LOCUS BC012760 2374 bp mRNA linear HUM 11-DEC-2003
DEFINITION Homo sapiens glycogen synthase kinase 3 beta, mRNA (cDNA clone
MGC:16182 IMAGE:3637163), complete cds.
ACCESSION BC012760
VERSION BC012760.2
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2374)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 2374)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (15-AUG-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT On Dec 9, 2003 this sequence version replaced BC012760.1.
Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Institute for Systems Biology
http://www.systemsbiology.org
contact: amadan@systemsbiology.org
Anup Madan, Jessica Fahey, Erin Helton, Mark Ketteman, Anuradha
Madan, Stephanie Rodrigues, Amy Sanchez and Michelle Whiting
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 24 Row: b Column: 21
This clone was selected for full length sequencing because it
passed the following selection criteria: Hexamer frequency ORF
analysis.
FEATURES Location/Qualifiers
source 1..2374
/db_xref="H-InvDB:HIT000087930"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:16182 IMAGE:3637163"
/tissue_type="Placenta, choriocarcinoma"
/clone_lib="NIH_MGC_21"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene 1..2374
/gene="GSK3B"
/db_xref="GeneID:2932"
/db_xref="MIM:605004"
CDS 983..2245
/gene="GSK3B"
/codon_start=1
/product="GSK3B protein"
/protein_id="AAH12760.1"
/db_xref="GeneID:2932"
/db_xref="MIM:605004"
/translation="MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATP
GQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMR
KLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKL
YMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYIC
SRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTP
TREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEA
CAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPT
NATAASDANTGDRGQTNNAASASASNST"
misc_feature 1148..2002
/gene="GSK3B"
/note="S_TKc; Region: Serine/Threonine protein kinases,
catalytic domain. Phosphotransferases of the serine or
threonine-specific kinase subfamily. The enzymatic
activity of these protein kinases is controlled by
phosphorylation of specific residues in the activation
segment of the catalytic domain, sometimes combined with
reversible conformational changes in the C-terminal
autoregulatory tail"
/db_xref="CDD:cd00180"
BASE COUNT 628 a 620 c 587 g 539 t
ORIGIN
1 cgggcttgtg ccgccgccgc cgccgccgcc gcccgggcca agtgacaaag gaaggaagga
61 agcgaggagg agccggcccc gcagccgctg acagggctct gggctggggc aaagcgcgga
121 cacttcctga gcgggcaccg agcagagccg aggggcggga gggcggccga gctgttgccg
181 cggacggggg agggggcccc gagggacgga agcggttgcc gggttcccat gtccccggcg
241 aatggggaac agtcgaggag ccgctgcctg gggtctgaag ggagctgcct ccgccaccgc
301 catggccgct ggatccagcc gccgcctgca gctgctcctg gcgcaatgag gagaggagcc
361 gccgccaccg ccaccgcccg cctctgactg actcgcgact ccgccgccct ctagttcgcc
421 gggcccctgc cgtcagcccg ccggatcccg cggctgccgg agctgcagcg tttcccgtcg
481 catttccgag ccaccccctc cctccctctc cctccctcct acccatcccc ctttctcttc
541 aagcgtgaga ctcgtgatcc ttccgccgct tcccttcttc attgactcgg aaaaaaaatc
601 cccgaggaaa atataatatt cgaagtactc attttcaatc aagtatttgc ccccgtttca
661 cgtgatacat atttttttag gatttgccct ctcttttctc tcctcccagg aaagggaggg
721 gaaagaattg tattttttcc caagtcctaa atcatctata tgttaaatat ccgtgccgat
781 ctgtcttgaa ggagaaatat atcgcttgtt ttgtttttta tagtatacaa aaggagtgaa
841 aagccaagag gacgaagtct ttttcttttt cttctgtggg agaacttaat gctgcattta
901 tcgttaacct aacaccccaa cataaagaca aaaggaagaa aaggaggaag gaaggaaaag
961 gtgattcgcg aagagagtga tcatgtcagg gcggcccaga accacctcct ttgcggagag
1021 ctgcaagccg gtgcagcagc cttcagcttt tggcagcatg aaagttagca gagacaagga
1081 cggcagcaag gtgacaacag tggtggcaac tcctgggcag ggtccagaca ggccacaaga
1141 agtcagctat acagacacta aagtgattgg aaatggatca tttggtgtgg tatatcaagc
1201 caaactttgt gattcaggag aactggtcgc catcaagaaa gtattgcagg acaagagatt
1261 taagaatcga gagctccaga tcatgagaaa gctagatcac tgtaacatag tccgattgcg
1321 ttatttcttc tactccagtg gtgagaagaa agatgaggtc tatcttaatc tggtgctgga
1381 ctatgttccg gaaacagtat acagagttgc cagacactat agtcgagcca aacagacgct
1441 ccctgtgatt tatgtcaagt tgtatatgta tcagctgttc cgaagtttag cctatatcca
1501 ttcctttgga atctgccatc gggatattaa accgcagaac ctcttgttgg atcctgatac
1561 tgctgtatta aaactctgtg actttggaag tgcaaagcag ctggtccgag gagaacccaa
1621 tgtttcgtat atctgttctc ggtactatag ggcaccagag ttgatctttg gagccactga
1681 ttatacctct agtatagatg tatggtctgc tggctgtgtg ttggctgagc tgttactagg
1741 acaaccaata tttccagggg atagtggtgt ggatcagttg gtagaaataa tcaaggtcct
1801 gggaactcca acaagggagc aaatcagaga aatgaaccca aactacacag aatttaaatt
1861 ccctcaaatt aaggcacatc cttggactaa ggtcttccga ccccgaactc caccggaggc
1921 aattgcactg tgtagccgtc tgctggagta tacaccaact gcccgactaa caccactgga
1981 agcttgtgca cattcatttt ttgatgaatt acgggaccca aatgtcaaac taccaaatgg
2041 gcgagacaca cctgcactct tcaacttcac cactcaagaa ctgtcaagta atccacctct
2101 ggctaccatc cttattcctc ctcatgctcg gattcaagca gctgcttcaa cccccacaaa
2161 tgccacagca gcgtcagatg ctaatactgg agaccgtgga cagaccaata atgctgcttc
2221 tgcatcagct tccaactcca cctgaacagt cccgagcagc cagctgcaca ggaaaaacca
2281 ccagttactt gagtgtcact cagcaacact ggtcacgttt ggaaagaata ttaaaaagag
2341 aaaaaaatcc tgttcaaaaa aaaaaaaaaa aaaa
//