LOCUS BC001874 2279 bp mRNA linear HUM 04-OCT-2003
DEFINITION Homo sapiens sequestosome 1, mRNA (cDNA clone MGC:1276
IMAGE:3535436), complete cds.
ACCESSION BC001874
VERSION BC001874.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2279)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 2279)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (29-JAN-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: DCTD/DTP
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Genome Sequence Centre,
BC Cancer Agency, Vancouver, BC, Canada
info@bcgsc.bc.ca
Steven Jones, Jennifer Asano, Ian Bosdet, Yaron Butterfield,
Susanna Chan, Readman Chiu, Chris Fjell, Erin Garland, Ran Guin,
Letticia Hsiao, Martin Krzywinski, Reta Kutsche, Oliver Lee, Soo
Sen Lee, Victor Ling, Carrie Mathewson, Candice McLeavy, Steven
Ness, Pawan Pandoh, Anna-Liisa Prabhu, Parvaneh Saeedi, Jacqueline
Schein, Duane Smailus, Michael Smith, Lorraine Spence, Jeff Stott,
Michael Thorne, Miranada Tsai, Natasja van den Bosch, Jill Vardy,
George Yang, Scott Zuyderduyn, Marco Marra.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 8 Row: i Column: 23.
FEATURES Location/Qualifiers
source 1..2279
/db_xref="H-InvDB:HIT000030713"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:1276 IMAGE:3535436"
/tissue_type="Lung, small cell carcinoma"
/clone_lib="NIH_MGC_7"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene 1..2279
/gene="SQSTM1"
/gene_synonym="p60"
/gene_synonym="p62"
/gene_synonym="ZIP3"
/db_xref="GeneID:8878"
/db_xref="MIM:601530"
CDS 512..1582
/gene="SQSTM1"
/gene_synonym="p60"
/gene_synonym="p62"
/gene_synonym="ZIP3"
/codon_start=1
/product="SQSTM1 protein"
/protein_id="AAH01874.1"
/db_xref="GeneID:8878"
/db_xref="MIM:601530"
/translation="MAMSYVKDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVIC
DGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFSHSRWLR
KVKHGHFGWPGWEMGPPGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESV
AAALSPLGIEVDIDVEHGGKRSRLTPVSPESSSTEEKSSSQPSSCCSDPSKPGGNVEG
ATQSLAEQMRKIALESEGRPEEQMESDNCSGGDDDWTHLSSKEVDPSTGELQSLQMPE
SEGPSSLDPSQEGPTGLKEAALYPHLPPEADPRLIESLSQMLSMGFSDEGGWLTRLLQ
TKNYDIGAALDTIQYSKHPPPL"
misc_feature 623..748
/gene="SQSTM1"
/gene_synonym="p60"
/gene_synonym="p62"
/gene_synonym="ZIP3"
/note="ZnF_ZZ; Region: Zinc-binding domain, present in
Dystrophin, CREB-binding protein. Putative zinc-binding
domain present in dystrophin-like proteins, and
CREB-binding protein/p300 homologues. The ZZ in dystrophin
appears to bind calmodulin. A missense mutation of one of
the conserved cysteines in dystrophin results in a patient
with Duchenne muscular dystrophy"
/db_xref="CDD:smart00291"
misc_feature 1439..1552
/gene="SQSTM1"
/gene_synonym="p60"
/gene_synonym="p62"
/gene_synonym="ZIP3"
/note="UBA; Region: Ubiquitin associated domain"
/db_xref="CDD:smart00165"
BASE COUNT 533 a 620 c 650 g 476 t
ORIGIN
1 cagccgcctt ccgcggccac cgccgggccc gctcccgccg ccgacgccca ggtgcgccag
61 gtgcgggccg ggcgggggtc gcgctcacct ttctggccgc tgagtgccgc gtaccaggac
121 agcgagagga aggcgcacag gcagaagagc agcagcgtca ggaaggtgcc attgcggagc
181 ctcatctcct cgggccaaca atttttttaa ggaaaaaaaa aaagtgactc agttgggcac
241 tgtggcctac gcctgtaatc caagtgagac agccaagtct aaaggggtcc cgctttggga
301 ggccgagacg ggcggatcac gaggtcagga gaccgagacc atcttagcta acacgtgtct
361 gcgagattaa tctctcatgg ccgctgcaca agaacctggc ttttagctga actaaggaga
421 aagtcctaca acagtttggc gtgcaacatg gggcttgaga aaggatgagg acggggactt
481 ggttgccttt tccagtgacg aggaattgac aatggccatg tcctacgtga aggatgacat
541 cttccgaatc tacattaaag agaaaaaaga gtgccggcgg gaccaccgcc caccgtgtgc
601 tcaggaggcg ccccgcaaca tggtgcaccc caatgtgatc tgcgatggct gcaatgggcc
661 tgtggtagga acccgctaca agtgcagcgt ctgcccagac tacgacttgt gtagcgtctg
721 cgagggaaag ggcttgcacc gggggcacac caagctcgca ttccccagcc ccttcgggca
781 cctgtctgag ggcttctcgc acagccgctg gctccggaag gtgaaacacg gacacttcgg
841 gtggccagga tgggaaatgg gtccaccagg aaactggagc ccacgtcctc ctcgtgcagg
901 ggaggcccgc cctggcccca cggcagaatc agcttctggt ccatcggagg atccgagtgt
961 gaatttcctg aagaacgttg gggagagtgt ggcagctgcc cttagccctc tgggcattga
1021 agttgatatc gatgtggagc acggagggaa aagaagccgc ctgacccccg tctctccaga
1081 gagttccagc acagaggaga agagcagctc acagccaagc agctgctgct ctgatcccag
1141 caagccgggt gggaatgttg agggcgccac gcagtctctg gcggagcaga tgagaaagat
1201 cgccttggag tccgaggggc gccctgagga acagatggag tcggataact gttcaggagg
1261 agatgatgac tggacccatc tgtcttcaaa agaagtggac ccgtctacag gtgaactcca
1321 gtccctacag atgccagaat ccgaagggcc aagctctctg gacccctccc aggagggacc
1381 cacagggctg aaggaagctg ccttgtaccc acatctcccg ccagaggctg acccgcggct
1441 gattgagtcc ctctcccaga tgctgtccat gggcttctct gatgaaggcg gctggctcac
1501 caggctcctg cagaccaaga actatgacat cggagcggct ctggacacca tccagtattc
1561 aaagcatccc ccgccgttgt gaccactttt gcccacctct tctgcgtgcc cctcttctgt
1621 ctcatagttg tgttaagctt gcgtagaatt gcaggtctct gtacgggcca gtttctctgc
1681 cttcttccag gatcaggggt tagggtgcaa gaagccattt agggcagcaa aacaagtgac
1741 atgaagggag ggtccctgtg tgtgtgtgtg ctgatgtttc ctgggtgccc tggctccttg
1801 cagcagggct gggcctgcga gacccaaggc tcactgcagc gcgctcctga cccctccctg
1861 caggggctac gttagcagcc cagcacatag cttgcctaat ggctttcact ttctcttttg
1921 ttttaaatga ctcataggtc cctgacattt agttgattat tttctgctac agacctggta
1981 cactctgatt ttagataaag taagcctagg tgttgtcagc aggcaggctg gggaggccag
2041 tgttgtgggc ttcctgctgg gactgagaag gctcacgaag ggcatccgca atgttggttt
2101 cactgagagc tgcctcctgg tctcttcacc actgtagttc tctcatttcc aaaccatcag
2161 ctgcttttaa aataagatct ctttgtagcc atcctgttaa atttgtaaac aatctaatta
2221 aatggcatca gcactttaac caaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaac
//