LOCUS BC013734 3394 bp mRNA linear HUM 15-JUL-2006
DEFINITION Homo sapiens prostaglandin-endoperoxide synthase 2 (prostaglandin
G/H synthase and cyclooxygenase), mRNA (cDNA clone MGC:9576
IMAGE:3880850), complete cds.
ACCESSION BC013734
VERSION BC013734.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3394)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 3394)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (04-SEP-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: DCTD/DTP/Gazdar
cDNA Library Preparation: Life Technologies, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Baylor College of Medicine Human Genome
Sequencing Center
Center code: BCM-HGSC
Web site: http://www.hgsc.bcm.tmc.edu/cdna/
Contact: amg@bcm.tmc.edu
Gunaratne, P.H., Garcia, A.M., Lu, X., Hulyk, S.W., Loulseged, H.,
Kowis, C.R., Sneed, A.J., Martin, R.G., Muzny, D.M., Nanavati,
A.N., Gibbs, R.A.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 21 Row: n Column: 20
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 4506264.
FEATURES Location/Qualifiers
source 1..3394
/db_xref="H-InvDB:HIT000036341"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:9576 IMAGE:3880850"
/tissue_type="Lung, large cell carcinoma"
/clone_lib="NIH_MGC_68"
/lab_host="DH10B"
/note="Vector: pCMV-SPORT6"
gene 1..3394
/gene="PTGS2"
/gene_synonym="COX-2"
/gene_synonym="COX2"
/gene_synonym="hCox-2"
/gene_synonym="PGG/HS"
/gene_synonym="PGHS-2"
/gene_synonym="PHS-2"
/db_xref="GeneID:5743"
/db_xref="HGNC:HGNC:9605"
/db_xref="MIM:600262"
CDS 121..1935
/gene="PTGS2"
/gene_synonym="COX-2"
/gene_synonym="COX2"
/gene_synonym="hCox-2"
/gene_synonym="PGG/HS"
/gene_synonym="PGHS-2"
/gene_synonym="PHS-2"
/codon_start=1
/product="prostaglandin-endoperoxide synthase 2
(prostaglandin G/H synthase and cyclooxygenase)"
/protein_id="AAH13734.1"
/db_xref="GeneID:5743"
/db_xref="HGNC:HGNC:9605"
/db_xref="MIM:600262"
/translation="MLARALLLCAVLALSHTANPCCSHPCQNRGVCMSVGFDQYKCDC
TRTGFYGENCSTPEFLTRIKLFLKPTPNTVHYILTHFKGFWNVVNNIPFLRNAIMSYV
LTSRSHLIDSPPTYNADYGYKSWEAFSNLSYYTRALPPVPDDCPTPLGVKGKKQLPDS
NEIVEKLLLRRKFIPDPQGSNMMFAFFAQHFTHQFFKTDHKRGPAFTNGLGHGVDLNH
IYGETLARQRKLRLFKDGKMKYQIIDGEMYPPTVKDTQAEMIYPPQVPEHLRFAVGQE
VFGLVPGLMMYATIWLREHNRVCDVLKQEHPEWGDEQLFQTSRLILIGETIKIVIEDY
VQHLSGYHFKLKFDPELLFNKQFQYQNRIAAEFNTLYHWHPLLPDTFQIHDQKYNYQQ
FIYNNSILLEHGITQFVESFTRQIAGRVAGGRNVPPAVQKVSQASIDQSRQMKYQSFN
EYRKRFMLKPYESFEELTGEKEMSAELEALYGDIDAVELYPALLVEKPRPDAIFGETM
VEVGAPFSLKGLMGNVICSPAYWKPSTFGGEVGFQIINTASIQSLICNNVKGCPFTSF
SVPDPELIKTVTINASSSRSGLDDINPTVLLKERSTEL"
BASE COUNT 1014 a 703 c 633 g 1044 t
ORIGIN
1 cttgcagtga gcgtcaggag cacgtccagg aactcctcag cagcgcctcc ttcagctcca
61 cagccagacg ccctcagaca gcaaagccta cccccgcgcc gcgccctgcc cgccgctgcg
121 atgctcgccc gcgccctgct gctgtgcgcg gtcctggcgc tcagccatac agcaaatcct
181 tgctgttccc acccatgtca aaaccgaggt gtatgtatga gtgtgggatt tgaccagtat
241 aagtgcgatt gtacccggac aggattctat ggagaaaact gctcaacacc ggaatttttg
301 acaagaataa aattatttct gaaacccact ccaaacacag tgcactacat acttacccac
361 ttcaagggat tttggaacgt tgtgaataac attcccttcc ttcgaaatgc aattatgagt
421 tatgtgttga catccagatc acatttgatt gacagtccac caacttacaa tgctgactat
481 ggctacaaaa gctgggaagc cttctctaac ctctcctatt atactagagc ccttcctcct
541 gtgcctgatg attgcccgac tcccttgggt gtcaaaggta aaaagcagct tcctgattca
601 aatgagattg tggaaaaatt gcttctaaga agaaagttca tccctgatcc ccagggctca
661 aacatgatgt ttgcattctt tgcccagcac ttcacgcatc agtttttcaa gacagatcat
721 aagcgagggc cagctttcac caacgggctg ggccatgggg tggacttaaa tcatatttac
781 ggtgaaactc tggctagaca gcgtaaactg cgccttttca aggatggaaa aatgaaatat
841 cagataattg atggagagat gtatcctccc acagtcaaag atactcaggc agagatgatc
901 taccctcctc aagtccctga gcatctacgg tttgctgtgg ggcaggaggt ctttggtctg
961 gtgcctggtc tgatgatgta tgccacaatc tggctgcggg aacacaacag agtatgcgat
1021 gtgcttaaac aggagcatcc tgaatggggt gatgagcagt tgttccagac aagcaggcta
1081 atactgatag gagagactat taagattgtg attgaagatt atgtgcaaca cttgagtggc
1141 tatcacttca aactgaaatt tgacccagaa ctacttttca acaaacaatt ccagtaccaa
1201 aatcgtattg ctgctgaatt taacaccctc tatcactggc atccccttct gcctgacacc
1261 tttcaaattc atgaccagaa atacaactat caacagttta tctacaacaa ctctatattg
1321 ctggaacatg gaattaccca gtttgttgaa tcattcacca ggcaaattgc tggcagggtt
1381 gctggtggta ggaatgttcc acccgcagta cagaaagtat cacaggcttc cattgaccag
1441 agcaggcaga tgaaatacca gtcttttaat gagtaccgca aacgctttat gctgaagccc
1501 tatgaatcat ttgaagaact tacaggagaa aaggaaatgt ctgcagagtt ggaagcactc
1561 tatggtgaca tcgatgctgt ggagctgtat cctgcccttc tggtagaaaa gcctcggcca
1621 gatgccatct ttggtgaaac catggtagaa gttggagcac cattctcctt gaaaggactt
1681 atgggtaatg ttatatgttc tcctgcctac tggaagccaa gcacttttgg tggagaagtg
1741 ggttttcaaa tcatcaacac tgcctcaatt cagtctctca tctgcaataa cgtgaagggc
1801 tgtcccttta cttcattcag tgttccagat ccagagctca ttaaaacagt caccatcaat
1861 gcaagttctt cccgctccgg actagatgat atcaatccca cagtactact aaaagaacgt
1921 tcgactgaac tgtagaagtc taatgatcat atttatttat ttatatgaac catgtctatt
1981 aatttaatta tttaataata tttatattaa actccttatg ttacttaaca tcttctgtaa
2041 cagaagtcag tactcctgtt gcggagaaag gagtcatact tgtgaagact tttatgtcac
2101 tactctaaag attttgctgt tgctgttaag tttggaaaac agtttttatt ctgttttata
2161 aaccagagag aaatgagttt tgacgtcttt ttacttgaat ttcaacttat attataagaa
2221 cgaaagtaaa gatgtttgaa tacttaaaca ctgtcacaag atggcaaaat gctgaaagtt
2281 tttacactgt cgatgtttcc aatgcatctt ccatgatgca ttagaagtaa ctaatgtttg
2341 aaattttaaa gtacttttgg tcatttttct gtcatcaaac aaaaacaggt atcagtgcat
2401 tattaaatga atatttaaat tagacattac cagtaatttc atgtctactt tttaaaatca
2461 gcaatgaaac aataatttga aatttctaaa ttcatagggt agaatcacct gtaaaagctt
2521 gtttgatttc ttaaagttat taaacttgta catataccaa aaagaagctg tcttggattt
2581 aaatctgtaa aatcagtaga aattttacta caattgcttg ttaaaatatt ttataagtga
2641 tgttcctttt tcaccaagag tataaacctt tttagtgtga ctgttaaaac ttccttttaa
2701 atcaaaatgc caaatttatt aaggtggtgg agccactgca gtgttatctt aaaataagaa
2761 tattttgttg agatattcca gaatttgttt atatggctgg taacatgtaa aatctatatc
2821 agcaaaaggg tctaccttta aaataagcaa taacaaagaa gaaaaccaaa ttattgttca
2881 aatttaggtt taaacttttg aagcaaactt ttttttatcc ttgtgcactg caggcctggt
2941 actcagattt tgctatgagg ttaatgaagt accaagctgt gcttgaataa cgatatgttt
3001 tctcagattt tctgttgtac agtttaattt agcagtccat atcacattgc aaaagtagca
3061 atgacctcat aaaatacctc ttcaaaatgc ttaaattcat ttcacacatt aattttatct
3121 cagtcttgaa gccaattcag taggtgcatt ggaatcaagc ctggctacct gcatgctgtt
3181 ccttttcttt tcttctttta gccattttgc taagagacac agtcttctca tcacttcgtt
3241 tctcctattt tgttttacta gtcttaagat cagagttcac tttctttgga ctctgcctat
3301 attttcttac ctgaactttt gcaagttttc aggtaaacct cagctcagga ctgctattta
3361 gctcctctta agaagattaa aaaaaaaaaa aaaa
//