaccagcg ctttgagtgc cacgttttct
2461 ggtgcgagcc taatgctggt aacgtgtctg aggcggtgca ggccgcctgc atgttacgat
2521 atcagaagtg cttggtagcc aggccgcctt ctcagaaagt tcgaccacct ccaccgccag
2581 cagattcagt aaccagaaga gtcacaacca atgtaaaacg aggggtctta tccctcattg
2641 acactttgaa acagaaacgc cctgtcaccg aaatgccata gctgcacatg caaaaggact
2701 cggctattta cctgaagatt gactagctac actaaagaaa atgaactccg ccatccgacc
2761 ttccatccag ttgctgatgc tttgtcttca gagaatttac ccttaaccaa gcagtgttag
2821 acaagcatgt tctctcgtct tgccaccatc atgtgatatg aaaagaagca tgaataattt
2881 tttttgctgt aagttacatc atgcgcagtg gaaggtcttt ttcttattgt aaatattgtg
2941 aacattactt aacttcacac acacacagag aagagtgtgg ccccacccct cctagtgaac
3001 taacgctgcg tccttggaat gaatgatgcg tgagttagtt tcactgtctt cttggctgga
3061 cctgtcacaa gcaaccttta agtcctacag cactttgccc tgttttcaac attggagtag
3121 gcactgcata gcagatacca ttgaattgct gtaaaaatag gatggcgagt ttgtgtttta
3181 atttttcata aaattgaacc tgttggttga caaaattggc tgttggcatc agtatagaaa
3241 ccaactggca gctttccctg acaagctctt tgacacatgg acaccatttc atgtctacag
3301 ctgtttgtgg gatgttggaa aaaaatgaaa cttcaaaatt gatgaaaaac taaattcgag
3361 gaattaaaat cgaacaaaac atagcctttc ttttccgatg gttttcaaac tgattatttt
3421 taaaagagat taataaaatc ataatgcatt ttgggtggga catatttcaa acttctgcct
3481 tatattgtac ggtgcagcta gagaattata gttcactatg gccattctct acataaacat
3541 taagatgaaa tactcctcat cagcctttca tccttagttt gagaattagc tgatatgcaa
3601 tttgaagttg aggaaatatc attgatattt ctatcatgca cgattatttt agatttctac
3661 caccgtgtga tttttgctag tccatgtgct agaggtaaac gttctgctgg aattctgcat
3721 ccagctctat ccccctctga tgctttttgc ccagaaagct gtctgtccat catgtattgt
3781 ccatggcaac aaattacatt aggttgaacc tttccttgat tttatgtatt taatattaga
3841 atttgttgga ctcaactaga tatatttttt aatttatatt ttttccattt tactttgaag
3901 atttgaaatg tttatacctg agcaaagtct acacaggagt aatggactgt ttaacaagtt
3961 tcccaaaaca gcattttcct gctccttcgt atgtaggtga gaaacttagc tggaaagaca
4021 tacaaattta gactctcgtt gacattgtcg ttttaaaagg aagttgctaa ggcgatcaat
4081 ctcaatatta gtcttgttta cttcttctta atgtcaaaat taacatttac aacatccaat
4141 tataaaagta atgctttatg tttataaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
4201 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
4261 aaaaa
//