LOCUS BC012064 3292 bp mRNA linear HUM 15-JUL-2006
DEFINITION Homo sapiens proprotein convertase subtilisin/kexin type 5, mRNA
(cDNA clone MGC:19910 IMAGE:4562734), complete cds.
ACCESSION BC012064
VERSION BC012064.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3292)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 3292)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (02-AUG-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: DCTD/DTP
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Genome Sequence Centre,
BC Cancer Agency, Vancouver, BC, Canada
info@bcgsc.bc.ca
Martin Hirst, Thomas Zeng, Ryan Morin, Michelle Moksa, Johnson
Pang, Diana Mah, Jing Wang, Kieth Fichter, Eric Chuah, Allen
Delaney, Rob Kirkpatrick, Agnes Baross, Sarah Barber, Mabel
Brown-John, Steve S. Chand, William Chow, Ryan Babakaiff, Dave
Wong, Corey Matsuo, Jaclyn Beland, Susan Gibson, Luis delRio, Ruth
Featherstone, Malachi Griffith, Obi Griffith, Ran Guin, Nancy Liao,
Kim MacDonald, Mike R. Mayo, Josh Moran, Diana Palmquist, JR
Santos, Duane Smailus, Jeff Stott, Miranda Tsai, George Yang,
Jacquie Schein, Asim Siddiqui,Steven Jones, Rob Holt, Marco Marra.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 29 Row: f Column: 8
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 20336245.
FEATURES Location/Qualifiers
source 1..3292
/db_xref="H-InvDB:HIT000035631"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:19910 IMAGE:4562734"
/tissue_type="Kidney, renal cell adenocarcinoma"
/clone_lib="NIH_MGC_14"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene 1..3292
/gene="PCSK5"
/gene_synonym="PC5"
/gene_synonym="PC6"
/gene_synonym="PC6A"
/gene_synonym="SPC6"
/db_xref="GeneID:5125"
/db_xref="HGNC:HGNC:8747"
/db_xref="MIM:600488"
CDS 478..3219
/gene="PCSK5"
/gene_synonym="PC5"
/gene_synonym="PC6"
/gene_synonym="PC6A"
/gene_synonym="SPC6"
/codon_start=1
/product="proprotein convertase subtilisin/kexin type 5"
/protein_id="AAH12064.1"
/db_xref="GeneID:5125"
/db_xref="HGNC:HGNC:8747"
/db_xref="MIM:600488"
/translation="MGWGSRCCCPGRLDLLCVLALLGGCLLPVCRTRVYTNHWAVKIA
GGFPEANRIASKYGFINIGQIGALKDYYHFYHSRTIKRSVISSRGTHSFISMEPKVEW
IQQQVVKKRTKRDYDFSRAQSTYFNDPKWPSMWYMHCSDNTHPCQSDMNIEGAWKRGY
TGKNIVVTILDDGIERTHPDLMQNYDALASCDVNGNDLDPMPRYDASNENKHGTRCAG
EVAAAANNSHCTVGIAFNAKIGGVRMLDGDVTDMVEAKSVSFNPQHVHIYSASWGPDD
DGKTVDGPAPLTRQAFENGVRMGRRGLGSVFVWASGNGGRSKDHCSCDGYTNSIYTIS
ISSTAESGKKPWYLEECSSTLATTYSSGESYDKKIITTDLRQRCTDNHTGTSASAPMA
AGIIALALEANPFLTWRDVQHVIVRTSRAGHLNANDWKTNAAGFKVSHLYGFGLMDAE
AMVMEAEKWTTVPRQHVCVESTDRQIKTIRPNSAVRSIYKASGCSDNPNRHVNYLEHV
VVRITITHPRRGDLAIYLTSPSGTRSQLLANRLFDHSMEGFKNWEFMTIHCWGERAAG
DWVLEVYDTPSQLRNFKTPGKLKEWSLVLYGTSVQPYSPTNEFPKVERFRYSRVEDPT
DDYGTEDYAGPCDPECSEVGCDGPGPDHCNDCLHYYYKLKNNTRICVSSCPPGHYHAD
KKRCRKCAPNCESCFGSHGDQCMSCKYGYFLNEETNSCVTHCPDGSYQDTKKNLCRKC
SENCKTCTEFHNCTECRDGLSLQGSRCSVSCEDGRYFNGQDCQPCHRFCATCAGAGAD
GCINCTEGYFMEDGRCVQSCSISYYFDHSSENGYKSCKKCDISCLTCNGPGFKNCTSC
PSGYLLDLGMCQMGAICKDATEESWAEGGFCMLVKKNNLCQRKVLQQLCCKTCTFQG"
BASE COUNT 826 a 870 c 937 g 659 t
ORIGIN
1 cggagggagc gctgggagcg agcaagcgag cgtttggagc ccgggccagc agagggggcg
61 cccggtcgct gcctgtaccg ctcccgctgg tcatctccgc cgcgctcggg ggccccggga
121 ggagcgagac cgagtcggag agtccgggag ccaagccggg cgaaacccaa ctgcggagga
181 cgcccgcccc actcagcctc ctcctgcgtc cgagccgggg agcatcgccg agcgccccac
241 gggccggaga gctgggagca caggtcccgg cagccccagg gatggtctag gagccggcgt
301 aaggctcgct gctctgctcc ctgccggggc tagccgcctc ctgccgatcg cccggggctg
361 cgagctgcgg cggcccgggg ctgctcgccg ggcggcgcag gccggagaag ttagttgtgc
421 gcgcccttag tgcgcggaac cagccagcga gcgagggagc agcgaggcgc cgggaccatg
481 ggctggggga gccgctgctg ctgcccggga cgtttggacc tgctgtgcgt gctggcgctg
541 ctcgggggct gcctgctccc cgtgtgtcgg acgcgcgtct acaccaacca ctgggcagtc
601 aaaatcgccg ggggcttccc ggaggccaac cgtatcgcca gcaagtacgg attcatcaac
661 ataggacaga taggggccct gaaggactac taccacttct accatagcag gacgattaaa
721 aggtcagtta tctcgagcag agggacccac agtttcattt caatggaacc aaaggtggaa
781 tggatccaac agcaagtggt aaaaaagcgg acaaagaggg attatgactt cagtcgtgcc
841 cagtctacct atttcaatga tcccaagtgg cccagcatgt ggtatatgca ctgcagtgac
901 aatacacatc cctgccagtc tgacatgaat atcgaaggag cctggaagag aggctacacg
961 ggaaagaaca ttgtggtcac tatcctggat gacggaattg agagaaccca tccagatctg
1021 atgcaaaact acgatgctct ggcaagttgc gacgtgaatg ggaatgactt ggacccaatg
1081 cctcgttatg atgcaagcaa cgagaacaag catgggactc gctgtgctgg agaagtggca
1141 gccgctgcaa acaattcgca ctgcacagtc ggaattgctt tcaacgccaa gatcggagga
1201 gtgcgaatgc tggacggaga tgtcacggac atggttgaag caaaatcagt tagcttcaac
1261 ccccagcacg tgcacattta cagcgccagc tggggcccgg atgatgatgg caagactgtg
1321 gacggaccag cccccctcac ccggcaagcc tttgaaaacg gcgttagaat ggggcggaga
1381 ggcctcggct ctgtgtttgt ttgggcatct ggaaatggtg gaaggagcaa agaccactgc
1441 tcctgtgatg gctacaccaa cagcatctac accatctcca tcagcagcac tgcagaaagc
1501 ggaaagaaac cttggtacct ggaagagtgt tcatccacgc tggccacaac ctacagcagc
1561 ggggagtcct acgataagaa aatcatcact acagatctga ggcagcgttg cacggacaac
1621 cacactggga cgtcagcctc agcccccatg gctgcaggca tcattgcgct ggccctggaa
1681 gccaatccgt ttctgacctg gagagacgta cagcatgtta ttgtcaggac ttcccgtgcg
1741 ggacatttga acgctaatga ctggaaaacc aatgctgctg gttttaaggt gagccatctt
1801 tatggatttg gactgatgga cgcagaagcc atggtgatgg aggcagagaa gtggaccacc
1861 gttccccggc agcacgtgtg tgtggagagc acagaccgac aaatcaagac aatccgccct
1921 aacagtgcag tgcgctccat ctacaaagct tcaggctgct cggataaccc caaccgccat
1981 gtcaactacc tggagcacgt cgttgtgcgc atcaccatca cccaccccag gagaggagac
2041 ctggccatct acctgacctc gccctctgga actaggtctc agcttttggc caacaggcta
2101 tttgatcact ccatggaagg attcaaaaac tgggagttca tgaccattca ttgctgggga
2161 gaaagagctg ctggtgactg ggtccttgaa gtttatgata ctccctctca gctaaggaac
2221 tttaagactc caggtaaatt gaaagaatgg tctttggtcc tctacggcac ctccgtgcag
2281 ccatattcac caaccaatga atttccgaaa gtggaacggt tccgctatag ccgagttgaa
2341 gaccccacag acgactatgg cacagaggat tatgcaggtc cctgcgaccc tgagtgcagt
2401 gaggttggct gtgacgggcc aggaccagac cactgcaatg actgtttgca ctactactac
2461 aagctgaaaa acaataccag gatctgtgtc tccagctgcc cccctggcca ctaccacgcc
2521 gacaagaagc gctgcaggaa gtgtgccccc aactgtgagt cctgctttgg gagccatggt
2581 gaccaatgca tgtcctgcaa atatggatac tttctgaatg aagaaaccaa cagctgtgtt
2641 actcactgcc ctgatgggtc atatcaggat accaagaaaa atctttgccg gaaatgcagt
2701 gaaaactgca agacatgtac tgaattccat aactgtacag aatgtaggga tgggttaagc
2761 ctgcagggat cccggtgctc tgtctcctgt gaagatggac ggtatttcaa cggccaggac
2821 tgccagccct gccaccgctt ctgcgccact tgtgctgggg caggagctga tgggtgcatt
2881 aactgcacag agggctactt catggaggat gggagatgcg tgcagagctg tagtatcagc
2941 tattactttg accactcttc agagaatgga tacaaatcct gcaaaaaatg tgatatcagt
3001 tgtttgacgt gcaatggccc aggattcaag aactgtacaa gctgccctag tgggtatctc
3061 ttagacttag gaatgtgtca aatgggagcc atttgcaagg atgcaacgga agagtcctgg
3121 gcggaaggag gcttctgtat gcttgtgaaa aagaacaatc tgtgccaacg gaaggttctt
3181 caacaacttt gctgcaaaac atgtacattt caaggctgag cagccatctt agatttcttt
3241 gttcctgtag acttatagat tattccatat tattaaaaaa aaaaaaaaaa aa
//