LOCUS BC001886 1649 bp mRNA linear HUM 15-JUL-2006
DEFINITION Homo sapiens ribonucleotide reductase M2 polypeptide, mRNA (cDNA
clone MGC:1551 IMAGE:3528619), complete cds.
ACCESSION BC001886
VERSION BC001886.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1649)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 1649)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (29-JAN-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Genome Sequence Centre,
BC Cancer Agency, Vancouver, BC, Canada
info@bcgsc.bc.ca
Martin Hirst, Thomas Zeng, Ryan Morin, Michelle Moksa, Johnson
Pang, Diana Mah, Jing Wang, Kieth Fichter, Eric Chuah, Allen
Delaney, Rob Kirkpatrick, Agnes Baross, Sarah Barber, Mabel
Brown-John, Steve S. Chand, William Chow, Ryan Babakaiff, Dave
Wong, Corey Matsuo, Jaclyn Beland, Susan Gibson, Luis delRio, Ruth
Featherstone, Malachi Griffith, Obi Griffith, Ran Guin, Nancy Liao,
Kim MacDonald, Mike R. Mayo, Josh Moran, Diana Palmquist, JR
Santos, Duane Smailus, Jeff Stott, Miranda Tsai, George Yang,
Jacquie Schein, Asim Siddiqui,Steven Jones, Rob Holt, Marco Marra.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 8 Row: k Column: 7
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 4557844.
FEATURES Location/Qualifiers
source 1..1649
/db_xref="H-InvDB:HIT000030721"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:1551 IMAGE:3528619"
/tissue_type="Muscle, rhabdomyosarcoma"
/clone_lib="NIH_MGC_17"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene 1..1649
/gene="RRM2"
/gene_synonym="R2"
/gene_synonym="RR2M"
/db_xref="GeneID:6241"
/db_xref="HGNC:HGNC:10452"
/db_xref="MIM:180390"
CDS 45..1214
/gene="RRM2"
/gene_synonym="R2"
/gene_synonym="RR2M"
/codon_start=1
/product="ribonucleotide reductase M2 polypeptide"
/protein_id="AAH01886.1"
/db_xref="GeneID:6241"
/db_xref="HGNC:HGNC:10452"
/db_xref="MIM:180390"
/translation="MLSLRVPLAPITDPQQLQLSPLKGLSLVDKENTPPALSGTRVLA
SKTARRIFQEPTEPKTKAAAPGVEDEPLLRENPRRFVIFPIEYHDIWQMYKKAEASFW
TAEEVDLSKDIQHWESLKPEERYFISHVLAFFAASDGIVNENLVERFSQEVQITEARC
FYGFQIAMENIHSEMYSLLIDTYIKDPKEREFLFNAIETMPCVKKKADWALRWIGDKE
ATYGERVVAFAAVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLM
FKHLVHKPSEERVREIIINAVRIEQEFLTEALPVKLIGMNCTLMKQYIEFVADRLMLE
LGFSKVFRVENPFDFMENISLEGKTNFFEKRVGEYQRMGVMSSPTENSFTLDADF"
BASE COUNT 453 a 376 c 393 g 427 t
ORIGIN
1 ccgtcctgtc ctggctgctc gctctgcttc gctgcgccgc cactatgctc tccctccgtg
61 tcccgctcgc gcccatcacg gacccgcagc agctgcagct ctcgccgctg aaggggctca
121 gcttggtcga caaggagaac acgccgccgg ccctgagcgg gacccgcgtc ctggccagca
181 agaccgcgag gaggatcttc caggagccca cggagccgaa aactaaagca gctgcccccg
241 gcgtggagga tgagccgctg ctgagagaaa acccccgccg ctttgtcatc ttccccatcg
301 agtaccatga tatctggcag atgtataaga aggcagaggc ttccttttgg accgccgagg
361 aggtggacct ctccaaggac attcagcact gggaatccct gaaacccgag gagagatatt
421 ttatatccca tgttctggct ttctttgcag caagcgatgg catagtaaat gaaaacttgg
481 tggagcgatt tagccaagaa gttcagatta cagaagcccg ctgtttctat ggcttccaaa
541 ttgccatgga aaacatacat tctgaaatgt atagtcttct tattgacact tacataaaag
601 atcccaaaga aagggaattt ctcttcaatg ccattgaaac gatgccttgt gtcaagaaga
661 aggcagactg ggccttgcgc tggattgggg acaaagaggc tacctatggt gaacgtgttg
721 tagcctttgc tgcagtggaa ggcattttct tttccggttc ttttgcgtcg atattctggc
781 tcaagaaacg aggactgatg cctggcctca cattttctaa tgaacttatt agcagagatg
841 agggtttaca ctgtgatttt gcttgcctga tgttcaaaca cctggtacac aaaccatcgg
901 aggagagagt aagagaaata attatcaatg ctgttcggat agaacaggag ttcctcactg
961 aggccttgcc tgtgaagctc attgggatga attgcactct aatgaagcaa tacattgagt
1021 ttgtggcaga cagacttatg ctggaactgg gttttagcaa ggttttcaga gtagagaacc
1081 catttgactt tatggagaat atttcactgg aaggaaagac taacttcttt gagaagagag
1141 taggcgagta tcagaggatg ggagtgatgt caagtccaac agagaattct tttaccttgg
1201 atgctgactt ctaaatgaac tgaagatgtg cccttacttg gctgattttt tttttccatc
1261 tcataagaaa aatcagctga agtgttacca actagccaca ccatgaattg tccgtaatgt
1321 tcattaacag catctttaaa actgtgtagc tacctcacaa ccagtcctgt ctgtttatag
1381 tgctggtagt atcacctttt gccagaaggc ctggctggct gtgacttacc atagcagtga
1441 caatggcagt cttggcttta aagtgagggg tgacccttta gtgagcttag cacagcggga
1501 ttaaacagtc ctttaaccag cacagccagt taaaagatgc agcctcactg cttcaacgca
1561 gattttaatg tttacttaaa tataaacctg gcactttaca aacaaataaa cattgtttgt
1621 actcacaaaa aaaaaaaaaa aaaaaaaaa
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