LOCUS BC018503 1333 bp mRNA linear HUM 06-OCT-2003
DEFINITION Homo sapiens transforming growth factor, beta 3, mRNA (cDNA clone
MGC:21261 IMAGE:4477175), complete cds.
ACCESSION BC018503
VERSION BC018503.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1333)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 1333)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (03-DEC-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: DCTD/DTP
cDNA Library Preparation: Life Technologies, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Baylor College of Medicine Human Genome
Sequencing Center
Center code: BCM-HGSC
Web site: http://www.hgsc.bcm.tmc.edu/cdna/
Contact: amg@bcm.tmc.edu
Gunaratne, P.H., Garcia, A.M., Lu, X., Hulyk, S.W., Loulseged, H.,
Kowis, C.R., Sneed, A.J., Martin, R.G., Muzny, D.M., Nanavati,
A.N., Gibbs, R.A.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 28 Row: d Column: 10
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 4507464.
FEATURES Location/Qualifiers
source 1..1333
/db_xref="H-InvDB:HIT000038354"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:21261 IMAGE:4477175"
/tissue_type="Prostate, adenocarcinoma."
/clone_lib="NIH_MGC_91"
/lab_host="DH10B"
/note="Vector: pCMV-SPORT6"
gene 1..1333
/gene="TGFB3"
/db_xref="GeneID:7043"
/db_xref="MIM:190230"
CDS 101..1030
/gene="TGFB3"
/codon_start=1
/product="TGFB3 protein"
/protein_id="AAH18503.1"
/db_xref="GeneID:7043"
/db_xref="MIM:190230"
/translation="MKMHLQRALVVLALLNFATVSLSLSTCTTLDFGHIKKKRVEAIR
GQILSKLRLTSPPEPTVMTHVPYQVLALYNSTRELLEEMHGEREEGCTQENTESEYYA
KEIHKFDMIQGLAEHNELAVCPKGITSKVFRFNVSSVEKNRTNLFRAEFRVLRVPNPS
SKRNEQRIELFQILRPDEHIAKQRYIGGKNLPTRGTAEWLSFDVTDTVREWLLRRESN
LGLEISIHCPCHTFQPNGDILENIHEVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNP
HLILMMIPPHRLDNPGQGGQRKKRALDTNYCFR"
misc_feature 203..790
/gene="TGFB3"
/note="TGFb_propeptide; Region: TGF-beta propeptide. This
propeptide is known as latency associated peptide (LAP) in
TGF-beta. LAP is a homodimer which is disulfide linked to
TGF-beta binding protein"
/db_xref="CDD:pfam00688"
BASE COUNT 371 a 363 c 329 g 270 t
ORIGIN
1 ggggaggccg cctggttttc ctccctcctt ctgcacgtct gctggggtct cttcctctcc
61 aggccttgcc gtccccctgg cctctcttcc cagctcacac atgaagatgc acttgcaaag
121 ggctctggtg gtcctggccc tgctgaactt tgccacggtc agcctctctc tgtccacttg
181 caccaccttg gacttcggcc acatcaagaa gaagagggtg gaagccatta ggggacagat
241 cttgagcaag ctcaggctca ccagcccccc tgagccaacg gtgatgaccc acgtccccta
301 tcaggtcctg gccctttaca acagcacccg ggagctgctg gaggagatgc atggggagag
361 ggaggaaggc tgcacccagg aaaacaccga gtcggaatac tatgccaaag aaatccataa
421 attcgacatg atccaggggc tggcggagca caacgaactg gctgtctgcc ctaaaggaat
481 tacctccaag gttttccgct tcaatgtgtc ctcagtggag aaaaatagaa ccaacctatt
541 ccgagcagaa ttccgggtct tgcgggtgcc caaccccagc tctaagcgga atgagcagag
601 gatcgagctc ttccagatcc ttcggccaga tgagcacatt gccaaacagc gctatatcgg
661 tggcaagaat ctgcccacac ggggcactgc cgagtggctg tcctttgatg tcactgacac
721 tgtgcgtgag tggctgttga gaagagagtc caacttaggt ctagaaatca gcattcactg
781 tccatgtcac acctttcagc ccaatggaga tatcctggaa aacattcacg aggtgatgga
841 aatcaaattc aaaggcgtgg acaatgagga tgaccatggc cgtggagatc tggggcgcct
901 caagaagcag aaggatcacc acaaccctca tctaatcctc atgatgattc ccccacaccg
961 gctcgacaac ccgggccagg ggggtcagag gaagaagcgg gctttggaca ccaattactg
1021 cttccggtga gactgggccc acatgggaac caacatctac tgcctgccta ctgcccaatg
1081 gctaggtcag gccccagagc caagccacac tcaacagagg gtccctgata ctattcacaa
1141 acatctccag gaagaagact gaaaatctct cacagagatt ttctctgtga aatctctttc
1201 tgttttcctg ggagtcccac tgtttttcca taggctaact ctggaaggag ctggctgaag
1261 taaatgagga aaactctgtg aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
1321 aaaaaaaaaa aaa
//