LOCUS BC017880 1546 bp mRNA linear HUM 03-FEB-2004
DEFINITION Homo sapiens iron-responsive element binding protein 2, mRNA (cDNA
clone IMAGE:4277855), complete cds.
ACCESSION BC017880
VERSION BC017880.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1546)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 1546)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (03-DEC-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: CLONTECH Laboratories, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Sequencing Group at the Stanford Human Genome
Center, Stanford University School of Medicine, Stanford, CA 94305
Web site: http://www-shgc.stanford.edu
Contact: (Dickson, Mark) mcd@paxil.stanford.edu
Dickson, M., Schmutz, J., Grimwood, J., Rodriquez, A., and Myers,
R. M.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 35 Row: k Column: 1
This clone was selected for full length sequencing because it
passed the following selection criteria: Hexamer frequency ORF
analysis, Similarity but not identity to protein
This clone has the following problem: The cds is short compared to
the longest cds in the locus.
FEATURES Location/Qualifiers
source 1..1546
/db_xref="H-InvDB:HIT000038177"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="IMAGE:4277855"
/tissue_type="Brain, primitive neuroectodermal"
/clone_lib="NIH_MGC_56"
/lab_host="DH10B"
/note="Vector: pDNR-LIB"
gene 1..1546
/gene="IREB2"
/gene_synonym="IRP2"
/gene_synonym="IRP2AD"
/db_xref="GeneID:3658"
/db_xref="MIM:147582"
CDS 55..1086
/gene="IREB2"
/gene_synonym="IRP2"
/gene_synonym="IRP2AD"
/codon_start=1
/product="IREB2 protein"
/protein_id="AAH17880.1"
/db_xref="GeneID:3658"
/db_xref="MIM:147582"
/translation="MDAPKAGYAFEYLIETLNDSSHKKFFDVSKLGTKYDVLPYSIRV
LLEAAVRNCDGFLMKKEDVMNILDWKTKQSNVEVPFFPARVLLQDFTGIPAMVDFAAM
REAVKTLGGDPEKVHPACPTDLTVDHSLQIDFSKCAIQNAPNPGGGDLQKAGKLSPLK
VQPKKLPCRGQTTCRGSCDSGELGRNSGTFSSQIENTPILCPFHLQPVPEPETVLKNQ
EVEFGRNRERLQFFKWSSRVFKNVAVIPPGTGMAHQINLEYLSRVVFEEKDLLFPDSV
VGTDSHITMVNGLGILGWGVGGIETEAVMLGLPVSLTLPEVVGCELTGSSNPFVTSID
VVLGITKVS"
misc_feature 223..477
/gene="IREB2"
/gene_synonym="IRP2"
/gene_synonym="IRP2AD"
/note="Aconitase; Region: Aconitase family (aconitate
hydratase)"
/db_xref="CDD:pfam00330"
misc_feature 700..1077
/gene="IREB2"
/gene_synonym="IRP2"
/gene_synonym="IRP2AD"
/note="Aconitase; Region: Aconitase family (aconitate
hydratase)"
/db_xref="CDD:pfam00330"
BASE COUNT 462 a 296 c 340 g 448 t
ORIGIN
1 cccccttctt cccccgctgg ccccctcccc ggagggataa tatggtctcc ggcgatggac
61 gccccaaaag caggatacgc ctttgagtac cttattgaaa cattaaatga cagttcacat
121 aagaagttct tcgatgtatc taaacttggc accaagtatg atgttctgcc ttactcaata
181 cgggtcttgt tggaagctgc tgtacgaaat tgtgatggct ttttaatgaa gaaggaagat
241 gttatgaaca ttttagactg gaaaaccaaa caaagcaatg ttgaagtgcc ctttttccct
301 gcccgtgttc ttcttcaaga ttttactgga ataccagcaa tggtggattt tgctgctatg
361 agggaggcag tgaaaactct tggaggtgat cctgagaaag tccatcctgc ttgtccgaca
421 gatcttacag ttgaccattc tttacaaatt gacttcagta aatgtgcaat acagaatgca
481 ccaaatcctg gaggtggtga cctgcagaaa gcaggaaagc tctctccact taaagtgcag
541 cctaagaagc ttccctgcag aggccagact acctgccgag gatcttgtga ttctggagaa
601 ctaggccgaa actcaggaac attttcttcg cagattgaga atacacccat cctgtgtcct
661 tttcatttgc aaccagtgcc tgaacctgaa acagtgttaa aaaatcaaga agtagaattc
721 ggcagaaatc gagagaggct tcagtttttt aagtggagtt caagagtttt taagaatgtg
781 gcagtgatcc ctcctggaac tggaatggct catcaaataa acttagaata tttgtcaaga
841 gtggtttttg aagaaaaaga cctcctcttc ccagacagtg tagtcggcac agattcacac
901 ataacgatgg tgaatggttt agggattctg gggtgggggg ttggaggcat tgaaacagaa
961 gcagttatgc ttggtctgcc agtttctctt actttaccag aggtggttgg atgtgagtta
1021 actgggtcat caaacccttt tgttacatcc attgatgttg ttcttggtat tacaaaggta
1081 agttaaagtt gtggtagctc tatgacttac tgaacattat ttttataaaa attgaagagc
1141 tctatgagag cagggatttg ggttcattac tgcatcctca ggtctcttga cgttagccac
1201 atcatcatag ttatcatagt aataacaaca aacagagcat ttagtttgta ctaataaata
1261 caaagaaatt tgttgtgttc acttatgtta gctcatttag tccttataac aagcctgtga
1321 gatggatact attactattc tcattgtaac tctgagaaaa ctaaggtaca gtagggttta
1381 gtgacttacc aaagggtcga aggcctgagt agtaaggggt agagcaaaga ttccaggcag
1441 tcagattctt gagtccattg tcttaaccat tatgccttat tagtgccttg ttgccttaat
1501 aaacacttgc tgactacaaa aaaaaaaaaa aaaaaaaaaa aaaaaa
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