LOCUS BC003592 3515 bp mRNA linear HUM 16-DEC-2006
DEFINITION Homo sapiens NLR family, pyrin domain containing 2, mRNA (cDNA
clone MGC:4340 IMAGE:2821428), complete cds.
ACCESSION BC003592
VERSION BC003592.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3515)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 3515)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (20-FEB-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: DCTD/DTP
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Genome Sequence Centre,
BC Cancer Agency, Vancouver, BC, Canada
info@bcgsc.bc.ca
Martin Hirst, Thomas Zeng, Ryan Morin, Michelle Moksa, Johnson
Pang, Diana Mah, Jing Wang, Kieth Fichter, Eric Chuah, Allen
Delaney, Rob Kirkpatrick, Agnes Baross, Sarah Barber, Mabel
Brown-John, Steve S. Chand, William Chow, Ryan Babakaiff, Dave
Wong, Corey Matsuo, Jaclyn Beland, Susan Gibson, Luis delRio, Ruth
Featherstone, Malachi Griffith, Obi Griffith, Ran Guin, Nancy Liao,
Kim MacDonald, Mike R. Mayo, Josh Moran, Diana Palmquist, JR
Santos, Duane Smailus, Jeff Stott, Miranda Tsai, George Yang,
Jacquie Schein, Asim Siddiqui,Steven Jones, Rob Holt, Marco Marra.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 9 Row: l Column: 3
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 8923472.
FEATURES Location/Qualifiers
source 1..3515
/db_xref="H-InvDB:HIT000031625"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:4340 IMAGE:2821428"
/tissue_type="Lung, small cell carcinoma"
/clone_lib="NIH_MGC_7"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene 1..3515
/gene="NLRP2"
/gene_synonym="CLR19.9"
/gene_synonym="FLJ20510"
/gene_synonym="NBS1"
/gene_synonym="PAN1"
/gene_synonym="PYPAF2"
/db_xref="GeneID:55655"
/db_xref="HGNC:HGNC:22948"
/db_xref="MIM:609364"
CDS 67..3255
/gene="NLRP2"
/gene_synonym="CLR19.9"
/gene_synonym="FLJ20510"
/gene_synonym="NBS1"
/gene_synonym="PAN1"
/gene_synonym="PYPAF2"
/codon_start=1
/product="NLR family, pyrin domain containing 2"
/protein_id="AAH03592.1"
/db_xref="GeneID:55655"
/db_xref="HGNC:HGNC:22948"
/db_xref="MIM:609364"
/translation="MVSSAQMGFNLQALLEQLSQDELSKFKYLITTFSLAHELQKIPH
KEVDKADGKQLVEILTTHCDSYWVEMASLQVFEKMHRMDLSERAKDEVREAALKSFNK
RKPLSLGITRKERPPLDVDEMLERFKTEAQAFTETKGNVICLGKEVFKGKKPDKDNRC
RYILKTKFREMWKSWPGDSKEVQVMAERYKMLIPFSNPRVLPGPFSYTVVLYGPAGLG
KTTLAQKLMLDWAEDNLIHKFKYAFYLSCRELSRLGPCSFAELVFRDWPELQDDIPHI
LAQARKILFVIDGFDELGAAPGALIEDICGDWEKKKPVPVLLGSLLNRVMLPKAALLV
TTRPRALRDLRILAEEPIYIRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALF
QLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQLRGALRTL
SLLAAQGLWAQTSVLHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQ
FLTALFYTLEKEEEEDRDGHTWDIGDVQKLLSGVERLRNPDLIQAGYYSFGLANEKRA
KELEATFGCRMSPDIKQELLRCDISCKGGHSTVTDLQELLGCLYESQEEELVKEVMAQ
FKEISLHLNAVDVVPSSFCVKHCRNLQKMSLQVIKENLPENVTASESDAEVERSQDDQ
HMLPFWTDLCSIFGSNKDLMGLAINDSFLSASLVRILCEQIASDTCHLQRVVFKNISP
ADAHRNLCLALRGHKTVTYLTLQGNDQDDMFPALCEVLRHPECNLRYLGLVSCSATTQ
QWADLSLALEVNQSLTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEAN
CKDLAAVLVVSRELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGC
CDLTKLLQEKSSLLCLDLGLNHIGVKGMKFLCEALRKPLCNLRCLWLWGCSIPPFSCE
DLCSALSCNQSLVTLDLGQNPLGSSGVKMLFETLTCSSGTLRTLRLKIDDFNDELNKL
LEEIEEKNPQLIIDTEKHHPWAERPSSHDFMI"
BASE COUNT 872 a 881 c 969 g 793 t
ORIGIN
1 cctcgtgccg ccctcatctc cgccggcgag tagggccagg tgttgggagc tcccacgtgg
61 gacaagatgg tgtcttcggc gcagatgggc ttcaacctgc aggctctcct ggagcagctc
121 agccaggatg agttgagcaa gttcaagtat ctgatcacga ccttctccct ggcacacgag
181 ctccagaaga tcccccacaa ggaggtagac aaggctgatg ggaagcaact ggtagaaatc
241 ctcaccaccc attgtgacag ctactgggtg gagatggcga gcctccaggt ctttgaaaag
301 atgcaccgaa tggatctgtc tgagagagca aaggatgaag tcagagaagc agctttgaaa
361 tcctttaata aaaggaaacc tctatcatta gggataacac ggaaagaacg accacctcta
421 gacgtggacg aaatgctgga gcgcttcaaa acagaagcac aagcgtttac agaaacgaaa
481 ggaaatgtca tctgcctggg taaagaagtc tttaaaggaa aaaagccaga caaagacaat
541 aggtgcaggt atatattgaa gacgaagttc cgggagatgt ggaagagctg gcctggagat
601 agcaaagagg tccaggttat ggctgagaga tacaagatgc tgatcccatt cagcaacccc
661 agggtgcttc ccgggccctt ctcatacacg gtggtgctgt atggtcctgc aggccttggg
721 aaaaccacgc tggcccagaa actaatgcta gactgggcag aggacaacct catccacaaa
781 ttcaaatatg cgttctacct cagctgcagg gagctcagcc gcctgggccc gtgcagtttt
841 gcagagctgg tcttcaggga ctggcctgaa ttgcaggatg acattccaca catcctagcc
901 caagcacgga aaatcttgtt cgtgattgac ggctttgatg agctgggagc cgcacctggg
961 gcgctgatcg aggacatctg cggggactgg gagaagaaga agccggtgcc cgtcctcctg
1021 gggagtttgc tgaacagggt gatgttaccc aaggccgccc tgctggtcac cacgcggccc
1081 agggccctga gggacctccg gatcctggcg gaggagccga tctacataag ggtggagggc
1141 ttcctggagg aggacaggag ggcctatttc ctgagacact ttggagacga ggaccaagcc
1201 atgcgtgcct ttgagctaat gaggagcaac gcggccctgt tccagctggg ctcggccccc
1261 gcggtgtgct ggatcgtgtg cacgactctg aagctgcaga tggagaaggg ggaggacccg
1321 gtccccacct gcctcacccg cacggggctg ttcctgcgtt tcctctgcag ccggttcccg
1381 cagggcgcac agctgcgggg cgcgctgcgg acgctgagcc tcctggccgc gcagggcctg
1441 tgggcgcaga cgtccgtgct tcaccgagag gatctggaaa ggctcggggt gcaggagtcc
1501 gacctccgtc tgttcctgga cggagacatc cttcgccagg acagagtctc caaaggctgc
1561 tactccttca tccacctcag cttccagcag tttctcactg ccctgttcta caccctggag
1621 aaggaggagg aagaggatag ggacggccac acctgggaca ttggggacgt acagaagctg
1681 ctttccggag tagaaagact caggaacccc gacctgatcc aagcaggcta ctactccttt
1741 ggcctcgcta acgagaagag agccaaggag ttggaggcca cttttggctg ccggatgtca
1801 ccggacatca aacaggaatt gctgcgatgc gacataagtt gtaagggtgg acattcaacg
1861 gtgacagacc tgcaggagct cctcggctgt ctgtacgagt ctcaggagga ggagctggtg
1921 aaggaggtga tggctcagtt caaagaaata tccctgcact taaatgcagt agacgttgtg
1981 ccatcttcat tctgcgtcaa gcactgtcga aacctgcaga aaatgtcact gcaggtaata
2041 aaggagaatc tcccggagaa tgtcactgcg tctgaatcag acgccgaggt tgagagatcc
2101 caggatgatc agcacatgct tcctttctgg acggaccttt gttccatatt tggatcaaat
2161 aaggatctga tgggtctagc aatcaatgat agctttctca gtgcctccct agtaaggatc
2221 ctgtgtgaac aaatagcctc tgacacctgt catctccaga gagtggtgtt caaaaacatt
2281 tccccagctg atgctcatcg gaacctctgc ctagctcttc gaggtcacaa gactgtaacg
2341 tatctgaccc ttcaaggcaa tgaccaggat gatatgtttc ccgcattgtg tgaggtcttg
2401 agacatccag aatgtaacct gcgatatctc gggttggtgt cttgttccgc taccactcag
2461 cagtgggctg atctctcctt ggcccttgaa gtcaaccagt ccctgacgtg cgtaaacctc
2521 tccgacaatg agcttctgga tgagggtgct aagttgctgt acacaacttt gagacacccc
2581 aagtgctttc tgcagaggtt gtcgttggaa aactgtcacc ttacagaagc caattgcaag
2641 gaccttgctg ctgtgttggt tgtcagccgg gagctgacac acctgtgctt ggccaagaac
2701 cccattggga atacaggggt gaagtttctg tgtgagggct tgaggtaccc cgagtgtaaa
2761 ctgcagacct tggtgctttg gaactgcgac ataactagcg atggctgctg cgatctcaca
2821 aagcttctcc aagaaaaatc aagcctgttg tgtttggatc tggggctgaa tcacatagga
2881 gttaagggaa tgaagttcct gtgtgaggct ttgaggaaac cactgtgcaa cttgagatgt
2941 ctgtggttgt ggggatgttc catccctccg ttcagttgtg aagacctctg ctctgccctc
3001 agctgcaacc agagcctcgt cactctggac ctgggtcaga atcccttggg gtctagtgga
3061 gtgaagatgc tgtttgaaac cttgacatgt tccagtggca ccctccggac actcaggttg
3121 aaaatagatg actttaatga tgaactcaat aagctgctgg aagaaataga agaaaaaaac
3181 ccacaactga ttattgatac tgagaaacat catccctggg cagaaaggcc ttcttctcat
3241 gacttcatga tctgaatccc cccgagtcat tcattctcca tgaagtcatc gattttccag
3301 gtgttggtga actgcctgtg actcctctcc tccccggccc ctacccctca gggataatga
3361 gttcattgct gggctagatg ttttagccat gattctgcct ctgttttata cctgcacaca
3421 tccttatctt tgttacatat gaaatatctg tatcacgggt atattgagag aaataaaggt
3481 gagagcattc acaaatgaaa aaaaaaaaaa aaaaa
//