LOCUS BC012527 3933 bp mRNA linear HUM 18-MAR-2009 DEFINITION Homo sapiens hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor), mRNA (cDNA clone MGC:10483 IMAGE:3842146), complete cds. ACCESSION BC012527 VERSION BC012527.2 KEYWORDS MGC. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 3933) AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A. CONSRTM Mammalian Gene Collection Program Team TITLE Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002) PUBMED 12477932 REFERENCE 2 (bases 1 to 3933) CONSRTM NIH MGC Project TITLE Direct Submission JOURNAL Submitted (15-AUG-2001) National Institutes of Health, Mammalian Gene Collection (MGC), Bethesda, MD 20892-2590, USA REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov COMMENT On Aug 19, 2003 this sequence version replaced BC012527.1. Contact: MGC help desk Email: cgapbs-r@mail.nih.gov Tissue Procurement: ATCC cDNA Library Preparation: Rubin Laboratory cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL) DNA Sequencing by: Institute for Systems Biology http://www.systemsbiology.org contact: amadan@systemsbiology.org Anup Madan, Jessica Fahey, Erin Helton, Mark Ketteman, Anuradha Madan, Stephanie Rodrigues, Amy Sanchez and Michelle Whiting Clone distribution: MGC clone distribution information can be found through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov Series: IRAL Plate: 14 Row: c Column: 12 This clone was selected for full length sequencing because it passed the following selection criteria: matched mRNA gi: 31077210. FEATURES Location/Qualifiers source 1..3933 /db_xref="H-InvDB:HIT000035850" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /clone="MGC:10483 IMAGE:3842146" /tissue_type="Placenta, choriocarcinoma" /clone_lib="NIH_MGC_21" /lab_host="DH10B-R" /note="Vector: pOTB7" gene 1..3933 /gene="HIF1A" /gene_synonym="bHLHe78" /gene_synonym="HIF-1alpha" /gene_synonym="HIF1" /gene_synonym="HIF1-ALPHA" /gene_synonym="MOP1" /gene_synonym="PASD8" /db_xref="GeneID:3091" /db_xref="HGNC:HGNC:4910" /db_xref="MIM:603348" CDS 255..2735 /gene="HIF1A" /gene_synonym="bHLHe78" /gene_synonym="HIF-1alpha" /gene_synonym="HIF1" /gene_synonym="HIF1-ALPHA" /gene_synonym="MOP1" /gene_synonym="PASD8" /codon_start=1 /product="hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)" /protein_id="AAH12527.1" /db_xref="GeneID:3091" /db_xref="HGNC:HGNC:4910" /db_xref="MIM:603348" /translation="MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQL PLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMV LTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKE QNTQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMT CLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIY EYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQC IVCVNYVVSGIIQHDLIFSLQQTECVLKPVESSDMKMTQLFTKVESEDTSSLFDKLKK EPDALTLLAPAAGDTIISLDFGSNDTETDDQQLEEVPLYNDVMLPSPNEKLQNINLAM SPLPTAETPKPLRSSADPALNQEVALKLEPNPESLELSFTMPQIQDQTPSPSDGSTRQ SSPEPNSPSEYCFYVDSDMVNEFKLELVEKLFAEDTEAKNPFSTQDTDLDLEMLAPYI PMDDDFQLRSFDQLSPLESSSASPESASPQSTVTVFQQTQIQEPTANATTTTATTDEL KTVTKDRMEDIKILIASPSPTHIHKETTSATSSPYRDTQSRTASPNRAGKGVIEQTEK SHPRSPNVLSVALSQRTTVPEEELNPKILALQNAQRKRKMEHDGSLFQAVGIGTLLQQ PDDHAATTSLSWKRVKGCKSSEQNGMEQKTIILIPSDLACRLLGQSMDESGLPQLTSY DCEVNAPIQGSRNLLQGEELLRALDQVN" BASE COUNT 1245 a 785 c 748 g 1155 t ORIGIN 1 caccctcttc gtcgcttcgg ccagtgtgtc gggctgggcc ctgacaagcc acctgaggag 61 aggctcggag ccgggcccgg accccggcga ttgccgcccg cttctctcta gtctcacgag 121 gggtttcccg cctcgcaccc ccacctctgg acttgccttt ccttctcttc tccgcgtgtg 181 gagggagcca gcgcttaggc cggagcgagc ctgggggccg cccgccgtga agacatcgcg 241 gggaccgatt caccatggag ggcgccggcg gcgcgaacga caagaaaaag ataagttctg 301 aacgtcgaaa agaaaagtct cgagatgcag ccagatctcg gcgaagtaaa gaatctgaag 361 ttttttatga gcttgctcat cagttgccac ttccacataa tgtgagttcg catcttgata 421 aggcctctgt gatgaggctt accatcagct atttgcgtgt gaggaaactt ctggatgctg 481 gtgatttgga tattgaagat gacatgaaag cacagatgaa ttgcttttat ttgaaagcct 541 tggatggttt tgttatggtt ctcacagatg atggtgacat gatttacatt tctgataatg 601 tgaacaaata catgggatta actcagtttg aactaactgg acacagtgtg tttgatttta 661 ctcatccatg tgaccatgag gaaatgagag aaatgcttac acacagaaat ggccttgtga 721 aaaagggtaa agaacaaaac acacagcgaa gcttttttct cagaatgaag tgtaccctaa 781 ctagccgagg aagaactatg aacataaagt ctgcaacatg gaaggtattg cactgcacag 841 gccacattca cgtatatgat accaacagta accaacctca gtgtgggtat aagaaaccac 901 ctatgacctg cttggtgctg atttgtgaac ccattcctca cccatcaaat attgaaattc 961 ctttagatag caagactttc ctcagtcgac acagcctgga tatgaaattt tcttattgtg 1021 atgaaagaat taccgaattg atgggatatg agccagaaga acttttaggc cgctcaattt 1081 atgaatatta tcatgctttg gactctgatc atctgaccaa aactcatcat gatatgttta 1141 ctaaaggaca agtcaccaca ggacagtaca ggatgcttgc caaaagaggt ggatatgtct 1201 gggttgaaac tcaagcaact gtcatatata acaccaagaa ttctcaacca cagtgcattg 1261 tatgtgtgaa ttacgttgtg agtggtatta ttcagcacga cttgattttc tcccttcaac 1321 aaacagaatg tgtccttaaa ccggttgaat cttcagatat gaaaatgact cagctattca 1381 ccaaagttga atcagaagat acaagtagcc tctttgacaa acttaagaag gaacctgatg 1441 ctttaacttt gctggcccca gccgctggag acacaatcat atctttagat tttggcagca 1501 acgacacaga aactgatgac cagcaacttg aggaagtacc attatataat gatgtaatgc 1561 tcccctcacc caacgaaaaa ttacagaata taaatttggc aatgtctcca ttacccaccg 1621 ctgaaacgcc aaagccactt cgaagtagtg ctgaccctgc actcaatcaa gaagttgcat 1681 taaaattaga accaaatcca gagtcactgg aactttcttt taccatgccc cagattcagg 1741 atcagacacc tagtccttcc gatggaagca ctagacaaag ttcacctgag cctaatagtc 1801 ccagtgaata ttgtttttat gtggatagtg atatggtcaa tgaattcaag ttggaattgg 1861 tagaaaaact ttttgctgaa gacacagaag caaagaaccc attttctact caggacacag 1921 atttagactt ggagatgtta gctccctata tcccaatgga tgatgacttc cagttacgtt 1981 ccttcgatca gttgtcacca ttagaaagca gttccgcaag ccctgaaagc gcaagtcctc 2041 aaagcacagt tacagtattc cagcagactc aaatacaaga acctactgct aatgccacca 2101 ctaccactgc caccactgat gaattaaaaa cagtgacaaa agaccgtatg gaagacatta 2161 aaatattgat tgcatctcca tctcctaccc acatacataa agaaactact agtgccacat 2221 catcaccata tagagatact caaagtcgga cagcctcacc aaacagagca ggaaaaggag 2281 tcatagaaca gacagaaaaa tctcatccaa gaagccctaa cgtgttatct gtcgctttga 2341 gtcaaagaac tacagttcct gaggaagaac taaatccaaa gatactagct ttgcagaatg 2401 ctcagagaaa gcgaaaaatg gaacatgatg gttcactttt tcaagcagta ggaattggaa 2461 cattattaca gcagccagac gatcatgcag ctactacatc actttcttgg aaacgtgtaa 2521 aaggatgcaa atctagtgaa cagaatggaa tggagcaaaa gacaattatt ttaataccct 2581 ctgatttagc atgtagactg ctggggcaat caatggatga aagtggatta ccacagctga 2641 ccagttatga ttgtgaagtt aatgctccta tacaaggcag cagaaaccta ctgcagggtg 2701 aagaattact cagagctttg gatcaagtta actgagcttt ttcttaattt cattcctttt 2761 tttggacact ggtggctcac tacctaaagc agtctattta tattttctac atctaatttt 2821 agaagcctgg ctacaatact gcacaaactt ggttagttca atttttgatc ccctttctac 2881 ttaatttaca ttaatgctct tttttagtat gttctttaat gctggatcac agacagctca 2941 ttttctcagt tttttggtat ttaaaccatt gcattgcagt agcatcattt taaaaaatgc 3001 acctttttat ttatttattt ttggctaggg agtttatccc tttttcgaat tatttttaag 3061 aagatgccaa tataattttt gtaagaaggc agtaaccttt catcatgatc ataggcagtt 3121 gaaaaatttt tacacctttt ttttcacatt ttacataaat aataatgctt tgccagcagt 3181 acgtggtagc cacaattgca caatatattt tcttaaaaaa taccagcagt tactcatgga 3241 atatattctg cgtttataaa actagttttt aagaagaaat tttttttggc ctatgaaatt 3301 gttaaacctg gaacatgaca ttgttaatca tataataatg attcttaaat gctgtatggt 3361 ttattattta aatgggtaaa gccatttaca taatatagaa agatatgcat atatctagaa 3421 ggtatgtggc atttatttgg ataaaattct caattcagag aaatcatctg atgtttctat 3481 agtcactttg ccagctcaaa agaaaacaat accctatgta gttgtggaag tttatgctaa 3541 tattgtgtaa ctgatattaa acctaaatgt tctgcctacc ctgttggtat aaagatattt 3601 tgagcagact gtaaacaaga aaaaaaaaat catgcattct tagcaaaatt gcctagtatg 3661 ttaatttgct caaaatacaa tgtttgattt tatgcacttt gtcgctatta acatcctttt 3721 tttcatgtag atttcaataa ttgagtaatt ttagaagcat tattttagga atatatagtt 3781 gtcacagtaa atatcttgtt ttttctatgt acattgtaca aatttttcat tccttttgct 3841 ctttgtggtt ggatctaaca ctaactgtat tgttttgtta catcaaataa acatcttctg 3901 tggaccaggc aaaaaaaaaa aaaaaaaaaa aaa //