LOCUS BC027179 1452 bp mRNA linear HUM 06-OCT-2003 DEFINITION Homo sapiens tyrosinase (oculocutaneous albinism IA), mRNA (cDNA clone MGC:9191 IMAGE:3923096), complete cds. ACCESSION BC027179 VERSION BC027179.1 KEYWORDS MGC. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1452) AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A. TITLE Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002) PUBMED 12477932 REFERENCE 2 (bases 1 to 1452) AUTHORS Strausberg,R. TITLE Direct Submission JOURNAL Submitted (04-APR-2002) National Institutes of Health, Mammalian Gene Collection (MGC), Cancer Genomics Office, National Cancer Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590, USA REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov COMMENT Contact: MGC help desk Email: cgapbs-r@mail.nih.gov Tissue Procurement: ATCC/DCTD/DTP cDNA Library Preparation: Life Technologies, Inc. cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL) DNA Sequencing by: Baylor College of Medicine Human Genome Sequencing Center Center code: BCM-HGSC Web site: http://www.hgsc.bcm.tmc.edu/cdna/ Contact: amg@bcm.tmc.edu Gunaratne, P.H., Garcia, A.M., Lu, X., Hulyk, S.W., Loulseged, H., Kowis, C.R., Sneed, A.J., Martin, R.G., Muzny, D.M., Nanavati, A.N., Gibbs, R.A. Clone distribution: MGC clone distribution information can be found through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov Series: IRAK Plate: 26 Row: d Column: 20 This clone was selected for full length sequencing because it passed the following selection criteria: matched mRNA gi: 24475623. FEATURES Location/Qualifiers source 1..1452 /db_xref="H-InvDB:HIT000040247" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /clone="MGC:9191 IMAGE:3923096" /tissue_type="Skin, melanotic melanoma." /clone_lib="NIH_MGC_72" /lab_host="DH10B" /note="Vector: pCMV-SPORT6" gene 1..1452 /gene="TYR" /gene_synonym="OCA1A" /gene_synonym="OCAIA" /db_xref="GeneID:7299" /db_xref="MIM:606933" CDS 62..1195 /gene="TYR" /gene_synonym="OCA1A" /gene_synonym="OCAIA" /codon_start=1 /product="TYR protein" /protein_id="AAH27179.1" /db_xref="GeneID:7299" /db_xref="MIM:606933" /translation="MLLAVLYCLLWSFQTSAGHFPRACVSSKNLMEKECCPPWSGDRS PCGQLSGRGSCQNILLSNAPLGPQFPFTGVDDRESWPSVFYNRTCQCSGNFMGFNCGN CKFGFWGPNCTERRLLVRRNIFDLSAPEKDKFFAYLTLAKHTISSDYVIPIGTYGQMK NGSTPMFNDINIYDLFVWMHYYVSMDALLGGSEIWRDIDFAHEAPAFLPWHRLFLLRW EQEIQKLTGDENFTIPYWDWRDAEKCDICTDEYMGGQHPTNPNLLSPASFFSSWQIVC SRLEEYNSHQSLCNGTPEGPLRRNPGNHDKSRTPRLPSSADVEFCLSLTQYESGSMDK AANFSFRNTLEEMGFLHVGWAGLKLLTSRDPPPWPPKMLGLQA" misc_feature 392..1096 /gene="TYR" /gene_synonym="OCA1A" /gene_synonym="OCAIA" /note="tyrosinase; Region: Common central domain of tyrosinase. This family also contains polyphenol oxidases and some hemocyanins. Binds two copper ions via two sets of three histidines. This family is related to pfam00372" /db_xref="CDD:pfam00264" BASE COUNT 401 a 331 c 317 g 403 t ORIGIN 1 aagagaaatc tgtgactcca attagccagt tcctgcagac cttgtgagga ctagaggaag 61 aatgctcctg gctgttttgt actgcctgct gtggagtttc cagacctccg ctggccattt 121 ccctagagcc tgtgtctcct ctaagaacct gatggagaag gaatgctgtc caccgtggag 181 cggggacagg agtccctgtg gccagctttc aggcagaggt tcctgtcaga atatccttct 241 gtccaatgca ccacttgggc ctcaatttcc cttcacaggg gtggatgacc gggagtcgtg 301 gccttccgtc ttttataata ggacctgcca gtgctctggc aacttcatgg gattcaactg 361 tggaaactgc aagtttggct tttggggacc aaactgcaca gagagacgac tcttggtgag 421 aagaaacatc ttcgatttga gtgccccaga gaaggacaaa ttttttgcct acctcacttt 481 agcaaagcat accatcagct cagactatgt catccccata gggacctatg gccaaatgaa 541 aaatggatca acacccatgt ttaacgacat caatatttat gacctctttg tctggatgca 601 ttattatgtg tcaatggatg cactgcttgg gggatctgaa atctggagag acattgattt 661 tgcccatgaa gcaccagctt ttctgccttg gcatagactc ttcttgttgc ggtgggaaca 721 agaaatccag aagctgacag gagatgaaaa cttcactatt ccatattggg actggcggga 781 tgcagaaaag tgtgacattt gcacagatga gtacatggga ggtcagcacc ccacaaatcc 841 taacttactc agcccagcat cattcttctc ctcttggcag attgtctgta gccgattgga 901 ggagtacaac agccatcagt ctttatgcaa tggaacgccc gagggacctt tacggcgtaa 961 tcctggaaac catgacaaat ccagaacccc aaggctcccc tcttcagctg atgtagaatt 1021 ttgcctgagt ttgacccaat atgaatctgg ttccatggat aaagctgcca atttcagctt 1081 tagaaataca ctggaagaga tgggatttct ccatgttggc tgggctggtc tcaaactcct 1141 gacctcaaga gatccaccac cttggcctcc caaaatgctg ggattacagg cttgagccac 1201 cacacctggc ctaacttcaa ggtatcaaag acaaattaac aatgtctgat gcatacatag 1261 gactgctttg taatcttcta cactaatgat ttgtactatt ttggtttcag aatccattta 1321 taactcttac aatatatgaa aaatttctgc cagcttttat ttatgtgggt tatatttatg 1381 actacttctc atttgtaaaa ctgaaataaa aagatcttgc atatttgtat taatttaaaa 1441 aaaaaaaaaa aa //