LOCUS BC001602 2025 bp mRNA linear HUM 15-JUL-2006
DEFINITION Homo sapiens CASP8 and FADD-like apoptosis regulator, mRNA (cDNA
clone MGC:2044 IMAGE:3542993), complete cds.
ACCESSION BC001602
VERSION BC001602.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2025)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 2025)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (03-JAN-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Louis M. Staudt, M.D., Ph.D.
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Genome Sequence Centre,
BC Cancer Agency, Vancouver, BC, Canada
info@bcgsc.bc.ca
Martin Hirst, Thomas Zeng, Ryan Morin, Michelle Moksa, Johnson
Pang, Diana Mah, Jing Wang, Kieth Fichter, Eric Chuah, Allen
Delaney, Rob Kirkpatrick, Agnes Baross, Sarah Barber, Mabel
Brown-John, Steve S. Chand, William Chow, Ryan Babakaiff, Dave
Wong, Corey Matsuo, Jaclyn Beland, Susan Gibson, Luis delRio, Ruth
Featherstone, Malachi Griffith, Obi Griffith, Ran Guin, Nancy Liao,
Kim MacDonald, Mike R. Mayo, Josh Moran, Diana Palmquist, JR
Santos, Duane Smailus, Jeff Stott, Miranda Tsai, George Yang,
Jacquie Schein, Asim Siddiqui,Steven Jones, Rob Holt, Marco Marra.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 8 Row: i Column: 12
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 21361768.
FEATURES Location/Qualifiers
source 1..2025
/db_xref="H-InvDB:HIT000030509"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:2044 IMAGE:3542993"
/tissue_type="Lymph, Burkitt lymphoma"
/clone_lib="NIH_MGC_8"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene 1..2025
/gene="CFLAR"
/gene_synonym="c-FLIP"
/gene_synonym="c-FLIPL"
/gene_synonym="c-FLIPR"
/gene_synonym="c-FLIPS"
/gene_synonym="CASH"
/gene_synonym="Casper"
/gene_synonym="CLARP"
/gene_synonym="FLAME"
/gene_synonym="FLAME-1"
/gene_synonym="FLIP"
/gene_synonym="I-FLICE"
/gene_synonym="MRIT"
/gene_synonym="USURPIN"
/db_xref="GeneID:8837"
/db_xref="HGNC:HGNC:1876"
/db_xref="MIM:603599"
CDS 260..1702
/gene="CFLAR"
/gene_synonym="c-FLIP"
/gene_synonym="c-FLIPL"
/gene_synonym="c-FLIPR"
/gene_synonym="c-FLIPS"
/gene_synonym="CASH"
/gene_synonym="Casper"
/gene_synonym="CLARP"
/gene_synonym="FLAME"
/gene_synonym="FLAME-1"
/gene_synonym="FLIP"
/gene_synonym="I-FLICE"
/gene_synonym="MRIT"
/gene_synonym="USURPIN"
/codon_start=1
/product="CASP8 and FADD-like apoptosis regulator"
/protein_id="AAH01602.1"
/db_xref="GeneID:8837"
/db_xref="HGNC:HGNC:1876"
/db_xref="MIM:603599"
/translation="MSAEVIHQVEEALDTDEKEMLLFLCRDVAIDVVPPNVRDLLDIL
RERGKLSVGDLAELLYRVRRFDLLKRILKMDRKAVETHLLRNPHLVSDYRVLMAEIGE
DLDKSDVSSLIFLMKDYMGRGKISKEKSFLDLVVELEKLNLVAPDQLDLLEKCLKNIH
RIDLKTKIQKYKQSVQGAGTSYRNVLQAAIQKSLKDPSNNFRLHNGRSKEQRLKEQLG
AQQEPVKKSIQESEAFLPQSIPEERYKMKSKPLGICLIIDCIGNETELLRDTFTSLGY
EVQKFLHLSMHGISQILGQFACMPEHRDYDSFVCVLVSRGGSQSVYGVDQTHSGLPLH
HIRRMFMGDSCPYLAGKPKMFFIQNYVVSEGQLEDSSLLEVDGPAMKNVEFKAQKRGL
CTVHREADFFWSLCTADMSLLEQSHSSPSLYLQCLSQKLRQERKRPLLDLHIELNGYM
YDWNSRVSAKEKYYVWLQHTLRKKLILSYT"
BASE COUNT 565 a 452 c 531 g 477 t
ORIGIN
1 cagcaccaag tccgcttcca ggctttcggt ttctttgcct ccatcttggg tgcgccttcc
61 cggcgtctag gggagcgaag gttgaggtgg cagcggcagg agagtccggc cgcgacagga
121 cgaactcccc cactggaaag gattctgaaa gaaatgaagt cagccctcag aaatgaagtt
181 gactgcctgc tggctttctg ttgactggcc cggagctgta ctgcaagacc cttgtgagct
241 tccctagtct aagagtagga tgtctgctga agtcatccat caggttgaag aagcacttga
301 tacagatgag aaggagatgc tgctcttttt gtgccgggat gttgctatag atgtggttcc
361 acctaatgtc agggaccttc tggatatttt acgggaaaga ggtaagctgt ctgtcgggga
421 cttggctgaa ctgctctaca gagtgaggcg atttgacctg ctcaaacgta tcttgaagat
481 ggacagaaaa gctgtggaga cccacctgct caggaaccct caccttgttt cggactatag
541 agtgctgatg gcagagattg gtgaggattt ggataaatct gatgtgtcct cattaatttt
601 cctcatgaag gattacatgg gccgaggcaa gataagcaag gagaagagtt tcttggacct
661 tgtggttgag ttggagaaac taaatctggt tgccccagat caactggatt tattagaaaa
721 atgcctaaag aacatccaca gaatagacct gaagacaaaa atccagaagt acaagcagtc
781 tgttcaagga gcagggacaa gttacaggaa tgttctccaa gcagcaatcc aaaagagtct
841 caaggatcct tcaaataact tcaggctcca taatgggaga agtaaagaac aaagacttaa
901 ggaacagctt ggcgctcaac aagaaccagt gaagaaatcc attcaggaat cagaagcttt
961 tttgcctcag agcatacctg aagagagata caagatgaag agcaagcccc taggaatctg
1021 cctgataatc gattgcattg gcaatgagac agagcttctt cgagacacct tcacttccct
1081 gggctatgaa gtccagaaat tcttgcatct cagtatgcat ggtatatccc agattcttgg
1141 ccaatttgcc tgtatgcccg agcaccgaga ctacgacagc tttgtgtgtg tcctggtgag
1201 ccgaggaggc tcccagagtg tgtatggtgt ggatcagact cactcagggc tccccctgca
1261 tcacatcagg aggatgttca tgggagattc atgcccttat ctagcaggga agccaaagat
1321 gttttttatt cagaactatg tggtgtcaga gggccagctg gaggacagca gcctcttgga
1381 ggtggatggg ccagcgatga agaatgtgga attcaaggct cagaagcgag ggctgtgcac
1441 agttcaccga gaagctgact tcttctggag cctgtgtact gcggacatgt ccctgctgga
1501 gcagtctcac agctcaccat ccctgtacct gcagtgcctc tcccagaaac tgagacaaga
1561 aagaaaacgc ccactcctgg atcttcacat tgaactcaat ggctacatgt atgattggaa
1621 cagcagagtt tctgccaagg agaaatatta tgtctggctg cagcacactc tgagaaagaa
1681 acttatcctc tcctacacat aagaaaccaa aaggctgggc gtagtggctc acacctgtaa
1741 tcccagcact ttgggaggcc aaggagggca gatcacttca ggtcaggagt tcgagaccag
1801 cctggccaac atggtaaacg ctgtccctag taaaaataca aaaattagct gggtgtgggt
1861 gtgggtacct gtattcccag ttacttggga ggctgaggtg ggaggatctt ttgaacccag
1921 gagttcaggg tcatagcatg ctgtgattgt gcctacgaat agccactgca taccaacctg
1981 ggcaatatag caagatccca tctctttaaa aaaaaaaaaa aaaaa
//