LOCUS       BC022996                2278 bp    mRNA    linear   HUM 04-OCT-2003
DEFINITION  Homo sapiens SH3-domain binding protein 2, mRNA (cDNA clone
            MGC:29882 IMAGE:5103986), complete cds.
ACCESSION   BC022996
VERSION     BC022996.1
KEYWORDS    MGC.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2278)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
   PUBMED   12477932
REFERENCE   2  (bases 1 to 2278)
  AUTHORS   Strausberg,R.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-FEB-2002) National Institutes of Health, Mammalian
            Gene Collection (MGC), Cancer Genomics Office, National Cancer
            Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
            USA
  REMARK    NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT     Contact: MGC help desk
            Email: cgapbs-r@mail.nih.gov
            Tissue Procurement: ATCC
            cDNA Library Preparation: Life Technologies, Inc.
            cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
            DNA Sequencing by: Baylor College of Medicine Human Genome
            Sequencing Center
            Center code: BCM-HGSC
            Web site: http://www.hgsc.bcm.tmc.edu/cdna/
            Contact: amg@bcm.tmc.edu
            Gunaratne, P.H., Garcia, A.M., Lu, X., Hulyk, S.W., Loulseged, H.,
            Kowis, C.R., Sneed, A.J., Martin, R.G., Muzny, D.M., Nanavati,
            A.N., Gibbs, R.A.
            
            Clone distribution: MGC clone distribution information can be found
            through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
            Series: IRAK Plate: 42 Row: l Column: 3
            This clone was selected for full length sequencing because it
            passed the following selection criteria: matched mRNA gi: 19923154.
FEATURES             Location/Qualifiers
     source          1..2278
                     /db_xref="H-InvDB:HIT000039693"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /clone="MGC:29882 IMAGE:5103986"
                     /tissue_type="Cervix, carcinoma"
                     /clone_lib="NIH_MGC_12"
                     /lab_host="DH10B"
                     /note="Vector: pCMV-SPORT6"
     gene            1..2278
                     /gene="SH3BP2"
                     /gene_synonym="CRBM"
                     /gene_synonym="CRPM"
                     /gene_synonym="RES4-23"
                     /db_xref="GeneID:6452"
                     /db_xref="MIM:602104"
     CDS             117..1802
                     /gene="SH3BP2"
                     /gene_synonym="CRBM"
                     /gene_synonym="CRPM"
                     /gene_synonym="RES4-23"
                     /codon_start=1
                     /product="SH3BP2 protein"
                     /protein_id="AAH22996.1"
                     /db_xref="GeneID:6452"
                     /db_xref="MIM:602104"
                     /translation="MAAEEMHWPVPMKAIGAQNLLTMPGGVAKAGYLHKKGGTQLQLL
                     KWPLRFVIIHKRCVYYFKSSTSASPQGAFSLSGYNRVMRAAEETTSNNVFPFKIIHIS
                     KKHRTWFFSASSEEERKSWMALLRREIGHFHEKKDLPLDTSDSSSDTDSFYGAVERPV
                     DISLSPYPTDNEDYEHDDEDDSYLEPDSPEPGRLEDALMHPPAYPPPPVPTPRKPAFS
                     DMPRAHSFTSKGPGPLLPPPPPKHGLPDVGLAAEDSKRDPLCPRRAEPCPRVPATPRR
                     MSDPPLSTMPTAPGLRKPPCFRESASPSPEPWTPGHGACSTSSAAIMATATSRNCDKL
                     KSFHLSPRGPPTSEPPPVPANKPKFLKIAEEDPPREAAMPGLFVPPVAPRPPALKLPV
                     PEAMARPAVLPRPEKPQLPHLQRSPPDGQSFRSFSFEKPRQPSQADTGGDDSDEDYEK
                     VPLPNSVFVNTTESCEVERLFKATSPRGEPQDGLYCIRNSSTKSGKVLVVWDETSNKV
                     RNYRIFEKDSKFYLEGEVLFVSVGSMVEHYHTHVLPSHQSLLLRHPYGYTGPR"
     misc_feature    195..509
                     /gene="SH3BP2"
                     /gene_synonym="CRBM"
                     /gene_synonym="CRPM"
                     /gene_synonym="RES4-23"
                     /note="PH; Region: Pleckstrin homology domain. Domain
                     commonly found in eukaryotic signalling proteins. The
                     domain family possesses multiple functions including the
                     abilities to bind inositol phosphates, and various
                     proteins. PH domains have been found to possess inserted
                     domains (such as in PLC gamma, syntrophins) and to be
                     inserted within other domains. Mutations in Brutons
                     tyrosine kinase (Btk) within its PH domain cause X-linked
                     agammaglobulinaemia (XLA) in patients. Point mutations
                     cluster into the positively charged end of the molecule
                     around the predicted binding site for phosphatidylinositol
                     lipids"
                     /db_xref="CDD:smart00233"
     misc_feature    1512..1748
                     /gene="SH3BP2"
                     /gene_synonym="CRBM"
                     /gene_synonym="CRPM"
                     /gene_synonym="RES4-23"
                     /note="SH2; Region: Src homology 2 domains"
                     /db_xref="CDD:smart00252"
BASE COUNT          471 a          779 c          661 g          367 t
ORIGIN      
        1 gcgggcggga cggagctgcg gcggcggcgg gtcccgcggg cgggagcgcc tggcggccga
       61 gtcaagccgc cgcctcgacc cagggcccgc gggccaggag agcgctcggc ggcttcatgg
      121 cggctgaaga gatgcattgg cctgtcccta tgaaggccat tggtgcccag aacctgctaa
      181 ccatgcctgg gggcgtggcc aaggctggct acctgcacaa gaagggcggt acccagctgc
      241 agctgctgaa atggcccctg cgctttgtca tcatccacaa acgctgcgtc tactacttca
      301 agagtagcac ctctgcctcc ccgcagggcg ccttctccct gagtggctat aaccgggtga
      361 tgcgggcggc tgaggagacc acgtccaaca acgttttccc cttcaagatc atccacatca
      421 gcaagaagca ccgcacgtgg ttcttctcgg cctcctccga ggaggagcgc aagagctgga
      481 tggccttgct gcgcagggag attggccact tccacgaaaa gaaagacctg cccttggaca
      541 ccagcgactc cagctcggac acagacagct tctacggcgc agttgagcgg cctgtggata
      601 tcagcctttc cccgtacccc acggacaatg aagactatga gcacgacgat gaggatgact
      661 cctacctgga gcctgactcc ccggagcccg gaaggcttga ggatgccctg atgcacccac
      721 cggcttaccc accaccccca gtgcccacgc ccaggaagcc agccttctct gacatgcccc
      781 gggcccactc ctttacctcc aagggccccg gtcccctact gccacccccg ccccctaagc
      841 acggcctccc agatgttggc ctggctgctg aggactccaa gagggaccca ctgtgcccga
      901 ggcgggctga gccttgcccc agggtacctg ctaccccccg aaggatgagc gatccccctc
      961 tgagcaccat gcccaccgca cccggcctcc ggaaaccccc ttgcttccgg gagagtgcca
     1021 gccccagccc ggagccctgg acccctggcc acggggcctg ctccacttcc agtgctgcca
     1081 tcatggccac tgccacctcc agaaactgtg acaaactcaa gtccttccac ctgtcccccc
     1141 gaggaccacc cacatctgag cccccacctg tgccagccaa caagcccaag ttcctgaaga
     1201 tagctgaaga ggacccccca agggaggcag ccatgcccgg actctttgtg ccccccgtgg
     1261 ctccccggcc tcctgcgctg aagctgccag tgcctgaggc catggcgcgg cccgcagtcc
     1321 tgcccaggcc agagaagccg cagctcccgc acctccagcg atcacccccc gatgggcaga
     1381 gtttcaggag cttctccttt gaaaagcccc ggcaaccctc acaggctgac actggcgggg
     1441 acgactcgga cgaggactat gagaaggtgc cactgcccaa ctcggtcttc gtcaacacca
     1501 cggagtcctg cgaagtggaa aggttgttca aggctacaag cccccgggga gagccccagg
     1561 atggactcta ctgcatccgg aactcctcta ccaagtcggg gaaggtcctg gttgtgtggg
     1621 acgaaacctc taacaaagtg aggaactatc gcatttttga gaaggactct aagttctacc
     1681 tggagggcga ggtcctgttt gtgagtgtgg gcagcatggt ggagcactac cacacccacg
     1741 tgctgcccag ccaccagagc ctgctgctgc ggcaccccta cggctacact gggcctaggt
     1801 gatggcagtc catgtggctg ccaggccaag gcagtcacag gggccctgac cccaggccac
     1861 acagacggac atgggcccac atgggagggt gagcaggagc aaggctgtgc ttgcctaggg
     1921 cctctgtgat ggacatctcg taggacccag ccagtctcat ccagcaggtt gggttctagg
     1981 gctgaaccag gcgccaggct ccagaggacg aagggactct gttgccccac actaacttgc
     2041 cctgtcccaa tcccagaaac ccaggaccaa gctgtgcctg ggctccaagg acaggaacac
     2101 tggtcccccc atcacactca cccctaagtg ggctgggagc caggcagggc cagggcagct
     2161 gggtgggggc cggggctggc cctgggaccc ccaggaacgc taagacacag gctccagtag
     2221 gggctgttgc ctccaataaa gcagcagtga gctttgcctt gaaaaaaaaa aaaaaaaa
//