LOCUS BC012342 3540 bp mRNA linear HUM 11-AUG-2006
DEFINITION Homo sapiens cylindromatosis (turban tumor syndrome), mRNA (cDNA
clone MGC:19923 IMAGE:4552767), complete cds.
ACCESSION BC012342
VERSION BC012342.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3540)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 3540)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (15-AUG-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Genome Sequence Centre,
BC Cancer Agency, Vancouver, BC, Canada
info@bcgsc.bc.ca
Martin Hirst, Thomas Zeng, Ryan Morin, Michelle Moksa, Johnson
Pang, Diana Mah, Jing Wang, Kieth Fichter, Eric Chuah, Allen
Delaney, Rob Kirkpatrick, Agnes Baross, Sarah Barber, Mabel
Brown-John, Steve S. Chand, William Chow, Ryan Babakaiff, Dave
Wong, Corey Matsuo, Jaclyn Beland, Susan Gibson, Luis delRio, Ruth
Featherstone, Malachi Griffith, Obi Griffith, Ran Guin, Nancy Liao,
Kim MacDonald, Mike R. Mayo, Josh Moran, Diana Palmquist, JR
Santos, Duane Smailus, Jeff Stott, Miranda Tsai, George Yang,
Jacquie Schein, Asim Siddiqui,Steven Jones, Rob Holt, Marco Marra.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 29 Row: c Column: 5
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 14165257.
FEATURES Location/Qualifiers
source 1..3540
/db_xref="H-InvDB:HIT000035766"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:19923 IMAGE:4552767"
/tissue_type="Uterus, leiomyosarcoma"
/clone_lib="NIH_MGC_46"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene 1..3540
/gene="CYLD"
/gene_synonym="CDMT"
/gene_synonym="CYLDI"
/gene_synonym="EAC"
/gene_synonym="HSPC057"
/gene_synonym="KIAA0849"
/gene_synonym="USPL2"
/db_xref="GeneID:1540"
/db_xref="HGNC:HGNC:2584"
/db_xref="MIM:605018"
CDS 277..3138
/gene="CYLD"
/gene_synonym="CDMT"
/gene_synonym="CYLDI"
/gene_synonym="EAC"
/gene_synonym="HSPC057"
/gene_synonym="KIAA0849"
/gene_synonym="USPL2"
/codon_start=1
/product="cylindromatosis (turban tumor syndrome)"
/protein_id="AAH12342.1"
/db_xref="GeneID:1540"
/db_xref="HGNC:HGNC:2584"
/db_xref="MIM:605018"
/translation="MSSGLWSQEKVTSPYWEERIFYLLLQECSVTDKQTQKLLKVPKG
SIGQYIQDRSVGHSRIPSAKGKKNQIGLKILEQPHAVLFVDEKDVVEINEKFTELLLA
ITNCEERFSLFKNRNRLSKGLQIDVGCPVKVQLRSGEEKFPGVVRFRGPLLAERTVSG
IFFGVELLEEGRGQGFTDGVYQGKQLFQCDEDCGVFVALDKLELIEDDDTALESDYAG
PGDTMQVELPPLEINSRVSLKVGETIESGTVIFCDVLPGKESLGYFVGVDMDNPIGNW
DGRFDGVQLCSFACVESTILLHINDIIPESVTQERRPPKLAFMSRGVGDKGSSSHNKP
KATGSTSDPGNRNRSELFYTLNGSSVDSQPQSKSKNTWYIDEVAEDPAKSLTEISTDF
DRSSPPLQPPPVNSLTTENRFHSLPFSLTKMPNTNGSIGHSPLSLSAQSVMEELNTAP
VQESPPLAMPPGNSHGLEVGSLAEVKENPPFYGVIRWIGQPPGLNEVLAGLELEDECA
GCTDGTFRGTRYFTCALKKALFVKLKSCRPDSRFASLQPVSNQIERCNSLAFGGYLSE
VVEENTPPKMEKEGLEIMIGKKKGIQGHYNSCYLDSTLFCLFAFSSVLDTVLLRPKEK
NDVEYYSETQELLRTEIVNPLRIYGYVCATKIMKLRKILEKVEAASGFTSEEKDPEEF
LNILFHHILRVEPLLKIRSAGQKVQDCYFYQIFMEKNEKVGVPTIQQLLEWSFINSNL
KFAEAPSCLIIQMPRFGKDFKLFKKIFPSLELNITDLLEDTPRQCRICGGLAMYECRE
CYDDPDISAGKIKQFCKTCNTQVHLHPKRLNHKYNPVSLPKDLPDWDWRHGCIPCQNM
ELFAVLCIETSHYVAFVKYGKDDSAWLFFDSMADRDGGQNGFNIPQVTPCPEVGEYLK
MSLEDLHSLDSRRIQGCARRLLCDAYMCMYQSPTMSLYK"
BASE COUNT 1065 a 679 c 827 g 969 t
ORIGIN
1 gtgtggggag ccggggccgg cccgggacgc gggctgggga gccggggcga ggggcgacgc
61 cccgccgccc gagtttcccc ctttctaggg tgaggatggt tctacacagc cacccggagt
121 tccttagttg aaaggtgcgc cctgctgtga cagcatggac accacgttgc tgaaaacatg
181 ctttgggact gccactgaat ttatcttttg cggttttatg acaaagttat tagtagtttc
241 ccttttttga attagtattt tgaagttaat atcacaatga gttcaggctt atggagccaa
301 gaaaaagtca cttcacccta ctgggaagag cggatttttt acttgcttct tcaagaatgc
361 agcgttacag acaaacaaac acaaaagctc cttaaagtac cgaagggaag tataggacag
421 tatattcaag atcgttctgt ggggcattca aggattcctt ctgcaaaagg caagaaaaat
481 cagattggat taaaaattct agagcaacct catgcagttc tctttgttga tgaaaaggat
541 gttgtagaga taaatgaaaa gttcacagag ttacttttgg caattaccaa ttgtgaggag
601 aggttcagcc tgtttaaaaa cagaaacaga ctaagtaaag gcctccaaat agacgtgggc
661 tgtcctgtga aagtacagct gagatctggg gaagaaaaat ttcctggagt tgtacgcttc
721 agaggacccc tgttagcaga gaggacagtc tccggaatat tctttggagt tgaattgctg
781 gaagaaggtc gtggtcaagg tttcactgac ggggtgtacc aagggaaaca gctttttcag
841 tgtgatgaag attgtggcgt gtttgttgca ttggacaagc tagaactcat agaagatgat
901 gacactgcat tggaaagtga ttacgcaggt cctggggaca caatgcaggt cgaacttcct
961 cctttggaaa taaactccag agtttctttg aaggttggag aaacaataga atctggaaca
1021 gttatattct gtgatgtttt gccaggaaaa gaaagcttag gatattttgt tggtgtggac
1081 atggataacc ctattggcaa ctgggatgga agatttgatg gagtgcagct ttgtagtttt
1141 gcgtgtgttg aaagtacaat tctattgcac atcaatgata tcatcccaga gagtgtgacg
1201 caggaaagga ggcctcccaa acttgccttt atgtcaagag gtgttgggga caaaggttca
1261 tccagtcata ataaaccaaa ggctacagga tctacctcag accctggaaa tagaaacaga
1321 tctgaattat tttatacctt aaatgggtct tctgttgact cacaaccaca atccaaatca
1381 aaaaatacat ggtacattga tgaagttgca gaagaccctg caaaatctct tacagagata
1441 tctacagact ttgaccgttc ttcaccacca ctccagcctc ctcctgtgaa ctcactgacc
1501 accgagaaca gattccactc tttaccattc agtctcacca agatgcccaa taccaatgga
1561 agtattggcc acagtccact ttctctgtca gcccagtctg taatggaaga gctaaacact
1621 gcacccgtcc aagagagtcc acccttggcc atgcctcctg ggaactcaca tggtctagaa
1681 gtgggctcat tggctgaagt taaggagaac cctcctttct atggggtaat ccgttggatc
1741 ggtcagccac caggactgaa tgaagtgctc gctggactgg aactggaaga tgagtgtgca
1801 ggctgtacgg atggaacctt cagaggcact cggtatttca cctgtgccct gaagaaggcg
1861 ctgtttgtga aactgaagag ctgcaggcct gactctaggt ttgcatcatt gcagccggtt
1921 tccaatcaga ttgagcgctg taactcttta gcatttggag gctacttaag tgaagtagta
1981 gaagaaaata ctccaccaaa aatggaaaaa gaaggcttgg agataatgat tgggaagaag
2041 aaaggcatcc agggtcatta caattcttgt tacttagact caaccttatt ctgcttattt
2101 gcttttagtt ctgttctgga cactgtgtta cttagaccca aagaaaagaa cgatgtagaa
2161 tattatagtg aaacccaaga gctactgagg acagaaattg ttaatcctct gagaatatat
2221 ggatatgtgt gtgccacaaa aattatgaaa ctgaggaaaa tacttgaaaa ggtggaggct
2281 gcatcaggat ttacctctga agaaaaagat cctgaggaat tcttgaatat tctgtttcat
2341 catattttaa gggtagaacc tttgctaaaa ataagatcag caggtcaaaa ggtacaagat
2401 tgttacttct atcaaatttt tatggaaaaa aatgagaaag ttggcgttcc cacaattcag
2461 cagttgttag aatggtcttt tatcaacagt aacctgaaat ttgcagaggc accatcatgt
2521 ctgattattc agatgcctcg atttggaaaa gactttaaac tatttaaaaa aatttttcct
2581 tctctggaat taaatataac agatttactt gaagacactc ccagacagtg ccggatatgt
2641 ggagggcttg caatgtatga gtgtagagaa tgctacgacg atccggacat ctcagctgga
2701 aaaatcaagc agttttgtaa aacctgcaac actcaagtcc accttcatcc gaagaggctg
2761 aatcataaat ataacccagt gtcacttccc aaagacttac ccgactggga ctggagacac
2821 ggctgcatcc cttgccagaa tatggagtta tttgctgttc tctgcataga aacaagccac
2881 tatgttgctt ttgtgaagta tgggaaggac gattctgcct ggctcttctt tgacagcatg
2941 gccgatcggg atggtggtca gaatggcttc aacattcctc aagtcacccc atgcccagaa
3001 gtaggagagt acttgaagat gtctctggaa gacctgcatt ccttggactc caggagaatc
3061 caaggctgtg cacgaagact gctttgtgat gcatatatgt gcatgtacca gagtccaaca
3121 atgagtttgt acaaataact ggggtcatcg ggaaaggcaa agaaactgaa ggcagagtcc
3181 taacgttgca tcttattcga gctggcagtt ctgttcacgt ccattgccgg caatggatgt
3241 ctttgtggtg atgatccttc agaaaaggat gcctctgttt aaaaacaaat tgcttttgtg
3301 tccctgaagt atttaataag aagcattttg cactctagaa agtatgtttg tgttggtttt
3361 ttaagaagtc taaatgaagt tattaatacc tgaagcttta agttaagtgc attgatcata
3421 tgatattttt ggaagcatac aattttaatt gtggaagttt aaagcctctt ttagtccctt
3481 gagaatgtaa ataaatgtgt cttctttatg gaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//