LOCUS       BC000621                3019 bp    mRNA    linear   HUM 21-OCT-2003
DEFINITION  Homo sapiens neural precursor cell expressed, developmentally
            down-regulated 4-like, mRNA (cDNA clone IMAGE:3346045), partial
            cds.
ACCESSION   BC000621
VERSION     BC000621.2
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3019)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
   PUBMED   12477932
REFERENCE   2  (bases 1 to 3019)
  AUTHORS   Strausberg,R.
  TITLE     Direct Submission
  JOURNAL   Submitted (15-NOV-2000) National Institutes of Health, Mammalian
            Gene Collection (MGC), Cancer Genomics Office, National Cancer
            Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
            USA
  REMARK    NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT     On Oct 8, 2003 this sequence version replaced BC000621.1.
            Contact: MGC help desk
            Email: cgapbs-r@mail.nih.gov
            Tissue Procurement: ATCC/DCTD/DTP
            cDNA Library Preparation: Rubin Laboratory
            cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
            DNA Sequencing by: National Institutes of Health Intramural
            Sequencing Center (NISC),
            Gaithersburg, Maryland;
            Web site: http://www.nisc.nih.gov/
            Contact: nisc_mgc@nhgri.nih.gov
            Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
            Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
            Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
            Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
            Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
            McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
            Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
            Young,A., Zhang,L.-H. and Green,E.D.
            
            Clone distribution: MGC clone distribution information can be found
            through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
            Series: IRAL Plate: 5 Row: o Column: 4
            This clone was selected for full length sequencing because it
            passed the following selection criteria: matched mRNA gi: 21361471.
FEATURES             Location/Qualifiers
     source          1..3019
                     /db_xref="H-InvDB:HIT000085851"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /clone="IMAGE:3346045"
                     /tissue_type="Skin, melanotic melanoma."
                     /clone_lib="NIH_MGC_20"
                     /lab_host="DH10B-R"
                     /note="Vector: pOTB7"
     gene            <1..3019
                     /gene="NEDD4L"
                     /gene_synonym="hNedd4-2"
                     /gene_synonym="KIAA0439"
                     /gene_synonym="RSP5"
                     /db_xref="GeneID:23327"
                     /db_xref="MIM:606384"
     CDS             <1..2568
                     /gene="NEDD4L"
                     /gene_synonym="hNedd4-2"
                     /gene_synonym="KIAA0439"
                     /gene_synonym="RSP5"
                     /codon_start=1
                     /product="NEDD4L protein"
                     /protein_id="AAH00621.2"
                     /db_xref="GeneID:23327"
                     /db_xref="MIM:606384"
                     /translation="RDDFLGQVDVPLSHLPTEDPTMERPYTFKDFLLRPRSHKSRVKG
                     FLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSNDSASQHQEELPPPPLPPGWEEK
                     VDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRHISEDLE
                     PEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQELSEELSRRLQIT
                     PDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSVAYVHTTPGLPSGWEERKD
                     AKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTL
                     SAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGR
                     PFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHN
                     SKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIF
                     EESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYS
                     ATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQI
                     TLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNE
                     NKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDV
                     NDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYG
                     SNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD"
     misc_feature    292..372
                     /gene="NEDD4L"
                     /gene_synonym="hNedd4-2"
                     /gene_synonym="KIAA0439"
                     /gene_synonym="RSP5"
                     /note="WW; Region: WW domain. The WW domain is a protein
                     module with two highly conserved tryptophans that binds
                     proline-rich peptide motifs in vitro"
                     /db_xref="CDD:pfam00397"
     misc_feature    799..2553
                     /gene="NEDD4L"
                     /gene_synonym="hNedd4-2"
                     /gene_synonym="KIAA0439"
                     /gene_synonym="RSP5"
                     /note="HUL4; Region: COG5021, HUL4, Ubiquitin-protein
                     ligase [Posttranslational modification, protein turnover,
                     chaperones]"
                     /db_xref="CDD:COG5021"
BASE COUNT          864 a          734 c          693 g          728 t
ORIGIN      
        1 cgagacgact tcctgggcca ggtggacgtg ccccttagtc accttccgac agaagatcca
       61 accatggagc gaccctatac atttaaggac tttctcctca gaccaagaag tcataagtct
      121 cgagttaagg gatttttgcg attgaaaatg gcctatatgc caaaaaatgg aggtcaagat
      181 gaagaaaaca gtgaccagag ggatgacatg gagcatggat gggaagttgt tgactcaaat
      241 gactcggctt ctcagcacca agaggaactt cctcctcctc ctctgcctcc cgggtgggaa
      301 gaaaaagtgg acaatttagg ccgaacttac tatgtcaacc acaacaaccg gaccactcag
      361 tggcacagac caagcctgat ggacgtgtcc tcggagtcgg acaataacat cagacagatc
      421 aaccaggagg cagcacaccg gcgcttccgc tcccgcaggc acatcagcga agacttggag
      481 cccgagccct cggagggcgg ggatgtcccc gagccttggg agaccatttc agaggaagtg
      541 aatatcgctg gagactctct cggtctggct ctgcccccac caccggcctc cccaggatct
      601 cggaccagcc ctcaggagct gtcagaggaa ctaagcagaa ggcttcagat cactccagac
      661 tccaatgggg aacagttcag ctctttgatt caaagagaac cctcctcaag gttgaggtca
      721 tgcagtgtca ccgacgcagt tgcagaacag ggccatctac caccgccatc agtggcctat
      781 gtacatacca cgccgggtct gccttcaggc tgggaagaaa gaaaagatgc taaggggcgc
      841 acatactatg tcaatcataa caatcgaacc acaacttgga ctcgacctat catgcagctt
      901 gcagaagatg gtgcgtccgg atcagccaca aacagtaaca accatctaat cgagcctcag
      961 atccgccggc ctcgtagcct cagctcgcca acagtaactt tatctgcccc gctggagggt
     1021 gccaaggact cacccgtacg tcgggctgtg aaagacaccc tttccaaccc acagtcccca
     1081 cagccatcac cttacaactc ccccaaacca caacacaaag tcacacagag cttcttgcca
     1141 cccggctggg aaatgaggat agcgccaaac ggccggccct tcttcattga tcataacaca
     1201 aagactacaa cctgggaaga tccacgtttg aaatttccag tacatatgcg gtcaaagaca
     1261 tctttaaacc ccaatgacct tggccccctt cctcctggct gggaagaaag aattcacttg
     1321 gatggccgaa cgttttatat tgatcataat agcaaaatta ctcagtggga agacccaaga
     1381 ctgcagaacc cagctattac tggtccggct gtcccttact ccagagaatt taagcagaaa
     1441 tatgactact tcaggaagaa attaaagaaa cctgctgata tccccaatag gtttgaaatg
     1501 aaacttcaca gaaataacat atttgaagag tcctatcgga gaattatgtc cgtgaaaaga
     1561 ccagatgtcc taaaagctag actgtggatt gagtttgaat cagagaaagg tcttgactat
     1621 gggggtgtgg ccagagaatg gttcttctta ctgtccaaag agatgttcaa cccctactac
     1681 ggcctctttg agtactctgc cacggacaac tacacccttc agatcaaccc taattcaggc
     1741 ctctgtaatg aggatcattt gtcctacttc acttttattg gaagagttgc tggtctggcc
     1801 gtatttcatg ggaagctctt agatggtttc ttcattagac cattttacaa gatgatgttg
     1861 ggaaagcaga taaccctgaa tgacatggaa tctgtggata gtgaatatta caactctttg
     1921 aaatggatcc tggagaatga ccctactgag ctggacctca tgttctgcat agacgaagaa
     1981 aactttggac agacatatca agtggatttg aagcccaatg ggtcagaaat aatggtcaca
     2041 aatgaaaaca aaagggaata tatcgactta gtcatccagt ggagatttgt gaacagggtc
     2101 cagaagcaga tgaacgcctt cttggaggga ttcacagaac tacttcctat tgatttgatt
     2161 aaaatttttg atgaaaatga gctggagttg ctcatgtgcg gcctcggtga tgtggatgtg
     2221 aatgactgga gacagcattc tatttacaag aacggctact gcccaaacca ccccgtcatt
     2281 cagtggttct ggaaggctgt gctactcatg gacgccgaaa agcgtatccg gttactgcag
     2341 tttgtcacag ggacatcgcg agtacctatg aatggatttg ccgaacttta tggttccaat
     2401 ggtcctcagc tgtttacaat agagcaatgg ggcagtcctg agaaactgcc cagagctcac
     2461 acatgcttta atcgccttga cttacctcca tatgaaacct ttgaagattt acgagagaaa
     2521 cttctcatgg ccgtggaaaa tgctcaagga tttgaagggg tggattaagc accctgtgcc
     2581 tcgggggtgg ttgttcttca agcaagttct gcttgcactt ttgcatttgc ctaacagact
     2641 tttgcagagg cgatggcaga gagcagctgc aggcatggtc cctggagccg agccttcacc
     2701 acgcactcgt ccaagttcgg atgcgggaac ctggtcccag cttgagttcc tgcctttccc
     2761 accacaaatt atcaactggt tgatgtgtac actaattaca tttcaggagg acttaatgct
     2821 atttatgttg tgcctctgca ggcaaagccc ttaataaata ttttacatcc tttctaatga
     2881 caatgaatgg aattaatcac tcaacaggta tagtattacg actcatgttt actttttaaa
     2941 atgatttaga ccgattttca gattttattt cgttatgatt aaagatgtct catgtacttg
     3001 gaaaaaaaaa aaaaaaaaa
//