LOCUS BC006247 3364 bp mRNA linear HUM 02-MAR-2004
DEFINITION Homo sapiens zinc finger protein 589, mRNA (cDNA clone
IMAGE:3945618), partial cds.
ACCESSION BC006247
VERSION BC006247.2
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3364)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 3364)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (09-APR-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT On Aug 19, 2003 this sequence version replaced BC006247.1.
Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: DCTD/DTP
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: National Institutes of Health Intramural
Sequencing Center (NISC),
Gaithersburg, Maryland;
Web site: http://www.nisc.nih.gov/
Contact: nisc_mgc@nhgri.nih.gov
Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
Young,A., Zhang,L.-H. and Green,E.D.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 15 Row: h Column: 3
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 7706726.
FEATURES Location/Qualifiers
source 1..3364
/db_xref="H-InvDB:HIT000086622"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="IMAGE:3945618"
/tissue_type="Lung, small cell carcinoma"
/clone_lib="NIH_MGC_7"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene <1..3364
/gene="ZNF589"
/gene_synonym="SZF1"
/db_xref="GeneID:51385"
CDS <1..1141
/gene="ZNF589"
/gene_synonym="SZF1"
/codon_start=2
/product="ZNF589 protein"
/protein_id="AAH06247.2"
/db_xref="GeneID:51385"
/translation="THGAATSFASCVRAQMWAPREQLLGWAAEALPAKDSAWPWEEKP
RYLGPVTFEDVAVLFTEAEWKRLSLEQRNLYKEVMLENLRNLVSLAESKPEVHTCPSC
PLAFGSQQFLSQDELHNHPIPGFHAGNQLHPGNPCPEDQPQSQHPSDKNHRGAEAEDQ
RVEGGVRPLFWSTNERGALVGFSSLFQRPPISSWGGNRILEIQLSPAQNASSEEVDRI
SKRAETPGFGAVRFGECALAFNQKSNLFRQKAVTAEKSSDKRQSQVCRECGRGFSRKS
QLIIHQRTHTGEKPYVCGECGRGFIVESVLRNHLSTHSGEKPYVCSHCGRGFSCKPYL
IRHQRTHTREKSFMCTVCGRGFREKSELIKHQRIHTGDKPYVCRD"
misc_feature 149..268
/gene="ZNF589"
/gene_synonym="SZF1"
/note="KRAB; Region: KRAB box. The KRAB domain (or
Kruppel-associated box) is present in about a third of
zinc finger proteins containing C2H2 fingers. The KRAB
domain is found to be involved in protein-protein
interactions. The KRAB domain is generally encoded by two
exons. The regions coded by the two exons are known as
KRAB-A and KRAB-B"
/db_xref="CDD:pfam01352"
misc_feature 791..856
/gene="ZNF589"
/gene_synonym="SZF1"
/note="zf-C2H2; Region: Zinc finger, C2H2 type. The C2H2
zinc finger is the classical zinc finger domain. The two
conserved cysteines and histidines co-ordinate a zinc ion.
The following pattern describes the zinc finger.
#-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be
any amino acid, and numbers in brackets indicate the
number of residues. The positions marked # are those that
are important for the stable fold of the zinc finger. The
final position can be either his or cys. The C2H2 zinc
finger is composed of two short beta strands followed by
an alpha helix. The amino terminal part of the helix binds
the major groove in DNA binding zinc fingers"
/db_xref="CDD:pfam00096"
misc_feature 1040..1108
/gene="ZNF589"
/gene_synonym="SZF1"
/note="zf-C2H2; Region: Zinc finger, C2H2 type. The C2H2
zinc finger is the classical zinc finger domain. The two
conserved cysteines and histidines co-ordinate a zinc ion.
The following pattern describes the zinc finger.
#-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be
any amino acid, and numbers in brackets indicate the
number of residues. The positions marked # are those that
are important for the stable fold of the zinc finger. The
final position can be either his or cys. The C2H2 zinc
finger is composed of two short beta strands followed by
an alpha helix. The amino terminal part of the helix binds
the major groove in DNA binding zinc fingers"
/db_xref="CDD:pfam00096"
BASE COUNT 896 a 803 c 884 g 781 t
ORIGIN
1 cacacacggt gctgctacct cgtttgcttc gtgcgtgcgt gcgcagatgt gggccccgcg
61 ggagcagcta ctgggctggg ctgcggaagc tctgcctgcc aaggattctg cctggccctg
121 ggaagagaag cctagatatc tgggaccagt gactttcgag gatgtggctg tgcttttcac
181 tgaggcagag tggaagagac tgagccttga gcagaggaac ctatacaaag aagtgatgct
241 ggaaaatctc aggaatctgg tctcattggc agaatcaaag ccagaagtcc atacctgccc
301 ttcttgccct ctggcctttg gcagtcagca gttcctcagc caagatgagc tacacaatca
361 tcctattcca ggtttccatg caggaaatca actccaccca ggaaatccct gcccagagga
421 tcagccacag tcacaacatc cttctgataa aaatcacagg ggggctgaag cagaagatca
481 acgagtggaa ggaggcgtca gacccttgtt ttggagtaca aatgaaaggg gggctttagt
541 gggtttctct agcctgttcc agagaccacc aataagctct tggggaggca acagaatatt
601 agagatacag ctcagtccag cccagaatgc aagctctgag gaagtagaca gaatttccaa
661 gagggcagaa accccagggt ttggagcagt caggtttggg gagtgtgcac tagcttttaa
721 ccagaagtca aacctgttca gacagaaggc agtcacagca gaaaaatctt cagacaaaag
781 gcagtcacag gtgtgcaggg agtgtgggcg aggctttagc aggaagtcac agctcatcat
841 acaccagagg acacacacag gagaaaagcc ttatgtctgc ggagagtgtg ggcgaggctt
901 tatagttgag tcagtcctcc gcaaccacct gagtacacac tccggggaga aaccttatgt
961 gtgcagccat tgtgggcgag gctttagctg caagccatac ctcatcagac atcagaggac
1021 acacacaagg gagaaatcgt ttatgtgcac agtgtgtggg cgaggctttc gtgaaaagtc
1081 agagctcatt aagcaccaga gaattcacac gggggataag ccttatgtgt gcagagattg
1141 aggccgaggc tttgtaagga gatcatgtct caacacacac cagaggatac attcagatga
1201 gaagcctttt gtttgcagag agtgtgggcg aggctttcgt gctaaatcaa ctctcctcct
1261 acaccagtgg acacattcag aggtgaaacc tcacgtgtgt gaggagtgtg ggcatggatt
1321 tagccagaag tcgtcgctca aatcacatcg gagaacacac tcaggggaga agccttatgt
1381 gtgtggggaa tgtgggcggg gatttagccg gaggatagtc ctcaatggac actggaggac
1441 acacacggga gagaagcctt acacgtgctt tgagtgtggg cgaaacttta gcctcaagtc
1501 cgctcttagt gtacatcaga ggatacactc tggggagaag ccttatgcat gcacggagtg
1561 tgggcaaggc tttatcacga aatcacagct catcagacac cagaggacac acacaggaga
1621 aaagccttat gtctgcggag agtgtgggcg aggctttata gctcagtcaa ccctccacta
1681 ccaccggagt acacactcca aggaaaaacc ttatgtgtgc agccagtgtg ggcgaggctt
1741 ttgtgataaa tcaactctcc tcgcacacga gcagacacat tcaggggaga agccttatgt
1801 gtgtggggaa tgtgggcggg gatttggccg gaagatactc ctcaacagac actggaggac
1861 acacacagga gagaaacctt acgcatgcat cgagtgtggg cgaaacttta gccacaagtc
1921 cactctcagc ttacatcaga ggatacactc gggggagaag ccttatgcat gcgtggagtg
1981 tgggcaaagc tttaggagaa agtcacagct catcatacac cagaagatac actcggggaa
2041 aagctttaga ggtgcaagga gtgaggatgt gattttagca acaagtcagc catcagccac
2101 accagcggaa atgcttaggg agaagccttg tttgtaaggt aatgtggaca gagctgtacg
2161 tggacatcat tacttgtcac gtgtcagagg acacactcgg gagaaacctt catggagtga
2221 gagtaaggtg ttggctggaa gtggcccctt aagagatact tggagtcaaa tctatccact
2281 gtacgcccac cccactcttg ttctaagagc tttggggaca gtcttttgac cccttacatt
2341 cctttagatg tgaagatgac agagatctaa cttctgagag cagaggtgtc aagtgacggt
2401 ccccttggag gaatggtctt tgcatctgac tacttccttc tgcaactgtg ttcttccatt
2461 agcttccatg acactctcct gctttatttt tttctacatc tctagccttt gctgtttcct
2521 ctcctacccc acctttagat tttactcaga gttcagtctc cagccctaca atctgaggga
2581 cacctttacc aggtcccctt cctaaccctc cagtcccaaa tccaagattc tttaaccaca
2641 ctctaaaagt tcttcagact caggacttaa acatagccac gccaccttgg ccttcaatga
2701 cagggatcta gcaatgctgc atcatcagcc ttccaatacc aggtttaagg gtattttaaa
2761 cacagctcct cttaaatcct ccaatctcag tacccagtgt tttagccatg ctcgggtggc
2821 taaattacat ccaggaatgg tgccagggcc tttagccatt tgtctctcct cacactccag
2881 ggcccatatg gcccaggttc tgacagtttg ccttactccc ttggcctggg gctagcccta
2941 cctgataccc tgtgtcaatg agtgtacctt ggagagctat ccactcaggc cccagtgcct
3001 ctatttgcta agggactctg ccacagaaaa gaaggggaga gatgttcatg taacctcaaa
3061 atacttaggc ttggttttga tgctagagag gaagaaggac ttggagagag agaaggaatg
3121 gctggtccag aggcttttgt ccactccctc tcactggaag tggttgatct ccagggaatc
3181 cccaaggtta gcctgcttag gggaagggct aggggtacct ggaatgtagg atctccccca
3241 tgcctggcct accaccctaa tgtgtccgga attggtgggt tcttggtctt gctgacttca
3301 agaatgaagc cgtggaccct cacggtgagt gttacaattc ttaaaaaaaa aaaaaaaaaa
3361 aaaa
//