LOCUS BC006221 2131 bp mRNA linear HUM 30-JAN-2008
DEFINITION Homo sapiens NK2 homeobox 1, mRNA (cDNA clone MGC:10523
IMAGE:3941576), complete cds.
ACCESSION BC006221
VERSION BC006221.2
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2131)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 2131)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (09-APR-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT On Aug 19, 2003 this sequence version replaced BC006221.1.
Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: DCTD/DTP
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: National Institutes of Health Intramural
Sequencing Center (NISC),
Gaithersburg, Maryland;
Web site: http://www.nisc.nih.gov/
Contact: nisc_mgc@nhgri.nih.gov
Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
Young,A., Zhang,L.-H. and Green,E.D.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 15 Row: e Column: 9
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 31881814.
FEATURES Location/Qualifiers
source 1..2131
/db_xref="H-InvDB:HIT000032680"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:10523 IMAGE:3941576"
/tissue_type="Lung, small cell carcinoma"
/clone_lib="NIH_MGC_7"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene 1..2131
/gene="NKX2-1"
/gene_synonym="BHC"
/gene_synonym="NK-2"
/gene_synonym="NKX2.1"
/gene_synonym="TEBP"
/gene_synonym="TTF-1"
/gene_synonym="TTF1"
/db_xref="GeneID:7080"
/db_xref="HGNC:HGNC:11825"
/db_xref="MIM:600635"
CDS 121..1236
/gene="NKX2-1"
/gene_synonym="BHC"
/gene_synonym="NK-2"
/gene_synonym="NKX2.1"
/gene_synonym="TEBP"
/gene_synonym="TTF-1"
/gene_synonym="TTF1"
/codon_start=1
/product="NK2 homeobox 1"
/protein_id="AAH06221.2"
/db_xref="GeneID:7080"
/db_xref="HGNC:HGNC:11825"
/db_xref="MIM:600635"
/translation="MSMSPKHTTPFSVSDILSPLEESYKKVGMEGGGLGAPLAAYRQG
QAAPPTAAMQQHAVGHHGAVTAAYHMTAAGVPQLSHSAVGGYCNGNLGNMSELPPYQD
TMRNSASGPGWYGANPDPRFPAISRFMGPASGMNMSGMGGLGSLGDVSKNMAPLPSAP
RRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKR
QAKDKAAQQQLQQDSGGGGGGGGTGCPQQQQAQQQSPRRVAVPVLVKDGKPCQAGAPA
PGAASLQGHAQQQAQHQAQAAQAAAAAISVGSGGAGLGAHPGHQPGSAGQSPDLAHHA
ASPAALQGQVSSLSHLNSSGSDYGTMSCSTLLYGRTW"
BASE COUNT 478 a 643 c 629 g 381 t
ORIGIN
1 ggcgactggg gctcagcgca gcgaagcccg atgtggtccg gaggcagtgg gaaggcgcgg
61 ggctgggagg ccgcggcggg agggaggagc agccccggca ggctcagccg ccgccgaatc
121 atgtcgatga gtccaaagca cacgactccg ttctcagtgt ctgacatctt gagtcccctg
181 gaggaaagct acaagaaagt gggcatggag ggcggcggcc tcggggctcc gctggcggcg
241 tacaggcagg gccaggcggc accgccaaca gcggccatgc agcagcacgc cgtggggcac
301 cacggcgccg tcaccgccgc ctaccacatg acggcggcgg gggtgcccca gctctcgcac
361 tccgccgtgg ggggctactg caacggcaac ctgggcaaca tgagcgagct gccgccgtac
421 caggacacca tgaggaacag cgcctctggc cccggatggt acggcgccaa cccagacccg
481 cgcttccccg ccatctcccg cttcatgggc ccggcgagcg gcatgaacat gagcggcatg
541 ggcggcctgg gctcgctggg ggacgtgagc aagaacatgg ccccgctgcc aagcgcgccg
601 cgcaggaagc gccgggtgct cttctcgcag gcgcaggtgt acgagctgga gcgacgcttc
661 aagcaacaga agtacctgtc ggcgccggag cgcgagcacc tggccagcat gatccacctg
721 acgcccacgc aggtcaagat ctggttccag aaccaccgct acaaaatgaa gcgccaggcc
781 aaggacaagg cggcgcagca gcaactgcag caggacagcg gcggcggcgg gggcggcggg
841 ggcaccgggt gcccgcagca gcaacaggct cagcagcagt cgccgcgacg cgtggcggtg
901 ccggtcctgg tgaaagacgg caaaccgtgc caggcgggtg cccccgcgcc gggcgccgcc
961 agcctacaag gccacgcgca gcagcaggcg cagcaccagg cgcaggccgc gcaggcggcg
1021 gcagcggcca tctccgtggg cagcggtggc gccggccttg gcgcacaccc gggccaccag
1081 ccaggcagcg caggccagtc tccggacctg gcgcaccacg ccgccagccc cgcggcgctg
1141 cagggccagg tatccagcct gtcccacctg aactcctcgg gctcggacta cggcaccatg
1201 tcctgctcca ccttgctata cggtcggacc tggtgagagg acgccgggcc ggccctagcc
1261 cagcgctctg cctcaccgct tccctcctgc ccgccacaca gaccaccatc caccgctgct
1321 ccacgcgctt cgacttttct taacaacctg gccgcgttta gaccaaggaa caaaaaaacc
1381 acaaaggcca aactgctgga cgtctttctt tttttccccc cctaaaattt gtgggttttt
1441 tttttaaaaa aaagaaaatg aaaaacaacc aagcgcatcc aatctcaagg aatctttaag
1501 cagagaaggg cataaaacag ctttggggtg tctttttttg gtgattcaaa tgggttttcc
1561 acgctagggc ggggcacaga ttggagaggg ctctgtgctg acatggctct ggactctaaa
1621 gaccaaactt cactctgggc acactctgcc agcaaagagg actcgcttgt aaataccagg
1681 attttttttt ttttttgaag ggaggacggg agctggggag aggaaagagt cttcaacata
1741 acccacttgt cactgacaca aaggaagtgc cccctccccg gcaccctctg gccgcctagg
1801 ctcagcggcg accgccctcc gcgaaaatag tttgtttaat gtgaacttgt agctgtaaaa
1861 cgctgtcaaa agttggacta aatgcctagt ttttagtaat ctgtacattt tgttgtaaaa
1921 agaaaaacca ctcccagtcc ccagcccttc acatttttta tgggcattga caaatctgtg
1981 tatattattt ggcagtttgg tatttgcggc gtcagtcttt ttctgttgta acttatgtag
2041 atatttggct taaatatagt tcctaagaag cttctaataa attatacaaa ttaaaaagat
2101 tctttttctg attaaaaaaa aaaaaaaaaa a
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