LOCUS BC005859 3368 bp mRNA linear HUM 02-MAR-2004
DEFINITION Homo sapiens zinc finger protein 589, mRNA (cDNA clone
IMAGE:3533214), partial cds.
ACCESSION BC005859
VERSION BC005859.2
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3368)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 3368)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (02-APR-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT On Aug 19, 2003 this sequence version replaced BC005859.1.
Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Institute for Systems Biology
http://www.systemsbiology.org
contact: amadan@systemsbiology.org
Anup Madan, Jessica Fahey, Erin Helton, Mark Ketteman, Anuradha
Madan, Stephanie Rodrigues, Amy Sanchez and Michelle Whiting
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 11 Row: d Column: 19
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 7706726.
FEATURES Location/Qualifiers
source 1..3368
/db_xref="H-InvDB:HIT000086544"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="IMAGE:3533214"
/tissue_type="Muscle, rhabdomyosarcoma"
/clone_lib="NIH_MGC_17"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene <1..3368
/gene="ZNF589"
/gene_synonym="SZF1"
/db_xref="GeneID:51385"
CDS <1..1120
/gene="ZNF589"
/gene_synonym="SZF1"
/codon_start=2
/product="ZNF589 protein"
/protein_id="AAH05859.2"
/db_xref="GeneID:51385"
/translation="LRACVRAQMWAPREQLLGWTAEALPAKDSAWPWEEKPRYLGPVT
FEDVAVLFTEAEWKRLSLEQRNLYKEVMLENLRNLVSLAESKPEVHTCPSCPLAFGSQ
QFLSQDELHNHPIPGFHAGNQLHPGNPCPEDQPQSQHPSDKNHRGAEAEDQRVEGGVR
PLFWSTNERGALVGFSSLFQRPPISSWGGNRILEIQLSPAQNASSEEVDRISKRAETP
GFGAVTFGECALAFNQKSNLFRQKAVTAEKSSDKRQSQVCRECGRGFSRKSQLIIHQR
THTGEKPYVCGECGRGFIVESVLRNHLSTHSGEKPYVCSHCGRGFSCKPYLIRHQRTH
TREKSFMCTVCGRGFREKSELIKHQRIHTGDKPYVCRD"
misc_feature 128..247
/gene="ZNF589"
/gene_synonym="SZF1"
/note="KRAB; Region: KRAB box. The KRAB domain (or
Kruppel-associated box) is present in about a third of
zinc finger proteins containing C2H2 fingers. The KRAB
domain is found to be involved in protein-protein
interactions. The KRAB domain is generally encoded by two
exons. The regions coded by the two exons are known as
KRAB-A and KRAB-B"
/db_xref="CDD:pfam01352"
misc_feature 770..835
/gene="ZNF589"
/gene_synonym="SZF1"
/note="zf-C2H2; Region: Zinc finger, C2H2 type. The C2H2
zinc finger is the classical zinc finger domain. The two
conserved cysteines and histidines co-ordinate a zinc ion.
The following pattern describes the zinc finger.
#-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be
any amino acid, and numbers in brackets indicate the
number of residues. The positions marked # are those that
are important for the stable fold of the zinc finger. The
final position can be either his or cys. The C2H2 zinc
finger is composed of two short beta strands followed by
an alpha helix. The amino terminal part of the helix binds
the major groove in DNA binding zinc fingers"
/db_xref="CDD:pfam00096"
misc_feature 1019..1087
/gene="ZNF589"
/gene_synonym="SZF1"
/note="zf-C2H2; Region: Zinc finger, C2H2 type. The C2H2
zinc finger is the classical zinc finger domain. The two
conserved cysteines and histidines co-ordinate a zinc ion.
The following pattern describes the zinc finger.
#-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be
any amino acid, and numbers in brackets indicate the
number of residues. The positions marked # are those that
are important for the stable fold of the zinc finger. The
final position can be either his or cys. The C2H2 zinc
finger is composed of two short beta strands followed by
an alpha helix. The amino terminal part of the helix binds
the major groove in DNA binding zinc fingers"
/db_xref="CDD:pfam00096"
BASE COUNT 919 a 795 c 879 g 775 t
ORIGIN
1 gcttcgtgcg tgcgtgcgcg cgcagatgtg ggccccgcgg gagcagctac tgggctggac
61 tgcggaagct ctgcctgcca aggattctgc ctggccctgg gaagagaagc ctagatatct
121 gggaccagtg actttcgagg atgtggctgt gcttttcact gaggcagagt ggaagagact
181 gagccttgag cagaggaacc tatacaaaga agtgatgctg gaaaatctca ggaatctggt
241 ctcattggca gaatcaaagc cagaagtcca tacctgccct tcttgccctc tggcctttgg
301 cagtcagcag ttcctcagcc aagatgagct acacaatcat cctattccag gtttccatgc
361 aggaaatcaa ctccacccag gaaatccctg cccagaggat cagccacagt cacaacatcc
421 ttctgataaa aatcacaggg gggctgaagc agaagatcaa cgagtggaag gaggcgtcag
481 acccttgttt tggagtacaa atgaaagggg ggctttagtg ggtttctcta gcctgttcca
541 gagaccacca ataagctctt ggggaggcaa cagaatatta gagatacagc tcagtccagc
601 ccagaatgca agctctgagg aagtagacag aatttccaag agggcagaaa ccccagggtt
661 tggagcagtc acgtttgggg agtgtgcact agcttttaac cagaagtcaa acctgttcag
721 acagaaggca gtcacagcag aaaaatcttc agacaaaagg cagtcacagg tgtgcaggga
781 gtgtgggcga ggctttagca ggaagtcaca gctcatcata caccagagga cacacacagg
841 agaaaagcct tatgtctgcg gagagtgtgg gcgaggcttt atagttgagt cagtcctccg
901 caaccacctg agtacacact ccggggagaa accttatgtg tgcagccatt gtgggcgagg
961 ctttagctgc aagccatacc tcatcagaca tcagaggaca cacacaaggg agaaatcgtt
1021 tatgtgcaca gtgtgtgggc gaggctttcg tgaaaagtca gagctcatta agcaccagag
1081 aattcacacg ggggataagc cttatgtgtg cagagattga ggccgaggct ttgtaaggag
1141 atcatgtctc aacacacacc agaggataca ttcagatgag aagccttttg tttgcagaga
1201 gtgtgggcga ggctttcgtg ctaaatcaac tctcctccta caccagtgga cacattcaga
1261 ggtgaaacct cacgtgtgtg aggagtgtgg gcatggattt agccagaagt cgtcgctcaa
1321 atcacatcgg agaacacact caggggagaa gccttatgtg tgtggggaat gtgggcgggg
1381 atttagccgg aggatagtcc tcaatggaca ctggaggaca cacacgggag agaagcctta
1441 cacgtgcttt gagtgtgggc gaaactttag cctcaagtcc gctcttagtg tacatcagag
1501 gatacactct ggggagaagc cttatgcatg cacggagtgt gggcaaggct ttatcacgaa
1561 atcacagctc atcagacacc agaggacaca cacaggagaa aagccttatg tctgcggaga
1621 gtgtgggcga ggctttatag ctcagtcaac cctccactac caccggagta cacactccaa
1681 ggaaaaacct tatgtgtgca gccagtgtgg gcgaggcttt tgtgataaat caactctcct
1741 cgcacacgag cagacacatt caggggagaa gccttatgtg tgtggggaat gtgggcgggg
1801 atttggccgg aagatactcc tcaacagaca ctggaggaca cacacaggag agaaacctta
1861 cgcatgcatc gagtgtgggc gaaactttag ccacaagtcc actctcagct tacatcagag
1921 gatacactcg ggggagaagc cttatgcatg cgtggagtgt gggcaaagct ttaggagaaa
1981 gtcacagctc atcatacacc agaagataca ctcggggaaa agctttagag gtgcaaggag
2041 tgaggatgtg attttagcaa caagtcagcc atcagccaca ccagcggaaa tgcttaggga
2101 gaagccttgt ttgtaaggta atgtggacag agctgtacgt ggacatcatt acttgtcacg
2161 tgtcagagga cacactcggg agaaaccttc atggagtgag agtaaggtgt tggctggaag
2221 tggcccctta agagatactt ggagtcaaat ctatccactg tacgcccacc ccactcttgt
2281 tctaagagct ttggggacag tcttttgacc ccttacattc ctttagatgt gaagatgaca
2341 gagatctaac ttctgagagc agaggtgtca agtgacggtc cccttggagg aatggtcttt
2401 gcatctgact acttccttct gcaactgtgt tcttccatta gcttccatga cactctcctg
2461 ctttattttt ttctacatct ctagcctttg ctgtttcctc tcctacccca cctttagatt
2521 ttactcagag ttcagtctcc agccctacaa tctgagggac acctttacca ggtccccttc
2581 ctaaccctcc agtcccaaat ccaagattct ttaaccacac tctaaaagtt cttcagactc
2641 aggacttaaa catagccacg ccaccttggc cttcaatgac agggatctag caatgctgca
2701 tcatcagcct tccaatacca ggtttaaggg tattttaaac acagctcctc ttaaatcctc
2761 caatctcagt acccagtgtt ttagccatgc tcgggtggct aaattacatc caggaatggt
2821 gccagggcct ttagccattt gtctctcctc acactccagg gcccatatgg cccaggttct
2881 gacagtttgc cttactccct tgggctgggg ctagccctac ctgataccct gtgtcaatga
2941 gtgtaccttg gagagctatc cactcaggcc ccagtgcctc tatttgctaa gggactctgc
3001 cacagaaaag aaggggagag atgttcatgt aacctcaaaa tacttaggct tggttttgat
3061 gctagagagg aaaaaggact tggagagaga gaaggaatgg ctggtccaga ggcttttgtc
3121 cactccctct cactggaagt ggttgatctc cagggaatcc ccaaggttag cctgcttagg
3181 ggaagggcta ggggtacctg gaatgtagga tctcccccat gcctggccta ccaccctaat
3241 gtgtctggaa ttggtgggtt cttggtcttg ctgacttcaa gaatgaagcc gtggaccctc
3301 acggtgagtg ttacaattct taaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
3361 aaaaaaaa
//