LOCUS BC011586 1302 bp mRNA linear HUM 03-FEB-2004
DEFINITION Homo sapiens aldo-keto reductase family 7, member A2 (aflatoxin
aldehyde reductase), mRNA (cDNA clone MGC:20401 IMAGE:4620484),
complete cds.
ACCESSION BC011586
VERSION BC011586.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1302)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 1302)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (30-JUL-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC/DCTD/DTP
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Genome Sequence Centre,
BC Cancer Agency, Vancouver, BC, Canada
info@bcgsc.bc.ca
Steve Jones, Sarah Barber, Mabel Brown-John, Yaron Butterfield,
Andy Chan, Steve S. Chand, William Chow, Alison Cloutier, Ruth
Featherstone, Malachi Griffith, Obi Griffith, Ran Guin, Nancy Liao,
Kim MacDonald, Amara Masson, Mike R. Mayo, Josh Moran, Ryan Morin,
Teika Olson, Diana Palmquist, Anca Petrescu, Anna Liisa Prahbu,
Parvaneh Saeedi, JR Santos, Angelique Schnerch, Ursula Skalska,
Duane Smailus, Jeff Stott, Miranda Tsai, George Yang, Jacquie
Schein, Asim Siddiqui, Rob Holt, Marco Marra.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 29 Row: i Column: 21.
FEATURES Location/Qualifiers
source 1..1302
/db_xref="H-InvDB:HIT000035311"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:20401 IMAGE:4620484"
/tissue_type="Skin, melanotic melanoma."
/clone_lib="NIH_MGC_20"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene 1..1302
/gene="AKR7A2"
/gene_synonym="AFAR"
/gene_synonym="AFAR1"
/gene_synonym="AFB1-AR1"
/gene_synonym="AKR7"
/db_xref="GeneID:8574"
/db_xref="MIM:603418"
CDS 37..1029
/gene="AKR7A2"
/gene_synonym="AFAR"
/gene_synonym="AFAR1"
/gene_synonym="AFB1-AR1"
/gene_synonym="AKR7"
/codon_start=1
/product="AKR7A2 protein"
/protein_id="AAH11586.1"
/db_xref="GeneID:8574"
/db_xref="MIM:603418"
/translation="MSRPPPPRVASVLGTMEMGRRMDAPASAAAVRAFLERGHTELDT
AFMYSDGQSETILGGLGLGLGGGDCRVKIATKANPWDGKSLKPDSVRSQLETSLKRLQ
CPQVDLFYLHAPDHGTPVEETLHACQRLHQEGKFVELGLSNYASWEVAEICTLCKSNG
WILPTVYQGMYNATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQP
VGRFFGNSWAETYRNRFWKEHHFEAIALVEKALQAAYGASAPSVTSAALRWMYHHSQL
QGAHGDAVILGMSSLEQLEQNLAATEEGPLEPAVVDAFNQAWHLVAHECPNYFR"
misc_feature 73..936
/gene="AKR7A2"
/gene_synonym="AFAR"
/gene_synonym="AFAR1"
/gene_synonym="AFB1-AR1"
/gene_synonym="AKR7"
/note="Aldo_ket_red; Region: Aldo/keto reductase family.
This family includes a number of K+ ion channel beta chain
regulatory domains - these are reported to have
oxidoreductase activity"
/db_xref="CDD:pfam00248"
BASE COUNT 261 a 396 c 382 g 263 t
ORIGIN
1 cttcgctctc cgccgcccga ggcccgcgcg ctcgccatgt cccggccacc gccaccgcgg
61 gtcgcctcgg tgctgggcac catggagatg gggcgccgca tggacgcgcc cgccagcgcc
121 gcggccgtgc gcgcctttct ggagcgcggc cacaccgaac tggacacggc cttcatgtac
181 agcgacggcc agtccgagac catcctgggc ggcctggggc tcgggctggg cggtggcgac
241 tgcagagtga aaattgccac caaggccaac ccttgggatg gaaaatcact aaagcctgac
301 agtgtccggt cccagctgga gacgtcattg aagaggctgc agtgtcccca agtggacctc
361 ttctacctac acgcacctga ccacggcacc ccggtggaag agacgctgca tgcctgccag
421 cggctgcacc aggagggcaa gttcgtggag cttggcctct ccaactatgc tagctgggaa
481 gtggccgaga tctgtaccct ctgcaagagc aatggctgga tcctgcccac tgtgtaccag
541 ggcatgtaca acgccaccac ccggcaggtg gaaacggagc tcttcccctg cctcaggcac
601 tttggactga ggttctatgc ctacaaccct ctggctgggg gcctgctgac tggcaagtac
661 aagtatgagg acaaggacgg gaaacagcct gtgggccgct tctttgggaa tagctgggct
721 gagacctaca ggaatcgctt ctggaaggag caccacttcg aggccattgc gttggtggag
781 aaggccctgc aggccgcata tggcgccagc gcccccagtg tgacctcggc tgccctccgg
841 tggatgtacc accactcaca gctgcagggt gcccacgggg acgcggtcat cctgggcatg
901 tccagcctgg agcagctgga gcagaacttg gcagcaacag aggaagggcc cctggagccg
961 gctgtcgtgg atgcctttaa tcaagcctgg catttggttg ctcacgaatg tcccaactac
1021 ttccgctagg cccatcatgg ctcaggctgc ccaaggcttt tctgtcacct cttttgttct
1081 ctcacactga ccagtcttgg ccttaagctg acttagaagg gtttttctga attgtctaga
1141 tccatgcatt atttttctag cttcctgcct tgctccctat tcactttaca ctgtgaaagg
1201 tggggggtga gtcccacttg agcgcttcct gttgaataaa gcaggcactt gacctggctg
1261 tagcctaggt cttgagtgaa ccccaaaaaa aaaaaaaaaa aa
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