LOCUS BC006334 1741 bp mRNA linear HUM 08-OCT-2003 DEFINITION Homo sapiens potassium voltage-gated channel, subfamily H (eag-related), member 6, mRNA (cDNA clone MGC:13157 IMAGE:4303609), complete cds. ACCESSION BC006334 VERSION BC006334.2 KEYWORDS MGC. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1741) AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A. TITLE Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002) PUBMED 12477932 REFERENCE 2 (bases 1 to 1741) AUTHORS Strausberg,R. TITLE Direct Submission JOURNAL Submitted (09-APR-2001) National Institutes of Health, Mammalian Gene Collection (MGC), Cancer Genomics Office, National Cancer Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590, USA REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov COMMENT On Aug 19, 2003 this sequence version replaced BC006334.1. Contact: MGC help desk Email: cgapbs-r@mail.nih.gov Tissue Procurement: ATCC cDNA Library Preparation: Rubin Laboratory cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL) DNA Sequencing by: National Institutes of Health Intramural Sequencing Center (NISC), Gaithersburg, Maryland; Web site: http://www.nisc.nih.gov/ Contact: nisc_mgc@nhgri.nih.gov Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B., Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S., Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P., Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R., Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C., McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W., Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L., Young,A., Zhang,L.-H. and Green,E.D. Clone distribution: MGC clone distribution information can be found through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov Series: IRAL Plate: 17 Row: o Column: 13 This clone was selected for full length sequencing because it passed the following selection criteria: matched mRNA gi: 27886650. FEATURES Location/Qualifiers source 1..1741 /db_xref="H-InvDB:HIT000032765" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /clone="MGC:13157 IMAGE:4303609" /tissue_type="Uterus, leiomyosarcoma" /clone_lib="NIH_MGC_46" /lab_host="DH10B-R" /note="Vector: pOTB7" gene 1..1741 /gene="KCNH6" /gene_synonym="ERG2" /gene_synonym="HERG2" /gene_synonym="Kv11.2" /db_xref="GeneID:81033" CDS 59..1567 /gene="KCNH6" /gene_synonym="ERG2" /gene_synonym="HERG2" /gene_synonym="Kv11.2" /codon_start=1 /product="KCNH6 protein" /protein_id="AAH06334.1" /db_xref="GeneID:81033" /translation="MPVRRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQMENCAIIYC NDGFCELFGYSRVEVMQQPCTCDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKD ASSFRCLVDVVPVKNEDGAVIMFILNFEDLAQLLAKCSSRSLSQRLLSQSFLGSEGSH GRPGGPGPGTGRGKYRTISQIPQFTLNFVEFNLEKHRSSSTTEIEIIAPHKVVERTQN VTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPY SAAFLLSDQDESRRGACSYTCSPLTVVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHP RRIAVHYFKGWFLIDMVAAIPFDLLIFRTGSDETTTLIGLLKTARLLRLVRVARKLDR YSEYGAAVLFLLMCTFALIAHWLACIWYAIGNVERPYLEHKIGWLDSLGVQLGKRYNG SDPASGPSVQDKYVTALYFTFSSLTSVGFGNVSPNTNSEKVFSICVMLIGCE" misc_feature 179..463 /gene="KCNH6" /gene_synonym="ERG2" /gene_synonym="HERG2" /gene_synonym="Kv11.2" /note="AtoS; Region: FOG: PAS/PAC domain [Signal transduction mechanisms]" /db_xref="CDD:COG2202" misc_feature 1064..1561 /gene="KCNH6" /gene_synonym="ERG2" /gene_synonym="HERG2" /gene_synonym="Kv11.2" /note="ion_trans; Region: Ion transport protein. This family contains Sodium, Potassium, Calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane. A bacterial structure of the protein is known for the last two helices but is not the Pfam family due to it lacking the first four helices" /db_xref="CDD:pfam00520" BASE COUNT 380 a 549 c 470 g 342 t ORIGIN 1 gcggagacgc cgggagccag tggcgcctgt ggctccgggc aggggccgcg gccgaaagat 61 gccggtccgc aggggccacg tcgctcccca aaacacttac ctggacacca tcatccgcaa 121 gttcgagggc caaagtcgga agttcctgat tgccaatgct cagatggaga actgcgccat 181 catttactgc aacgacggct tctgcgaact cttcggctac tcccgagtgg aggtgatgca 241 gcaaccctgc acctgcgact tcctcacagg ccccaacaca ccaagcagcg ccgtgtcccg 301 cctagcgcag gccctgctgg gggctgagga gtgcaaggtg gacatcctct actaccgcaa 361 ggatgcctcc agcttccgct gcctggtaga tgtggtgccc gtgaagaacg aggacggggc 421 tgtcatcatg ttcattctca acttcgagga cctggcccag ctcctggcca agtgcagcag 481 ccgcagcttg tcccagcgcc tgttgtccca gagcttcctg ggctccgagg gctctcatgg 541 caggccaggc ggaccagggc caggcacagg caggggcaag tacaggacca tcagccagat 601 cccacagttc acgctcaact tcgtggagtt caacttggag aagcaccgct ccagctccac 661 cacggagatt gagatcatcg cgccccataa ggtggtggag cggacacaga acgtcactga 721 gaaggtcacc caggtcctgt ccctgggcgc ggatgtgctg ccggagtaca agctgcaggc 781 gccgcgcatc caccgctgga ccatcctgca ctacagcccc ttcaaggccg tgtgggactg 841 gctcatcctg ctgctggtca tctacacggc tgtcttcacg ccctactcag ccgccttcct 901 gctcagcgac caggacgaat cacggcgtgg ggcctgcagc tatacctgca gtcccctcac 961 tgtggtggat ctcatcgtgg acatcatgtt cgtcgtggac atcgtcatca acttccgcac 1021 cacctatgtc aacaccaatg atgaggtggt cagccacccc cgccgcatcg ccgtccacta 1081 cttcaagggc tggttcctca ttgacatggt ggccgccatc cctttcgacc tcctgatctt 1141 ccgcactggc tccgatgaga ccacaaccct gattgggcta ttgaagacag cgcggctgct 1201 gcggctggtg cgcgtagcac ggaagctgga ccgctactct gagtatgggg cggctgtgct 1261 cttcttgctc atgtgcacct tcgcgctcat agcgcactgg ctggcctgca tctggtacgc 1321 catcggcaat gtggagcggc cctacctaga acacaagatc ggctggctgg acagcctggg 1381 tgtgcagctt ggcaagcgct acaacggcag cgacccagcc tcgggcccct cggtgcagga 1441 caagtatgtc acagccctct acttcacctt cagcagcctc accagcgtgg gcttcggcaa 1501 tgtctcgccc aacaccaact ccgagaaggt cttctccatc tgcgtcatgc tcatcggctg 1561 tgagtgagac ctcatgccac ggcctaactt catgctctgg tcttacccgt gaaattttat 1621 gtgtagtttt gtactgagat agaacataac acatagcaac aattcatgca gtacactgat 1681 cctaagtgtg cagcacaatg aattaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 1741 a //