LOCUS BC011795 3187 bp mRNA linear HUM 03-OCT-2003
DEFINITION Homo sapiens NDRG family member 4, mRNA (cDNA clone MGC:19632
IMAGE:4139594), complete cds.
ACCESSION BC011795
VERSION BC011795.2
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3187)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 3187)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (30-JUL-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT On Aug 19, 2003 this sequence version replaced BC011795.1.
Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: National Institutes of Health Intramural
Sequencing Center (NISC),
Gaithersburg, Maryland;
Web site: http://www.nisc.nih.gov/
Contact: nisc_mgc@nhgri.nih.gov
Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
Young,A., Zhang,L.-H. and Green,E.D.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 27 Row: n Column: 8.
FEATURES Location/Qualifiers
source 1..3187
/db_xref="H-InvDB:HIT000035458"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:19632 IMAGE:4139594"
/tissue_type="Muscle, rhabdomyosarcoma"
/clone_lib="NIH_MGC_17"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene 1..3187
/gene="NDRG4"
/gene_synonym="KIAA1180"
/gene_synonym="SMAP-8"
/db_xref="GeneID:65009"
CDS 95..1114
/gene="NDRG4"
/gene_synonym="KIAA1180"
/gene_synonym="SMAP-8"
/codon_start=1
/product="NDRG4 protein"
/protein_id="AAH11795.1"
/db_xref="GeneID:65009"
/translation="MPECWDGEHDIETPYGLLHVVIRGSPKGNRPAILTYHDVGLNHK
LCFNTFFNFEDMQEITKHFVVCHVDAPGQQVGASQFPQGYQFPSMEQLAAMLPSVVQH
FGFKYVIGIGVGAGAYVLAKFALIFPDLVEGLVLVNIDPNGKGWIDWAATKLSGLTST
LPDTVLSHLFSQEELVNNTELVQSYRQQIGNVVNQANLQLFWNMYNSRRDLDINRPGT
VPNAKTLRCPVMLVVGDNAPAEDGVVECNSKLDPTTTTFLKMADSGGLPQVTQPGKLT
EAFKYFLQGMGYMPSASMTRLARSRTASLTSASSVDGSRPQACTHSESSEGLGQVNHT
MEVSC"
misc_feature 116..964
/gene="NDRG4"
/gene_synonym="KIAA1180"
/gene_synonym="SMAP-8"
/note="Ndr; Region: Ndr family. This family consists of
proteins from different gene families: Ndr1/RTP/Drg1,
Ndr2, and Ndr3. Their similarity was previously noted. The
precise molecular and cellular function of members of this
family is still unknown. Yet, they are known to be
involved in cellular differentiation events. The Ndr1
group was the first to be discovered. Their expression is
repressed by the proto-oncogenes N-myc and c-myc, and in
line with this observation, Ndr1 protein expression is
down-regulated in neoplastic cells, and is reactivated
when differentiation is induced by chemicals such as
retinoic acid. Ndr2 and Ndr3 expression is not under the
control of N-myc or c-myc. Ndr1 expression is also
activated by several chemicals: tunicamycin and
homocysteine induce Ndr1 in human umbilical endothelial
cells"
/db_xref="CDD:pfam03096"
BASE COUNT 710 a 874 c 887 g 716 t
ORIGIN
1 atctcccact cgagctgccc ccgccctctg gacccgagtg actcaggcct ttgtttgtcc
61 ttcctggtag aggcgggttc cctccctcgg caagatgccg gagtgctggg atggggaaca
121 tgacatcgag acaccctacg gccttctgca tgtagtgatc cggggctccc ccaaggggaa
181 ccgcccagcc atcctcacct accatgatgt gggcctcaac cacaaactat gcttcaacac
241 cttcttcaac ttcgaggaca tgcaggagat caccaagcac tttgtggtgt gtcacgtgga
301 tgcccctgga caacaggtgg gggcgtcgca gtttcctcag gggtaccagt tcccctccat
361 ggagcagctg gctgccatgc tccccagcgt ggtgcagcat ttcgggttca agtatgtgat
421 tggcatcgga gtgggcgccg gagcctatgt gctggccaag tttgcactca tcttccccga
481 cctggtggag gggctggtgc tggtgaacat cgaccccaat ggcaaaggct ggatagactg
541 ggctgccacc aagctctccg gcctaactag cactttaccc gacacggtgc tctcccacct
601 cttcagccag gaggagctgg tgaacaacac agagttggtg cagagctacc ggcagcagat
661 tgggaacgtg gtgaaccagg ccaacctgca gctcttctgg aacatgtaca acagccgcag
721 agacctggac attaaccggc ctggaacggt gcccaatgcc aagacgctcc gctgccccgt
781 gatgctggtg gttggggata atgcacccgc tgaggacggg gtggtggagt gcaactccaa
841 actggacccg accactacga ccttcctgaa gatggcagac tctggagggc tgccccaggt
901 cacacagcca gggaagctga ctgaagcctt caaatacttc ctgcaaggca tgggctacat
961 gccctcagcc agcatgaccc gcctggcacg ctcccgcact gcatccctca ccagtgccag
1021 ctcggtggat ggcagccgcc cacaggcctg cacccactca gagagcagcg aggggctggg
1081 ccaggtcaac cacaccatgg aggtgtcctg ttgaagccct tgatcccgct gacgacgccc
1141 acgtcgaggc cccaccgcca tccttgcgcc ggctcatgtt ccctttagtt tatttttgtg
1201 agggcaaagg ggaggaaatg gggttctgtt tgaaaaaaat gaggggatct tagatgctgc
1261 agcagaacag tctccaggtg ttttaagggg ctcagtcctc ctcatcccat ctcactctcc
1321 gtggtaactt agccaacttg acccctctca tcccactccc ggcggcccag gcacagaagg
1381 gcagggccat agggagggag attcgctacg gatccaggcc attcctgggt gagcccttgg
1441 gcaggcatgt ttggagatga gagaggcttc gagagggtgg gtgctgggcc acaggggtgc
1501 ggggccagct caggcactgg cgtgggagcc ctgggagacc ccttccccca ccctccacca
1561 agcacacctg tttctgtctc atagcacatg tgacaatcat ctggacaaca gccacaaggg
1621 ggcgctcgga ccaggcagcc actttcctgg tgctctctgg gcccagctgg tgctgtaggg
1681 ccacgcaggc aggggcgtca aggggtttct ctgcccaagg aagacagaac atggagaacc
1741 gtcagggcag gaaccccaca gactgtccct tccagcccac actctgccac ctcctggccc
1801 tgtcccaatt ctgagccaag gcctccccga ggcagaagtt gcctggtcct ctgtccccac
1861 agtgacctga ctgggggtga gggagaagga ggagagagcc catgtgtggt gtgtgtgccc
1921 ctgagaactt cgtggtgact gcctttggga gcccgcaggt ggccagaggc aggggtagct
1981 gagttcctgg agaccccttt tttgccccca ggttccccag agggcaacgc catcagtagc
2041 agtgtggtgt ttcaggcaga gctctggcca ggctgtgcca gtgtgtcccg gacgcatcac
2101 taaggaagag agagtttatt tagtcaactg gcccaaggca gcgaggcttc tacagtccca
2161 caccccatag ccgcctgggc tggggcttac tgggggctga aggttctgga catgaacaag
2221 ggtcaggtag aagagaaagg cttcccctac accccagcct cctgctgtcc cctgaagccc
2281 aggactgcgt tgtatgcttt ccatccactc accttacccc atagcatctt gcggcccaga
2341 aaccagagcc atttgtctca gaccctaaat caataatcac aaaccccaaa acgggagaga
2401 gcagtgaaaa catgcagggc tgtggacggg ggaagggttg tggcgggtgt tctgaggctg
2461 agaggacacc tatatgcgta tttcctctac acacatcacc ccccttctat aatcttaagc
2521 catgactagc ctggtggcgt gttagtttct gcccagttct accccctcat gtgcttcttc
2581 tgaatactga atgtgactgt ttgaaagctg gtagaattca tccctcttac tgtagataac
2641 actgcaaatc ttggaatttt gttttttgct gtttccagat gtatctataa atatctatac
2701 attatatgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgta catcgggtcc tcccatgtgt
2761 ggtgttcttc tggaggttgt ctctttggtc aaggtgaact tttaatgttt attattttct
2821 tctccgcaca aagtaaagag cctaattttg tgtattctgg tggctgctgt catgagatga
2881 taaaatgtaa aacaaaactc tagtcaacgt agaaagagtt aactgtgctg aaaaactaat
2941 aaagaaccta agaagaattc cagtgtggtg atgccatgcc catcatggga ggcttttgga
3001 gaaacagaat gtttgggcag gggctgctgg tgctgcttgg gttttgggtt gagggtgcta
3061 ggagaggatg gtctccaccc atctttctat ttccagtaca cgtcacatta ttttaccggt
3121 gagatgagaa tgtcacaaac attaaaagcc ttatgtgctc aaaaaaaaaa aaaaaaaaaa
3181 aaaaaaa
//