LOCUS       BC022532                2443 bp    mRNA    linear   HUM 04-AUG-2008
DEFINITION  Homo sapiens prion protein, mRNA (cDNA clone MGC:26679
            IMAGE:4813982), complete cds.
ACCESSION   BC022532
VERSION     BC022532.1
KEYWORDS    MGC.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2443)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
   PUBMED   12477932
REFERENCE   2  (bases 1 to 2443)
  CONSRTM   NIH MGC Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-FEB-2002) National Institutes of Health, Mammalian
            Gene Collection (MGC), Bethesda, MD 20892-2590, USA
  REMARK    NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT     Contact: MGC help desk
            Email: cgapbs-r@mail.nih.gov
            Tissue Procurement: Miklos Palkovits, M.D., Ph.D.
            cDNA Library Preparation: Michael J. Brownstein (NHGRI) &  Shiraki
            Toshiyuki and Piero Carninci (RIKEN)
            cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
            DNA Sequencing by: Sequencing Group at the Stanford Human Genome
            Center, Stanford University School of Medicine, Stanford, CA  94305
            Web site:       http://www-shgc.stanford.edu
            Contact:  (Dickson, Mark) mcd@paxil.stanford.edu
            Dickson, M., Schmutz, J., Grimwood, J., Rodriquez, A., and Myers,
            R. M.
            
            Clone distribution: MGC clone distribution information can be found
            through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
            Series: IRAK Plate: 32 Row: k Column: 12
            This clone was selected for full length sequencing because it
            passed the following selection criteria: Hexamer frequency ORF
            analysis, Similarity but not identity to protein.
FEATURES             Location/Qualifiers
     source          1..2443
                     /db_xref="H-InvDB:HIT000039610"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /clone="MGC:26679 IMAGE:4813982"
                     /tissue_type="Brain, hippocampus"
                     /clone_lib="NIH_MGC_95"
                     /lab_host="DH10B"
                     /note="Vector: pBluescriptR"
     gene            1..2443
                     /gene="PRNP"
                     /gene_synonym="ASCR"
                     /gene_synonym="CD230"
                     /gene_synonym="prion"
                     /gene_synonym="PrP"
                     /gene_synonym="PrP27-30"
                     /gene_synonym="PrP33-35C"
                     /gene_synonym="PrPc"
                     /db_xref="GeneID:5621"
                     /db_xref="HGNC:HGNC:9449"
                     /db_xref="MIM:176640"
     CDS             61..822
                     /gene="PRNP"
                     /gene_synonym="ASCR"
                     /gene_synonym="CD230"
                     /gene_synonym="prion"
                     /gene_synonym="PrP"
                     /gene_synonym="PrP27-30"
                     /gene_synonym="PrP33-35C"
                     /gene_synonym="PrPc"
                     /codon_start=1
                     /product="prion protein"
                     /protein_id="AAH22532.1"
                     /db_xref="GeneID:5621"
                     /db_xref="HGNC:HGNC:9449"
                     /db_xref="MIM:176640"
                     /translation="MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSP
                     GGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKP
                     SKPKTNMKHMAGAAAAGAVVGGLGGYVLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQ
                     VYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQY
                     ERESQAYYKRGSSMVLFSSPPVILLISFLIFLIVG"
BASE COUNT          683 a          502 c          583 g          675 t
ORIGIN      
        1 agtcgctgac agccgcggcg ccgcgagctt ctcctctcct cacgaccgag agcagtcatt
       61 atggcgaacc ttggctgctg gatgctggtt ctctttgtgg ccacatggag tgacctgggc
      121 ctctgcaaga agcgcccgaa gcctggagga tggaacactg ggggcagccg atacccgggg
      181 cagggcagcc ctggaggcaa ccgctaccca cctcagggcg gtggtggctg ggggcagcct
      241 catggtggtg gctgggggca gcctcatggt ggtggctggg ggcagcccca tggtggtggc
      301 tggggacagc ctcatggtgg tggctggggt caaggaggtg gcacccacag tcagtggaac
      361 aagccgagta agccaaaaac caacatgaag cacatggctg gtgctgcagc agctggggca
      421 gtggtggggg gccttggcgg ctacgtgctg ggaagtgcca tgagcaggcc catcatacat
      481 ttcggcagtg actatgagga ccgttactat cgtgaaaaca tgcaccgtta ccccaaccaa
      541 gtgtactaca ggcccatgga tgagtacagc aaccagaaca actttgtgca cgactgcgtc
      601 aatatcacaa tcaagcagca cacggtcacc acaaccacca agggggagaa cttcaccgag
      661 accgacgtta agatgatgga gcgcgtggtt gagcagatgt gtatcaccca gtacgagagg
      721 gaatctcagg cctattacaa gagaggatcg agcatggtcc tcttctcctc tccacctgtg
      781 atcctcctga tctctttcct catcttcctg atagtgggat gaggaaggtc ttcctgtttt
      841 caccatcttt ctaatctttt tccagcttga gggaggcggt atccacctgc agccctttta
      901 gtggtggtgt ctcactcttt cttctctctt tgtcccggat aggctaatca atacccttgg
      961 cactgatggg cactggaaaa catagagtag acctgagatg ctggtcaagc cccctttgat
     1021 tgagttcatc atgagccgtt gctaatgcca ggccagtaaa agtataacag caaataacca
     1081 ttggttaatc tggacttatt tttggactta gtgcaacagg ttgaggctaa aacaaatctc
     1141 agaacagtct gaaatacctt tgcctggata cctctggctc cttcagcagc tagagctcag
     1201 tatactaatg ccctatctta gtagagattt catagctatt tagagatatt ttccatttta
     1261 agaaaacccg acaacatttc tgccaggttt gttaggaggc cacatgatac ttattcaaaa
     1321 aaatcctaga gattcttagc tcttgggatg caggctcagc ccgctggagc atgagctctg
     1381 tgtgtaccga gaactggggt gatgttttac ttttcacagt atgggctaca cagcagctgt
     1441 tcaacaagag taaatattgt cacaacactg aacctctggc tagaggacat attcacagtg
     1501 aacataactg taacatatat gaaaggcttc tgggacttga aatcaaatgt ttgggaatgg
     1561 tgcccttgga ggcaacctcc cattttagat gtttaaagga ccctatatgt ggcattcctt
     1621 tctttaaact ataggtaatt aaggcagctg aaaagtaaat tgccttctag acactgaagg
     1681 caaatctcct ttgtccattt acctggaaac cagaatgatt ttgacataca ggagagctgc
     1741 agttgtgaaa gcaccatcat catagaggat gatgtaatta aaaaatggtc agtgtgcaaa
     1801 gaaaagaact gcttgcattt ctttatttct gtctcataat tgtcaaaaac cagaattagg
     1861 tcaagttcat agtttctgta attggctttt gaatcaaaga atagggagac aatctaaaaa
     1921 atatcttagg ttggagatga cagaaatatg attgatttga agtggaaaaa gaaattctgt
     1981 taatgttaat taaagtaaaa ttattccctg gattgtttga tattgtcacc tagcagatat
     2041 gtattacttt tctgcaatgt tattattggc ttgcactttg tgagtattct atgtaaaaat
     2101 atatatgtat ataaaatata tattgcatag gacagactta ggagttttgt ttagagcagt
     2161 taacatctga agtgtctaat gcattaactt ttgtaaggta ctgaatactt aatatgtggg
     2221 aaaccctttt gcgtggtcct taggcttaca atgtgcactg aatcgtttca tgtaagaatc
     2281 caaagtggac accattaaca ggtctttgaa atatgcatgt actttatatt ttctatattt
     2341 gtaactttgc atgttcttgt tttgttatat aaaaaaattg taaatgttta atatctgact
     2401 gaaattaaac gagcgaagat gagcaccaaa aaaaaaaaaa aaa
//