LOCUS BC002417 2449 bp mRNA linear HUM 15-JUL-2006
DEFINITION Homo sapiens kelch-like ECH-associated protein 1, mRNA (cDNA clone
MGC:1114 IMAGE:3163902), complete cds.
ACCESSION BC002417
VERSION BC002417.2
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2449)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 2449)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (05-FEB-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT On Sep 16, 2003 this sequence version replaced BC002417.1.
Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: National Institutes of Health Intramural
Sequencing Center (NISC),
Gaithersburg, Maryland;
Web site: http://www.nisc.nih.gov/
Contact: nisc_mgc@nhgri.nih.gov
Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
Young,A., Zhang,L.-H. and Green,E.D.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 5 Row: c Column: 19
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 45269143.
FEATURES Location/Qualifiers
source 1..2449
/db_xref="H-InvDB:HIT000030878"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:1114 IMAGE:3163902"
/tissue_type="Brain, neuroblastoma"
/clone_lib="NIH_MGC_19"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene 1..2449
/gene="KEAP1"
/gene_synonym="INrf2"
/gene_synonym="KIAA0132"
/gene_synonym="KLHL19"
/gene_synonym="MGC10630"
/gene_synonym="MGC1114"
/gene_synonym="MGC20887"
/gene_synonym="MGC4407"
/gene_synonym="MGC9454"
/db_xref="GeneID:9817"
/db_xref="HGNC:HGNC:23177"
/db_xref="MIM:606016"
CDS 31..1905
/gene="KEAP1"
/gene_synonym="INrf2"
/gene_synonym="KIAA0132"
/gene_synonym="KLHL19"
/gene_synonym="MGC10630"
/gene_synonym="MGC1114"
/gene_synonym="MGC20887"
/gene_synonym="MGC4407"
/gene_synonym="MGC9454"
/codon_start=1
/product="kelch-like ECH-associated protein 1"
/protein_id="AAH02417.1"
/db_xref="GeneID:9817"
/db_xref="HGNC:HGNC:23177"
/db_xref="MIM:606016"
/translation="MQPDPRPSGAGACCRFLPLQSQCPEGAGDAVMYASTECKAEVTP
SQHGNRTFSYTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLAS
SSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAV
MYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQE
EFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSL
TPNFLQMQLQKCEILQSDSRCKDYLVKIFEELTLHKPTQVMPCRAPKVGRLIYTAGGY
FRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSA
LDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEW
HLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRS
GAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRI
YVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSGRSGVGVAVTMEPCRKQIDQQNCTC
"
BASE COUNT 535 a 699 c 748 g 467 t
ORIGIN
1 gtggtggtgt tgcttatctt ctggaacccc atgcagccag atcccaggcc tagcggggct
61 ggggcctgct gccgattcct gcccctgcag tcacagtgcc ctgagggggc aggggacgcg
121 gtgatgtacg cctccactga gtgcaaggcg gaggtgacgc cctcccagca tggcaaccgc
181 accttcagct acaccctgga ggatcatacc aagcaggcct ttggcatcat gaacgagctg
241 cggctcagcc agcagctgtg tgacgtcaca ctgcaggtca agtaccagga tgcaccggcc
301 gcccagttca tggcccacaa ggtggtgctg gcctcatcca gccctgtctt caaggccatg
361 ttcaccaacg ggctgcggga gcagggcatg gaggtggtgt ccattgaggg tatccacccc
421 aaggtcatgg agcgcctcat tgaattcgcc tacacggcct ccatctccat gggcgagaag
481 tgtgtcctcc acgtcatgaa cggtgctgtc atgtaccaga tcgacagcgt tgtccgtgcc
541 tgcagtgact tcctggtgca gcagctggac cccagcaatg ccatcggcat cgccaacttc
601 gctgagcaga ttggctgtgt ggagttgcac cagcgtgccc gggagtacat ctacatgcat
661 tttggggagg tggccaagca agaggagttc ttcaacctgt cccactgcca actggtgacc
721 ctcatcagcc gggacgacct gaacgtgcgc tgcgagtccg aggtcttcca cgcctgcatc
781 aactgggtca agtacgactg cgaacagcga cggttctacg tccaggcgct gctgcgggcc
841 gtgcgctgcc actcgttgac gccgaacttc ctgcagatgc agctgcagaa gtgcgagatc
901 ctgcagtccg actcccgctg caaggactac ctggtcaaga tcttcgagga gctcaccctg
961 cacaagccca cgcaggtgat gccctgccgg gcgcccaagg tgggccgcct gatctacacc
1021 gcgggcggct acttccgaca gtcgctcagc tacctggagg cttacaaccc cagtgacggc
1081 acctggctcc ggttggcgga cctgcaggtg ccgcggagcg gcctggccgg ctgcgtggtg
1141 ggcgggctgt tgtacgccgt gggcggcagg aacaactcgc ccgacggcaa caccgactcc
1201 agcgccctgg actgttacaa ccccatgacc aatcagtggt cgccctgcgc ccccatgagc
1261 gtgccccgta accgcatcgg ggtgggggtc atcgatggcc acatctatgc cgtcggcggc
1321 tcccacggct gcatccacca caacagtgtg gagaggtatg agccagagcg ggatgagtgg
1381 cacttggtgg ccccaatgct gacacgaagg atcggggtgg gcgtggctgt cctcaatcgt
1441 ctcctttatg ccgtgggggg ctttgacggg acaaaccgcc ttaattcagc tgagtgttac
1501 tacccagaga ggaacgagtg gcgaatgatc acagcaatga acaccatccg aagcggggca
1561 ggcgtctgcg tcctgcacaa ctgtatctat gctgctgggg gctatgatgg tcaggaccag
1621 ctgaacagcg tggagcgcta cgatgtggaa acagagacgt ggactttcgt agcccccatg
1681 aagcaccggc gaagtgccct ggggatcact gtccaccagg ggagaatcta cgtccttgga
1741 ggctatgatg gtcacacgtt cctggacagt gtggagtgtt acgacccaga tacagacacc
1801 tggagcgagg tgacccgaat gacatcgggc cggagtgggg tgggcgtggc tgtcaccatg
1861 gagccctgcc ggaagcagat tgaccagcag aactgtacct gttgaggcac ttttgtttct
1921 tgggcaaaaa tacagtccaa tggggagtat cattgttttt gtacaaaaac cgggactaaa
1981 agaaaagaca gcactgcaaa taacccatct tccgggaagg gaggccagga tgcctcagtg
2041 ttaaaatgac atctcaaaag aagtccaaag cgggaatcat gtgcccctca gcggagcccc
2101 gggagtgtcc aagacagcct ggctgggaaa gggggtgtgg aaagagcagg cttccaggag
2161 agaggccccc aaaccctctg gccgggtaat aggcctgggt cccactcacc catgccggca
2221 gctgtcacca tgtgatttat tcttggatac ctgggagggg gccaatgggg gcctcagggg
2281 gaggccccct ctggaaatgt ggttcccagg gatgggcctg tacatagaag ccaccggatg
2341 gcacttcccc accggatgga cagttatttt gttgataagt aaccctgtaa ttttccaagg
2401 aaaataaaga acagactaac tagtgtcttt caaaaaaaaa aaaaaaaaa
//