LOCUS       BC012527                3933 bp    mRNA    linear   HUM 18-MAR-2009
DEFINITION  Homo sapiens hypoxia inducible factor 1, alpha subunit (basic
            helix-loop-helix transcription factor), mRNA (cDNA clone MGC:10483
            IMAGE:3842146), complete cds.
ACCESSION   BC012527
VERSION     BC012527.2
KEYWORDS    MGC.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3933)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
   PUBMED   12477932
REFERENCE   2  (bases 1 to 3933)
  CONSRTM   NIH MGC Project
  TITLE     Direct Submission
  JOURNAL   Submitted (15-AUG-2001) National Institutes of Health, Mammalian
            Gene Collection (MGC), Bethesda, MD 20892-2590, USA
  REMARK    NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT     On Aug 19, 2003 this sequence version replaced BC012527.1.
            Contact: MGC help desk
            Email: cgapbs-r@mail.nih.gov
            Tissue Procurement: ATCC
            cDNA Library Preparation: Rubin Laboratory
            cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
            DNA Sequencing by: Institute for Systems Biology
            http://www.systemsbiology.org
            contact: amadan@systemsbiology.org
            Anup Madan, Jessica Fahey, Erin Helton, Mark Ketteman, Anuradha
            Madan, Stephanie Rodrigues, Amy Sanchez and Michelle Whiting
            
            Clone distribution: MGC clone distribution information can be found
            through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
            Series: IRAL Plate: 14 Row: c Column: 12
            This clone was selected for full length sequencing because it
            passed the following selection criteria: matched mRNA gi: 31077210.
FEATURES             Location/Qualifiers
     source          1..3933
                     /db_xref="H-InvDB:HIT000035850"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /clone="MGC:10483 IMAGE:3842146"
                     /tissue_type="Placenta, choriocarcinoma"
                     /clone_lib="NIH_MGC_21"
                     /lab_host="DH10B-R"
                     /note="Vector: pOTB7"
     gene            1..3933
                     /gene="HIF1A"
                     /gene_synonym="bHLHe78"
                     /gene_synonym="HIF-1alpha"
                     /gene_synonym="HIF1"
                     /gene_synonym="HIF1-ALPHA"
                     /gene_synonym="MOP1"
                     /gene_synonym="PASD8"
                     /db_xref="GeneID:3091"
                     /db_xref="HGNC:HGNC:4910"
                     /db_xref="MIM:603348"
     CDS             255..2735
                     /gene="HIF1A"
                     /gene_synonym="bHLHe78"
                     /gene_synonym="HIF-1alpha"
                     /gene_synonym="HIF1"
                     /gene_synonym="HIF1-ALPHA"
                     /gene_synonym="MOP1"
                     /gene_synonym="PASD8"
                     /codon_start=1
                     /product="hypoxia inducible factor 1, alpha subunit (basic
                     helix-loop-helix transcription factor)"
                     /protein_id="AAH12527.1"
                     /db_xref="GeneID:3091"
                     /db_xref="HGNC:HGNC:4910"
                     /db_xref="MIM:603348"
                     /translation="MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQL
                     PLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMV
                     LTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKE
                     QNTQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMT
                     CLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIY
                     EYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQC
                     IVCVNYVVSGIIQHDLIFSLQQTECVLKPVESSDMKMTQLFTKVESEDTSSLFDKLKK
                     EPDALTLLAPAAGDTIISLDFGSNDTETDDQQLEEVPLYNDVMLPSPNEKLQNINLAM
                     SPLPTAETPKPLRSSADPALNQEVALKLEPNPESLELSFTMPQIQDQTPSPSDGSTRQ
                     SSPEPNSPSEYCFYVDSDMVNEFKLELVEKLFAEDTEAKNPFSTQDTDLDLEMLAPYI
                     PMDDDFQLRSFDQLSPLESSSASPESASPQSTVTVFQQTQIQEPTANATTTTATTDEL
                     KTVTKDRMEDIKILIASPSPTHIHKETTSATSSPYRDTQSRTASPNRAGKGVIEQTEK
                     SHPRSPNVLSVALSQRTTVPEEELNPKILALQNAQRKRKMEHDGSLFQAVGIGTLLQQ
                     PDDHAATTSLSWKRVKGCKSSEQNGMEQKTIILIPSDLACRLLGQSMDESGLPQLTSY
                     DCEVNAPIQGSRNLLQGEELLRALDQVN"
BASE COUNT         1245 a          785 c          748 g         1155 t
ORIGIN      
        1 caccctcttc gtcgcttcgg ccagtgtgtc gggctgggcc ctgacaagcc acctgaggag
       61 aggctcggag ccgggcccgg accccggcga ttgccgcccg cttctctcta gtctcacgag
      121 gggtttcccg cctcgcaccc ccacctctgg acttgccttt ccttctcttc tccgcgtgtg
      181 gagggagcca gcgcttaggc cggagcgagc ctgggggccg cccgccgtga agacatcgcg
      241 gggaccgatt caccatggag ggcgccggcg gcgcgaacga caagaaaaag ataagttctg
      301 aacgtcgaaa agaaaagtct cgagatgcag ccagatctcg gcgaagtaaa gaatctgaag
      361 ttttttatga gcttgctcat cagttgccac ttccacataa tgtgagttcg catcttgata
      421 aggcctctgt gatgaggctt accatcagct atttgcgtgt gaggaaactt ctggatgctg
      481 gtgatttgga tattgaagat gacatgaaag cacagatgaa ttgcttttat ttgaaagcct
      541 tggatggttt tgttatggtt ctcacagatg atggtgacat gatttacatt tctgataatg
      601 tgaacaaata catgggatta actcagtttg aactaactgg acacagtgtg tttgatttta
      661 ctcatccatg tgaccatgag gaaatgagag aaatgcttac acacagaaat ggccttgtga
      721 aaaagggtaa agaacaaaac acacagcgaa gcttttttct cagaatgaag tgtaccctaa
      781 ctagccgagg aagaactatg aacataaagt ctgcaacatg gaaggtattg cactgcacag
      841 gccacattca cgtatatgat accaacagta accaacctca gtgtgggtat aagaaaccac
      901 ctatgacctg cttggtgctg atttgtgaac ccattcctca cccatcaaat attgaaattc
      961 ctttagatag caagactttc ctcagtcgac acagcctgga tatgaaattt tcttattgtg
     1021 atgaaagaat taccgaattg atgggatatg agccagaaga acttttaggc cgctcaattt
     1081 atgaatatta tcatgctttg gactctgatc atctgaccaa aactcatcat gatatgttta
     1141 ctaaaggaca agtcaccaca ggacagtaca ggatgcttgc caaaagaggt ggatatgtct
     1201 gggttgaaac tcaagcaact gtcatatata acaccaagaa ttctcaacca cagtgcattg
     1261 tatgtgtgaa ttacgttgtg agtggtatta ttcagcacga cttgattttc tcccttcaac
     1321 aaacagaatg tgtccttaaa ccggttgaat cttcagatat gaaaatgact cagctattca
     1381 ccaaagttga atcagaagat acaagtagcc tctttgacaa acttaagaag gaacctgatg
     1441 ctttaacttt gctggcccca gccgctggag acacaatcat atctttagat tttggcagca
     1501 acgacacaga aactgatgac cagcaacttg aggaagtacc attatataat gatgtaatgc
     1561 tcccctcacc caacgaaaaa ttacagaata taaatttggc aatgtctcca ttacccaccg
     1621 ctgaaacgcc aaagccactt cgaagtagtg ctgaccctgc actcaatcaa gaagttgcat
     1681 taaaattaga accaaatcca gagtcactgg aactttcttt taccatgccc cagattcagg
     1741 atcagacacc tagtccttcc gatggaagca ctagacaaag ttcacctgag cctaatagtc
     1801 ccagtgaata ttgtttttat gtggatagtg atatggtcaa tgaattcaag ttggaattgg
     1861 tagaaaaact ttttgctgaa gacacagaag caaagaaccc attttctact caggacacag
     1921 atttagactt ggagatgtta gctccctata tcccaatgga tgatgacttc cagttacgtt
     1981 ccttcgatca gttgtcacca ttagaaagca gttccgcaag ccctgaaagc gcaagtcctc
     2041 aaagcacagt tacagtattc cagcagactc aaatacaaga acctactgct aatgccacca
     2101 ctaccactgc caccactgat gaattaaaaa cagtgacaaa agaccgtatg gaagacatta
     2161 aaatattgat tgcatctcca tctcctaccc acatacataa agaaactact agtgccacat
     2221 catcaccata tagagatact caaagtcgga cagcctcacc aaacagagca ggaaaaggag
     2281 tcatagaaca gacagaaaaa tctcatccaa gaagccctaa cgtgttatct gtcgctttga
     2341 gtcaaagaac tacagttcct gaggaagaac taaatccaaa gatactagct ttgcagaatg
     2401 ctcagagaaa gcgaaaaatg gaacatgatg gttcactttt tcaagcagta ggaattggaa
     2461 cattattaca gcagccagac gatcatgcag ctactacatc actttcttgg aaacgtgtaa
     2521 aaggatgcaa atctagtgaa cagaatggaa tggagcaaaa gacaattatt ttaataccct
     2581 ctgatttagc atgtagactg ctggggcaat caatggatga aagtggatta ccacagctga
     2641 ccagttatga ttgtgaagtt aatgctccta tacaaggcag cagaaaccta ctgcagggtg
     2701 aagaattact cagagctttg gatcaagtta actgagcttt ttcttaattt cattcctttt
     2761 tttggacact ggtggctcac tacctaaagc agtctattta tattttctac atctaatttt
     2821 agaagcctgg ctacaatact gcacaaactt ggttagttca atttttgatc ccctttctac
     2881 ttaatttaca ttaatgctct tttttagtat gttctttaat gctggatcac agacagctca
     2941 ttttctcagt tttttggtat ttaaaccatt gcattgcagt agcatcattt taaaaaatgc
     3001 acctttttat ttatttattt ttggctaggg agtttatccc tttttcgaat tatttttaag
     3061 aagatgccaa tataattttt gtaagaaggc agtaaccttt catcatgatc ataggcagtt
     3121 gaaaaatttt tacacctttt ttttcacatt ttacataaat aataatgctt tgccagcagt
     3181 acgtggtagc cacaattgca caatatattt tcttaaaaaa taccagcagt tactcatgga
     3241 atatattctg cgtttataaa actagttttt aagaagaaat tttttttggc ctatgaaatt
     3301 gttaaacctg gaacatgaca ttgttaatca tataataatg attcttaaat gctgtatggt
     3361 ttattattta aatgggtaaa gccatttaca taatatagaa agatatgcat atatctagaa
     3421 ggtatgtggc atttatttgg ataaaattct caattcagag aaatcatctg atgtttctat
     3481 agtcactttg ccagctcaaa agaaaacaat accctatgta gttgtggaag tttatgctaa
     3541 tattgtgtaa ctgatattaa acctaaatgt tctgcctacc ctgttggtat aaagatattt
     3601 tgagcagact gtaaacaaga aaaaaaaaat catgcattct tagcaaaatt gcctagtatg
     3661 ttaatttgct caaaatacaa tgtttgattt tatgcacttt gtcgctatta acatcctttt
     3721 tttcatgtag atttcaataa ttgagtaatt ttagaagcat tattttagga atatatagtt
     3781 gtcacagtaa atatcttgtt ttttctatgt acattgtaca aatttttcat tccttttgct
     3841 ctttgtggtt ggatctaaca ctaactgtat tgttttgtta catcaaataa acatcttctg
     3901 tggaccaggc aaaaaaaaaa aaaaaaaaaa aaa
//