LOCUS BC014482 3347 bp mRNA linear HUM 15-JUL-2006
DEFINITION Homo sapiens signal transducer and activator of transcription 3
(acute-phase response factor), mRNA (cDNA clone MGC:23173
IMAGE:4909141), complete cds.
ACCESSION BC014482
VERSION BC014482.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3347)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 3347)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (17-SEP-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Genome Sequence Centre,
BC Cancer Agency, Vancouver, BC, Canada
info@bcgsc.bc.ca
Martin Hirst, Thomas Zeng, Ryan Morin, Michelle Moksa, Johnson
Pang, Diana Mah, Jing Wang, Kieth Fichter, Eric Chuah, Allen
Delaney, Rob Kirkpatrick, Agnes Baross, Sarah Barber, Mabel
Brown-John, Steve S. Chand, William Chow, Ryan Babakaiff, Dave
Wong, Corey Matsuo, Jaclyn Beland, Susan Gibson, Luis delRio, Ruth
Featherstone, Malachi Griffith, Obi Griffith, Ran Guin, Nancy Liao,
Kim MacDonald, Mike R. Mayo, Josh Moran, Diana Palmquist, JR
Santos, Duane Smailus, Jeff Stott, Miranda Tsai, George Yang,
Jacquie Schein, Asim Siddiqui,Steven Jones, Rob Holt, Marco Marra.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 34 Row: p Column: 2.
FEATURES Location/Qualifiers
source 1..3347
/db_xref="H-InvDB:HIT000036730"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:23173 IMAGE:4909141"
/tissue_type="Pancreas, epithelioid carcinoma"
/clone_lib="NIH_MGC_42"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene 1..3347
/gene="STAT3"
/gene_synonym="APRF"
/gene_synonym="FLJ20882"
/gene_synonym="MGC16063"
/db_xref="GeneID:6774"
/db_xref="HGNC:HGNC:11364"
/db_xref="MIM:102582"
CDS 133..2445
/gene="STAT3"
/gene_synonym="APRF"
/gene_synonym="FLJ20882"
/gene_synonym="MGC16063"
/codon_start=1
/product="signal transducer and activator of transcription
3 (acute-phase response factor)"
/protein_id="AAH14482.1"
/db_xref="GeneID:6774"
/db_xref="HGNC:HGNC:11364"
/db_xref="MIM:102582"
/translation="MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWA
YAASKESHATLVFHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIA
RIVARCLWEESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQ
KMKVVENLQDDFDFNYKTLKSQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIV
SELAGLLSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQ
TRQQIKKLEELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPD
RPLVIKTGVQFTTKVRLLVKFPELNYQLKIKVCIDKDSGDVAALRGSRKFNILGTNTK
VMNMEESNNGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETEVYHQGL
KIDLETHSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVL
SWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYSGCQITWAKFCKENMAGKGFSFWVWLD
NIIDLVKKYILALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSKEGGVTFTWV
EKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIMDATNILVSPLVYLYPDIPKEEA
FGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNN
GEGAEPSAGGQFESLTFDMELTSECATSPM"
BASE COUNT 909 a 829 c 859 g 750 t
ORIGIN
1 cgctgtctct ccccctcggc tcggagaggc ccttcggcct gagggagcct cgccgcccgt
61 ccccggcaca cgcgcagccc cggcctctcg gcctctgccg gagaaacagt tgggacccct
121 gattttagca ggatggccca atggaatcag ctacagcagc ttgacacacg gtacctggag
181 cagctccatc agctctacag tgacagcttc ccaatggagc tgcggcagtt tctggcccct
241 tggattgaga gtcaagattg ggcatatgcg gccagcaaag aatcacatgc cactttggtg
301 tttcataatc tcctgggaga gattgaccag cagtatagcc gcttcctgca agagtcgaat
361 gttctctatc agcacaatct acgaagaatc aagcagtttc ttcagagcag gtatcttgag
421 aagccaatgg agattgcccg gattgtggcc cggtgcctgt gggaagaatc acgccttcta
481 cagactgcag ccactgcggc ccagcaaggg ggccaggcca accaccccac agcagccgtg
541 gtgacggaga agcagcagat gctggagcag caccttcagg atgtccggaa gagagtgcag
601 gatctagaac agaaaatgaa agtggtagag aatctccagg atgactttga tttcaactat
661 aaaaccctca agagtcaagg agacatgcaa gatctgaatg gaaacaacca gtcagtgacc
721 aggcagaaga tgcagcagct ggaacagatg ctcactgcgc tggaccagat gcggagaagc
781 atcgtgagtg agctggcggg gcttttgtca gcgatggagt acgtgcagaa aactctcacg
841 gacgaggagc tggctgactg gaagaggcgg caacagattg cctgcattgg aggcccgccc
901 aacatctgcc tagatcggct agaaaactgg ataacgtcat tagcagaatc tcaacttcag
961 acccgtcaac aaattaagaa actggaggag ttgcagcaaa aagtttccta caaaggggac
1021 cccattgtac agcaccggcc gatgctggag gagagaatcg tggagctgtt tagaaactta
1081 atgaaaagtg cctttgtggt ggagcggcag ccctgcatgc ccatgcatcc tgaccggccc
1141 ctcgtcatca agaccggcgt ccagttcact actaaagtca ggttgctggt caaattccct
1201 gagttgaatt atcagcttaa aattaaagtg tgcattgaca aagactctgg ggacgttgca
1261 gctctcagag gatcccggaa atttaacatt ctgggcacaa acacaaaagt gatgaacatg
1321 gaagaatcca acaacggcag cctctctgca gaattcaaac acttgaccct gagggagcag
1381 agatgtggga atgggggccg agccaattgt gatgcttccc tgattgtgac tgaggagctg
1441 cacctgatca cctttgagac cgaggtgtat caccaaggcc tcaagattga cctagagacc
1501 cactccttgc cagttgtggt gatctccaac atctgtcaga tgccaaatgc ctgggcgtcc
1561 atcctgtggt acaacatgct gaccaacaat cccaagaatg taaacttttt taccaagccc
1621 ccaattggaa cctgggatca agtggccgag gtcctgagct ggcagttctc ctccaccacc
1681 aagcgaggac tgagcatcga gcagctgact acactggcag agaaactctt gggacctggt
1741 gtgaattatt cagggtgtca gatcacatgg gctaaatttt gcaaagaaaa catggctggc
1801 aagggcttct ccttctgggt ctggctggac aatatcattg accttgtgaa aaagtacatc
1861 ctggcccttt ggaacgaagg gtacatcatg ggctttatca gtaaggagcg ggagcgggcc
1921 atcttgagca ctaagcctcc aggcaccttc ctgctaagat tcagtgaaag cagcaaagaa
1981 ggaggcgtca ctttcacttg ggtggagaag gacatcagcg gtaagaccca gatccagtcc
2041 gtggaaccat acacaaagca gcagctgaac aacatgtcat ttgctgaaat catcatgggc
2101 tataagatca tggatgctac caatatcctg gtgtctccac tggtctatct ctatcctgac
2161 attcccaagg aggaggcatt cggaaagtat tgtcggccag agagccagga gcatcctgaa
2221 gctgacccag gtagcgctgc cccatacctg aagaccaagt ttatctgtgt gacaccaacg
2281 acctgcagca ataccattga cctgccgatg tccccccgca ctttagattc attgatgcag
2341 tttggaaata atggtgaagg tgctgaaccc tcagcaggag ggcagtttga gtccctcacc
2401 tttgacatgg agttgacctc ggagtgcgct acctccccca tgtgaggagc tgagaacgga
2461 agctgcagaa agatacgact gaggcgccta cctgcattct gccacccctc acacagccaa
2521 accccagatc atctgaaact actaactttg tggttccaga ttttttttaa tctcctactt
2581 ctgctatctt tgagcaatct gggcactttt aaaaatagag aaatgagtga atgtgggtga
2641 tctgctttta tctaaatgca aataaggatg tgttctctga gacccatgat caggggatgt
2701 ggcggggggt ggctagaggg agaaaaagga aatgtcttgt gttgttttgt tcccctgccc
2761 tcctttctca gcagcttttt gttattgttg ttgttgttct tagacaagtg cctcctggtg
2821 cctgcggcat ccttctgcct gtttctgtaa gcaaatgcca caggccacct atagctacat
2881 actcctggca ttgcactttt taaccttgct gacatccaaa tagaagatag gactatctaa
2941 gccctaggtt tctttttaaa ttaagaaata ataacaatta aagggcaaaa aacactgtat
3001 cagcatagcc tttctgtatt taagaaactt aagcagccgg gcatggttgc tcacgcctgt
3061 aatcccagca ctttgggagg ccgaggcgga tcataaggtc aggagatcaa gaccatcctg
3121 gctaacacgg tgaaaccccg tctctactaa aagtacaaaa aattagctgg gtgtggtggt
3181 gggcgcctgt agtcccagct actcgggagg ctgaggcagg agaatcgctt gaacctgaga
3241 ggcggaggtt gcagtgagcc aaaattgcac cactgcacac tgcactccat cctgggcgac
3301 agtctgagac tctgtctcaa aaaaaaaaaa aaaaaaaaaa aaaaaaa
//