LOCUS       BC019291                1450 bp    mRNA    linear   HUM 15-JUL-2006
DEFINITION  Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1,
            mRNA (cDNA clone MGC:4057 IMAGE:2823545), complete cds.
ACCESSION   BC019291
VERSION     BC019291.1
KEYWORDS    MGC.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1450)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
   PUBMED   12477932
REFERENCE   2  (bases 1 to 1450)
  CONSRTM   NIH MGC Project
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2001) National Institutes of Health, Mammalian
            Gene Collection (MGC), Bethesda, MD 20892-2590, USA
  REMARK    NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT     Contact: MGC help desk
            Email: cgapbs-r@mail.nih.gov
            Tissue Procurement: DCTD/DTP
            cDNA Library Preparation: Rubin Laboratory
            cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
            DNA Sequencing by: Genome Sequence Centre,
            BC Cancer Agency, Vancouver, BC, Canada
            info@bcgsc.bc.ca
            Martin Hirst, Thomas Zeng, Ryan Morin, Michelle Moksa, Johnson
            Pang, Diana Mah, Jing Wang, Kieth Fichter, Eric Chuah, Allen
            Delaney, Rob Kirkpatrick, Agnes Baross, Sarah Barber, Mabel
            Brown-John, Steve S. Chand, William Chow, Ryan Babakaiff, Dave
            Wong, Corey Matsuo, Jaclyn Beland, Susan Gibson, Luis delRio, Ruth
            Featherstone, Malachi Griffith, Obi Griffith, Ran Guin, Nancy Liao,
            Kim MacDonald,  Mike R. Mayo, Josh Moran, Diana Palmquist, JR
            Santos, Duane Smailus, Jeff Stott, Miranda Tsai, George Yang,
            Jacquie Schein, Asim Siddiqui,Steven Jones, Rob Holt, Marco Marra.
            
            Clone distribution: MGC clone distribution information can be found
            through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
            Series: IRAL Plate: 9 Row: a Column: 18
            This clone was selected for full length sequencing because it
            passed the following selection criteria: matched mRNA gi: 18375500.
FEATURES             Location/Qualifiers
     source          1..1450
                     /db_xref="H-InvDB:HIT000038611"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /clone="MGC:4057 IMAGE:2823545"
                     /tissue_type="Lung, small cell carcinoma"
                     /clone_lib="NIH_MGC_7"
                     /lab_host="DH10B-R"
                     /note="Vector: pOTB7"
     gene            1..1450
                     /gene="APEX1"
                     /gene_synonym="APE"
                     /gene_synonym="APE1"
                     /gene_synonym="APEN"
                     /gene_synonym="APX"
                     /gene_synonym="HAP1"
                     /gene_synonym="REF-1"
                     /gene_synonym="REF1"
                     /db_xref="GeneID:328"
                     /db_xref="HGNC:HGNC:587"
                     /db_xref="MIM:107748"
     CDS             218..1174
                     /gene="APEX1"
                     /gene_synonym="APE"
                     /gene_synonym="APE1"
                     /gene_synonym="APEN"
                     /gene_synonym="APX"
                     /gene_synonym="HAP1"
                     /gene_synonym="REF-1"
                     /gene_synonym="REF1"
                     /codon_start=1
                     /product="APEX nuclease (multifunctional DNA repair
                     enzyme) 1"
                     /protein_id="AAH19291.1"
                     /db_xref="GeneID:328"
                     /db_xref="HGNC:HGNC:587"
                     /db_xref="MIM:107748"
                     /translation="MPKRGKKGAVAEDGDELRTEPEAKKSKTAAKKNDKEAAGEGPAL
                     YEDPPDQKTSPSGKPATLKICSWNVDGLRAWIKKKGLDWVKEEAPDILCLQETKCSEN
                     KLPAELQELPGLSHQYWSAPSDKEGYSGVGLLSRQCPLKVSYGIGEEEHDQEGRVIVA
                     EFDSFVLVTAYVPNAGRGLVRLEYRQRWDEAFRKFLKGLASRKPLVLCGDLNVAHEEI
                     DLRNPKGNKKNAGFTPQERQGFGELLQAVPLADSFRHLYPNTPYAYTFWTYMMNARSK
                     NVGWRLDYFLLSHSLLPALCDSKIRSKALGSDHCPITLYLAL"
BASE COUNT          400 a          344 c          374 g          332 t
ORIGIN      
        1 gaggagctag gctgccatcg ggccggtgca gatacggggt tgctcttttg ctcataagag
       61 gggcttcgct ggcagtctga acggcaagct tgagtcagga cccttaatta agatcctcaa
      121 ttggctggag ggcagatctc gcgagtaggg caacgcggta aaaatattgc ttcggtgggt
      181 gacgcggtac agctgcccaa gggcgttcgt aacgggaatg ccgaagcgtg ggaaaaaggg
      241 agcggtggcg gaagacgggg atgagctcag gacagagcca gaggccaaga agagtaagac
      301 ggccgcaaag aaaaatgaca aagaggcagc aggagagggc ccagccctgt atgaggaccc
      361 cccagatcag aaaacctcac ccagtggcaa acctgccaca ctcaagatct gctcttggaa
      421 tgtggatggg cttcgagcct ggattaagaa gaaaggatta gattgggtaa aggaagaagc
      481 cccagatata ctgtgccttc aagagaccaa atgttcagag aacaaactac cagctgaact
      541 tcaggagctg cctggactct ctcatcaata ctggtcagct ccttcggaca aggaagggta
      601 cagtggcgtg ggcctgcttt cccgccagtg cccactcaaa gtttcttacg gcataggcga
      661 ggaggagcat gatcaggaag gccgggtgat tgtggctgaa tttgactcgt ttgtgctggt
      721 aacagcatat gtacctaatg caggccgagg tctggtacga ctggagtacc ggcagcgctg
      781 ggatgaagcc tttcgcaagt tcctgaaggg cctggcttcc cgaaagcccc ttgtgctgtg
      841 tggagacctc aatgtggcac atgaagaaat tgaccttcgc aaccccaagg ggaacaaaaa
      901 gaatgctggc ttcacgccac aagagcgcca aggcttcggg gaattactgc aggctgtgcc
      961 actggctgac agctttaggc acctctaccc caacacaccc tatgcctaca ccttttggac
     1021 ttatatgatg aatgctcgat ccaagaatgt tggttggcgc cttgattact ttttgttgtc
     1081 ccactctctg ttacctgcat tgtgtgacag caagatccgt tccaaggccc tcggcagtga
     1141 tcactgtcct atcaccctat acctagcact gtgacaccac ccctaaatca ctttgagcct
     1201 gggaaataag ccccctcaac taccattcct tctttaaaca ctcttcagag aaatctgcat
     1261 tctatttctc atgtataaaa ctaggaatcc tccaaccagg ctcctgtgat agagttcttt
     1321 taagcccaag attttttatt tgagggtttt ttgtttttta aaaaaaaatt gaacaaagac
     1381 tactaatgac tttgtttgaa ttatccacat gaaaataaag agccatagtt tcaaaaaaaa
     1441 aaaaaaaaaa
//