LOCUS BC008775 3616 bp mRNA linear HUM 03-OCT-2003
DEFINITION Homo sapiens nardilysin (N-arginine dibasic convertase), mRNA (cDNA
clone MGC:2024 IMAGE:3138712), complete cds.
ACCESSION BC008775
VERSION BC008775.2
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3616)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 3616)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (25-MAY-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT On Aug 19, 2003 this sequence version replaced BC008775.1.
Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: National Institutes of Health Intramural
Sequencing Center (NISC),
Gaithersburg, Maryland;
Web site: http://www.nisc.nih.gov/
Contact: nisc_mgc@nhgri.nih.gov
Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
Young,A., Zhang,L.-H. and Green,E.D.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 4 Row: p Column: 11
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 4505452.
FEATURES Location/Qualifiers
source 1..3616
/db_xref="H-InvDB:HIT000033959"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:2024 IMAGE:3138712"
/tissue_type="Placenta, choriocarcinoma"
/clone_lib="NIH_MGC_21"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene 1..3616
/gene="NRD1"
/db_xref="GeneID:4898"
/db_xref="MIM:602651"
CDS 100..3552
/gene="NRD1"
/codon_start=1
/product="NRD1 protein"
/protein_id="AAH08775.1"
/db_xref="GeneID:4898"
/db_xref="MIM:602651"
/translation="MLRRVTVAAVCATRRKLCEAGRELAALWGIETRGRCEDSAAARP
FPILAMPGRNKAKSTCSCPDLQPNGQDLGENSRVARLGADESEEEGRRGSLSNAGDPE
IVKSPSDPKQYRYIKLQNGLQALLISDLSNMEGKTGNTTDDEEEEEVEEEEDDDEDSG
AEIEDDDEEGFDDEDEFDDEHDDDLDTEDNELEELEERAEARKKTTEKQSAAALCVGV
GSFADPDDLPGLAHFLEHMVFMGSLKYPDENGFDAFLKKHGGSDNASTDCERTVFQFD
VQRKYFKEALDRWAQFFIHPLMIRDAIDREVEAVDSEYQLARPSDANRKEMLFGSLAR
PGHPMGKFFWGNAETLKHEPRKNNIDTHARLREFWMRYYSSHYMTLVVQSKETLDTLE
KWVTEIFSQIPNNGLPRPNFGHLTDPFDTPAFNKLYRVVPIRKIHALTITWALPPQQQ
HYRVKPLHYISWLVGHEGKGSILSFLRKKCWALALFGGNGETGFEQNSTYSVFSISIT
LTDEGYEHFYEVAYTVFQYLKMLQKLGPEKRIFEEIRKIEDNEFHYQEQTDPVEYVEN
MCENMQLYPLQDILTGDQLLFEYKPEVIGEALNQLVPQKANLVLLSGANEGKCDLKEK
WFGTQYSIEDIENSWAELWNSNFELNPDLHLPAENKYIATDFTLKAFDCPETEYPVKI
VNTPQGCLWYKKDNKFKIPKAYIRFHLISPLIQKSAANVVLFDIFVNILTHNLAEPAY
EADVAQLEYKLVAGEHGLIIRVKGFNHKLPLLFQLIIDYLAEFNSTPAVFTMITEQLK
KTYFNILIKPETLAKDVRLLILEYARWSMIDKYQALMDGLSLESLLSFVKEFKSQLFV
EGLVQGNVTSTESMDFLKYVVDKLNFKPLEQEMPVQFQVVELPSGHHLCKVKALNKGD
ANSEVTVYYQSGTRSLREYTLMELLVMHMEEPCFDFLRTKQTLGYHVYPTCRNTSGIL
GFSVTVGTQATKYNSEVVDKKIEEFLSSFEEKIENLTEEAFNTQVTALIKLKECEDTH
LGEEVDRNWNEVVTQQYLFDRLAHEIEALKSFSKSDLVNWFKAHRGPGSKMLSVHVVG
YGKYELEEDGTPSSEDSNSSCEVMQLTYLPTSPLLADCIIPITDIRAFTTTLNLLPYH
KIVK"
misc_feature 406..486
/gene="NRD1"
/note="Ptr; Region: Secreted/periplasmic Zn-dependent
peptidases, insulinase-like [Posttranslational
modification, protein turnover, chaperones]"
/db_xref="CDD:COG1025"
misc_feature 727..3363
/gene="NRD1"
/note="Ptr; Region: Secreted/periplasmic Zn-dependent
peptidases, insulinase-like [Posttranslational
modification, protein turnover, chaperones]"
/db_xref="CDD:COG1025"
BASE COUNT 1088 a 727 c 877 g 924 t
ORIGIN
1 gcggctgcgg cagcaccagg gccggccgcc accgcctcta gaacgcggag gaggtgggtc
61 ctgggaagcg ggatgtccat cgctccagct tggtggtgaa tgctgaggag agtcactgtt
121 gctgcagtct gtgccacccg gaggaagttg tgtgaggccg ggcgggagct cgcggcgctc
181 tggggaatcg aaacgcgggg tcggtgcgaa gactctgctg ctgccagacc ctttcctatt
241 ctggccatgc ctggaaggaa caaggcgaag tctacctgca gctgccctga cctgcagccc
301 aatggacagg atctgggcga gaacagccgg gttgcccgtc taggagcgga tgaatctgag
361 gaagagggac ggagggggtc tctcagtaat gctggggacc ctgagatcgt caagtctccc
421 agcgacccca agcaataccg atacatcaaa ttacagaatg gcttgcaggc acttctgatt
481 tcagacctaa gtaatatgga aggtaaaaca ggaaatacaa cagatgatga agaagaagag
541 gaggtggagg aagaagaaga tgatgatgaa gattctggag ctgaaataga agatgacgat
601 gaagagggtt ttgatgatga agatgagttt gatgatgaac atgatgatga tcttgatact
661 gaggataatg aattggaaga attagaagag agagcagaag ctagaaaaaa aactactgaa
721 aaacagtctg cagcggctct ttgtgttgga gttgggagtt tcgctgatcc agatgacctg
781 ccggggctgg cacacttttt ggagcacatg gtattcatgg gtagtttgaa atatccagat
841 gagaatggat ttgatgcctt cctgaagaag catgggggta gtgataatgc ctcaactgat
901 tgtgaacgca ctgtctttca gtttgatgtc cagaggaagt acttcaagga agctcttgat
961 agatgggcgc agttcttcat ccacccacta atgatcagag atgcaattga ccgtgaagtt
1021 gaagctgttg atagtgaata tcaacttgca aggccttctg atgcaaacag aaaggaaatg
1081 ttgtttggaa gccttgctag acctggccat cctatgggaa aatttttttg gggaaatgct
1141 gagacgctca agcatgagcc aagaaagaat aatattgata cacatgctag attgagagaa
1201 ttctggatgc gttactactc ttctcattac atgactttag tggttcaatc caaagaaaca
1261 ctggatactt tggaaaagtg ggtgactgaa atcttctctc agataccaaa caatgggtta
1321 cccagaccaa actttggcca tttaacggat ccatttgaca caccagcatt taacaaactt
1381 tatagagttg ttccaatcag aaaaattcat gctctgacca tcacatgggc acttcctcct
1441 caacagcaac attacagggt gaagccactt cattatatat cctggctggt tggacatgaa
1501 ggcaaaggca gcattctttc tttccttagg aaaaaatgct gggctcttgc actgtttggt
1561 ggaaatggtg agacaggatt tgagcaaaat tctacttatt cagtgttcag catttctatt
1621 acattgactg atgagggtta tgaacatttt tatgaggttg cttacactgt ctttcagtat
1681 ttaaaaatgc tgcagaagct aggcccagaa aaaagaattt ttgaagagat tcggaaaatt
1741 gaggataatg aatttcatta ccaagaacag acagatccag ttgagtatgt ggaaaacatg
1801 tgtgagaaca tgcagctgta cccattgcag gacattctca ctggagatca gcttcttttt
1861 gaatacaagc cagaagtcat tggtgaagcc ttgaatcagc tagttcctca aaaagcaaat
1921 cttgttttac tgtctggtgc taatgaggga aaatgtgacc tcaaggagaa atggtttgga
1981 actcaatata gtatagaaga tattgaaaac tcttgggctg aactgtggaa tagtaatttc
2041 gaattaaatc cagatcttca tcttccagct gaaaacaagt acatagccac ggactttacg
2101 ttgaaggctt tcgattgccc ggaaacagaa tacccagtta aaattgtgaa tactccacaa
2161 ggttgcctgt ggtataagaa agacaacaaa ttcaaaatcc ccaaagcata tatacgtttc
2221 catctaattt caccgttgat acagaaatct gcagcaaatg tggtcctctt tgatatcttt
2281 gtcaatatcc ttacgcataa ccttgcggaa ccagcttatg aagcagatgt ggcacagctg
2341 gagtataaac tggtagctgg agaacatggt ttaattattc gagtgaaagg atttaaccac
2401 aaactacctc tactgtttca gctcattatt gactacttag ctgagttcaa ttccacacca
2461 gctgtcttta caatgataac tgagcagttg aagaagacct actttaacat cctcatcaag
2521 cctgagactt tggccaaaga tgtacggctt ttaatcttgg aatatgcccg ttggtctatg
2581 attgacaagt accaggcttt gatggacggc ctttcccttg agtctctgct gagcttcgtc
2641 aaagaattca aatcccagct ctttgtggag ggcctggtac aagggaatgt cacaagcaca
2701 gaatctatgg atttcctgaa atatgttgtt gacaaactaa acttcaagcc tctggagcag
2761 gagatgcctg tgcagttcca ggtggtagag ctgcccagtg gccaccatct atgcaaagtg
2821 aaagctctga acaagggtga tgccaactct gaagtcactg tgtactacca gtcaggtacc
2881 aggagtctaa gagaatatac gcttatggag ctgcttgtga tgcacatgga agaaccttgt
2941 tttgacttcc ttcgaaccaa gcagaccctt gggtaccatg tctaccctac ctgtaggaac
3001 acatccggga ttctaggatt ttctgtcact gtggggactc aggcaaccaa atacaattct
3061 gaagttgttg ataagaagat agaagagttt ctttctagct ttgaggagaa gattgagaac
3121 ctcactgaag aggcattcaa cacccaggtc acagctctca tcaagctgaa ggagtgtgag
3181 gatacccacc ttggggagga ggtggatagg aactggaatg aagtggttac acagcagtac
3241 ctctttgacc gccttgccca cgagattgaa gcactgaagt cattctcaaa atcagacctg
3301 gtcaactggt tcaaggccca tagagggcca ggaagtaaaa tgctcagcgt tcatgttgtt
3361 ggatatggga agtatgaact ggaagaggat ggtacccctt ctagtgagga ttcaaattct
3421 tcttgtgaag tgatgcagct gacctacctg ccaacctctc ctctgctggc agattgtatc
3481 atccccatta ctgatatcag ggctttcaca acaacactca accttctccc ctaccataaa
3541 atagtcaaat aaataaactg cagtcacgtt ggcctgaaaa aaaaaaaaaa aaaaaaaaaa
3601 aaaaaaaaaa aaaaaa
//