LOCUS BC014469 2377 bp mRNA linear HUM 15-JUL-2006
DEFINITION Homo sapiens cyclin-dependent kinase inhibitor 2B (p15, inhibits
CDK4), mRNA (cDNA clone MGC:23110 IMAGE:4871014), complete cds.
ACCESSION BC014469
VERSION BC014469.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2377)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 2377)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (17-SEP-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC/DCTD/DTP
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Genome Sequence Centre,
BC Cancer Agency, Vancouver, BC, Canada
info@bcgsc.bc.ca
Martin Hirst, Thomas Zeng, Ryan Morin, Michelle Moksa, Johnson
Pang, Diana Mah, Jing Wang, Kieth Fichter, Eric Chuah, Allen
Delaney, Rob Kirkpatrick, Agnes Baross, Sarah Barber, Mabel
Brown-John, Steve S. Chand, William Chow, Ryan Babakaiff, Dave
Wong, Corey Matsuo, Jaclyn Beland, Susan Gibson, Luis delRio, Ruth
Featherstone, Malachi Griffith, Obi Griffith, Ran Guin, Nancy Liao,
Kim MacDonald, Mike R. Mayo, Josh Moran, Diana Palmquist, JR
Santos, Duane Smailus, Jeff Stott, Miranda Tsai, George Yang,
Jacquie Schein, Asim Siddiqui,Steven Jones, Rob Holt, Marco Marra.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 34 Row: l Column: 10
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 47132608.
FEATURES Location/Qualifiers
source 1..2377
/db_xref="H-InvDB:HIT000036719"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:23110 IMAGE:4871014"
/tissue_type="Skin, melanotic melanoma, high MDR."
/clone_lib="NIH_MGC_49"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene 1..2377
/gene="CDKN2B"
/gene_synonym="INK4B"
/gene_synonym="MTS2"
/gene_synonym="P15"
/gene_synonym="TP15"
/db_xref="GeneID:1030"
/db_xref="HGNC:HGNC:1788"
/db_xref="MIM:600431"
CDS 329..745
/gene="CDKN2B"
/gene_synonym="INK4B"
/gene_synonym="MTS2"
/gene_synonym="P15"
/gene_synonym="TP15"
/codon_start=1
/product="cyclin-dependent kinase inhibitor 2B (p15,
inhibits CDK4)"
/protein_id="AAH14469.1"
/db_xref="GeneID:1030"
/db_xref="HGNC:HGNC:1788"
/db_xref="MIM:600431"
/translation="MREENKGMPSGGGSDEGLASAAARGLVEKVRQLLEAGADPNGVN
RFGRRAIQVMMMGSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRA
GARLDVRDAWGRLPVDLAEERGHRDVAGYLRTATGD"
BASE COUNT 605 a 567 c 663 g 542 t
ORIGIN
1 gtgaggactc cgcgacgcgt ccgcaccctg cggccagagc ggctttgagc tcggctgcgt
61 ccgcgctagg cgctttttcc cagaagcaat ccaggcgcgc ccgctggttc ttgagcgcca
121 ggaaaagccc ggagctaacg accggccgct cggccactgc acggggcccc aagccgcaga
181 aggacgacgg gagggtaatg aagctgagcc caggtctcct aggaaggaga gagtgcgccg
241 gagcagcgtg ggaaagaagg gaagagtgtc gttaagttta cggccaacgg tggattatcc
301 gggccgctgc gcgtctgggg gctgcggaat gcgcgaggag aacaagggca tgcccagtgg
361 gggcggcagc gatgagggtc tggccagcgc cgcggcgcgg ggactagtgg agaaggtgcg
421 acagctcctg gaagccggcg cggatcccaa cggagtcaac cgtttcggga ggcgcgcgat
481 ccaggtcatg atgatgggca gcgcccgcgt ggcggagctg ctgctgctcc acggcgcgga
541 gcccaactgc gcagaccctg ccactctcac ccgaccggtg catgatgctg cccgggaggg
601 cttcctggac acgctggtgg tgctgcaccg ggccggggcg cggctggacg tgcgcgatgc
661 ctggggtcgt ctgcccgtgg acttggccga ggagcggggc caccgcgacg ttgcagggta
721 cctgcgcaca gccacggggg actgacgcca ggttccccag ccgcccacaa cgactttatt
781 ttcttaccca atttcccacc cccacccacc taattcgatg aaggctgcca acggggagcg
841 gcggaaagcc tgtaagcctg caagcctgtc tgagactcac aggaaggagg agccgaccgg
901 gaataacctt ccatacattt ttttctttgt cttatctggc cctcgacact caccatgaag
961 cgaaacacag agaagcggat ttccagggat atttaggagt gtgtgacatt ccaggggtcg
1021 tttgcttttc agggttttct gagggaaagt gcatatgaaa tccttgactg gacctggtgg
1081 ctacgaatct tccgatggat gaatctccca ctccagcgct gagtgggaga aggcagtgat
1141 tagcacttgg gtgacggcag tcgatgcgtt cactccaatg tctgctgagg agttatggtg
1201 aacccacaac ttaggcccta gcggcagaaa ggaaaacctg aagactgagg acaaagtgga
1261 ggagggccga ggtgggcttc agtaagtccc cggcggcgct ttagtttgag cgcatggcaa
1321 gtcacatgcg taaacgacac tctctggaag ccctggagac cctcgcccaa ctccaccaga
1381 tagcagaggg gtaagagagg atgtgcaagc gacgacagat gctaaaatcc ctggatcacg
1441 acgctgcaga gcacctttgc acaggatgct ggcctttgct cttactacac tgaggagaga
1501 ttcccgcggg ttccgcaggc agactacaca ggatgaggtg gtggagtgga gtgagagcaa
1561 ttgtaacggt taactgtaac gttttctttc acacacacac acacacacac acacacacac
1621 atgctaggat gcggaaatcc ccttatgact tgctactttt tgattttgtg atattttgta
1681 ctttttagtt gttcagcaac tgtcttattt aatggggaga ttttaagtaa cataactagt
1741 ggctctcagt taaaatgtga ggaagaacta cagctcttaa atgtagcaat ggcactgttg
1801 caaactcagt gcaaacgcct agattgcttt cttcttaacc tatttatttc tttgttaaat
1861 ttttctgatt gtttccttta tagagtgtct cagggtgcag aggtcagact aagaaatatt
1921 ccaaatgtct tttagaagat agatgcactt atgcagtaaa ttatcttggg atagttccca
1981 aaagattgct gaaaaagtag attgagtata aaaacttgaa aatatatgat ggctcgtggg
2041 atgtcctact atcactgaac aaactaaagg tgcactgctt tgggatttaa tttccagggt
2101 tgcttgatca ttatatcatt ggaacaactg atacttcact actttaataa agaattaaca
2161 gagattgaac tccaagaggt gggtaatttg gtttaaaaat acatgttcat gggtttacca
2221 ctaactcctg agaaatgtta aaggttcaca ggggttccct tctctcaatg tttgtaataa
2281 ttgctcataa gcaataccag caattcataa aaactgctta cttatgccat agaaaattaa
2341 acacaaagtg tatacatgta aaaaaaaaaa aaaaaaa
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