LOCUS BC018514 2990 bp mRNA linear HUM 07-OCT-2003
DEFINITION Homo sapiens solute carrier family 19 (thiamine transporter),
member 2, mRNA (cDNA clone MGC:17044 IMAGE:3872233), complete cds.
ACCESSION BC018514
VERSION BC018514.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2990)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 2990)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (03-DEC-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Life Technologies, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Baylor College of Medicine Human Genome
Sequencing Center
Center code: BCM-HGSC
Web site: http://www.hgsc.bcm.tmc.edu/cdna/
Contact: amg@bcm.tmc.edu
Gunaratne, P.H., Garcia, A.M., Lu, X., Hulyk, S.W., Loulseged, H.,
Kowis, C.R., Sneed, A.J., Martin, R.G., Muzny, D.M., Nanavati,
A.N., Gibbs, R.A.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 13 Row: l Column: 15.
FEATURES Location/Qualifiers
source 1..2990
/db_xref="H-InvDB:HIT000038356"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:17044 IMAGE:3872233"
/tissue_type="Eye, retinoblastoma"
/clone_lib="NIH_MGC_67"
/lab_host="DH10B"
/note="Vector: pCMV-SPORT6"
gene 1..2990
/gene="SLC19A2"
/gene_synonym="TC1"
/gene_synonym="THT1"
/gene_synonym="THTR1"
/gene_synonym="TRMA"
/db_xref="GeneID:10560"
/db_xref="MIM:603941"
CDS 166..1056
/gene="SLC19A2"
/gene_synonym="TC1"
/gene_synonym="THT1"
/gene_synonym="THTR1"
/gene_synonym="TRMA"
/codon_start=1
/product="SLC19A2 protein"
/protein_id="AAH18514.1"
/db_xref="GeneID:10560"
/db_xref="MIM:603941"
/translation="MDVPGPVSRRAAAAAATVLLRTARVRRECWFLPTALLCAYGFFA
SLRPSEPFLTPYLLGPDKNLTEREEPKPDRLLVLKVLWNDFLMCYSSRPLLCWSVWWA
LSTCGYFQVVNYTQGLWEKVMPSRYAAIYNGGVEAVSTLLGAVAVFAVGYIKISWSTW
GEMTLSLFSLLIAAAVYIMDTVGNIWVCYASYVVFRIIYMLLITIATFQIAANLSMER
YALVFGVNTFIALALQTLLTLIVVDASGLGLEITTQFLIYASYFALIAVVFLASGAVS
VMKKCRKLEDPQSSSQVTTS"
misc_feature 253..369
/gene="SLC19A2"
/gene_synonym="TC1"
/gene_synonym="THT1"
/gene_synonym="THTR1"
/gene_synonym="TRMA"
/note="Folate_carrier; Region: Reduced folate carrier. The
reduced folate carrier (a transmembrane glycoprotein)
transports reduced folate into mammalian cells via the
carrier mediated mechanism (as opposed to the receptor
mediated mechanism) it also transports cytotoxic folate
analogues used in chemotherapy, such as methotrexate
(MTX). Mammalian cells have an absolute requirement for
exogenous folates which are needed for growth, and
biosynthesis of macromolecules"
/db_xref="CDD:pfam01770"
misc_feature 376..930
/gene="SLC19A2"
/gene_synonym="TC1"
/gene_synonym="THT1"
/gene_synonym="THTR1"
/gene_synonym="TRMA"
/note="Folate_carrier; Region: Reduced folate carrier. The
reduced folate carrier (a transmembrane glycoprotein)
transports reduced folate into mammalian cells via the
carrier mediated mechanism (as opposed to the receptor
mediated mechanism) it also transports cytotoxic folate
analogues used in chemotherapy, such as methotrexate
(MTX). Mammalian cells have an absolute requirement for
exogenous folates which are needed for growth, and
biosynthesis of macromolecules"
/db_xref="CDD:pfam01770"
BASE COUNT 808 a 552 c 630 g 1000 t
ORIGIN
1 gggtaaagct gggggttctg tagccggagg cggcggcgag tccagaacgt cctggcctta
61 cagggagaag gcgtcactcg cggttacaag tgcctgaccc tcactccagt tggcggagga
121 ggagaaggaa ggggccgggc cgggtcccct cccctcgcgc cccggatgga tgtgcccggc
181 ccggtgtctc ggcgggcggc ggcggcggcg gccactgtgc tcctgcggac cgctcgggtc
241 cgtcgcgaat gctggttctt gccgaccgcg ctgctctgcg cctacggctt cttcgccagc
301 ctcaggccgt ccgagccctt cctgaccccg tacctgctgg ggccggacaa gaacctgacc
361 gagagggagg aacccaagcc agaccgtctc cttgtattga aagtactatg gaatgatttc
421 ctgatgtgct actcctctcg ccctcttctc tgctggtctg tgtggtgggc cctctctacc
481 tgtggctatt ttcaagttgt gaactacaca cagggcctgt gggagaaagt gatgccttct
541 cgctatgctg ctatctataa tggtggcgtg gaggccgttt caaccttact gggtgctgtt
601 gctgtgtttg cagttggtta tataaaaata tcctggtcaa cttggggaga aatgacatta
661 tctctctttt ctctcctgat tgctgctgca gtgtatatca tggacactgt gggtaacatt
721 tgggtgtgct atgcatccta tgttgtcttc agaatcatct acatgttact catcacgata
781 gcaacttttc aaattgctgc aaacctcagc atggaacgct atgccctagt atttggtgta
841 aataccttca ttgccctggc actgcagacg ctgctcactc taattgtggt agatgccagt
901 ggccttggat tagaaattac cactcagttt ttgatctatg ccagttattt tgcactcatc
961 gctgtggttt tcctggccag tggtgcagtc agtgttatga agaaatgtag aaagctggaa
1021 gatccacaat caagttctca agtaaccact tcataatata ctgctgaagg gcttcttctt
1081 atagcaagaa ctctgcacag caactgcctg gatgtatttg attttttaaa gcgtagacat
1141 atatttatga atgtgcattt cttgacttca cagcagccac ttgactaata ccttgtgttc
1201 cgggaataac atgatactat tcagaggagc cagaagtaaa gtttatttca tggattattt
1261 atgagagcta atttaaggat gacttttttt ctgattcaaa agtgaacttg attttaaaaa
1321 ccagtcaaga gcaatcaaag cagcacatgg tgttgtatac ttcattagca agtgagtttg
1381 gtgttttata ggtcacatat gtctgtatct acttagccag atgcttggcc tggtgggacc
1441 agggctccac agaggccaca aaatgttgca agtcatgatg gatggaaata tgttctaaca
1501 gcatctgcct ctattcaatt taattcttat ttctgtgtta ctcatgtaca ttggtctttc
1561 tacatagtta ttctatcact ggcaatattt gttctggttt agtgttctgt attttaaggt
1621 gtacgtatca tttctaattt taagttattt taaaaaaatt catcatatga atgttcttgg
1681 ttcccattgt gacgattatt tatttctgta aaatttgttt agaagtacgt ttttgcatta
1741 ttcatatgct tcccagagaa gctcatttag ttagaaaata aggcaagttt tgaagcctgc
1801 taaatgaaga gacttaagaa agcttaaggt acgcttgctt gtctttaaat cttcaatatg
1861 aaggactatt aattccaaga ttaaaagttc atatataggc taaagatgta actaggccat
1921 ttgtatttgt attccctttt atttccaaaa taaaatgaaa aatctttttt taataatttc
1981 atccctattt atagttttta tattaatttg tttttcttat ccaagtaaag atgtcaatag
2041 gaattgcatt agtccaaggc ctttttcata aactgagcct cttttcaatt atttcaatgg
2101 gacaggaact aggatagatg tgattcctgc atttttttac cttaaatctg cctttgtttc
2161 taaaggtaga tcatcttgaa tatttgctta aaattgctag tgatttcatt accaagttac
2221 ttgaaaaaat gttctatatg catttaattc tgaaatcagt ctaccaaggg gctgctagta
2281 tatgtcagac atgaaaacta ttttaaagct gactttgttg ccttatcttg aaaagaatct
2341 agataggtgc ttttaactgg ggtattaact tttttagaat gacacagctg aacagtgtta
2401 ataatagtgt gtcaagattg caaagtcgac atactcattt ggtttaagca ggaatcctag
2461 aagcaaatgg atggggataa gaataggtca ttttctattc accatccttt actattaagg
2521 gaaaggaaaa gaacactagc taaggaaggg aaagggaagt gatatcataa aagtagcaac
2581 cttcatttta cattctgtct gtttttcttt ttttgctttg ttttgtttgt gctaatttgg
2641 gaattgtgta ctccgaaaca agtagaaaag tgctgtttga gggattttat taaatctttt
2701 tttaatggaa tgtggtacaa attgttcatg ttaccaaagc aatatttccc tggaatttaa
2761 ttcaaagttt gtggcataca acctgagcct tttcttatat aagacaagaa tatgttcaca
2821 tcttggtatg tggccatatt tatagaatgc tgaactcaat gtgcaagttg tactgtatgc
2881 agttttgtaa ataagtgaaa ataatttgtt gtacttttta ttcaattctg tatagattat
2941 aaaattattt ttattaaata aatattttac agtaaaaaaa aaaaaaaaaa
//