LOCUS BC012418 1975 bp mRNA linear HUM 15-JUL-2006
DEFINITION Homo sapiens carboxylesterase 1 (monocyte/macrophage serine
esterase 1), mRNA (cDNA clone MGC:9220 IMAGE:3879691), complete
cds.
ACCESSION BC012418
VERSION BC012418.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1975)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 1975)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (15-AUG-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: DCTD/DTP/Gazdar
cDNA Library Preparation: Life Technologies, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Baylor College of Medicine Human Genome
Sequencing Center
Center code: BCM-HGSC
Web site: http://www.hgsc.bcm.tmc.edu/cdna/
Contact: amg@bcm.tmc.edu
Gunaratne, P.H., Garcia, A.M., Lu, X., Hulyk, S.W., Loulseged, H.,
Kowis, C.R., Sneed, A.J., Martin, R.G., Muzny, D.M., Nanavati,
A.N., Gibbs, R.A.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 21 Row: m Column: 7
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 7706474.
FEATURES Location/Qualifiers
source 1..1975
/db_xref="H-InvDB:HIT000035806"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:9220 IMAGE:3879691"
/tissue_type="Lung, large cell carcinoma"
/clone_lib="NIH_MGC_68"
/lab_host="DH10B"
/note="Vector: pCMV-SPORT6"
gene 1..1975
/gene="CES1"
/gene_synonym="ACAT"
/gene_synonym="CEH"
/gene_synonym="CES1A1"
/gene_synonym="CES1A1a"
/gene_synonym="CES1A1b"
/gene_synonym="CES1A1c"
/gene_synonym="CES1A2"
/gene_synonym="CES2"
/gene_synonym="HMSE"
/gene_synonym="HMSE1"
/gene_synonym="SES1"
/gene_synonym="TGH"
/db_xref="GeneID:1066"
/db_xref="HGNC:HGNC:1863"
/db_xref="MIM:114835"
CDS 63..1763
/gene="CES1"
/gene_synonym="ACAT"
/gene_synonym="CEH"
/gene_synonym="CES1A1"
/gene_synonym="CES1A1a"
/gene_synonym="CES1A1b"
/gene_synonym="CES1A1c"
/gene_synonym="CES1A2"
/gene_synonym="CES2"
/gene_synonym="HMSE"
/gene_synonym="HMSE1"
/gene_synonym="SES1"
/gene_synonym="TGH"
/codon_start=1
/product="carboxylesterase 1 (monocyte/macrophage serine
esterase 1)"
/protein_id="AAH12418.1"
/db_xref="GeneID:1066"
/db_xref="HGNC:HGNC:1863"
/db_xref="MIM:114835"
/translation="MWLPALVLATLAASAAWGHPSSPPVVDTVHGKVLGKFVSLEGFA
QPVAIFLGIPFAKPPLGPLRFTPPQPAEPWSFVKNATSYPPMCTQDPKAGQLLSELFT
NRKENIPLKLSEDCLYLNIYTPADLTKKNRLPVMVWIHGGGLMVGAASTYDGLALAAH
ENVVVVTIQYRLGIWGFFSTGDEHSRGNWGHLDQVAALRWVQDNIASFGGNPGSVTIF
GESAGGESVSVLVLSPLAKNLFHRAISESGVALTSVLVKKGDVKPLAEQIAITAGCKT
TTSAVMVHCLRQKTEEELLETTLKMKFLSLDLQGDPRESQPLLGTVIDGMLLLKTPEE
LQAERNFHTVPYMVGINKQEFGWLIPMLMSYPLSEGQLDQKTAMSLLWKSYPLVCIAK
ELIPEATEKYLGGTDDTVKKKDLFLDLIADVMFGVPSVIVARNHRDAGAPTYMYEFQY
RPSFSSDMKPKTVIGDHGDELFSVFGAPFLKEGASEEEIRLSKMVMKFWANFARNGNP
NGEGLPHWPEYNQKEGYLQIGANTQAAQKLKDKEVAFWTNLFAKKAVEKPPQTEHIEL
"
BASE COUNT 489 a 490 c 553 g 443 t
ORIGIN
1 agcacagtcc ctctgagctg cacggagacc tcgcaggccc ccggaactgt cgcccttcca
61 ggatgtggct ccctgctctt gtcctggcca ctctcgctgc ttccgcggct tgggggcatc
121 cgtcctcgcc acctgtggtg gacaccgtgc atggcaaagt gctggggaag ttcgtcagct
181 tagaaggatt tgcacagcct gtggccattt tcctgggaat cccttttgcc aagccgcctc
241 ttggacccct gaggtttact ccaccgcagc ctgcagaacc atggagcttt gtgaagaatg
301 ccacctcgta ccctcctatg tgcacccaag atcccaaggc ggggcagtta ctctcagagc
361 tatttacaaa ccgaaaggag aacattcctc tcaagctttc tgaagactgt ctttacctca
421 atatttacac tcctgctgac ttgaccaaga aaaacaggct gccggtgatg gtgtggatcc
481 acggaggggg gctgatggtg ggtgcggcat caacctatga tgggctggcc cttgctgccc
541 atgaaaacgt ggtggtggtg accattcaat atcgcctggg catctgggga ttcttcagca
601 caggggatga acacagccgg gggaactggg gtcacctgga ccaggtggct gccctgcgct
661 gggtccagga caacattgcc agctttggag ggaacccagg ctctgtgacc atctttggag
721 agtcagcggg aggagaaagt gtctctgttc ttgttttgtc tccattggcc aagaatctct
781 tccaccgggc catttctgag agtggcgtgg ccctcacttc tgttctggtg aagaaaggtg
841 atgtcaagcc cttggctgag caaattgcta tcactgctgg gtgcaaaacc accacctctg
901 ctgtcatggt tcactgcctg cgacagaaga cggaagagga gctcttggag acgacattga
961 aaatgaaatt cttatctctg gacttacagg gagaccccag agagagtcaa ccccttctgg
1021 gcactgtgat tgatgggatg ctgctgctga aaacacctga agagcttcaa gctgaaagga
1081 atttccacac tgtcccctac atggtcggaa ttaacaagca ggagtttggc tggttgattc
1141 caatgttgat gagctatcca ctctccgaag ggcaactgga ccagaagaca gccatgtcac
1201 tcctgtggaa gtcctatccc cttgtttgca ttgctaagga actgattcca gaagccactg
1261 agaaatactt aggaggaaca gacgacactg tcaaaaagaa agacctgttc ctggacttga
1321 tagcagatgt gatgtttggt gtcccatctg tgattgtggc ccggaaccac agagatgctg
1381 gagcacccac ctacatgtat gagtttcagt accgtccaag cttctcatca gacatgaaac
1441 ccaagacggt gataggagac cacggggatg agctcttctc cgtctttggg gccccatttt
1501 taaaagaggg tgcctcagaa gaggagatca gacttagcaa gatggtgatg aaattctggg
1561 ccaactttgc tcgcaatgga aaccccaatg gggaagggct gccccactgg ccagagtaca
1621 accagaagga agggtatctg cagattggtg ccaacaccca ggcggcccag aagctgaagg
1681 acaaagaagt agctttctgg accaacctct ttgccaagaa ggcagtggag aagccacccc
1741 agacagaaca catagagctg tgaatgaaga tccagccggc cttgggagcc tggaggagca
1801 aagactgggg tcttttgcga aagggattgc aggttcagaa ggcatcttac catggctggg
1861 gaattgtctg gtggtggggg gcaggggaca gaggccatga aggagcaagt tttgtatttg
1921 tgacctcagc tttgggaata aaggatcttt tgaaggccaa aaaaaaaaaa aaaaa
//