LOCUS       BC004903                1828 bp    mRNA    linear   HUM 15-JUL-2006
DEFINITION  Homo sapiens cerebral cavernous malformation 2, mRNA (cDNA clone
            MGC:4607 IMAGE:3501896), complete cds.
ACCESSION   BC004903
VERSION     BC004903.2
KEYWORDS    MGC.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1828)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
   PUBMED   12477932
REFERENCE   2  (bases 1 to 1828)
  CONSRTM   NIH MGC Project
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2001) National Institutes of Health, Mammalian
            Gene Collection (MGC), Bethesda, MD 20892-2590, USA
  REMARK    NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT     On Aug 19, 2003 this sequence version replaced BC004903.1.
            Contact: MGC help desk
            Email: cgapbs-r@mail.nih.gov
            Tissue Procurement: ATCC
            cDNA Library Preparation: Rubin Laboratory
            cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
            DNA Sequencing by: Institute for Systems Biology
            http://www.systemsbiology.org
            contact: amadan@systemsbiology.org
            Anup Madan, Jessica Fahey, Erin Helton, Mark Ketteman, Anuradha
            Madan, Stephanie Rodrigues, Amy Sanchez and Michelle Whiting
            
            Clone distribution: MGC clone distribution information can be found
            through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
            Series: IRAL Plate: 11 Row: k Column: 3
            This clone was selected for full length sequencing because it
            passed the following selection criteria: matched mRNA gi: 71067339.
FEATURES             Location/Qualifiers
     source          1..1828
                     /db_xref="H-InvDB:HIT000032071"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /clone="MGC:4607 IMAGE:3501896"
                     /tissue_type="Brain, neuroblastoma"
                     /clone_lib="NIH_MGC_19"
                     /lab_host="DH10B-R"
                     /note="Vector: pOTB7"
     gene            1..1828
                     /gene="CCM2"
                     /gene_synonym="MGC4067"
                     /gene_synonym="MGC4607"
                     /gene_synonym="PP10187"
                     /db_xref="GeneID:83605"
                     /db_xref="HGNC:HGNC:21708"
                     /db_xref="MIM:607929"
     CDS             82..1416
                     /gene="CCM2"
                     /gene_synonym="MGC4067"
                     /gene_synonym="MGC4607"
                     /gene_synonym="PP10187"
                     /codon_start=1
                     /product="cerebral cavernous malformation 2"
                     /protein_id="AAH04903.1"
                     /db_xref="GeneID:83605"
                     /db_xref="HGNC:HGNC:21708"
                     /db_xref="MIM:607929"
                     /translation="MEEEGKKGKKPGIVSPFKRVFLKGEKSRDKKAHEKVTERRPLHT
                     VVLSLPERVEPDRLLSDYIEKEVKYLGQLTSIPGYLNPSSRTEILHFIDNAKRAHQLP
                     GHLTQEHDAVLSLSAYNVKLAWRDGEDIILRVPIHDIAAVSYVRDDAAHLVVLKTAQD
                     PGISPSQSLCAESSRGLSAGSLSESAVGPVEACCLVILAAESKVAAEELCCLLGQVFQ
                     VVYTESTIDFLDRAIFDGASTPTHHLSLHSDDSSTKVDIKETYEVEASTFCFPESVDV
                     GGASPHSKTISESELSASATELLQDYMLTLRTKLSSQEIQQFAALLHEYRNGASIHEF
                     CINLRQLYGDSRKFLLLGLRPFIPEKDSQHFENFLETIGVKDGRGIITDSFGRHRRAL
                     STTSSSTTNGNRATGSSDDRSAPSEGDEWDRMISDISSDIEALGCSMDQDSA"
BASE COUNT          410 a          508 c          569 g          341 t
ORIGIN      
        1 cccgggtcga gcatgtagcg gctgctggcg gcggggctcc cggggcgggc cgggcgggcc
       61 gcgggagccg cacgcggcga tatggaagag gagggcaaga agggcaagaa gcctggaatt
      121 gtctcgccat ttaaacgagt attcctaaaa ggtgaaaaga gtagagataa gaaagcccat
      181 gagaaggtga cagagaggcg ccctctgcac actgtggtgt tgtcattgcc tgagcgcgtc
      241 gagccagaca gactgctgag cgactatatt gagaaggagg taaagtattt aggtcagtta
      301 acgtccatac caggatacct gaatccctcc agtaggactg aaatcctgca tttcatagac
      361 aatgcaaaga gagcccacca gcttccggga cacttgactc aggagcacga tgctgtgctc
      421 agcctgtctg cgtacaacgt caagctggcc tggagggacg gggaggatat catcctcagg
      481 gtgcccatcc atgacatcgc cgccgtctcc tatgttcggg atgacgctgc acacctggtg
      541 gtcctgaaga cagcccagga cccagggatc tcccccagcc agagtctgtg tgcggaaagt
      601 tccagaggcc tcagtgcagg ctccctgtcg gagagtgcag ttgggcccgt ggaggcatgc
      661 tgcctggtca tcctggctgc agagagcaag gtcgctgcgg aggagctttg ctgtctgcta
      721 ggccaggtct tccaggttgt ttacacggag tccaccatcg actttctgga cagagcgata
      781 tttgatgggg cctctacccc gacccaccac ctgtccctgc acagcgatga ctcttctaca
      841 aaagtggaca ttaaggagac ctacgaggtg gaagccagca ctttctgctt ccctgaatct
      901 gtggatgtgg gtggtgcatc accccacagc aagaccatca gtgagagcga gctgagcgcc
      961 agcgccactg agctgctgca ggactacatg ctgacgctgc gcaccaagct gtcatcacag
     1021 gagatccagc agtttgcagc actgctgcac gagtaccgca atggggcctc tatccacgag
     1081 ttctgcatca acctgcggca gctctacggg gacagccgca agttcctgct gcttggtctg
     1141 aggcccttca tccctgagaa ggacagccag cacttcgaga acttcctgga gaccattggc
     1201 gtgaaggatg gccgcggcat catcactgac agctttggca ggcaccggcg ggccctgagc
     1261 accacatcca gttccaccac caatgggaac agggccacgg gcagctctga tgaccggtcg
     1321 gcaccctcag agggggatga gtgggaccgc atgatctcgg acatcagcag cgacattgag
     1381 gcgctgggct gcagcatgga ccaggactca gcatgatgga cagtggatgg gggggcaccc
     1441 acaccttccg cgcagtcgtc ataggccttc ccagaaggag ctgcccagac ctgcgtgtca
     1501 gcccttggtg gtggccaggg agaggcgccc ggtgcagatg gccccgggcg gcccaggtcc
     1561 tctactgtga aggagcaggg agctgccgag ggacacgagc ctcagtgcgg ggtggaaggc
     1621 tctttgcctt gtccaccagg gctcagccaa gccctgcagt gtgtccccgc tcggggaggg
     1681 cccggccgag cgggcaggga gagccagtcc tgtcggctgg gcccttggac ggctgtcagt
     1741 tttgcacatg atgttcctat tgtaactctc agagacctta aaaagaagtt tactgcaatg
     1801 tgaataattt aaaaaaaaaa aaaaaaaa
//