LOCUS BC003547 1931 bp mRNA linear HUM 15-JUL-2006
DEFINITION Homo sapiens sirtuin (silent mating type information regulation 2
homolog) 2 (S. cerevisiae), mRNA (cDNA clone MGC:1105
IMAGE:3536728), complete cds.
ACCESSION BC003547
VERSION BC003547.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1931)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 1931)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (20-FEB-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: DCTD/DTP
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Genome Sequence Centre,
BC Cancer Agency, Vancouver, BC, Canada
info@bcgsc.bc.ca
Martin Hirst, Thomas Zeng, Ryan Morin, Michelle Moksa, Johnson
Pang, Diana Mah, Jing Wang, Kieth Fichter, Eric Chuah, Allen
Delaney, Rob Kirkpatrick, Agnes Baross, Sarah Barber, Mabel
Brown-John, Steve S. Chand, William Chow, Ryan Babakaiff, Dave
Wong, Corey Matsuo, Jaclyn Beland, Susan Gibson, Luis delRio, Ruth
Featherstone, Malachi Griffith, Obi Griffith, Ran Guin, Nancy Liao,
Kim MacDonald, Mike R. Mayo, Josh Moran, Diana Palmquist, JR
Santos, Duane Smailus, Jeff Stott, Miranda Tsai, George Yang,
Jacquie Schein, Asim Siddiqui,Steven Jones, Rob Holt, Marco Marra.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 8 Row: n Column: 7
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 13775601.
FEATURES Location/Qualifiers
source 1..1931
/db_xref="H-InvDB:HIT000031585"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:1105 IMAGE:3536728"
/tissue_type="Lung, small cell carcinoma"
/clone_lib="NIH_MGC_7"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene 1..1931
/gene="SIRT2"
/gene_synonym="SIR2L2"
/db_xref="GeneID:22933"
/db_xref="HGNC:HGNC:10886"
/db_xref="MIM:604480"
CDS 257..1315
/gene="SIRT2"
/gene_synonym="SIR2L2"
/codon_start=1
/product="sirtuin (silent mating type information
regulation 2 homolog) 2 (S. cerevisiae)"
/protein_id="AAH03547.1"
/db_xref="GeneID:22933"
/db_xref="HGNC:HGNC:10886"
/db_xref="MIM:604480"
/translation="MDFLRNLFSQTLSLGSQKERLLDELTLEGVARYMQSERCRRVIC
LVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFEISYFKKHPEPFFALAKELY
PGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVS
ASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVD
LLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMIMGLGGGMDFDSKK
AYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQSGAGVPNPSTSASPKK
SPPPAKDEARTTEREKPQ"
BASE COUNT 444 a 601 c 522 g 364 t
ORIGIN
1 cgaaagcgcg tctgcggccg caatgtctgc tgagagttgt agttctgtgc cctatcacgg
61 ccactcccat ttctggtgcc gtcacgggac agagcagtcg gtgacaggac agagcagtcg
121 gtgacgggac acagtggttg gtgacgggac agagcggtcg gtgacagcct caagggcttc
181 agcaccgcgc ccatggcaga gccagaccga ctcagattca gactctgagg gaggagccgc
241 tggtggagaa gcagacatgg acttcctgcg gaacttattc tcccagacgc tcagcctggg
301 cagccagaag gagcgtctgc tggacgagct gaccttggaa ggggtggccc ggtacatgca
361 gagcgaacgc tgtcgcagag tcatctgttt ggtgggagct ggaatctcca catccgcagg
421 catccccgac tttcgctctc catccaccgg cctctatgac aacctagaga agtaccatct
481 tccctaccca gaggccatct ttgagatcag ctatttcaag aaacatccgg aacccttctt
541 cgccctcgcc aaggaactct atcctgggca gttcaagcca accatctgtc actacttcat
601 gcgcctgctg aaggacaagg ggctactcct gcgctgctac acgcagaaca tagataccct
661 ggagcgaata gccgggctgg aacaggagga cttggtggag gcgcacggca ccttctacac
721 atcacactgc gtcagcgcca gctgccggca cgaatacccg ctaagctgga tgaaagagaa
781 gatcttctct gaggtgacgc ccaagtgtga agactgtcag agcctggtga agcctgatat
841 cgtctttttt ggtgagagcc tcccagcgcg tttcttctcc tgtatgcagt cagacttcct
901 gaaggtggac ctcctcctgg tcatgggtac ctccttgcag gtgcagccct ttgcctccct
961 catcagcaag gcacccctct ccacccctcg cctgctcatc aacaaggaga aagctggcca
1021 gtcggaccct ttcctgggga tgattatggg cctcggagga ggcatggact ttgactccaa
1081 gaaggcctac agggacgtgg cctggctggg tgaatgcgac cagggctgcc tggcccttgc
1141 tgagctcctt ggatggaaga aggagctgga ggaccttgtc cggagggagc acgccagcat
1201 agatgcccag tcgggggcgg gggtccccaa ccccagcact tcagcttccc ccaagaagtc
1261 cccgccacct gccaaggacg aggccaggac aacagagagg gagaaacccc agtgacagct
1321 gcatctccca ggcgggatgc cgagctcctc agggacagct gagccccaac cgggcctggc
1381 cccctcttaa ccagcagttc ttgtctgggg agctcagaac atcccccaat ctcttacagc
1441 tccctcccca aaactggggt cccagcaacc ctggccccca accccagcaa atctctaaca
1501 cctcctagag gccaaggctt aaacaggcat ctctaccagc cccactgtct ctaaccactc
1561 ctgggctaag gagtaacctc cctcatctct aactgccccc acggggccag ggctacccca
1621 gaacttttaa ctcttccagg acagggagct tcgggccccc actctgtctc ctgcccccgg
1681 gggcctgtgg ctaagtaaac catacctaac ctaccccagt gtgggtgtgg gcctctgaat
1741 ataacccaca cccagcgtag ggggagtctg agccgggagg gctcccgagt ctctgccttc
1801 agctcccaaa gtgggtggtg ggcccccttc acgtgggacc cacttcccat gctggatggg
1861 cagaagacat tgcttattgg agacaaatta aaaacaaaaa caactaacaa aaaaaaaaaa
1921 aaaaaaaaaa a
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