LOCUS BC010403 1461 bp mRNA linear ROD 26-JUL-2018
DEFINITION Mus musculus presenilin 2, mRNA (cDNA clone MGC:13863
IMAGE:4038761), complete cds.
ACCESSION BC010403
VERSION BC010403.2
KEYWORDS MGC.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (bases 1 to 1461)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 1461)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (09-JUL-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
REFERENCE 3 (bases 1 to 1461)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (26-JUL-2018) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK Sequence update by database staff to remove vector contamination
COMMENT On Jul 26, 2018 this sequence version replaced BC010403.1.
Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Lothar Hennighausen Ph.D., Robin Humphreys
cDNA Library Preparation: Life Technologies, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Institute for Systems Biology
http://www.systemsbiology.org
contact: amadan@systemsbiology.org
Anup Madan, Jessica Fahey, Erin Helton, Mark Ketteman, Anuradha
Madan, Stephanie Rodrigues, Amy Sanchez and Michelle Whiting
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 18 Row: i Column: 3
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 6755187.
FEATURES Location/Qualifiers
source 1..1461
/organism="Mus musculus"
/mol_type="mRNA"
/strain="mix FVB/N, C57BL/6J"
/db_xref="taxon:10090"
/clone="MGC:13863 IMAGE:4038761"
/tissue_type="Mammary tumor. WAP-TGF alpha model. 7 months
old, gross tissue."
/clone_lib="NCI_CGAP_Mam5"
/lab_host="DH10B"
/note="Vector: pCMV-SPORT6"
gene 1..1461
/gene="Psen2"
/gene_synonym="ALG-3"
/gene_synonym="PS-2"
/gene_synonym="PS2"
/db_xref="GeneID:19165"
/db_xref="MGI:MGI:109284"
CDS 14..1360
/gene="Psen2"
/gene_synonym="ALG-3"
/gene_synonym="PS-2"
/gene_synonym="PS2"
/codon_start=1
/product="Psen2 protein"
/protein_id="AAH10403.1"
/db_xref="GeneID:19165"
/db_xref="MGI:MGI:109284"
/translation="MLAFMASDSEEEVCDERTSLMSAESPTSRSCQEGRPGPEDGEST
AQWRTQESEEDCEEDPDRYACSGAPGRPSGLEEELTLKYGAKHVIMLFVPVTLCMIVV
VATIKSVRFYTEKNGQLIYTPFTEDTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLY
KYRCYKFIHGWLIMSSLMLLFLFTYIYLGEVLKTYNVAMDYPTLFLAVWNFGAVGMVC
IHWKGPLVLQQAYLIVISALMALVFIKYLPEWSAWVILGAISVYDLVAVLCPKGPLRM
LVETAQERNEPIFPALIYSSAMVWTVGMAKLDPSSQGALQLPYDPEMEEDSYDSFGEP
SYPEAFEAPLPGYPGEELEEEEERGVKLGLGDFIFYSVLVGKAAATGNGDWNTTLACF
IAILIGLCLTLLLLAVFKKALPALPISITFGLIFYFSTDNLVRPFMDTLASHQLYI"
misc_feature 239..1330
/gene="Psen2"
/gene_synonym="ALG-3"
/gene_synonym="PS-2"
/gene_synonym="PS2"
/note="Presenilin; Region: Presenilin. Mutations in
presenilin-1 are a major cause of early onset Alzheimer's
disease. It has been found that presenilin-1 binds to
beta-catenin in-vivo. This family also contains SPE
proteins from C.elegans"
/db_xref="CDD:pfam01080"
BASE COUNT 295 a 418 c 412 g 336 t
ORIGIN
1 ggcggagcag accatgctcg cattcatggc ctctgacagc gaggaagagg tgtgtgatga
61 gcggacgtcc ttgatgtcag ccgagagccc cacatctcgc tcctgccagg aaggcaggcc
121 aggcccggag gatggagaga gcactgccca gtggaggact caggagagcg aagaagactg
181 tgaagaggac ccggaccgct acgcatgcag tggggctcct gggcgaccgt cgggcctgga
241 ggaagagctg accctcaagt atggggcgaa gcatgtgatc atgctattcg tgcctgtcac
301 gctgtgtatg atcgtggtgg tggccactat caagtctgtg cgtttctaca ctgagaagaa
361 cgggcagctc atctacacgc ccttcacgga ggacacgccc tcggtgggcc agcggctcct
421 caactccgtg cttaacaccc tcatcatgat cagcgtcatc gtagtcatga ccatcttcct
481 cgtggtactc tacaagtatc gatgctacaa gttcatccat ggctggctga tcatgtcctc
541 cctgatgctc ctcttcttgt tcacctacat ctacctcggg gaagtgctca agacctacaa
601 tgtggccatg gactatccca cactcttcct ggctgtctgg aacttcgggg cagtgggcat
661 ggtgtgcatc cactggaagg ggcctctggt gctgcagcag gcttacctta ttgtgatcag
721 cgcactcatg gccctggtgt tcatcaagta cctgccggag tggtctgcct gggtcatctt
781 gggtgccatc tctgtgtacg atctcgtggc cgtgctgtgc cccaaagggc cactgaggat
841 gctggtggaa actgcccagg agagaaatga gcccatattt cctgccctga tatactcatc
901 tgccatggtg tggacggtgg gcatggcaaa gctggacccc tcctctcaag gagcgctgca
961 gctcccctat gacccagaga tggaagaaga ctcctacgac agttttggag aaccctcata
1021 ccctgaagcc ttcgaagctc ccctgcctgg ctacccaggg gaggagctgg aggaggagga
1081 ggaaaggggc gtgaagctcg gcctgggaga cttcatcttc tacagcgtcc tggtgggcaa
1141 ggctgcagcc actggcaacg gagactggaa cactacgctg gcctgtttta tcgccatcct
1201 cattggcttg tgtctcaccc tcctgctgct tgctgtgttc aagaaggctc tgcccgccct
1261 ccccatctcc atcacctttg gactcatctt ctacttctcc acagacaacc tggtgcgccc
1321 tttcatggac actctggcct cccaccagct ctacatctga caggagccag gcggaggctc
1381 cgagagctat gggggcgtca ctggatgcag gtgtatagtt ttacactcta gtgccatata
1441 ttttttaaag aaattttctt t
//