LOCUS BC014214 3103 bp mRNA linear HUM 08-OCT-2003 DEFINITION Homo sapiens adaptor-related protein complex 2, alpha 1 subunit, mRNA (cDNA clone MGC:20679 IMAGE:4111165), complete cds. ACCESSION BC014214 VERSION BC014214.2 KEYWORDS MGC. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 3103) AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A. TITLE Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002) PUBMED 12477932 REFERENCE 2 (bases 1 to 3103) AUTHORS Strausberg,R. TITLE Direct Submission JOURNAL Submitted (10-SEP-2001) National Institutes of Health, Mammalian Gene Collection (MGC), Cancer Genomics Office, National Cancer Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590, USA REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov COMMENT On Aug 20, 2003 this sequence version replaced BC014214.1. Contact: MGC help desk Email: cgapbs-r@mail.nih.gov Tissue Procurement: ATCC cDNA Library Preparation: Rubin Laboratory cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL) DNA Sequencing by: National Institutes of Health Intramural Sequencing Center (NISC), Gaithersburg, Maryland; Web site: http://www.nisc.nih.gov/ Contact: nisc_mgc@nhgri.nih.gov Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B., Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S., Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P., Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R., Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C., McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W., Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L., Young,A., Zhang,L.-H. and Green,E.D. Clone distribution: MGC clone distribution information can be found through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov Series: IRAL Plate: 30 Row: b Column: 4 This clone was selected for full length sequencing because it passed the following selection criteria: matched mRNA gi: 19913415. FEATURES Location/Qualifiers source 1..3103 /db_xref="H-InvDB:HIT000036581" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /clone="MGC:20679 IMAGE:4111165" /tissue_type="Muscle, rhabdomyosarcoma" /clone_lib="NIH_MGC_17" /lab_host="DH10B-R" /note="Vector: pOTB7" gene 1..3103 /gene="AP2A1" /gene_synonym="ADTAA" /gene_synonym="AP2-ALPHA" /gene_synonym="CLAPA1" /db_xref="GeneID:160" /db_xref="MIM:601026" CDS 110..3058 /gene="AP2A1" /gene_synonym="ADTAA" /gene_synonym="AP2-ALPHA" /gene_synonym="CLAPA1" /codon_start=1 /product="AP2A1 protein" /protein_id="AAH14214.1" /db_xref="GeneID:160" /db_xref="MIM:601026" /translation="MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKF KGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNKYTEKQIGYLFISVLV NSNSELIRLINNAIKNDLASRNPTFMCLALHCIANVGSREMGEAFAADIPRILVAGDS MDSVKQSAALCLLRLYKASPDLVPMGEWTARVVHLLNDQHMGVVTAAVSLITCLCKKN PDDFKTCVSLAVSRLSRIVSSASTDLQDYTYYFVPAPWLSVKLLRLLQCYPLPEDAAV KGRLVECLETVLNKAQEPPKSKKVQHSNAKNAILFETISLIIHYDSEPNLLVRACNQL GQFLQHRETNLRYLALESMCTLASSEFSHEAVKTHIDTVINALKTERDVSVRQRAADL LYAMCDRSNAKQIVSEMLRYLETADYAIREEIVLKVAILAEKYAVDYSWYVDTILNLI RIAGDYVSEEVWYRVLQIVTNRDDVQGYAAKTVFEALQAPACHENMVKVGGYILGEFG NLIAGDPRSSPPVQFSLLHSKFHLCSVATRALLLSTYIKFINLFPETKATIQGVLRAG SQLRNADVELQQRAVEYLTLSSVASTDVLATVLEEMPPFPERESSILAKLKRKKGPGA GSALDDGRRDPSSNDINGGMEPTPSTVSTPSPSADLLGLRAAPPPAAPPASAGAGNLL VDVFDGPAAQPSLGPTPEEAFLSPGPEDIGPPIPEADELLNKFVCKNNGVLFENQLLQ IGVKSEFRQNLGRMYLFYGNKTSVQFQNFSPTVVHPGDLQTQLAVQTKRVAAQVDGGA QVQQVLNIECLRDFLTPPLLSVRFRYGGAPQALTLKLPVTINKFFQPTEMAAQDFFQR WKQLSLPQQEAQKIFKANHPMDAEVTKAKLLGFGSALLDNVDPNPGDREDTRVWGMPG TFLRPFVFLFLFICCCLHSGGLGGVPLPPFPPQAQRGEGPGKWMSPPLPPHPVVAPPT PSPSRGCVLL" misc_feature 194..1882 /gene="AP2A1" /gene_synonym="ADTAA" /gene_synonym="AP2-ALPHA" /gene_synonym="CLAPA1" /note="Adaptin_N; Region: Adaptin N terminal region. This family consists of the N terminal region of various alpha, beta and gamma subunits of the AP-1, AP-2 and AP-3 adaptor protein complexes. The adaptor protein (AP) complexes are involved in the formation of clathrin-coated pits and vesicles. The N-terminal region of the various adaptor proteins (APs) is constant by comparison to the C-terminal which is variable within members of the AP-2 family" /db_xref="CDD:pfam01602" misc_feature 2279..2584 /gene="AP2A1" /gene_synonym="ADTAA" /gene_synonym="AP2-ALPHA" /gene_synonym="CLAPA1" /note="Alpha_adaptinC2; Region: pfam02883, Alpha_adaptinC2, Adaptin C-terminal domain. Alpha adaptin is a heterotetramer which regulates clathrin-bud formation. The carboxyl-terminal appendage of the alpha subunit regulates translocation of endocytic accessory proteins to the bud site. This ig-fold domain is found in alpha, beta and gamma adaptins" /db_xref="CDD:pfam02883" misc_feature 2633..2818 /gene="AP2A1" /gene_synonym="ADTAA" /gene_synonym="AP2-ALPHA" /gene_synonym="CLAPA1" /note="Alpha_adaptin_C; Region: Alpha adaptin AP2, C-terminal domain. Alpha adaptin is a hetero tetramer which regulates clathrin-bud formation. The carboxyl-terminal appendage of the alpha subunit regulates translocation of endocytic accessory proteins to the bud site" /db_xref="CDD:pfam02296" BASE COUNT 627 a 1009 c 881 g 586 t ORIGIN 1 gctcggctcc ttggcgctgc ctggggtcct ttccgcccgg tccccgcttg ccagcccccg 61 ctgctctgtg ccctgtccgg ccaggcctgg agccgacacc accgccatca tgccggccgt 121 gtccaagggc gatgggatgc gggggctcgc ggtgttcatc tccgacatcc ggaactgtaa 181 gagcaaagag gcggaaatta agagaatcaa caaggaactg gccaacatcc gctccaagtt 241 caaaggagac aaagccttgg atggctacag taagaaaaaa tatgtgtgta aactgctttt 301 catcttcctg cttggccatg acattgactt tgggcacatg gaggctgtga atctgttgag 361 ttccaataaa tacacagaga agcaaatagg ttacctgttc atttctgtgc tggtgaactc 421 gaactcggag ctgatccgcc tcatcaacaa cgccatcaag aatgacctgg ccagccgcaa 481 ccccaccttc atgtgcctgg ccctgcactg catcgccaac gtgggcagcc gggagatggg 541 cgaggccttt gccgctgaca tcccccgcat cctggtggcc ggggacagca tggacagtgt 601 caagcagagt gcggccctgt gcctccttcg actgtacaag gcctcgcctg acctggtgcc 661 catgggcgag tggacggcgc gtgtggtaca cctgctcaat gaccagcaca tgggtgtggt 721 cacggccgcc gtcagcctca tcacctgtct ctgcaagaag aacccagatg acttcaagac 781 gtgcgtctct ctggctgtgt cgcgcctgag ccggatcgtc tcctctgcct ccaccgacct 841 ccaggactac acctactact tcgtcccagc accctggctc tcggtgaagc tcctgcggct 901 gctgcagtgc tacccgcttc cagaggatgc ggctgtgaag gggcggctgg tggaatgtct 961 ggagactgtg ctcaacaagg cccaggagcc ccccaaatcc aagaaggtgc agcattccaa 1021 cgccaagaac gccatcctct tcgagaccat cagcctcatc atccactatg acagtgagcc 1081 caacctcctg gttcgggcct gcaaccagct gggccagttc ctgcagcacc gggagaccaa 1141 cctgcgctac ctggccctgg agagcatgtg cacgctggcc agctccgagt tctcccatga 1201 agccgtcaag acgcacattg acaccgtcat caatgccctc aagacggagc gggacgtcag 1261 cgtgcggcag cgggcggctg acctcctcta cgccatgtgt gaccggagca atgccaagca 1321 gatcgtgtcg gagatgctgc ggtacctgga gacggcagac tacgccatcc gcgaggagat 1381 cgtcctgaag gtggccatcc tggccgagaa gtacgccgtg gactacagct ggtacgtgga 1441 caccatcctc aacctcatcc gcattgcggg cgactacgtg agtgaggagg tgtggtaccg 1501 tgtgctacag atcgtcacca accgtgatga cgtccagggc tatgccgcca agaccgtctt 1561 tgaggcgctc caggcccctg cctgtcacga gaacatggtg aaggttggcg gctacatcct 1621 tggggagttt gggaacctga ttgctgggga cccccgctcc agccccccag tgcagttctc 1681 cctgctccac tccaagttcc atctgtgcag cgtggccacg cgggcgctgc tgctgtccac 1741 ctacatcaag ttcatcaacc tcttccccga gaccaaggcc accatccagg gcgtcctgcg 1801 ggccggctcc cagctgcgca atgctgacgt ggagctgcag cagcgagccg tggagtacct 1861 caccctcagc tcagtggcca gcaccgacgt cctggccacg gtgctggagg agatgccgcc 1921 cttccccgag cgcgagtcgt ccatcctggc caagctgaaa cgcaagaagg ggccaggggc 1981 cggcagcgcc ctggacgatg gccggaggga ccccagcagc aacgacatca acgggggcat 2041 ggagcccacc cccagcactg tgtcgacgcc ctcgccctcc gccgacctcc tggggctgcg 2101 ggcagcccct cccccggcag cacccccggc ttctgcagga gcagggaacc ttctggtgga 2161 cgtcttcgat ggcccggccg cccagcccag cctggggccc acccccgagg aggccttcct 2221 cagcccaggt cctgaggaca tcggccctcc cattccggaa gccgatgagt tgctgaataa 2281 gtttgtgtgt aagaacaacg gggtcctgtt cgagaaccag ctgctgcaga tcggagtcaa 2341 gtcagagttc cgacagaacc tgggccgcat gtatctcttc tatggcaaca agacctcggt 2401 gcagttccag aatttctcac ccactgtggt tcacccggga gacctccaga ctcagctggc 2461 tgtgcagacc aagcgcgtgg cggcgcaggt ggacggcggc gcgcaggtgc agcaggtgct 2521 caatatcgag tgcctgcggg acttcctgac gcccccgctg ctgtccgtgc gcttccggta 2581 cggtggcgcc ccccaggccc tcaccctgaa gctcccagtg accatcaaca agttcttcca 2641 gcccaccgag atggcggccc aggatttctt ccagcgctgg aagcagctga gcctccctca 2701 acaggaggcg cagaaaatct tcaaagccaa ccaccccatg gacgcagaag ttactaaggc 2761 caagcttctg gggtttggct ctgctctcct ggacaatgtg gaccccaacc ctggtgacag 2821 agaagacacc agggtttggg ggatgcctgg gactttcctc cggccttttg tatttttatt 2881 tttgttcatc tgctgctgtt tacattctgg ggggttaggg ggagtccccc tccctccctt 2941 tcccccccaa gcacagaggg gagaggggcc agggaagtgg atgtctcctc ccctcccacc 3001 ccaccctgtt gtagcccctc ctaccccctc cccatccagg ggctgtgtat tattgtgagc 3061 gaataaacag agagacgcta aaaaaaaaaa aaaaaaaaaa aaa //