LOCUS BC012171 1352 bp mRNA linear HUM 03-FEB-2004
DEFINITION Homo sapiens aldo-keto reductase family 7, member A2 (aflatoxin
aldehyde reductase), mRNA (cDNA clone MGC:20417 IMAGE:4642811),
complete cds.
ACCESSION BC012171
VERSION BC012171.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1352)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 1352)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (02-AUG-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC/DCTD/DTP
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Genome Sequence Centre,
BC Cancer Agency, Vancouver, BC, Canada
info@bcgsc.bc.ca
Steve Jones, Sarah Barber, Mabel Brown-John, Yaron Butterfield,
Andy Chan, Steve S. Chand, William Chow, Alison Cloutier, Ruth
Featherstone, Malachi Griffith, Obi Griffith, Ran Guin, Nancy Liao,
Kim MacDonald, Amara Masson, Mike R. Mayo, Josh Moran, Ryan Morin,
Teika Olson, Diana Palmquist, Anca Petrescu, Anna Liisa Prahbu,
Parvaneh Saeedi, JR Santos, Angelique Schnerch, Ursula Skalska,
Duane Smailus, Jeff Stott, Miranda Tsai, George Yang, Jacquie
Schein, Asim Siddiqui, Rob Holt, Marco Marra.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 29 Row: l Column: 13.
FEATURES Location/Qualifiers
source 1..1352
/db_xref="H-InvDB:HIT000035710"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:20417 IMAGE:4642811"
/tissue_type="Skin, melanotic melanoma."
/clone_lib="NIH_MGC_20"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene 1..1352
/gene="AKR7A2"
/gene_synonym="AFAR"
/gene_synonym="AFAR1"
/gene_synonym="AFB1-AR1"
/gene_synonym="AKR7"
/db_xref="GeneID:8574"
/db_xref="MIM:603418"
CDS 85..1077
/gene="AKR7A2"
/gene_synonym="AFAR"
/gene_synonym="AFAR1"
/gene_synonym="AFB1-AR1"
/gene_synonym="AKR7"
/codon_start=1
/product="AKR7A2 protein"
/protein_id="AAH12171.1"
/db_xref="GeneID:8574"
/db_xref="MIM:603418"
/translation="MSRPPPPRVASVLGTMEMGRRMDAPASAAAVRAFLERGHTELDT
AFMYSDGQSETILGGLGLGLGGGDCRVKIATKANPWDGKSLKPDSVRSQLETSLKRLQ
CPQVDLFYLHAPDHGTPVEETLHACQRLHQEGKFVELGLSNYASWEVAEICTLCKSNG
WILPTVYQGMYNATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQP
VGRFFGNSWAETYRNRFWKEHHFEAIALVEKALQAAYGASAPSVTSAALRWMYHHSQL
QGAHGDAVILGMSSLEQLEQNLAATEEGPLEPAVVDAFNQAWHLVAHECPNYFR"
misc_feature 121..984
/gene="AKR7A2"
/gene_synonym="AFAR"
/gene_synonym="AFAR1"
/gene_synonym="AFB1-AR1"
/gene_synonym="AKR7"
/note="Aldo_ket_red; Region: Aldo/keto reductase family.
This family includes a number of K+ ion channel beta chain
regulatory domains - these are reported to have
oxidoreductase activity"
/db_xref="CDD:pfam00248"
BASE COUNT 266 a 417 c 397 g 272 t
ORIGIN
1 ctgagtgccg cgtctcgcgt agtctcccgc gccgccgtcc actgcgcgct tcgctctccg
61 ccgcccgagg cccgcgcgct cgccatgtcc cggccaccgc caccgcgggt cgcctcggtg
121 ctgggcacca tggagatggg gcgccgcatg gacgcgcccg ccagcgccgc ggccgtgcgc
181 gcctttctgg agcgcggcca caccgaactg gacacggcct tcatgtacag cgacggccag
241 tccgagacca tcctgggcgg cctggggctc gggctgggcg gtggcgactg cagagtgaaa
301 attgccacca aggccaaccc ttgggatgga aaatcactaa agcctgacag tgtccggtcc
361 cagctggaga cgtcattgaa gaggctgcag tgtccccaag tggacctctt ctacctacac
421 gcacctgacc acggcacccc ggtggaagag acgctgcatg cctgccagcg gctgcaccag
481 gagggcaagt tcgtggagct tggcctctcc aactatgcta gctgggaagt ggccgagatc
541 tgtaccctct gcaagagcaa tggctggatc ctgcccactg tgtaccaggg catgtacaac
601 gccaccaccc ggcaggtgga aacggagctc ttcccctgcc tcaggcactt tggactgagg
661 ttctatgcct acaaccctct ggctgggggc ctgctgactg gcaagtacaa gtatgaggac
721 aaggacggga aacagcctgt gggccgcttc tttgggaata gctgggctga gacctacagg
781 aatcgcttct ggaaggagca ccacttcgag gccattgcgt tggtggagaa ggccctgcag
841 gccgcatatg gcgccagcgc ccccagtgtg acctcggctg ccctccggtg gatgtaccac
901 cactcacagc tgcagggtgc ccacggggac gcggtcatcc tgggcatgtc cagcctggag
961 cagctggagc agaacttggc agcaacagag gaagggcccc tggagccggc tgtcgtggat
1021 gcctttaatc aagcctggca tttggttgct cacgaatgtc ccaactactt ccgctaggcc
1081 catcatggct caggctgccc aaggcttttc tgtcacctct tttgttctct cacactgacc
1141 agtcttggcc ttaagctgac ttagaagggt ttttctgaat tgtctagatc catgcattat
1201 ttttctagct tcctgccttg ctccctattc actttacact gtgaaaggtg gggggtgagt
1261 cccacttgag cgcttcctgt tgaataaagc aggcacttga cctggctgta gcctaggtct
1321 tgagtgaacc ccaaaaaaaa aaaaaaaaaa aa
//