LOCUS BC001039 3465 bp mRNA linear HUM 16-DEC-2006
DEFINITION Homo sapiens NLR family, pyrin domain containing 2, mRNA (cDNA
clone MGC:1031 IMAGE:3504594), complete cds.
ACCESSION BC001039
VERSION BC001039.2
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3465)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 3465)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (11-DEC-2000) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT On Sep 16, 2003 this sequence version replaced BC001039.1.
Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Institute for Systems Biology
http://www.systemsbiology.org
contact: amadan@systemsbiology.org
Anup Madan, Jessica Fahey, Erin Helton, Mark Ketteman, Anuradha
Madan, Stephanie Rodrigues, Amy Sanchez and Michelle Whiting
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 7 Row: g Column: 11
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 8923472.
FEATURES Location/Qualifiers
source 1..3465
/db_xref="H-InvDB:HIT000030091"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:1031 IMAGE:3504594"
/tissue_type="Placenta, choriocarcinoma"
/clone_lib="NIH_MGC_21"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene 1..3465
/gene="NLRP2"
/gene_synonym="CLR19.9"
/gene_synonym="FLJ20510"
/gene_synonym="NBS1"
/gene_synonym="PAN1"
/gene_synonym="PYPAF2"
/db_xref="GeneID:55655"
/db_xref="HGNC:HGNC:22948"
/db_xref="MIM:609364"
CDS 23..3211
/gene="NLRP2"
/gene_synonym="CLR19.9"
/gene_synonym="FLJ20510"
/gene_synonym="NBS1"
/gene_synonym="PAN1"
/gene_synonym="PYPAF2"
/codon_start=1
/product="NLR family, pyrin domain containing 2"
/protein_id="AAH01039.1"
/db_xref="GeneID:55655"
/db_xref="HGNC:HGNC:22948"
/db_xref="MIM:609364"
/translation="MVSSAQMGFNLQALLEQLSQDELSKFKYLITTFSLAHELQKIPH
KEVDKADGKQLVEILTTHCDSYWVEMASLQVFEKMHRMDLSERAKDEVREAALKSFNK
RKPLSLGITRKERPPLDVDEMLERFKTEAQAFTETKGNVICLGKEVFKGKKPDKDNRC
RYILKTKFREMWKSWPGDSKEVQVMAERYKMLIPFSNPRVLPGPFSYTVVLYGPAGLG
KTTLAQKLMLDWAEDNLIHKFKYAFYLSCRELSRLGPCSFAELVFRDWPELQDDIPHI
LAQARKILFVIDGFDELGAAPGALIEDICGDWEKKKPVPVLLGSLLNRVMLPKAALLV
TTRPRALRDLRILAEEPIYIRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALF
QLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQLRGALRTL
SLLAAQGLWAQTSVLHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQ
FLTALFYTLEKEEEEDRDGHTWDIGDVQKLLSGVERLRNPDLIQAGYYSFGLANEKRA
KELEATFGCRMSPDIKQELLRCDISCKGGHSTVTDLQELLGCLYESQEEELVKEVMAQ
FKEISLHLNAVDVVPSSFCVKHCRNLQKMSLQVIKENLPENVTASESDAEVERSQDDQ
HMLPFWTDLCSIFGSNKDLMGLAINDSFLSASLVRILCEQIASDTCHLQRVVFKNISP
ADAHRNLCLALRGHKTVTYLTLQGNDQDDMFPALCEVLRHPECNLRYLGLVSCSATTQ
QWADLSLALEVNQSLTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEAN
CKDLAAVLVVSRELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGC
CDLTKLLQEKSSLLCLDLGLNHIGVKGMKFLCEALRKPLCNLRCLWLWGCSIPPFSCE
DLCSALSCNQSLVTLDLGQNPLGSSGVKMLFETLTCSSGTLRTLRLKIDDFNDELNKL
LEEIEEKNPQLIIDTEKHHPWEERPSSHDFMI"
BASE COUNT 865 a 863 c 956 g 781 t
ORIGIN
1 gggagctccc acgtgggaca agatggtgtc ttcggcgcag atgggcttca acctgcaggc
61 tctcctggag cagctcagcc aggatgagtt gagcaagttc aagtatctga tcacgacctt
121 ctccctggca cacgagctcc agaagatccc ccacaaggag gtagacaagg ctgatgggaa
181 gcaactggta gaaatcctca ccacccattg tgacagctac tgggtggaga tggcgagcct
241 ccaggtcttt gaaaagatgc accgaatgga tctgtctgag agagcaaagg atgaagtcag
301 agaagcagct ttgaaatcct ttaataaaag gaagcctcta tcattaggga taacacggaa
361 agaacgacca cctctagacg tggacgaaat gctggagcgc ttcaaaacag aagcacaagc
421 gtttacagaa acgaaaggaa atgtcatctg cctgggtaaa gaagtcttta aaggaaaaaa
481 gccagacaaa gacaataggt gcaggtatat attgaagacg aagttccggg agatgtggaa
541 gagctggcct ggagatagca aagaggtcca ggttatggct gagagataca agatgctgat
601 cccattcagc aaccccaggg tgcttcccgg gcccttctca tacacggtgg tgctgtatgg
661 tcctgcaggc cttgggaaaa ccacgctggc ccagaaacta atgctagact gggcagagga
721 caacctcatc cacaaattca aatatgcgtt ctacctcagc tgcagggagc tcagccgcct
781 gggcccgtgc agttttgcag agctggtctt cagggactgg cctgaattgc aggatgacat
841 tccacacatc ctagcccaag cacggaaaat cttgttcgtg attgacggct ttgatgagct
901 gggagccgca cctggggcgc tgatcgagga catctgcggg gactgggaga agaagaagcc
961 ggtgcccgtc ctcctgggga gtttgctgaa cagggtgatg ttacccaagg ccgccctgct
1021 ggtcaccacg cggcccaggg ccctgaggga cctccggatc ctggcggagg agccgatcta
1081 cataagggtg gagggcttcc tggaggagga caggagggcc tatttcctga gacactttgg
1141 agacgaggac caagccatgc gtgcctttga gctaatgagg agcaacgcgg ccctgttcca
1201 gctgggctcg gcccccgcgg tgtgctggat cgtgtgcacg actctgaagc tgcagatgga
1261 gaagggggag gacccggtcc ccacctgcct cacccgcacg gggctgttcc tgcgtttcct
1321 ctgcagccgg ttcccgcagg gcgcacagct gcggggcgcg ctgcggacgc tgagcctcct
1381 ggccgcgcag ggcctgtggg cgcagacgtc cgtgcttcac cgagaggatc tggaaaggct
1441 cggggtgcag gagtccgacc tccgtctgtt cctggacgga gacatcctcc gccaggacag
1501 agtctccaaa ggctgctact ccttcatcca cctcagcttc cagcagtttc tcactgccct
1561 gttctacacc ctggagaagg aggaggaaga ggatagggac ggccacacct gggacattgg
1621 ggacgtacag aagctgcttt ccggagtaga aagactcagg aaccccgacc tgatccaagc
1681 aggctactac tcctttggcc tcgctaacga gaagagagcc aaggagttgg aggccacttt
1741 tggctgccgg atgtcaccgg acatcaaaca ggaattgctg cgatgcgaca taagttgtaa
1801 gggtggacat tcaacggtga cagacctgca ggagctgctc ggctgtctgt acgagtctca
1861 ggaggaggag ctggtgaagg aggtgatggc tcagttcaaa gaaatatccc tgcacttaaa
1921 tgcagtagac gttgtgccat cttcattctg cgtcaagcac tgtcgaaacc tgcagaaaat
1981 gtcactgcag gtaataaagg agaatctccc ggagaatgtc actgcgtctg aatcagacgc
2041 cgaggttgag agatcccagg atgatcagca catgcttcct ttctggacgg acctttgttc
2101 catatttgga tcaaataagg atctgatggg tctagcaatc aatgatagct ttctcagtgc
2161 ctccctagta aggatcctgt gtgaacaaat agcctctgac acctgtcatc tccagagagt
2221 ggtgttcaaa aacatttccc cagctgatgc tcatcggaac ctctgcctag ctcttcgagg
2281 tcacaagact gtaacgtatc tgacccttca aggcaatgac caggatgata tgtttcccgc
2341 attgtgtgag gtcttgagac atccagaatg taacctgcga tatctcgggt tggtgtcttg
2401 ttccgctacc actcagcagt gggctgatct ctccttggcc cttgaagtca accagtccct
2461 gacgtgcgta aacctctccg acaatgagct tctggatgag ggtgctaagt tgctgtacac
2521 aactttgaga caccccaagt gctttctgca gaggttgtcg ttggaaaact gtcaccttac
2581 agaagccaat tgcaaggacc ttgctgctgt gttggttgtc agccgggagc tgacacacct
2641 gtgcttggcc aagaacccca ttgggaatac aggggtgaag tttctgtgtg agggcttgag
2701 gtaccccgag tgtaaactgc agaccttggt gctttggaac tgcgacataa ctagcgatgg
2761 ctgctgcgat ctcacaaagc ttctccaaga aaaatcaagc ctgttgtgtt tggatctggg
2821 gctgaatcac ataggagtta agggaatgaa gttcctgtgt gaggctttga ggaaaccact
2881 gtgcaacttg agatgtctgt ggttgtgggg atgttccatc cctccgttca gttgtgaaga
2941 cctctgctct gccctcagct gcaaccagag cctcgtcact ctggacctgg gtcagaatcc
3001 cttggggtct agtggagtga agatgctgtt tgaaaccttg acatgttcca gtggcaccct
3061 ccggacactc aggttgaaaa tagatgactt taatgatgaa ctcaataagc tgctggaaga
3121 aatagaagaa aaaaacccac aactgattat tgatactgag aaacatcatc cctgggaaga
3181 aaggccttct tctcatgact tcatgatctg aatccccccg agtcattcat tctccatgaa
3241 gtcatcgatt ttccaggtgt gggtgaactg cctgtgactc ctctcctccc ccgcccctac
3301 ccctcaggga taatgagttc attgctgggc tagatgtttt agccatgatt ctgcctctgt
3361 tttatacctg cacacatcct tatctttgtt acatatgaaa tatctgtatc acgggtatat
3421 tgagagaaat aaaggtgaga gcattcaaaa aaaaaaaaaa aaaaa
//