LOCUS BC005821 2357 bp mRNA linear HUM 04-AUG-2008
DEFINITION Homo sapiens phosphatase and tensin homolog, mRNA (cDNA clone
MGC:11227 IMAGE:3937787), complete cds.
ACCESSION BC005821
VERSION BC005821.2
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2357)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 2357)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (02-APR-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT On Dec 9, 2003 this sequence version replaced BC005821.1.
Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: DCTD/DTP
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Institute for Systems Biology
http://www.systemsbiology.org
contact: amadan@systemsbiology.org
Anup Madan, Jessica Fahey, Erin Helton, Mark Ketteman, Anuradha
Madan, Stephanie Rodrigues, Amy Sanchez and Michelle Whiting
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 14 Row: b Column: 18
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 38505204.
FEATURES Location/Qualifiers
source 1..2357
/db_xref="H-InvDB:HIT000032458"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:11227 IMAGE:3937787"
/tissue_type="Lung, small cell carcinoma"
/clone_lib="NIH_MGC_7"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene 1..2357
/gene="PTEN"
/gene_synonym="MMAC1"
/gene_synonym="PTEN1"
/gene_synonym="TEP1"
/db_xref="GeneID:5728"
/db_xref="HGNC:HGNC:9588"
/db_xref="MIM:601728"
CDS 837..2048
/gene="PTEN"
/gene_synonym="MMAC1"
/gene_synonym="PTEN1"
/gene_synonym="TEP1"
/codon_start=1
/product="phosphatase and tensin homolog"
/protein_id="AAH05821.1"
/db_xref="GeneID:5728"
/db_xref="HGNC:HGNC:9588"
/db_xref="MIM:601728"
/translation="MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEG
VYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIK
PFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRT
RDKKGVTIPSQRRYVYYYSYLLKNHLDYRPVALLFHKMMFETIPMFSGGTCNPQFVVC
QLKVKIYSSNSGPTRREDKFMYFEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHFWVN
TFFIPGPEETSEKVENGSLCDQEIDSICSIERADNDKEYLVLTLTKNDLDKANKDKAN
RYFSPNFKVKLYFTKTVEEPSNPEASSSTSVTPDVSDNEPDHYRYSDTTDSDPENEPF
DEDQHTQITKV"
BASE COUNT 659 a 561 c 584 g 553 t
ORIGIN
1 ctctcggaag ctgcagccat gatggaagtt tgagagttga gccgctgtga ggcgaggccg
61 ggctcaggcg agggagatga gagacggcgg cggccgcggc ccggagcccc tctcagcgcc
121 tgtgagcagc cgcgggggca gcgccctcgg ggagccggcc ggcctgcggc ggcggcagcg
181 gcggcgtttc tcgcctcctc ttcgtctttt ctaaccgtgc agcctcttcc tcggcttctc
241 ctgaaaggga aggtggaagc cgtgggctcg ggcgggagcc ggctgaggcg cggcggcggc
301 ggcggcacct cccgctcctg gagcgggggg gagaagcggc ggcggcggcg gccgcggcgg
361 ctgcagctcc agggaggggg tctgagtcgc ctgtcaccat ttccagggct gggaacgccg
421 gagagttggt ctctcccctt ctactgcctc caacacggcg gcggcggcgg cggcacatcc
481 agggacccgg gccggtttta aacctcccgt ccgccgccgc cgcacccccc gtggcccggg
541 ctccggaggc cgccggcgga ggcagccgtt cggaggatta ttcgtcttct ccccattccg
601 ctgccgccgc tgccaggcct ctggctgctg aggagaagca ggcccagtcg ctgcaaccat
661 ccagcagccg ccgcagcagc cattacccgg ctgcggtcca gagccaagcg gcggcagagc
721 gaggggcatc agctaccgcc aagtccagag ccatttccat cctgcagaag aagccccgcc
781 accagcagct tctgccatct ctctcctcct ttttcttcag ccacaggctc ccagacatga
841 cagccatcat caaagagatc gttagcagaa acaaaaggag atatcaagag gatggattcg
901 acttagactt gacctatatt tatccaaaca ttattgctat gggatttcct gcagaaagac
961 ttgaaggcgt atacaggaac aatattgatg atgtagtaag gtttttggat tcaaagcata
1021 aaaaccatta caagatatac aatctttgtg ctgaaagaca ttatgacacc gccaaattta
1081 attgcagagt tgcacaatat ccttttgaag accataaccc accacagcta gaacttatca
1141 aacccttttg tgaagatctt gaccaatggc taagtgaaga tgacaatcat gttgcagcaa
1201 ttcactgtaa agctggaaag ggacgaactg gtgtaatgat atgtgcatat ttattacatc
1261 ggggcaaatt tttaaaggca caagaggccc tagatttcta tggggaagta aggaccagag
1321 acaaaaaggg agtaactatt cccagtcaga ggcgctatgt gtattattat agctacctgt
1381 taaagaatca tctggattat agaccagtgg cactgttgtt tcacaagatg atgtttgaaa
1441 ctattccaat gttcagtggc ggaacttgca atcctcagtt tgtggtctgc cagctaaagg
1501 tgaagatata ttcctccaat tcaggaccca cacgacggga agacaagttc atgtactttg
1561 agttccctca gccgttacct gtgtgtggtg atatcaaagt agagttcttc cacaaacaga
1621 acaagatgct aaaaaaggac aaaatgtttc acttttgggt aaatacattc ttcataccag
1681 gaccagagga aacctcagaa aaagtagaaa atggaagtct atgtgatcaa gaaatcgata
1741 gcatttgcag tatagagcgt gcagataatg acaaggaata tctagtactt actttaacaa
1801 aaaatgatct tgacaaagca aataaagaca aagccaaccg atacttttct ccaaatttta
1861 aggtgaagct gtacttcaca aaaacagtag aggagccgtc aaatccagag gctagcagtt
1921 caacttctgt aacaccagat gttagtgaca atgaacctga tcattataga tattctgaca
1981 ccactgactc tgatccagag aatgaacctt ttgatgaaga tcagcataca caaattacaa
2041 aagtctgaat ttttttttta tcaagaggga taaaacacca tgaaaataaa cttgaataaa
2101 ctgaaaatgg accttttttt ttttaatggc aataggacat tgtgtcagat taccagttat
2161 aggaacaatt ctcttttcct gaccaatctt gttttaccct atacatccac agggttttga
2221 cacttgttgt ccagttgaaa aaaggttgtg tagctgtgtc atgtatatac ctttttgtgt
2281 caaaaggaca tttaaaattc aattaggatt aataaagatg gcactttccc gttttaaaaa
2341 aaaaaaaaaa aaaaaaa
//