LOCUS BC010852 1345 bp mRNA linear HUM 03-FEB-2004
DEFINITION Homo sapiens aldo-keto reductase family 7, member A2 (aflatoxin
aldehyde reductase), mRNA (cDNA clone MGC:8910 IMAGE:3898226),
complete cds.
ACCESSION BC010852
VERSION BC010852.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1345)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 1345)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (12-JUL-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Life Technologies, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Sequencing Group at the Stanford Human Genome
Center, Stanford University School of Medicine, Stanford, CA 94305
Web site: http://www-shgc.stanford.edu
Contact: (Dickson, Mark) mcd@paxil.stanford.edu
Dickson, M., Schmutz, J., Grimwood, J., Rodriquez, A., and Myers,
R. M.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 14 Row: k Column: 6
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 4502020.
FEATURES Location/Qualifiers
source 1..1345
/db_xref="H-InvDB:HIT000035071"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:8910 IMAGE:3898226"
/tissue_type="Pancreas, epithelioid carcinoma"
/clone_lib="NIH_MGC_70"
/lab_host="DH10B"
/note="Vector: pCMV-SPORT6"
gene 1..1345
/gene="AKR7A2"
/gene_synonym="AFAR"
/gene_synonym="AFAR1"
/gene_synonym="AFB1-AR1"
/gene_synonym="AKR7"
/db_xref="GeneID:8574"
/db_xref="MIM:603418"
CDS 86..1078
/gene="AKR7A2"
/gene_synonym="AFAR"
/gene_synonym="AFAR1"
/gene_synonym="AFB1-AR1"
/gene_synonym="AKR7"
/codon_start=1
/product="AKR7A2 protein"
/protein_id="AAH10852.1"
/db_xref="GeneID:8574"
/db_xref="MIM:603418"
/translation="MSRPPPPRVASVLGTMEMGRRMDAPASAAAVRAFLERGHTELDT
AFMYSDGQSETILGGLGLGLGGGDCRVKIATKANPWDGKSLKPDSVRSQLETSLKRLQ
CPQVDLFYLHAPDHGTPVEETLHACQRLHQEGKFVELGLSNYASWEVAEICTLCKSNG
WILPTVYQGMYNATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQP
VGRFFGNSWAETYRNRFWKEHHFEAIALVEKALQAAYGASAPSVTSAALRWMYHHSQL
QGAHGDAVILGMSSLEQLEQNLAATEEGPLEPAVVDAFNQAWHLVAHECPNYFR"
misc_feature 122..985
/gene="AKR7A2"
/gene_synonym="AFAR"
/gene_synonym="AFAR1"
/gene_synonym="AFB1-AR1"
/gene_synonym="AKR7"
/note="Aldo_ket_red; Region: Aldo/keto reductase family.
This family includes a number of K+ ion channel beta chain
regulatory domains - these are reported to have
oxidoreductase activity"
/db_xref="CDD:pfam00248"
BASE COUNT 262 a 413 c 398 g 272 t
ORIGIN
1 gctgagtgcc gcgtctcgcg tagtctcccg cgccgccgtc cactgcgcgc ttcgctctcc
61 gccgcccgag gcccgcgcgc tcgccatgtc ccggccaccg ccaccgcggg tcgcctcggt
121 gctgggcacc atggagatgg ggcgccgcat ggacgcgccc gccagcgccg cggccgtgcg
181 cgcctttctg gagcgcggcc acaccgaact ggacacggcc ttcatgtaca gcgacggcca
241 gtccgagacc atcctgggcg gcctggggct cgggctgggc ggtggcgact gcagagtgaa
301 aattgccacc aaggccaacc cttgggatgg aaaatcacta aagcctgaca gtgtccggtc
361 ccagctggag acgtcattga agaggctgca gtgtccccaa gtggacctct tctacctaca
421 cgcacctgac cacggcaccc cggtggaaga gacgctgcat gcctgccagc ggctgcacca
481 ggagggcaag ttcgtggagc ttggcctctc caactatgct agctgggaag tggccgagat
541 ctgtaccctc tgcaagagca atggctggat cctgcccact gtgtaccagg gcatgtacaa
601 cgccaccacc cggcaggtgg aaacggagct cttcccctgc ctcaggcact ttggactgag
661 gttctatgcc tacaaccctc tggctggggg cctgctgact ggcaagtaca agtatgagga
721 caaggacggg aaacagcctg tgggccgctt ctttgggaat agctgggctg agacctacag
781 gaatcgcttc tggaaggagc accacttcga ggccattgcg ttggtggaga aggccctgca
841 ggccgcatat ggcgccagcg cccccagtgt gacctcggct gccctccggt ggatgtacca
901 ccactcacag ctgcagggtg cccacgggga cgcggtcatc ctgggcatgt ccagcctgga
961 gcagctggag cagaacttgg cagcaacaga ggaagggccc ctggagccgg ctgtcgtgga
1021 tgcctttaat caagcctggc atttggttgc tcacgaatgt cccaactact tccgctaggc
1081 ccatcatggc tcaggctgcc caaggctttt ctgtcacctc ttttgttctc tcacactgac
1141 cagtcttggc cttaagctga cttagaaggg tttttctgaa ttgtctagat ccatgcatta
1201 tttttctagc ttcctgcctt gctccctatt cactttacac tgtgaaaggt ggggggtgag
1261 tcccacttga gcgcttcctg ttgaataaag caggcacttg acctggctgt agcctaggtc
1321 ttgagtgaaa aaaaaaaaaa aaaaa
//