LOCUS BC020618 1117 bp mRNA linear HUM 03-JAN-2005
DEFINITION Homo sapiens ATP-binding cassette, sub-family B (MDR/TAP), member
4, mRNA (cDNA clone IMAGE:4767591), complete cds.
ACCESSION BC020618
VERSION BC020618.2
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1117)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 1117)
AUTHORS Director MGC Project.
TITLE Direct Submission
JOURNAL Submitted (03-JAN-2002) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT On Sep 16, 2003 this sequence version replaced BC020618.1.
Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: CLONTECH
cDNA Library Preparation: CLONTECH Laboratories, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Sequencing Group at the Stanford Human Genome
Center, Stanford University School of Medicine, Stanford, CA 94305
Web site: http://www-shgc.stanford.edu
Contact: (Dickson, Mark) mcd@paxil.stanford.edu
Dickson, M., Schmutz, J., Grimwood, J., Rodriquez, A., and Myers,
R. M.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 37 Row: k Column: 18
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 9961253
This clone has the following problem: The cds is short compared to
the longest cds in the locus.
FEATURES Location/Qualifiers
source 1..1117
/db_xref="H-InvDB:HIT000090185"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="IMAGE:4767591"
/tissue_type="Liver"
/clone_lib="NIH_MGC_76"
/lab_host="DH10B"
/note="Vector: pDNR-LIB"
gene 1..1117
/gene="ABCB4"
/gene_synonym="ABC21"
/gene_synonym="MDR2/3"
/gene_synonym="MDR3"
/gene_synonym="PFIC-3"
/gene_synonym="PGY3"
/db_xref="GeneID:5244"
/db_xref="MIM:171060"
CDS 8..547
/gene="ABCB4"
/gene_synonym="ABC21"
/gene_synonym="MDR2/3"
/gene_synonym="MDR3"
/gene_synonym="PFIC-3"
/gene_synonym="PGY3"
/codon_start=1
/product="ABCB4 protein"
/protein_id="AAH20618.1"
/db_xref="GeneID:5244"
/db_xref="MIM:171060"
/translation="MDLEAAKNGTAWRPTSAEGDFELGISSKQKRKKTKTVKMIGVLT
LFRYSDWQDKLFMSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSL
LNPGKILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQ
EIGWFDINDTTELNTRLTE"
BASE COUNT 356 a 197 c 245 g 319 t
ORIGIN
1 ggctgagatg gatcttgagg cggcaaagaa cggaacagcc tggcgcccca cgagcgcgga
61 gggcgacttt gaactgggca tcagcagcaa acaaaaaagg aaaaaaacga agacagtgaa
121 aatgattgga gtattaacat tgtttcgata ctccgattgg caggataaat tgtttatgtc
181 gctgggtacc atcatggcca tagctcacgg atcaggtctc cccctcatga tgatagtatt
241 tggagagatg actgacaaat ttgttgatac tgcaggaaac ttctcctttc cagtgaactt
301 ttccttgtcg ctgctaaatc caggcaaaat tctggaagaa gaaatgacta gatatgcata
361 ttactactca ggattgggtg ctggagttct tgttgctgcc tatatacaag tttcattttg
421 gactttggca gctggtcgac agatcaggaa aattaggcag aagttttttc atgctattct
481 acgacaggaa ataggatggt ttgacatcaa tgacaccact gaactcaata cgcggctaac
541 agagtaggta cattgttaat gtcacacttt catatagaaa ttaattactg tgtgaaaata
601 tgtcaaggaa agattttaaa tgaaaaatgt tactagattg agcatctgat ctatattaga
661 aatcgatcat ctggcagcca tgtctagcag catctatagc ctatgccatt gcatgttggc
721 tttcccccaa ggtgcatagt aggtttattt gaggactgaa ttcacatctt atacctgttt
781 atttctcatg gaactttcta ctgcaggacg tgacaggtgc tagactgtca gtaaagatgg
841 ttgaatcaat gaatagatga ttgaattaat ttacaaagag acttgcttta gtaattgtca
901 actcttcact tattcaacaa atatttgagg gtgtttcatg tgcgaagtac cattctgtgt
961 gttcgtaata tatcagtgaa caaagcacag atctctgtcc ttttggtgct tacattccag
1021 tagagggaga tagatgataa actttcctga ctgggagtcc tggcaaaggc atcctgagca
1081 aataagtcaa aaaaaaaaaa aaaaaaaaaa aaaaaaa
//