LOCUS BC023626 1451 bp mRNA linear HUM 23-DEC-2003
DEFINITION Homo sapiens Rho GTPase activating protein 4, mRNA (cDNA clone
IMAGE:4766128), partial cds.
ACCESSION BC023626
VERSION BC023626.2
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1451)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 1451)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (05-FEB-2002) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT On Dec 19, 2003 this sequence version replaced BC023626.1.
Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Louis Staudt
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: National Institutes of Health Intramural
Sequencing Center (NISC),
Gaithersburg, Maryland;
Web site: http://www.nisc.nih.gov/
Contact: nisc_mgc@nhgri.nih.gov
Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
Young,A., Zhang,L.-H. and Green,E.D.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 33 Row: l Column: 8
This clone was selected for full length sequencing because it
passed the following selection criteria: Hexamer frequency ORF
analysis.
FEATURES Location/Qualifiers
source 1..1451
/db_xref="H-InvDB:HIT000090822"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="IMAGE:4766128"
/tissue_type="Primary B-Cells from Tonsils"
/clone_lib="NIH_MGC_48"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene <1..1451
/gene="ARHGAP4"
/gene_synonym="C1"
/gene_synonym="KIAA0131"
/gene_synonym="RGC1"
/gene_synonym="RhoGAP4"
/db_xref="GeneID:393"
/db_xref="MIM:300023"
CDS <1..1073
/gene="ARHGAP4"
/gene_synonym="C1"
/gene_synonym="KIAA0131"
/gene_synonym="RGC1"
/gene_synonym="RhoGAP4"
/codon_start=3
/product="ARHGAP4 protein"
/protein_id="AAH23626.1"
/db_xref="GeneID:393"
/db_xref="MIM:300023"
/translation="PLFPPDLFGELLASSELEATAERVEHVSRLLWRLPAPVLVVLRY
LFTFLNHLAQYSDENMMDPYNLAVCFGPTLLPVPAGQDPVALQGRVNQLVQTLIVQPD
RVFPPLTSLPGPVYEKCMAPPSASCLGDAQLESLGADNEPELEAEMPAQEDDLEGVVE
AVACFAYTGRTAQELSFRRGDVLRLHERASSDWWRGEHNGMRGLIPHKYITLPAGTEK
QVVGAGLQTAGESGSSPEGLLASELVHRPEPCTSPEAMGPSGHRRRCLVPASPEQHVE
VDKAVAQNMDSVFKELLGKTSVRQGLGPASTTSPSPGPRSPKAPPSSRLGRNKGFSRG
PGAPASPSASHPQGLDTTPKPH"
misc_feature 3..308
/gene="ARHGAP4"
/gene_synonym="C1"
/gene_synonym="KIAA0131"
/gene_synonym="RGC1"
/gene_synonym="RhoGAP4"
/note="RhoGAP; Region: GTPase-activator protein for
Rho-like GTPases"
/db_xref="CDD:smart00324"
misc_feature 471..638
/gene="ARHGAP4"
/gene_synonym="C1"
/gene_synonym="KIAA0131"
/gene_synonym="RGC1"
/gene_synonym="RhoGAP4"
/note="SH3; Region: Src homology 3 domains"
/db_xref="CDD:smart00326"
BASE COUNT 262 a 483 c 471 g 235 t
ORIGIN
1 ccccactctt ccccccagac ctgttcggcg agctgctggc ttcttcggag ctggaggcca
61 cagcggagag ggtggagcac gtgagccgcc tgctgtggcg gctgcccgcg ccggtgctgg
121 tggttctgcg ctacctcttc accttcctca accacctggc ccagtacagc gatgagaaca
181 tgatggaccc ctacaacctg gccgtgtgct tcgggcccac gctgctaccg gtgcccgctg
241 ggcaggaccc ggtggcgctg cagggccggg tgaaccagct ggtgcagacg ctcatagtgc
301 agcccgatcg ggtcttcccg cccctgacct cgctgcctgg ccccgtctac gagaagtgca
361 tggcaccgcc ttccgccagc tgcctggggg acgcccagct ggagagcctg ggggcggaca
421 atgagccgga gctggaagcc gagatgcccg cacaggagga tgacctggag ggggtcgtgg
481 aggctgtggc ctgctttgcc tacacgggcc gcacagccca ggagctgagc ttccggcggg
541 gggacgtact gcggctgcac gagagggcct cgagcgactg gtggcggggg gagcacaacg
601 gcatgcgggg cctcatcccc cacaagtata tcacgctgcc cgccgggacg gagaagcagg
661 tggtgggcgc agggctgcag actgcagggg agtctgggag cagtcccgag ggcctcctgg
721 catcggagct ggtccaccgg ccagagccat gcacctcacc tgaggccatg ggaccctctg
781 gacacagacg acgctgcttg gtcccagcct ccccagagca acacgtggag gtggataagg
841 ctgtggcaca gaacatggac tctgtgttta aggagctctt gggaaagacc tctgtccgcc
901 agggccttgg gccagcatct accacctctc ccagtcctgg gccccgaagc ccaaaggccc
961 cgcccagcag ccgcctgggc aggaacaaag gcttctcccg gggccctggg gccccagcct
1021 caccctcagc ttcccacccc cagggcctag acacgacccc caagccacac tgaggtgccg
1081 ctgctggaga tgcgtgcccc cggcggctac ccgctggacc ggccactctc cccagccccc
1141 ttgcttctct ccagccctgt ccagcaagtg cagggtgcct gcacttcacc ctgtgcagag
1201 aggtgggatg gggccgtgca cacagggatg cccgctccac atcctgcctg cccctcagcc
1261 ctggcccagg ccccttttgg aggcagctga ggaaggatgc tggggaaagc cctcttctgc
1321 agctttgtgg aaggctgatc agtggctgct gggtggcggg tacccttgct cagatgcctg
1381 gcagggctgg gtggcgattc ataaagacct cgtgttgatt cccaaaaaaa aaaaaaaaaa
1441 aaaaaaaaaa a
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