LOCUS BC002961 1835 bp mRNA linear HUM 01-SEP-2006
DEFINITION Homo sapiens Wiskott-Aldrich syndrome (eczema-thrombocytopenia),
mRNA (cDNA clone IMAGE:3542929), partial cds.
ACCESSION BC002961
VERSION BC002961.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1835)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 1835)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (06-FEB-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Louis M. Staudt, M.D., Ph.D.
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Genome Sequence Centre,
BC Cancer Agency, Vancouver, BC, Canada
info@bcgsc.bc.ca
Martin Hirst, Thomas Zeng, Ryan Morin, Michelle Moksa, Johnson
Pang, Diana Mah, Jing Wang, Kieth Fichter, Eric Chuah, Allen
Delaney, Rob Kirkpatrick, Agnes Baross, Sarah Barber, Mabel
Brown-John, Steve S. Chand, William Chow, Ryan Babakaiff, Dave
Wong, Corey Matsuo, Jaclyn Beland, Susan Gibson, Luis delRio, Ruth
Featherstone, Malachi Griffith, Obi Griffith, Ran Guin, Nancy Liao,
Kim MacDonald, Mike R. Mayo, Josh Moran, Diana Palmquist, JR
Santos, Duane Smailus, Jeff Stott, Miranda Tsai, George Yang,
Jacquie Schein, Asim Siddiqui,Steven Jones, Rob Holt, Marco Marra.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 8 Row: k Column: 10
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 4507908.
FEATURES Location/Qualifiers
source 1..1835
/db_xref="H-InvDB:HIT000086195"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="IMAGE:3542929"
/tissue_type="Lymph, Burkitt lymphoma"
/clone_lib="NIH_MGC_8"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene <1..1835
/gene="WAS"
/gene_synonym="WASP"
/db_xref="GeneID:7454"
/db_xref="HGNC:HGNC:12731"
/db_xref="MIM:300392"
CDS <1..1545
/gene="WAS"
/gene_synonym="WASP"
/codon_start=1
/product="WAS protein"
/protein_id="AAH02961.1"
/db_xref="GeneID:7454"
/db_xref="HGNC:HGNC:12731"
/db_xref="MIM:300392"
/translation="RASPEKTRAESTMSGGPMGGRPGGRGAPAVQQNIPSTLLQDHEN
QRLFEMLGRKCLTLATAVVQLYLALPPGAEHWTKEHCGAVCFVKDNPQKSYFIRLYGL
QAGRLLWEQELYSQLVYSTPTPFFHTFAGDDCQAGLNFADEDEAQAFRALVQEKIQKR
NQRQSGDRRQLPPPPTPANEERRGGLPPLPLHPGGDQGGPPVGPLSLGLATVDIQNPD
ITSSRYRGLPAPGPSPADKKRSGKKKISKADIGAPSGFKHVSHVGWDPQNGFDVNNLD
PDLRSLFSRAGISEAQLTDAETSKLIYDFIEDQGGLEAVRQEMRRQEPLPPPPPPSRG
GNQLPRPPIVGGNKGRSGPLPPVPLGIAPPPPTPRGPPPPGRGGPPPPPPPATGRSGP
LPPPPPGAGGPPMPPPPPPPPPPPSSGNGPAPPPLPPALVPAGGLAPGGGRGALLDQI
RQGIQLNKTPGAPESSALQPPPQSSEGLVGALMHVMQKRSRAIHSSDEGEDQAGDEDE
DDEWDD"
BASE COUNT 427 a 614 c 484 g 310 t
ORIGIN
1 agagcctcgc cagagaagac aagggcagaa agcaccatga gtgggggccc aatgggagga
61 aggcccgggg gccgaggagc accagcggtt cagcagaaca taccctccac cctcctccag
121 gaccacgaga accagcgact ctttgagatg cttggacgaa aatgcttgac gctggccact
181 gcagttgttc agctgtacct ggcgctgccc cctggagctg agcactggac caaggagcat
241 tgtggggctg tgtgcttcgt gaaggataac ccccagaagt cctacttcat ccgcctttac
301 ggccttcagg ctggtcggct gctctgggaa caggagctgt actcacagct tgtctactcc
361 acccccaccc ccttcttcca caccttcgct ggagatgact gccaagcggg gctgaacttt
421 gcagacgagg acgaggccca ggccttccgg gccctcgtgc aggagaagat acaaaaaagg
481 aatcagaggc aaagtggaga cagacgccag ctacccccac caccaacacc agccaatgaa
541 gagagaagag gagggctccc acccctgccc ctgcatccag gtggagacca aggaggccct
601 ccagtgggtc cgctctccct ggggctggcg acagtggaca tccagaaccc tgacatcacg
661 agttcacgat accgtgggct cccagcacct ggacctagcc cagctgataa gaaacgctca
721 gggaagaaga agatcagcaa agctgatatt ggtgcaccca gtggattcaa gcatgtcagc
781 cacgtggggt gggaccccca gaatggattt gacgtgaaca acctcgaccc agatctgcgg
841 agtctgttct ccagggcagg aatcagcgag gcccagctca ccgacgccga gacctctaaa
901 cttatctacg acttcattga ggaccagggt gggctggagg ctgtgcggca ggagatgagg
961 cgccaggagc cacttccgcc gcccccaccg ccatctcgag gagggaacca gctcccccgg
1021 ccccctattg tggggggtaa caagggtcgt tctggtccac tgccccctgt acctttgggg
1081 attgccccac ccccaccaac accccgggga cccccacccc caggccgagg gggccctcca
1141 ccaccacccc ctccagctac tggacgttct ggaccactgc cccctccacc ccctggagct
1201 ggtgggccac ccatgccacc accaccgcca ccaccgccac cgccgcccag ctccgggaat
1261 ggaccagccc ctcccccact ccctcctgct ctggtgcctg ccgggggcct ggcccctggt
1321 gggggtcggg gagcgctttt ggatcaaatc cggcagggaa ttcagctgaa caagacccct
1381 ggggccccag agagctcagc gctgcagcca ccacctcaga gctcagaggg actggtgggg
1441 gccctgatgc acgtgatgca gaagagaagc agagccatcc actcctccga cgaaggggag
1501 gaccaggctg gcgatgaaga tgaagatgat gaatgggatg actgagtggc tgagttactt
1561 gctgccctgt gctcctcccc gcaggacatg gctccccctc cacctgctct gtgcccaccc
1621 tccactctcc tcttccaggc ccccaacccc ccatttcttc cccaccaacc cctccaatgc
1681 tgttatccct gcctggtcct cacactcacc caacaatccc aaggcccttt ttatacaaaa
1741 attctcagtt ctcttcactc aaggattttt aaagaaaaat aaaagaattg tctttctgtc
1801 tctcaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa
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