LOCUS       BC011571                3745 bp    mRNA    linear   HUM 09-JUN-2008
DEFINITION  Homo sapiens itchy E3 ubiquitin protein ligase homolog (mouse),
            mRNA (cDNA clone MGC:20230 IMAGE:4560366), complete cds.
ACCESSION   BC011571
VERSION     BC011571.1
KEYWORDS    MGC.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3745)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
   PUBMED   12477932
REFERENCE   2  (bases 1 to 3745)
  CONSRTM   NIH MGC Project
  TITLE     Direct Submission
  JOURNAL   Submitted (30-JUL-2001) National Institutes of Health, Mammalian
            Gene Collection (MGC), Bethesda, MD 20892-2590, USA
  REMARK    NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT     Contact: MGC help desk
            Email: cgapbs-r@mail.nih.gov
            Tissue Procurement: DCTD/DTP
            cDNA Library Preparation: Rubin Laboratory
            cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
            DNA Sequencing by: Genome Sequence Centre,
            BC Cancer Agency, Vancouver, BC, Canada
            info@bcgsc.bc.ca
            Martin Hirst, Thomas Zeng, Ryan Morin, Michelle Moksa, Johnson
            Pang, Diana Mah, Jing Wang, Kieth Fichter, Eric Chuah, Allen
            Delaney, Rob Kirkpatrick, Agnes Baross, Sarah Barber, Mabel
            Brown-John, Steve S. Chand, William Chow, Ryan Babakaiff, Dave
            Wong, Corey Matsuo, Jaclyn Beland, Susan Gibson, Luis delRio, Ruth
            Featherstone, Malachi Griffith, Obi Griffith, Ran Guin, Nancy Liao,
            Kim MacDonald,  Mike R. Mayo, Josh Moran, Diana Palmquist, JR
            Santos, Duane Smailus, Jeff Stott, Miranda Tsai, George Yang,
            Jacquie Schein, Asim Siddiqui,Steven Jones, Rob Holt, Marco Marra.
            
            Clone distribution: MGC clone distribution information can be found
            through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
            Series: IRAL Plate: 29 Row: e Column: 13
            This clone was selected for full length sequencing because it
            passed the following selection criteria: matched mRNA gi: 27477108.
FEATURES             Location/Qualifiers
     source          1..3745
                     /db_xref="H-InvDB:HIT000035298"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /clone="MGC:20230 IMAGE:4560366"
                     /tissue_type="Kidney, renal cell adenocarcinoma"
                     /clone_lib="NIH_MGC_14"
                     /lab_host="DH10B-R"
                     /note="Vector: pOTB7"
     gene            1..3745
                     /gene="ITCH"
                     /gene_synonym="AIF4"
                     /gene_synonym="AIP4"
                     /gene_synonym="dJ468O1.1"
                     /gene_synonym="NAPP1"
                     /db_xref="GeneID:83737"
                     /db_xref="HGNC:HGNC:13890"
                     /db_xref="MIM:606409"
     CDS             137..2848
                     /gene="ITCH"
                     /gene_synonym="AIF4"
                     /gene_synonym="AIP4"
                     /gene_synonym="dJ468O1.1"
                     /gene_synonym="NAPP1"
                     /codon_start=1
                     /product="ITCH protein"
                     /protein_id="AAH11571.1"
                     /db_xref="GeneID:83737"
                     /db_xref="HGNC:HGNC:13890"
                     /db_xref="MIM:606409"
                     /translation="MSDSGSQLGSMGSLTMKSQLQITVISAKLKENKKNWFGPSPYVE
                     VTVDGQSKKTEKCNNTNSPKWKQPLTVIVTPVSKLHFRVWSHQTLKSDVLLGTAALDI
                     YETLKSNNMKLEEVVVTLQLGGDKEPTETIGDLSICLDGLQLESEVVTNGETTCSENG
                     VSLCLPRLECNSAISAHCNLCLPGLSDSPISASRVAGFTGASQNDDGSRSKDETRVST
                     NGSDDPEDAGAGENRRVSGNNSPSLSNGGFKPSRPPRPSRPPPPTPRRPASVNGSPSA
                     TSESDGSSTGSLPPTNTNTNTSEGATSGLIIPLTISGGSGPRPLNPVTQAPLPPGWEQ
                     RVDQHGRVYYVDHVEKRTTWDRPEPLPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLE
                     SVRNYEQWQLQRSQLQGAMQQFNQRFIYGNQDLFATSQSKEFDPLGPLPPGWEKRTDS
                     NGRVYFVNHNTRITQWEDPRSQGQLNEKPLPEGWEMRFTVDGIPYFVDHNRRTTTYID
                     PRTGKSALDNGPQIAYVRDFKAKVQYFRFWCQQLAMPQHIKITVTRKTLFEDSFQQIM
                     SFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQI
                     NPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFSLPFYKRILNKPVGLKDLESIDP
                     EFYNSLIWVKENNIEECDLEMYFSVDKEILGEIKSHDLKPNGGNILVTEENKEEYIRM
                     VAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAI
                     YRHYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVGGFADLMGSNGPQKFCI
                     EKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQE"
BASE COUNT         1133 a          748 c          837 g         1027 t
ORIGIN      
        1 gtctagggac tgaggagtcg ccgccgcccc gagtcccggt accatgcatt tcacagtggc
       61 cttgtggaga caacgcctta acccaaggaa gtgactcaaa ctgtgagaac ttcaggtttt
      121 ccaacctatt ggtggtatgt ctgacagtgg atcacaactt ggttcaatgg gtagcctcac
      181 catgaaatca cagcttcaga tcactgtcat ctcagcaaaa cttaaggaaa ataagaagaa
      241 ttggtttgga ccaagtcctt acgtagaggt cacagtagat ggacagtcaa agaagacaga
      301 aaaatgcaac aacacaaaca gtcccaagtg gaagcaaccc cttacagtta tcgttacccc
      361 tgtgagtaaa ttacattttc gtgtgtggag tcaccagaca ctgaaatctg atgttttgtt
      421 gggaactgct gcattagata tttatgaaac attaaagtca aacaatatga aacttgaaga
      481 agtagttgtg actttgcagc ttggaggtga caaagagcca acagagacaa taggagactt
      541 gtcaatttgt cttgatgggc tacagttaga gtctgaagtt gttaccaatg gtgaaactac
      601 atgttcagaa aatggggttt cgctctgttt gcccaggctg gagtgcaata gtgcgatctc
      661 ggctcactgc aacctctgcc tcccgggttt aagtgattct cctatctcag cctcccgagt
      721 agctgggttt acaggtgctt ctcagaatga tgatggctcc agatccaagg atgaaacaag
      781 agtgagcaca aatggatcag atgaccctga agatgcagga gctggtgaaa ataggagagt
      841 cagtgggaat aattctccat cactctcaaa tggtggtttt aaaccttcta gacctccaag
      901 accttcacga ccaccaccac ccaccccacg tagaccagca tctgtcaatg gttcaccatc
      961 tgccacttct gaaagtgatg ggtctagtac aggctctctg ccgccgacaa atacaaatac
     1021 aaatacatct gaaggagcaa catctggatt aataattcct cttactatat ctggaggctc
     1081 aggccctagg ccattaaatc ctgtaactca agctcccttg ccacctggtt gggagcagag
     1141 agtggaccag cacgggcgag tttactatgt agatcatgtt gagaaaagaa caacatggga
     1201 tagaccagaa cctctacctc ctggctggga acggcgggtt gacaacatgg gacgtattta
     1261 ttatgttgac catttcacaa gaacaacaac gtggcagagg ccaacactgg aatccgtccg
     1321 gaactatgaa caatggcagc tacagcgtag tcagcttcaa ggagcaatgc agcagtttaa
     1381 ccagagattc atttatggga atcaagattt atttgctaca tcacaaagta aagaatttga
     1441 tcctcttggt ccattgccac ctggatggga gaagagaaca gacagcaatg gcagagtata
     1501 tttcgtcaac cacaacacac gaattacaca atgggaagac cccagaagtc aaggtcaatt
     1561 aaatgaaaag cccttacctg aaggttggga aatgagattc acagtggatg gaattccata
     1621 ttttgtggac cacaatagaa gaactaccac ctatatagat ccccgcacag gaaaatctgc
     1681 cctagacaat ggacctcaga tagcctatgt tcgggacttc aaagcaaagg ttcagtattt
     1741 ccggttctgg tgtcagcaac tggccatgcc acagcacata aagattacag tgacaagaaa
     1801 aacattgttt gaggattcct ttcaacagat aatgagcttc agtccccaag atctgcgaag
     1861 acgtttgtgg gtgatttttc caggagaaga aggtttagat tatggaggtg tagcaagaga
     1921 atggttcttt cttttgtcac atgaagtgtt gaacccaatg tattgcctgt ttgaatatgc
     1981 agggaaggat aactactgct tgcagataaa ccccgcttct tacatcaatc cagatcacct
     2041 gaaatatttt cgttttattg gcagatttat tgccatggct ctgttccatg ggaaattcat
     2101 agacacgggt ttttctttac cattctataa gcgtatcttg aacaaaccag ttggactcaa
     2161 ggatttagaa tctattgatc cagaatttta caattctctc atctgggtta aggaaaacaa
     2221 tattgaggaa tgtgatttgg aaatgtactt ctccgttgac aaagaaattc taggtgaaat
     2281 taagagtcat gatctgaaac ctaatggtgg caatattctt gtaacagaag aaaataaaga
     2341 ggaatacatc agaatggtag ctgagtggag gttgtctcga ggtgttgaag aacagacaca
     2401 agctttcttt gaaggcttta atgaaattct tccccagcaa tatttgcaat actttgatgc
     2461 aaaggaatta gaggtccttt tatgtggaat gcaagagatt gatttgaatg actggcaaag
     2521 acatgccatc taccgtcatt atgcaaggac cagcaaacaa atcatgtggt tttggcagtt
     2581 tgttaaagaa attgataatg agaagagaat gagacttctg cagtttgtta ctggaacctg
     2641 ccgattgcca gtaggaggat ttgctgatct catggggagc aatggaccac agaaattctg
     2701 cattgaaaaa gttgggaaag aaaattggct acccagaagt catacctgtt ttaatcgcct
     2761 ggacctgcca ccatacaaga gctatgagca actgaaggaa aagctgttgt ttgccataga
     2821 agaaacagaa ggatttggac aagagtaact tctgagaact tgcaccatga atgggcaaga
     2881 acttatttgc aatgtttgtc cttctctgcc tgttgcacat cttgtaaaat tggacaatgg
     2941 ctctttagag agttatctga gtgtaagtaa attaatgttc tcatttagat ttatctccca
     3001 gtgatttcta ctcagcgttt ccagaaatca ggtctgcaaa tgactagtca gaaccttgct
     3061 taacatgaga ttttaacaca acaatgaaat ttgccttgtc ttattccact agtttattcc
     3121 tttaacaaca atattttatg tgtgtcaaaa gtctcacttg ggagtagtgt ttttttcttt
     3181 tagacattct gcagacatgc agggaagtcc tttggtaact gcaatataca agattttcct
     3241 attaagcctc ttggtaagag gcatttgtta aaagtgcaag cttactcctg cttctgggga
     3301 tgtgagcaaa attcgggctt gtgttctccc tctcatttta gtctgacttg actattgttt
     3361 ttcctttctg gcgcatgaat ccatacatca ttcctggaag tgaggcaaga ctcttgcatc
     3421 tctacaaagt agttttgtca atttgaattc agggaaaagt tggtcacagc ctgcaaatga
     3481 cttcatttgg aagtctgatt gtttcagttg cctgacaaat actacacttt acaaacaatg
     3541 ttaacactgt gattccttca ttgttttaag aagttaacct agggccgggc atggtggctc
     3601 atacctgtaa tcctagcact ctgggaggcc gaggcaggag gatcccttta gcccaggagt
     3661 taaagaccag cctgggcaac atagggagac cctgtctttt ttttgggcag cgtggtgggg
     3721 gataaataaa aaaaaaaaaa aaaaa
//