LOCUS BC018919 3484 bp mRNA linear HUM 15-JUL-2006
DEFINITION Homo sapiens mutated in colorectal cancers, mRNA (cDNA clone
MGC:12732 IMAGE:4131685), complete cds.
ACCESSION BC018919
VERSION BC018919.2
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3484)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 3484)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (07-DEC-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT On Dec 9, 2003 this sequence version replaced BC018919.1.
Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: National Institutes of Health Intramural
Sequencing Center (NISC),
Gaithersburg, Maryland;
Web site: http://www.nisc.nih.gov/
Contact: nisc_mgc@nhgri.nih.gov
Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
Young,A., Zhang,L.-H. and Green,E.D.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 17 Row: i Column: 20
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 4505128.
FEATURES Location/Qualifiers
source 1..3484
/db_xref="H-InvDB:HIT000038472"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:12732 IMAGE:4131685"
/tissue_type="Muscle, rhabdomyosarcoma"
/clone_lib="NIH_MGC_17"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene 1..3484
/gene="MCC"
/db_xref="GeneID:4163"
/db_xref="HGNC:HGNC:6935"
/db_xref="MIM:159350"
CDS 531..3020
/gene="MCC"
/codon_start=1
/product="mutated in colorectal cancers"
/protein_id="AAH18919.1"
/db_xref="GeneID:4163"
/db_xref="HGNC:HGNC:6935"
/db_xref="MIM:159350"
/translation="MNSGVAMKYGNDSSAELSELHSAALASLKGDIVELNKRLQQTER
ERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERITELHSVIAELNKKIDRLQGT
TIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQSTMVTADMDNCSDLNS
ELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGR
DLYPNLAEERSRWEKELAGLREENESLTAMLCSKEEELNRTKATMNAIREERDRLRRR
VRELQTRLQSVQATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSK
TRSESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSAISESK
IREFEVETERLNSRIEHLKSQNDLLTITLEECKSNAERMSMLVGKYESNATALRLALQ
YSEQCIEAYELLLALAESEQSLILGQFRAAGVGSSPGDQSGDENITQMLKRAHDCRKT
AENAAKALLMKLDGSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDE
QRLKDYIQQLKNDRAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLENAVLMQELMA
MKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVHIEHLKSEVEEQKEQRMRSL
SSTSSGSKDKPGKECADAASPALSLAELRTTCSENELAAEFTNAIRREKKLKARVQEL
VSALERLTKSSEIRHQQSAEFVNDLKRANSNLVAAYEKAKKKHQNKLKKLESQMMAMV
ERHETQVRMLKQRIALLEEENSRPHTNETSL"
BASE COUNT 933 a 919 c 1015 g 617 t
ORIGIN
1 gaaacttcgg cgtgaagtgc agctccgctc cggctccctc tagctttctt tccttctctg
61 gaatccgagg cgcggatctt cctcgcccca ccgccctagt tttttcggga gctcgccggt
121 gccctctagg gtgtcggctc gtgctgggaa gtgccctcca tcctggtaat ggggggcggc
181 gaggcaccgt aggagtggcg aggcggcgcc cagggtggca ctgccccgga acggggcgct
241 gggtgcgcgc gggagggtcc ccgcgcgggc tccgccgctg ccgcagctgc gagcgcgccg
301 cgccaccgag cctcctgcag caatggctcg tccgtgaaac gcgagccacg gctgctcttt
361 ttaagagtgc ctgcatcctc cgtttgcgct tcgcaactgt cctgggtgaa aatggctgtc
421 tagactaaaa tgtggcagaa gggaccaagc agtggatatt gagcctgtga agtccaactc
481 ttaagctccg agacctgggg gactgagagc ccagctctga aaagtgcatc atgaattccg
541 gagttgccat gaaatatgga aacgactcct cggccgagct gagtgagctc cattcagcag
601 ccctggcatc actaaaggga gatatagtgg aacttaataa acgtctccag caaacagaga
661 gggaacggga ccttctggaa aagaaattgg ccaaggcaca gtgcgagcag tcccacctca
721 tgagagagca tgaggatgtc caggagcgaa cgacgcttcg ctatgaggaa cgcatcacag
781 agctccacag cgtcattgcg gagctcaaca agaagataga ccgtctgcaa ggcaccacca
841 tcagggagga agatgagtac tcagaactgc gatcagaact cagccagagc caacacgagg
901 tcaacgagga ctctcgaagc atggaccaag accagacctc tgtctctatc cccgaaaacc
961 agtctaccat ggttactgct gacatggaca actgcagtga cctgaactca gaactgcaga
1021 gggtgctgac agggctggag aatgttgtct gcggcaggaa gaagagcagc tgcagcctct
1081 ccgtggccga ggtggacagg cacattgagc agctcaccac agccagcgag cactgtgacc
1141 tggctattaa gacagtcgag gagattgagg gggtgcttgg ccgggacctg tatcccaacc
1201 tggctgaaga gaggtctcgg tgggagaagg agctggctgg gctgagggaa gagaatgaga
1261 gcctgactgc catgctgtgc agcaaagagg aagaactgaa ccggactaag gccaccatga
1321 atgccatccg ggaagagcgg gaccggctcc ggaggagggt cagagagctt caaactcgac
1381 tacagagcgt gcaggccaca ggtccctcca gccctggccg cctcacttcc accaaccgcc
1441 cgattaaccc cagcactggg gagctgagca caagcagcag cagcaatgac attcccatcg
1501 ccaagattgc tgagagggtg aagctatcaa agacaaggtc cgaatcgtca tcatctgatc
1561 ggccagtcct gggctcagaa atcagtagca taggggtatc cagcagtgtg gctgaacacc
1621 tggcccactc acttcaggac tgctccaata tccaagagat tttccaaaca ctctactcac
1681 acggatctgc catctcagaa agcaagatta gagagtttga ggtggaaaca gaacggctga
1741 atagccggat tgagcacctc aaatcccaaa atgacctcct gaccataacc ttggaggaat
1801 gtaaaagcaa tgccgagagg atgagcatgc tggtgggaaa atacgaatcc aatgccacag
1861 cgctgaggct ggccttgcag tacagcgagc agtgcatcga agcctacgaa ctcctcctgg
1921 cgctggcaga gagtgagcag agcctcatcc tggggcagtt ccgagcggcg ggcgtggggt
1981 cctcccctgg agaccagtcg ggggatgaaa acatcactca gatgctcaag cgagctcatg
2041 actgccggaa gacagctgag aatgctgcca aggccctgct catgaagctg gacggcagct
2101 gtgggggagc ctttgccgtg gccggctgca gcgtgcagcc ctgggagagc ctttcctcca
2161 acagccacac cagcacaacc agctccacag ccagtagttg cgacaccgag ttcactaaag
2221 aagacgagca gaggctgaag gattatatcc agcagctcaa gaatgacagg gctgcggtca
2281 agctgaccat gctggagctg gaaagcatcc acatcgatcc tctcagctat gacgtcaagc
2341 ctcggggaga cagccagagg ctggatctgg aaaacgcagt gcttatgcag gagctcatgg
2401 ccatgaagga ggagatggcc gagttgaagg cccagctcta cctactggag aaagagaaga
2461 aggccctgga gctgaagctg agcacgcggg aggcccagga gcaggcctac ctggtgcaca
2521 ttgagcacct gaagtccgag gtggaggagc agaaggagca gcggatgcga tccctcagct
2581 ccaccagcag cggcagcaaa gataaacctg gcaaggagtg tgctgatgct gcctccccag
2641 ctctgtccct agctgaactc aggacaacgt gcagcgagaa tgagctggct gcggagttca
2701 ccaacgccat tcgtcgagaa aagaagttga aggccagagt tcaagagctg gtgagtgcct
2761 tggagagact caccaagagc agtgaaatcc gacatcagca atctgcagag ttcgtgaatg
2821 atctaaagcg ggccaacagc aacctggtgg ctgcctatga gaaagcaaag aaaaagcatc
2881 aaaacaaact gaagaagtta gagtcgcaga tgatggccat ggtggagaga catgagaccc
2941 aagtgaggat gctcaagcaa agaatagctc tgctagagga ggagaactcc aggccacaca
3001 ccaatgaaac ttcgctttaa tcagcactca cgcaccggag ttctgcccat gggaagtaaa
3061 ctgcagcagg ccactgggga cagaagggcc catgtacttg ttgggaggag gaggaaaggg
3121 aaggctggca ggtaggtcgg cacttggaca atggagtgcc ccaactcaac ccttggggtg
3181 actggccatg gtgacattgt ggactgtatc cagaggtgcc cgctcttccc tcctgggccc
3241 acaacagcgt gtaaacacat gttctgtgcc tgctcagcag agcctcgttt ctgctttcag
3301 cactcactct ccccctcctc ttctggtctg gcggctgtgc atcagtggga tcccagacat
3361 ttgtttctgt aagattttcc attgtatcct ctttttggta gatgctgggc tcatcttcta
3421 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
3481 aaaa
//