LOCUS BC008857 2928 bp mRNA linear HUM 23-DEC-2003
DEFINITION Homo sapiens nuclear factor of activated T-cells, cytoplasmic,
calcineurin-dependent 4, mRNA (cDNA clone IMAGE:4109469), partial
cds.
ACCESSION BC008857
VERSION BC008857.2
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2928)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 2928)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (25-MAY-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT On Dec 19, 2003 this sequence version replaced BC008857.1.
Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: National Institutes of Health Intramural
Sequencing Center (NISC),
Gaithersburg, Maryland;
Web site: http://www.nisc.nih.gov/
Contact: nisc_mgc@nhgri.nih.gov
Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
Young,A., Zhang,L.-H. and Green,E.D.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 26 Row: a Column: 21.
FEATURES Location/Qualifiers
source 1..2928
/db_xref="H-InvDB:HIT000087164"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="IMAGE:4109469"
/tissue_type="Muscle, rhabdomyosarcoma"
/clone_lib="NIH_MGC_17"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene <1..2928
/gene="NFATC4"
/gene_synonym="NF-ATc4"
/gene_synonym="NFAT3"
/db_xref="GeneID:4776"
/db_xref="MIM:602699"
CDS <1..2531
/gene="NFATC4"
/gene_synonym="NF-ATc4"
/gene_synonym="NFAT3"
/codon_start=3
/product="NFATC4 protein"
/protein_id="AAH08857.2"
/db_xref="GeneID:4776"
/db_xref="MIM:602699"
/translation="IPRPPPPRPGMHSPPPRPAPSPGTWESQPARSVRLGGPGGGAGG
AGGGRVLECPSIRITSISPTPEPPAALEDNPDAWGDGSPRDYPPPEGFGGYREAGAQG
GGAFFSPSPGSSSLSSWSFFSDASDEAALYAACDEVESELNEAASRFGLGSPLPSPRA
SPRPWTPEDPWSLYGPSPGGRGPEDSWLLLSAPGPTPASPRPASPCGKRRYSSSGTPS
SASPALSRRGSLGEEGSEPPPPPPLPLARDPGSPGPFDYVGAPPAESIPQKTRRTSSE
QAVALPRSEEPASCNGKLPLGAEESVAPPGGSRKEVAGMDYLAVPSPLAWSKARIGGH
SPIFRTSALPPLDWPLPSQYEQLELRIEVQPRAHHRAHYETEGSRGAVKAAPGGHPVV
KLLGYSEKPLTLQMFIGTADERNLRPHAFYQVHRITGKMVATASYEAVVSGTKVLEMT
LLPENNMAANIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHVPQGGGKVVSV
QAASVPIECSQRSAQELPQVEAYSPSACSVRGGEELVLTGSNFLPDSKVVFIERGPDG
KLQWEEEATVNRLQSNEVTLTLTVPEYSNKRVSRPVQVYFYVSNGRRKRSPTQSFRFL
PVICKEEPLPDSSLRGFPSASATPFGTDMDFSPPRPPYPSYPHEDPACETPYLSEGFG
YGMPPLYPQTGPPPSYRPGLRMFPETRGTTGCAQPPAVSFLPRPFPSDPYGGRGSSFP
LGLPFSPPAPFRPPPLPASPPLEGPFPSQSDVHPLPAEGYNKVGPGYGPGEGAPEQEK
SRGGYSSGFRDSVPIQGITLEEVSEIIGRDLSGFPAPPGEEPPA"
misc_feature 1074..1556
/gene="NFATC4"
/gene_synonym="NF-ATc4"
/gene_synonym="NFAT3"
/note="RHD; Region: Rel homology domain (RHD). Proteins
containing the Rel homology domain (RHD) are eukaryotic
transcription factors. The RHD is composed of two
structural domains. This is the N-terminal domain that is
similar to that found in P53. The C-terminal domain has an
immunoglobulin-like fold (See pfam01833) that binds to
DNA"
/db_xref="CDD:pfam00554"
misc_feature 1575..1853
/gene="NFATC4"
/gene_synonym="NF-ATc4"
/gene_synonym="NFAT3"
/note="IPT; Region: ig-like, plexins, transcription
factors"
/db_xref="CDD:smart00429"
BASE COUNT 572 a 948 c 865 g 543 t
ORIGIN
1 gtattccccg acctccaccc cctcggcctg gcatgcattc gccaccgccg cgaccagccc
61 cctcacctgg cacctgggag agccagcccg ccaggtcggt gaggctggga ggaccaggag
121 ggggtgctgg gggtgctggg ggtggccgtg ttctcgagtg tcccagcatc cgcatcacct
181 ccatctctcc cacgccggag ccgccagcag cgctggagga caaccctgat gcctgggggg
241 acggctctcc tagagattac cccccaccag aaggctttgg gggctacaga gaagcagggg
301 cccagggtgg gggggccttc ttcagcccaa gccctggcag cagcagcctg tcctcgtgga
361 gcttcttctc cgatgcctct gacgaggcag ccctgtatgc agcctgcgac gaggtggagt
421 ctgagctaaa tgaggcggcc tcccgctttg gcctgggctc cccgctgccc tcgccccggg
481 cctcccctcg gccatggacc cccgaagatc cctggagcct gtatggtcca agccccggag
541 gccgagggcc agaggatagc tggctactcc tcagtgctcc tgggcccacc ccagcctccc
601 cgcggcctgc ctctccatgt ggcaagcggc gctattccag ctcgggaacc ccatcttcag
661 cctccccagc tctgtcccgc cgtggcagcc tgggggaaga ggggtctgag ccacctccac
721 cacccccatt gcctctggcc cgggacccgg gctcccctgg tccctttgac tatgtggggg
781 ccccaccagc tgagagcatc cctcagaaga cacggcggac ttccagcgag caggcagtgg
841 ctctgcctcg gtctgaggag cctgcctcat gcaatgggaa gctgcccttg ggagcagagg
901 agtctgtggc tcctccagga ggttcccgga aggaggtggc tggcatggac tacctggcag
961 tgccctcccc actcgcttgg tccaaggccc ggattggggg acacagccct atcttcagga
1021 cctctgccct acccccactg gactggcctc tgcccagcca atatgagcag ctggagctga
1081 ggatcgaggt acagcctaga gcccaccacc gggcccacta tgagacagaa ggcagccgtg
1141 gagctgtcaa agctgcccct ggcggtcacc ccgtagtcaa gctcctaggc tacagtgaga
1201 agccactgac cctacagatg ttcatcggca ctgcagatga aaggaacctg cggcctcatg
1261 ccttctatca ggtgcaccgt atcacaggca agatggtggc cacggccagc tatgaagccg
1321 tagtcagtgg caccaaggtg ttggagatga ctctgctgcc tgagaacaac atggcggcca
1381 acattgactg cgcgggaatc ctgaagcttc ggaattcaga cattgagctt cggaagggtg
1441 agacggacat cgggcgcaaa aacacacgtg tacggctggt gttccgggta cacgtgcccc
1501 agggcggcgg gaaggtcgtc tcagtacagg cagcatcggt gcccatcgag tgctcccagc
1561 gctcagccca ggagctgccc caggtggagg cctacagccc cagtgcctgc tctgtgagag
1621 gaggcgagga actggtactg accggctcca acttcctgcc agactccaag gtggtgttca
1681 ttgagagggg tcctgatggg aagctgcaat gggaggagga ggccacagtg aaccgactgc
1741 agagcaacga ggtgacgctg accctgactg tccccgagta cagcaacaag agggtttccc
1801 ggccagtcca ggtctacttt tatgtctcca atgggcggag gaaacgcagt cctacccaga
1861 gtttcaggtt tctgcctgtg atctgcaaag aggagcccct accggactca tctctgcggg
1921 gtttcccttc agcatcggca accccctttg gcactgacat ggacttctca ccacccaggc
1981 ccccctaccc ctcctatccc catgaagacc ctgcttgcga aactccttac ctatcagaag
2041 gcttcggcta tggcatgccc cctctgtacc cccagacggg gcccccacca tcctacagac
2101 cgggcctgcg gatgttccct gagactaggg gtaccacagg ttgtgcccaa ccacctgcag
2161 tttccttcct tccccgcccc ttccctagtg acccgtatgg agggcggggc tcctctttcc
2221 ccctggggct gccattctct ccgccagccc cctttcggcc gcctcctctt cctgcatccc
2281 caccgcttga aggccccttc ccttcccaga gtgatgtgca tcccctacct gctgagggat
2341 acaataaggt agggccaggc tatggccctg gggagggggc tccggagcag gagaaatcca
2401 ggggtggcta cagcagcggc ttccgagaca gtgtccctat ccagggtatc acgctggagg
2461 aagtgagtga gatcattggc cgagacctga gtggcttccc tgcacctcct ggagaagagc
2521 ctcctgcctg aaccacgtga actgtcatca cctggcaacc ccagccccag cctcagccct
2581 gccccctttc cctccttcct ggagtggtgg ctacagaagc ttggggccaa ccctggctcc
2641 tctttcccca gcttctgtct gtctcactgt cttccctccc ctcccccagc tgaggtgtgg
2701 ccctcaggcc tggtgctgcc ttggagggct gggggaagga gtgtgtggag gagggaggag
2761 ggtgaagact gaggctaggt gccagaatgg actggagtga aggcgtgtct agagtgtggg
2821 ctggctgttg tgctggaaag ctggggacag gttgatggta ataaactgct caatgaccag
2881 taaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa
//