LOCUS BC014243 4224 bp mRNA linear HUM 15-JUL-2006
DEFINITION Homo sapiens tyrosine kinase 2, mRNA (cDNA clone MGC:20776
IMAGE:4591726), complete cds.
ACCESSION BC014243
VERSION BC014243.2
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4224)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 4224)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (10-SEP-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT On Aug 19, 2003 this sequence version replaced BC014243.1.
Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: DCTD/DTP
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: National Institutes of Health Intramural
Sequencing Center (NISC),
Gaithersburg, Maryland;
Web site: http://www.nisc.nih.gov/
Contact: nisc_mgc@nhgri.nih.gov
Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
Young,A., Zhang,L.-H. and Green,E.D.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 30 Row: l Column: 8
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 34222294.
FEATURES Location/Qualifiers
source 1..4224
/db_xref="H-InvDB:HIT000036596"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:20776 IMAGE:4591726"
/tissue_type="Kidney, renal cell adenocarcinoma"
/clone_lib="NIH_MGC_14"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene 1..4224
/gene="TYK2"
/gene_synonym="JTK1"
/db_xref="GeneID:7297"
/db_xref="HGNC:HGNC:12440"
/db_xref="MIM:176941"
CDS 342..3905
/gene="TYK2"
/gene_synonym="JTK1"
/codon_start=1
/product="tyrosine kinase 2"
/protein_id="AAH14243.1"
/db_xref="GeneID:7297"
/db_xref="HGNC:HGNC:12440"
/db_xref="MIM:176941"
/translation="MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWV
TFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLY
FRIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEF
VNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRS
FRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVP
VCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVN
KEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRPREPLWAYFCDFRDITHVVLKEHC
VSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIRDG
IHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVAQRSQAPDGMQSLRLRKFPIE
QQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRG
ARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDE
DPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPE
NIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNI
LLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKW
GFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQR
PSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLY
CYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEK
SLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHSQHYIHRDLAARNVL
LDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFG
VTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYH
LMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC"
BASE COUNT 852 a 1298 c 1279 g 795 t
ORIGIN
1 gttcgagctt gtgttccccc ggaagggtga gtctggacgc gggcgcggaa ggagcgcggc
61 cggaggtcct caggaagaag ccgcggggac tggctgcgct tgacaggctg cacttggatg
121 ggagcacctg gtgcctcggg actgctccga tgcccgggtc tgtgctgaat gtgtaatatg
181 cggaactata ttgaaacatt acaaccatct tttgatggca acaccctgag gacctccctt
241 ttccagatgg ggaaactgag gcccagaatt gctaagtggc ttgcttgagt tgacacaggg
301 agctccagga ctcaccctca gctgagccac ctgccgggag catgcctctg cgccactggg
361 ggatggccag gggcagtaag cccgttgggg atggagccca gcccatggct gccatgggag
421 gcctgaaggt gcttctgcac tgggctggtc caggcggcgg ggagccctgg gtcactttca
481 gtgagtcatc gctgacagct gaggaagtct gcatccacat tgcacataaa gttggtatca
541 ctcctccttg cttcaatctc tttgccctct tcgatgctca ggcccaagtc tggttgcccc
601 caaaccacat cctagagatc cccagagatg caagcctgat gctatatttc cgcataaggt
661 tttatttccg gaactggcat ggcatgaatc ctcgggaacc ggctgtgtac cgttgtgggc
721 ccccaggaac cgaggcatcc tcagatcaga cagcacaggg gatgcaactc ctggacccag
781 cctcatttga gtacctcttt gagcagggca agcatgagtt tgtgaatgac gtggcatcac
841 tgtgggagct gtcgaccgag gaggagatcc accactttaa gaatgagagc ctgggcatgg
901 cctttctgca cctctgtcac ctcgctctcc gccatggcat ccccctggag gaggtggcca
961 agaagaccag cttcaaggac tgcatcccgc gctccttccg ccggcatatc cggcagcaca
1021 gcgccctgac ccggctgcgc cttcggaacg tcttccgcag gttcctgcgg gacttccagc
1081 cgggccgact ctcccagcag atggtcatgg tcaaatacct agccacactc gagcggctgg
1141 caccccgctt cggcacagag cgtgtgcccg tgtgccacct gaggctgctg gcccaggccg
1201 agggggagcc ctgctacatc cgggacagtg gggtggcccc tacagaccct ggccctgagt
1261 ctgctgctgg gcccccaacc cacgaggtgc tggtgacagg cactggtggc atccagtggt
1321 ggccagtaga ggaggaggtg aacaaggagg agggttctag tggcagcagt ggcaggaacc
1381 cccaagccag cctgtttggg aagaaggcca aggctcacaa ggcagtcggc cagccggcag
1441 acaggccgcg ggagccactg tgggcctact tctgtgactt ccgggacatc acccacgtgg
1501 tgctgaaaga gcactgtgtc agcatccacc ggcaggacaa caagtgcctg gagctgagct
1561 tgccttcccg ggctgcggcg ctgtccttcg tgtcgctggt ggacggctat ttccgcctga
1621 cggccgactc cagccactac ctgtgccacg aggtggctcc cccacggctg gtgatgagca
1681 tccgggatgg gatccacgga cccctgctgg agccatttgt gcaggccaag ctgcggcccg
1741 aggacggcct gtacctcatt cactggagca ccagccaccc ctaccgcctg atcctcacag
1801 tggcccagcg tagccaggca ccagacggca tgcagagctt gcggctccga aagttcccca
1861 ttgagcagca ggacggggcc ttcgtgctgg agggctgggg ccggtccttc cccagcgttc
1921 gggaacttgg ggctgccttg cagggctgct tgctgagggc cggggatgac tgcttctctc
1981 tgcgtcgctg ttgcctgccc caaccaggag aaacctccaa tctcatcatc atgcgggggg
2041 ctcgggccag ccccaggaca ctcaacctca gccagctcag cttccaccgg gttgaccaga
2101 aggagatcac ccagctgtcc cacttgggcc agggcacaag gaccaacgtg tatgagggcc
2161 gcctgcgagt ggagggcagc ggggaccctg aggagggcaa gatggatgac gaggaccccc
2221 tcgtgcctgg cagggaccgt gggcaggagc tacgagtggt gctcaaagtg ctggacccta
2281 gtcaccatga catcgccctg gccttctacg agacagccag cctcatgagc caggtctccc
2341 acacgcacct ggccttcgtg catggcgtct gtgtgcgcgg ccctgaaaat atcatggtga
2401 cagagtacgt ggagcacgga cccctggatg tgtggctgcg gagggagcgg ggccatgtgc
2461 ccatggcttg gaagatggtg gtggcccagc agctggccag cgccctcagc tacctggaga
2521 acaagaacct ggttcatggt aatgtgtgtg gccggaacat cctgctggcc cggctggggt
2581 tggcagaggg caccagcccc ttcatcaagc tgagtgatcc tggcgtgggc ctgggcgccc
2641 tctccaggga ggagcgggtg gagaggatcc cctggctggc ccccgaatgc ctaccaggtg
2701 gggccaacag cctaagcacc gccatggaca agtgggggtt tggcgccacc ctcctggaga
2761 tctgctttga cggagaggcc cctctgcaga gccgcagtcc ctccgagaag gagcatttct
2821 accagaggca gcaccggctg cccgagccct cctgcccaca gctggccaca ctcaccagcc
2881 agtgtctgac ctatgagcca acccagaggc catcattccg caccatcctg cgtgacctca
2941 cccggctgca gccccacaat cttgctgacg tcttgactgt gaacccggac tcaccggcgt
3001 cggaccctac ggttttccac aagcgctatt tgaaaaagat ccgagatctg ggcgagggtc
3061 acttcggcaa ggtcagcttg tactgctacg atccgaccaa cgacggcact ggcgagatgg
3121 tggcggtgaa agccctcaag gcagactgcg gcccccagca ccgctcgggc tggaagcagg
3181 agattgacat tctgcgcacg ctctaccacg agcacatcat caagtacaag ggctgctgcg
3241 aggaccaagg cgagaagtcg ctgcagctgg tcatggagta cgtgcccctg ggcagcctcc
3301 gagactacct gccccggcac agcatcgggc tggcccagct gctgctcttc gcccagcaga
3361 tctgcgaggg catggcctat ctgcactcgc agcactacat ccaccgagac ctagccgcgc
3421 gcaacgtgct gctggacaac gacaggctgg tcaagatcgg ggactttggc ctagccaagg
3481 ccgtgcccga aggccacgag tactaccgcg tgcgcgagga tggggacagc cccgtgttct
3541 ggtatgcccc agagtgcctg aaggagtata agttctacta tgcgtcagat gtctggtcct
3601 tcggggtgac cctgtatgag ctgctgacgc actgtgactc cagccagagc ccccccacga
3661 aattccttga gctcataggc attgctcagg gtcagatgac agttctgaga ctcactgagt
3721 tgctggaacg aggggagagg ctgccacggc ccgacaaatg tccctgtgag gtctatcatc
3781 tcatgaagaa ctgctgggag acagaggcgt cctttcgccc aaccttcgag aacctcatac
3841 ccattctgaa gacagtccat gagaagtacc aaggccaggc cccttcagtg ttcagcgtgt
3901 gctgaggcac aatggcagcc ctgcctggga ggactggacc aggcagtggc tgcagaggga
3961 gcctcctgct ccctgctcca ggatgaaacc aagaggggga tgtcagcctc acccacaccg
4021 tgtgccttac tcctgtctag agaccccacc tctgtgaact tatttttctt tcttggccgt
4081 gagcctaacc atgatcttga gggacccaac atttgtaggg gcactaatcc agcccttaaa
4141 tcccccagct tccaaacttg aggcccacca tctccaccat ctggtaataa actcatgttt
4201 tctctgaaaa aaaaaaaaaa aaaa
//